posted
39 kDa (BmpA) band on WB test. I'd like to hear from those who have tested positive for this band. geographic area of infection. symptoms. severity. length of illness etc. Thanks in advance.
cantgiveupyet
Frequent Contributor (1K+ posts)
Member # 8165
posted
I know that you are asking for positive, but i tested IND for band 39 on IGG.
here are my results
IGM 41+ 31IND
IGG 39IND 41+ 66+
Im in Southeastern PA...ive been sick since i was hit hard in August of 2005.
symptoms started with dizziness...panic like attacks...sensitivity to light, frequent urination. vivid vision, unable to drive, unable to go into stores, Numbness of right side of body. low tolerance to heat.
Now i have bladder pain, not getting signal, knee pain, pelvic tightness (possible related to joint/muscles)..lower right back pain. Arm muscle pain. neck stiffness....
posted
Thanks for the reminder. I consider "indeterminate" to be a positive, so I'd like to hear from those folks as well.
Posts: 294 | From nevada | Registered: Sep 2005
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timaca
Frequent Contributor (1K+ posts)
Member # 6911
posted
positive on band 39. I live in AZ. I believe I was bit in AZ. I've been sick since fall of 2003. Been in treatment for 1 year. Severity: needed 4 1/2 months of IVs to feel like I was in the land of the living again. I have been hit with just about every symptom possible except my smell has been fine. If you want more specifics about symptoms please state.
Timaca
Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005
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bpeck
Frequent Contributor (1K+ posts)
Member # 3235
posted
39 kDa is the antibody response for proteins expressed on every pathogen strain of borrelia that causes Lyme - It's specific for no other bacteria- So by itself you can't tell which strain you're infected with. (one of the European strains or North american).
Depending on the year- I've had ++, + and IND on this band (one year on my IgM the only 2 positive were 41 and 39 kDa). And I think I was infected by blood transfusion.
What are you wondering about?
Barb
-------------------- Barb Peck (Elder LymeNet user). Lyme since 1975 Transfusion Posts: 1882 | From VT | Registered: Oct 2002
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Bullseye rashes (3) in 1992. I never saw a tick but I got it in the Cleveland, Ohio area metroparks.
Too many symptoms to list but first was eye pain and floaters, then joint pain....followed by neuro syndrome 7 months later....weakness, numbness, dragging a leg, visions problems,fevers, elevated liver enzymes, brain fog, rashes etc......
Received treatment for about 4 months. I was better but never really normal. Went into remission about 5 years later. Then wham! it all hit again in 2005.
I have MS like symptoms but all MS tests, MRI's are negative. I did get the fibro diagnosis.
Posts: 340 | From Ohio | Registered: Oct 2005
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"Microbial adhesion to and colonization of host tissue is an early, critical event in an infection process.
In the case of Lyme disease, host tissue adherence appears to be of importance during different stages of the disease process.
Initially, during an infected tick's blood meal, a small number of spirochetes are deposited in the dermis of the host, where the bacteria appear to colonize collagen fibers (4, 5).
As the infection disseminates to other tissues, bacteria may colonize additional extracellular matrix structures, and host cells may be involved.
We previously showed that adherence of B. burgdorferi to collagen fibers involved a specific binding of the spirochete to decorin, a dermatan sulfate proteoglycan that is associated with and "decorates" collagen fibers, whereas a direct binding to collagen could not be demonstrated (6-9).
A dermal route of entry into the host appears to be important for the development of disease.
Spirochetes administered intravenously are rapidly and effectively cleared by Kupffer cells in the liver (10), whereas those inoculated intradermally consistently establish infection (11).
Perhaps the initial dermal colonization allows the organism to adapt to in vivo conditions before blood stream dissemination."
Posts: 294 | From nevada | Registered: Sep 2005
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I've seen a Lyme Literate Doctor speak at the Lyme Disease Association of South Eastern PA who said that he has seen that people with a + 39 kDa are the sickest.
He practices in SE PA.
You seem to be coming to the same conclusion.
Corgilla
-------------------- "I'll never forget good old Whatsisname." Posts: 694 | From PA | Registered: Jun 2003
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
I don't think I will be much help, but I love theories, so...On Igenex I tested pos for 39, none of the others:
IGG 30 ++++ 31 IND 39 IND 41 + 93 +
IGM 31 IND 39+ 41+
Sorry, no clue where I got it, when I got it, or how I got it.
I am from Chicago, lived in NYC, and spent summers on the west coast, also travelled to europe, where I recieved one of my bullseyes.
2 Bullseye rashes one in 2001, one in 2003.
Both LLMD's have suggested I have had it for at least 20 years, but I know for sure life turned bad in 2001, after the first "strange" rash.
I have: Arthritis, Menstural Problems, Fatigue, Carpal Tunnel, Sensory Neuropathy, Tachycardia, Migraines, Cognitive Problems, Heart Murmur, Joint Swelling, Irritabillity, Floaters, Foot Pain, Feeling of Suffocating, Bladder Problems, Night Sweats, Hard to Stand, Nausea, Shoulder Dislocations, Tendonitis, Horizontal Ridges in Nails, Asthma, Intolerance to Cold and Heat, Light and Sound Sensitivity, Breast Pain, and Stiff Neck.
I was diagnosed in Jan.
I have been on antibiotics since October, but only because I didn't know what was wrong with me and refused to stop taking them after a brief but definite improvement before the unknown hell of what is now a herx.
I have been on Doxy since Jan. and feel tremendously better. But I am going to have to switch b/c of the burning and infection of my face.
So, while I probably have not added much, I am curious to know your theory.
Posts: 243 | From chicago | Registered: Dec 2005
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cantgiveupyet
Frequent Contributor (1K+ posts)
Member # 8165
posted
LP we have the same IGG.
Cant wait to hear the theory.....welcome :-)
-------------------- "Say it straight simple and with a smile."
"Thus the task is, not so much to see what no one has seen yet, But to think what nobody has thought yet, About what everybody sees."
-Schopenhauer
pos babs, bart, igenex WB igm/igg Posts: 3156 | From Lyme limbo | Registered: Oct 2005
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Michelle M
Frequent Contributor (1K+ posts)
Member # 7200
posted
quote:
I'm interested in your complete WB results. Which lab. If 39kDa is all by itself that's OK. Again, please try and list you geographic location of infection. Whether you remember being bit. By what type of bug? If so, where on your body. Did you acquire the classic "rash". Your symptoms. Length of time infected. Treatment. Effective treatment. Current status. Any lingering/unresolved symptoms. Again, thanks.
IGeneX Western Blot (omitting negative bands)
IGM: 23-25++ 28+ 31+++ 41+ 58+ 66+ 18 IND 30 IND 39 IND 45 IND 93 IND
IGG: 23-25 IND 30 IND 31 IND 39 IND 41 IND 45 IND 58 IND 66 IND
Bitten 4+ years ago in Shingletown (far northern California) by a really TINY tick under right breast; he may have been there for a while when discovered. DID have a rash that stuck around a few weeks, though not a dramatic big scary one like all the pictures, which is why I didn't worry about it at the time.
Symtoms kicked in a year later, made no connection to tick bite, including 24/7 blinding headaches leading me to believe I must have a brain tumour. Curiously my body/joints have not been much bothered with exception of nerve problems in my arms.
Even LLMD admits I have a very strange presentation of Lyme but assures me it is indeed Lyme, or more accurately neuroborreliosis, and NOT MS as neuro duck labelled me. Multiple frontal lobe brain lesions on MRI. Spinal tap was clear for Bb, but showed elevated proteins and opening pressure.
In treatment for close to a year now, stretches of headache-free periods now at almost a record two months! Idiot-brain and memory still a real problem. Multi-tasking at work is frightful. One thing at a time, please. Fatigue improving slowly. Pass the Provigil!
Keep at it, everyone!
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
IgeneX negative bands not included
IGG 18+ 28IND 39++ 41+++ 45IND 58++ 66IND 93IND
IGM 31IND 39IND 41IND
Coombs Canyon near Pendleton Oregon 1959 tick bite on left chest, don't know if I had a rash or not.
Sick off and on since then - as a child - high fevers, seizures, unexplained weight gain, joint pain, suicidal thoughts, severe depression, anxiety, trouble sleeping, nightmares, weakness and some I'm sure I've thankfully forgotten.
The few times I've had antibiotics for a month or more, I've had a remission for several years. I always avoided antibiotics because they made me so ill.
I've had several big crashes since the bite but as an adult the biggest crashes after the birth of my daughter (I was 24) 1979. Final big crash started in 1986 - been disabled since 1988. I suspect I had a massive dissemination througout my tissues during this final crash because I suddenly got what looked like cellulite all over my body, even in places you would not expect to see this, like the top of the shoulders. This happened before I had much weight gain but I was having fluid gain problems at the time. I think it was a collagen breakdown. From what I read in Buhner's book, Bb makes a soup out of our collagen and feeds on it.
As an adult Low blood volume, orthostatic hypotension, hyporeninism, hypoaldosterone, no periods since early 30's, massive fluid swings, sleep apnea, depression, anxiety, severe fatigue, wake up constantly during the night, headaches, weakness, air hunger, severe all over muscle pain, severe joint pain, anxiety and a list of symptoms too long to include.
Oddly enough, my cognitive ability remains fairly good most of the time unless I get too fatigued. Sometimes I will be foggy if I'm in a flare but I'm pretty good most of the time, unlike my siblings.
Years after the dysautonomia diagnosis (hypotension, low blood volume) I was diagnosed with fibromyalgia and CFIDS. Over the years I've balanced my system and managed my symptoms via muscle testing. Without being able to mitigate my symptoms these past 15 years I think I would have killed myself because before I found muscle testing I was seriously contemplating it.
My mother and all of my siblings are sick with similar symptoms, some of our kids too. I'm flying to see an LLMD this coming Sunday. I expect to finally get a diagnosis of lyme but I guess one never knows.
I'd be very interested in the theory behind 39.
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
Welcome, Would you be so kind as to post your stats for this thread? Thanks, Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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No real "theory" ...........yet. Just seeking to gather a pool of info on a possible subset of lymies. I've got some hunches.
Me? Let's just say I'm Bowen 1:128 and lit up a Quest WB at 39kDa...which is saying quite a bit. Best guess is transmission by mosquito bites. In hindsight, many small (quarter) size EMs? on my legs (wearing shorts). Calaveras County, CA. Symptoms I'll leave out for now, for fear of contaminating the responses.
I really wish we could utilise this board to generate some statistical profiles. You'd be surprised how easy it is to start seeing patterns with even a limited set of data.
posted
welcome, I agree with you, it would be interesting and possibly even educational to set up a database.
Obviously, there is a problem with an anonymous forum for accuracy. But if every member had the option to answer a "questionaire" and their privacy was secured we could see some patterns.
You could search for 39 and see the precentage of people that had + for it and with that the precentage people with each symptom, location, time period, treatment.
I think it is a great idea.
For example, I am interested in 30 kda 'cause very few people seem to have it. And it was the only thing I tested strongly for.
Each person could have a profile designated by a number or choose not to show their profile but still be included in the results. And each person with a number could have the option to be blind emailed, if someone with similar problems was interested in talking to them.
We need to be our own doctors, and our own researchers.
Posts: 243 | From chicago | Registered: Dec 2005
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Bitten on the left thigh in So Calif. I remember seeing the tick and the bite. Unfortunately, I didn't know what it was, having never seen a tick before.
Yes it turned into the classic bullseye over the next week or two.
Tons of symptoms initially. Droopy eyes, ringing ears, traveling numbness has affected every part of my body,brain fog, headache, electric current like feelings in the head, stiff neck, stiff spine, aching muscles, shooting pains in various areas, double vision, conjunctivitis, profound fatigue and weakness, heart palpitations, depression, anxiety, weight gain, arthralgia everywhere, inability to walk properly (MS like), tremors, both fine and spastic in the hands and of the head, flu-like symptoms, w/severe sore throat and chest congestion.
I was bitten in the early summer of 2004, began getting sx in the fall of 2004, and wasn't diagnosed until fall of 2005..
I've been on Ketek 400mg BID and 1.2mu Bicillin LA since last October. This protocol has helped a lot, in addition to hot baths. I'm also going to start doing ozone sauna treatments soon.
On a daily basis these are the sx I still have: feet hurt and tingle, arthralgia, but much less severe, ears ring constantly, some flu like feelings, but that's much improved, chest is now clear. Double vision, conjunctivitis, heart palpitations gone, but still have droopy eye and brain fog occasionally, esp when I feel tired or overdo. Most symptoms much improved or gone. Fatigue and brain fog are still my biggest problems, although they're much better as well. I just can't go out and exert myself too much or else I crash.
Posts: 449 | From Pasadena, CA, usa | Registered: Aug 2005
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WB at 39kDa...which is saying quite a bit. Best guess is transmission by mosquito bites. In hindsight, many small (quarter) size EMs? on my legs (wearing shorts). Calaveras County, CA.
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