It looks like grapefruit juice also interferes with the P450 3A4 pathway (just like diflucan, although to a lesser degree I suppose). Has anyone seen a positive effect with grapefruit juice?
[ 14. May 2006, 03:51 PM: Message edited by: david1097 ]
Posts: 1184 | From north america | Registered: Feb 2003
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Ann-OH
Frequent Contributor (5K+ posts)
Member # 2020
posted
up. All this microbiology goes right over my head, but a dear friend has been put on Diflucan for Lyme. Would love to hear how others are doing on it.
Fluconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 alpha-demethylation. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. The subsequent loss of normal sterols correlates with the accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole.[end quote]
posted
I recently had the genomics test done. It showed that I also have trouble with the P450 pathway, shows that I can't take diflucan or flagyl because I have trouble getting estrogen out of my body and these meds block that process
Interesting because I have noticed that when I take long term diflucan or flagyl (over one month) My boobs get bigger and sore. I couldn't figure that out. All the doctors would just look at me and say "I have never heard this"
Well my husband was loving it but I wasn't
It also showed that I am mising a glatathoine gene! I only have 2 not 3! No wonder I have neuro lyme with elevated mercury levels.
Posts: 315 | From USA | Registered: May 2005
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
May I ask how much this test costed and was it covered by insurance?
I just got billed $956 for test that was performed last year. It was a CD-57 test for an NK count.
Go figure! Insurance said they wont cover it, my father just keeps sending it back and telling them to go to hell.
He helps witht the bills.
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
Problem with grapefruit juice is it interfears with so many abx's.
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