LymeNet Flash: CSF, Blood brain barrier, telithromycin-Ketek

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»	LymeNet Flash » Questions and Discussion » Medical Questions » CSF, Blood brain barrier, telithromycin-Ketek

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Topic: CSF, Blood brain barrier, telithromycin-Ketek

LYMESCIENCE
LymeNet Contributor
Member # 9259

posted

Can anyone find numbers relating to Ketek's penetration into the CNS??

Alternativly, has anyone been told it crosses the BBB?

Any info is appriciated:)

Posts: 559 | From Cary, NC | Registered: May 2006 | IP: Logged |

treepatrol
Honored Contributor (10K+ posts)
Member # 4117

posted

All though it has good penetration deep tissue .From what I have read.
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Radioactivity was widely distributed in the rat after oral and intravenous administration, although
levels in the central nervous system were low, indicating poor passage through the blood-brain barrier.
Levels of radioactivity in tissue decreased in parallel to plasma levels with almost complete
elimination of radioactivity by 24 hours after dosing.

From:
http://www.fda.gov/ohrms/dockets/ac/03/briefing/3919B1_01_Aventis-KETEK.pdf

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Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003 | IP: Logged |

Mathias
Frequent Contributor (1K+ posts)
Member # 5298

posted

Good question. Most macrolides do not have good BBB penetration, being this is a close cousin, it will probably be similar.

I saw an interesting post some time ago that stated that Zithromax accumulates in high levels in the brain but has only low level CSF concentrations.

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Mathias

Posts: 1242 | From New Jersey | Registered: Feb 2004 | IP: Logged |

luke339
LymeNet Contributor
Member # 8580

posted

Ketek is listed as not going into to CNS. Zithromax has a poor rating for CSF but good rating for the brain, strange. Mathias is right about that.

Posts: 167 | From Los Angeles | Registered: Jan 2006 | IP: Logged |

Areneli
Frequent Contributor (1K+ posts)
Member # 6740

posted

From the group of macrolides only Rulid gets throught the BBB right into the brain.

Ketek is a close relative to macrolides and doesn't go into the brain.

Posts: 1538 | From Planet Earth | Registered: Jan 2005 | IP: Logged |

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