posted
Im trying to learn more about anti-fibrin/blood-thiners that are available at local health stores.
I know about the highly regarded Rights Regulate.Heres my questions.Has anyone tried Natto-K by Enzymedico? I did see Wobensine(sp?),but it was in the Anti-inflamitory/joint pain relief section,dose it do both jobs? Thanks Alan
-------------------- Charter member of the ~ Delux Toasting Club ~ Our Moto: "Take No Prisoners" Posts: 95 | From San Diego | Registered: Nov 2005
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Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
I've been using it for a couple of years and it has worked very well. It might be a consideration though that I was treated with heparin prior to that for 4 years. So my pipes were already free of fibrin. I don't know how well it would have done if I was starting from scratch.
I think it is a good product though.
Posts: 1251 | From california | Registered: Apr 2005
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-------------------- Charter member of the ~ Delux Toasting Club ~ Our Moto: "Take No Prisoners" Posts: 95 | From San Diego | Registered: Nov 2005
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posted
Nattokinase did not seem to be strong enough for hubby -- doc recommended something like 10 or 15 capsules I think. I think lumbrokinase is stronger -- he tried that too. What we ended up with though is heparin as it is covered by insurance.
The wobenzyme supposedly helps also. Hubby can't take it because he usually has gastritis and it needs to be taken on an empty stomach.
Also should consider taking things like good fats and Vitamin E as well. And to help brain function might consider the circulation boosters like gingko and/or vinpocetine.
Bea Seibert
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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Look up Boluoke. (pronounced bo-loo-kee) It's a specific brand of lumbrokinase that is the best fibrin buster and blood thinner from my experience. It was prescribed for me in place of heparin because it does not have the side effects (bruising) of heparin.
Awhile back I used Rechts Regulat in place of Boluoke and it didn't seem to be as effective. I don't know....I couldn't seem to discern any benefit from the Rechts Regulat but maybe I wasn't taking enough. I took it 2-3 times a day.
Both things are very expensive.
-CLC Posts: 81 | From NJ | Registered: Mar 2005
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
Herbal Supplements That Modulate Coagulation in Cancer Patients Garlic, ginger, ginkgo, and ginseng, known as the "4 Gs," are the most popular herbal supplements used by cancer patients that modulate coagulation. Other herbal supplements that have been demonstrated to interact with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are bromelain, cayenne, chamomile, feverfew, dong quai, eleuthero/Siberian, licorice, bilberry, turmeric, meadowsweet, and willow. Those containing coumarin (chamomile, motherwort, horse chestnut, fenugreek, and red clover) and tamarind enhance the risk of bleeding.
Garlic Garlic is the most extensively researched herbal remedy in the United States and elsewhere, although there is considerable variation in the nature of the research. The major putative active constituents of garlic contain sulfur. Intact cloves contain alliin, which is stable.When a clove is cut, the enzyme alliinase (a C-S lyase)[1] reacts with alliin to form various strong-odored compounds associated with garlic, including the thiosulfinate allicin. Thiosulfinates are highly reactive, consisting of two linked sulfur atoms with an oxygen molecule attached to one. They transform relatively quickly to other substances. Alliin is short-lived and can launch many derivatives, including a large number of related thiosulfinates. Three of the more widely studied stable metabolites are diallyl sulfide, diallyl disulfide, and S-allyl cysteine. Other stable metabolites include ajoene, methyl ajoene, vinyldithiins, diallyl trisulfide, and S-allyl mercaptocysteine. Additional sulfides include methyl allyl trisulfide, allyl propyl disulfide, and allyl mercaptan. In addition, garlic contains fructosans and saponins as potentially active substances.[15]
Garlic has been reported to have antithrombotic properties.[16,17] It contains inhibitors of adenosine deaminase and cyclic AMP phosphodiesterase, which could account for antithrombotic and vasodilatory actions. Ajoene, an antithrombotic substance, is present in small quantities in some forms of macerated garlic.[18] Ajoene [(E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide) is a potent antiplatelet compound isolated from alcoholic extracts of garlic (Allium sativum). Ajoene reversibly inhibits in vitro platelet aggregation as well as release reaction induced by all known agonists, suggesting that ajoene may be useful for the acute prevention of thrombus formation induced by vascular damage.[19] Garlic has antiplatelet aggregation properties in a dose-dependent manner. Aqueous extract of garlic inhibited aggregation induced by adenosine diphosphate, collagen, arachidonate, epinephrine, and calcium ionophore A23187 in a dose-dependent manner. Garlic appears to contain components that might exert their effects at various stages involved in the process of platelet aggregation.[20] In addition, serious hematologic side effects have been reported when garlic has been taken in conjunction with blood-thinning prescription drugs such as warfarin.[21] Garlic changes pharmacokinetic variables of paracetamol, decreases blood concentrations of warfarin, and produces hypoglycemia when taken with chlorpropamide.[21]
Although there have been no randomized, controlled clinical trials on the use of garlic supplements in the preoperative period to examine their effect on bleeding risk, the properties of the constituents and metabolites of garlic to potentially inhibit platelet aggregation and antithrombotic action warrant discontinuation of this herbal supplement prior to surgery. Since the half-life of elimination of garlic is 10 to 30 hours, the patient should discontinue supplementation for a minimum of 2 to 3 days prior to surgery to avoid bleeding and poor surgical wound healing in this potentially nutritionally compromised patient population.
Ginger Ginger is the rhizome part of the plant whose botanical name is Zingiber officinale. Its Chinese name is sheng jiang or shen jing. The plant is also known as Jamaica ginger, ingwer, gengibre, palu, shokyo, shoga, and other names in various cultures. Powdered ginger is the dried rhizome that contains 1% to 4% essential oil, but its composition varies considerably depending on the region where it is grown. Sesquiterpene hydrocarbons cause the characteristic ginger aroma. These compounds include (-)-zingiberene, (+)-ar-curcumene, (-)�-sesquiphellan-drene, and �-bisabolene. The active constituents in ginger are thought to be chemicals known as gingerols [1-(3′-methoxy-4′-hydroxyphenyl)-5-hydroxyalkan-3-ones] and shogaols, their dehydration products, which are responsible for the sharp taste of ginger.[22]
Ginger has been shown to act as a potent inhibitor of thromboxane synthetase, raising levels of prostacyclin without a concomitant rise in prostaglandin E2 or prostaglandin F2 alpha having implications in bleeding times.[23] Patients who are taking anticoagulant drugs or those who have blood coagulation disorders may be at risk if they are also taking ginger supplementation. On the other hand, ginger has been known for its antiemetic properties and has been demonstrated to be as effective as the drug droperidol in the prevention of postoperative nausea and vomiting after outpatient gynecologic surgery.[24] The effect of ginger on postoperative nausea and vomiting was reported to be equal to or better than that of metoclopramide,[25] with significantly fewer cases of postoperative nausea and vomiting in 60 patients taking ginger compared with those taking placebo.[26] However, a double-blind, randomized study[27] found that ginger did not prevent postsurgical nausea and vomiting. In examining the mechanism of action, it is likely that gin-ger's antinausea and antimotion sickness effects derive from its influence on gastric activity and do not involve the central nervous system.[22]
Since no pharmacokinetics (PK) trials on ginger supplementation have been completed yet, the elimination half-life of ginger is unavailable to make a recommendation for its discontinuation a specific number of days prior to surgery based on empirical evidence. However, with the known implications of ginger on coagulation, it would be prudent to discontinue supplements a minimum of 5 to 7 days prior to surgery.
Ginkgo Biloba Ginkgo biloba has been used for thousands of years in China and is widely used in Europe for the treatment of blood circulation disorders. It was the third best-selling herbal product in the US health food market in 1997.[28] The extract is obtained from the leaves of the Ginkgo biloba tree, also known as the maidenhair or kew tree, the oldest known living tree species. The active ingredients in Ginkgo biloba are believed to be two compounds -- flavone glycosides and terpene lactones -- found in the extracts of the whole leaf. Flavone glycosides include three separate bioflavonoids: quercetin (also present in certain vegetables such as red and yellow onion), kaempferol, and isorhamnetin. Terpene lactones are unique to ginkgo and have not been found in any other plant. The flavones act as antioxidants, and the terpene lactones (ginkgolides) inhibit blood clotting.[29]
Ginkgo contains compounds that act as anticoagulants, inhibiting platelet aggregation.[30,31] Long-term use has been associated with increased bleeding time and spontaneous hemorrhage and thus is contraindicated in patients taking prescription anticoagulants such as warfarin. The use of aspirin and NSAIDs combined with Ginkgo biloba extracts has been reported to cause bleeding into the brain and eyes.[32,33] Although the bleeding resolves after discontinuing the ginkgo usage, the combination of ginkgo with aspirin or any drug with anticoagulant action should be avoided during the perioperative period. Other ginkgo interactions include raised blood pressure when combined with a thiazide diuretic and coma when combined with trazodone.[21] Since no trials on the elimination half-life of ginkgo have been conducted, a recommendation to discontinue ginger supplementation prior to surgery lacks empirical evidence. However, with the known implications of ginkgo on coagulation, it would be prudent to discontinue supplements a minimum of 5 to 7 days prior to surgery.
Ginseng Ginseng has been used for centuries in traditional Chinese medicine for diabetes and many conditions associated with aging, including reduced stamina and cognitive decline. The most commonly available and most popular varieties in the United States are the Chinese/Korean variety (Panax ginseng) and the American variety (Panax quinquefolium). The chief constituents responsible for the activity of ginseng are the ginsenosides or panaxocides. Chemical analysis indicates that there are at least four active compounds -- saponin glycoside, panaxin, panacene, and panaxic acid.[34,35]
Ginsenosides have been shown to inhibit platelet aggregation in vitro.[36,37] Animal studies have demonstrated that ginsenocides prolong coagulation times of thrombin and activated partial thromboplastin.[38] A few case reports suggest that ginseng increases bleeding time in subjects taking warfarin, but subsequent animal studies show no significant impact of ginseng on the pharmaco-kinetics/pharmacodynamics of warfarin when the two are concomitantly administered.[39] Yuan et al[40] recently reported that American ginseng administered to 20 patients for a 4-week period reduced the anticoagulant effects of warfarin. Ginseng has also been shown to raise blood pressure, and its use is contraindicated with estrogens or corticosteroids due to possible additive effects.[41] Ginseng has also been reported to cause headache, tremulousness, and manic episodes in patients treated with phenelzine sulfate.[21,41] Pharmacokinetics studies are currently limited to animal models, with elimination half-lives in rabbits ranging between 0.8 and 7.4 hours.[42] Therefore, recommendations to discontinue supplement use 24 hours prior to surgery are warranted.
In summary, the effect of herbal supplements taken perioperatively in wound healing has not been established in clinical trials. However, there is sufficient data that poor platelet aggregation can affect wound healing, as demonstrated in prospective studies in patients using anticoagulant therapies.[43,44] Currently, there are no studies examining the adverse effect of specific herbal supplements on wound healing. With the current knowledge of the pharmacokinetic properties of herbal supplements -- specifically, adverse effects such as inhibition of platelet aggregation -- these herbal supplements may modulate surgical wound healing. To avoid endangering this patient population, this issue would be better addressed in retrospective observations rather than prospective randomized trials.
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Maximum Strength Nattokinase NSK-SD� From traditional Japanese soy food comes a breakthrough supplement. Nattokinase (nat-oh-KY-nase), an enzyme that is extracted from the fermented soy food called ``natto.'' Natto is regarded by the Japanese as a very healthy food and has been consumed there for centuries. Nattokinase, however, has only recently been discovered, isolated and investigated. The research and anecdotal reports are very promising, suggesting that nattokinase confers several important health benefits.
Who discovered Nattokinase (Nattokinase)? Dr. Hiroyuki Sumi, M.D., Ph.D. discovered nattokinase in the 1980's. Dr. Sumi had studied about 200 different foods from around the world, and found that natto was the best fibrinolytic agent (see below). He did further research and was able to isolate the specific enzyme responsible for this fibrinolytic activity. He named this enzyme nattokinase. *
What is fibrin and why does it matter? Fibrin is a protein that naturally forms in the blood after trauma or injury. Fibrin may also form in the absence of any trauma or injury. When unhealthy fibrin formation occurs, there are major implications for cardiovascular health. The consequences can include:
Formation of unhealthy blood clots Increased blood viscosity (thicker) Impaired circulation Effects on blood pressure Blood cells are more likely to stick to vessel walls, especially veins, in a process that further encourages the development of unhealthy clots Many common health conditions, from mild (sore, aching muscles) to life-threatening (stroke), are either caused by or worsened by increased blood viscosity and unhealthy clot formation.
What is a fibrinolytic enzyme? A fibrinolytic enzyme is an enzyme that breaks down or dissolves fibrin. There are 3000 + enzymes in the human body yet only one, plasmin, breaks down fibrin. Unfortunately, the body's production of fibrinolytic enzymes tend to decline with age. Nattokinase and plasmin are known as fibrinolytic enzymes. *
Is Nattokinase safe? Yes. Toxicity studies on nattokinase have indicated no toxicity for this ingredient.
Can Nattokinase be taken with other medications? Nattokinase can be taken in conjunction with other medications. However, if you are pregnant or breastfeeding, or taking prescription medications, please consult with your health care professional before using Nattokinase.
If your doctor is not familiar with Nattokinase�, please contact us so we may provide them with information and address any concerns they may have. Call 800.860.9583
Why Pure Prescriptions� Brand of Nattokinase? Pure Prescriptions offers the same Nattokinase NSK-SD that has been used and proven in clinical studies. The Pure Prescriptions brand of Nattokinase is maximum strength and uses a healthy vegetarian encapsulation in various sizes, 90 and economical 180 count.
Not all Nattokinase is the same, there are safety considerations to be aware of.
It's important to be cautious about the potential hazards we subject our bodies to. And the same holds true for what we should put into our bodies to enhance out health in a safe manner.
Nattokinase NSK-SD� is a potent fibrinolytic from natto, a traditional Japanese fermented soy-based cheese. It has been shown to assist in the healthy flow of blood by supporting the circulatory system of the body.
It's essential that your nattokinase doesn't include Vitamin K in order to prevent an adverse interaction with drugs such as Coumadin�. Thus, our patented process extracts all traces of Vitamin K. To validate the product's safety, more than $1 million has been invested in studies. Plus, NSK-SD contains an unprecedented high activity of nattokinase, over 20,000 fibrin units per gram (FU/g), that's more than 200% the effectiveness of other nattokinase products.
So when it's difficult to tell the difference between one nattokinase and another, trust the one that's been tested, proven and is more effective.
Maximum Strength Nattokinase NSK-SD: validated safe with No Vitamin K. Genuine Nattokinase NSK-SD� is available from Pure Prescriptions.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
I used the one by Enzymedica that you were asking about. Seemed to be the best value at the time. I haven't shopped for better prices in a few months now.
Posts: 1251 | From california | Registered: Apr 2005
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Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
Keep a couple of things in mind as regards to Trees post about anticoagulants. There are several steps in the clotting cascade and the various herbs/supplements that were recommended affect different parts of that clotting cascade.
For instance gingko and ginger I think it was, affect platelets. They prevent platelets from sticking together.
NattoK, Lumbrokinase and the other fibrin busters as they have been called work on the fibrin part of the clotting cascade. The fibrin buildup is what causes the thick sticky blood. That is the issue that was talked about a few days ago on the thread "You Aren't Getting Well".
Taking gingko, ginger, garlic or the likes will NOT remove the fibrin from you blood like we are looking to have done. This is not to say that platelets sticking together is not also a problem for you, but that would be addressed a little bit differently. Example, when I was diagnosed with hypercoagulation, it was also noted that I had a small amount of platelet activation. I was prescribed the heparin to remove the fibrin, but I was also recommended to take a baby aspirin for the platelets sticking together.
Posts: 1251 | From california | Registered: Apr 2005
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
I use serraflazyme (serrapeptase) from Cardiovascular research.
Fibrin buster, blood thinner, helps reduce edema, used for pain. I don't know how it compares with the others but it has been used in Europe for several decades and has quite a few studies that show it is effective. It is reasonably priced. I take 2 2X per day on an empty stomach.
For the millions of Americans who take anti-inflammatory medications to relieve pain and to promote cardiovascular health,1 there is a supplement that shows great promise. The name of this supplement is Serrapeptase and doctors in Europe have been prescribing it to treat everything from pain to atherosclerotic plaques.
Serrapeptase, technically called Serrato Peptidase, is a proteolytic enzyme, which means that it chops up or digests protein. It is produced by bacteria in the gut of silkworms and is used to digest their cocoons. When this enzyme is isolated and coated in the form of a tablet, it has been shown to act as an anti-inflammatory and a pain-blocker, much like aspirin, ibuprofen and other nonsteroidal anti-inflamitory drugs (NSAIDs). What's more, preliminary research indicates that Serrapeptase may even help inhibit plaque build-up in arteries, thereby preventing atherosclerosis (hardening of the arteries) and a resulting heart attack or stroke. Therefore, much like aspirin, this naturally derived enzyme may work to prevent inflammation, pain, heart attack and stroke. Unlike aspirin and other over-the-counter (OTC) NSAIDs, Serrapeptase has not been shown to cause ulcers and stomach bleeding.
Serrapeptase is thought to work in three ways:
It may reduce inflammation by thinning the fluids formed from injury, and facilitating the fluid's drainage. This in turn, also speeds tissue repair. It may help alleviate pain by inhibiting the release of pain-inducing amines called bradykinin. It may enhance cardiovascular health by breaking down the protein by-products of blood coagulation called fibrin. Conveniently, Serrapeptase is able to dissolve the fibrin and other dead or damaged tissue without harming living tissue. This could enable the dissolution of atherosclerotic plaques without causing any harm to the inside of the arteries. Serrapeptase has been used in Europe and Asia for over 25 years. Because the enzyme digests or dissolves all nonliving tissue, including blood clots, cysts and arterial plaque, it is used to treat a variety of conditions, including sprains and torn ligaments, postoperative swelling, venous thrombosis (clots in the legs), ear, nose and throat infections and atherosclerosis.
Abroad, Serrapeptase is marketed under a variety of names including, DanzenTM, AniflazymTM, and SerraZymeTM. In the United States, it has been used and marketed as Serrapeptase since 1997. A pain-reliever and anti-inflammatory supplement that has anti-clotting activities without the risk of stomach bleeding? Sounds too good to be true? Let's look at the research.
The data When searching PubMed for Serrapeptase, one can find close to 40 clinical studies, most of which are from European or Asian researchers, since Serrapeptase has not hit the mainstream in the U.S. The studies, on the whole, conclude that Serrapeptase can have tremendous benefits.
For example, one multi-center, double-blind, randomized trial done at the Institute of Clinical Otorhinolaryngology at the University of Naples, in Italy, found that Serrapeptase acted as an effective anti-inflammatory to improve ear, nose and throat disorders, and the supplement reduced pain. The study, which used 193 people and lasted eight days, also found that Serrapeptase caused no significant side effects.2
Another multi-center, double-blind study, published in the journal, Pharmatherapeutica, found that Serrapeptase reduced swelling in patients who underwent surgery to treat empyema (a collection of pus in the cavity between the lung and the membrane that surrounds it). This study included 174 patients and showed no adverse side effects. Another study involving post-operative swelling, and done by German researchers, showed that patients who had ankle surgery and were given Serrapeptase had a 50% reduction in swelling, while those patients who did not receive Serrapeptase had no reduction in swelling. Patients taking the supplement were also relieved of all pain by the tenth day after surgery.3
A small study (involving 20 patients) done over a period of six weeks and published in the Journal of the Association of Physicians in India, found that Serrapeptase may help improve carpal tunnel syndrome. No significant side effects were observed.4
Another use for Serrapeptase involves the treatment of fibrocystic breast disease. In one double-blind study published in the Singapore Medical Journal, 70 women with breast engorgement were randomly divided into a treatment and placebo group. There was more reduction of breast pain and swelling in the women receiving Serrapeptase than there was for the women who did not receive the supplement. Again, no adverse reactions were reported.5
As for the cardiovascular benefits of Serrapeptase, the evidence supporting this is mostly anecdotal and based in large part on the research of the late Hans A. Nieper, M.D., an internist from Hannover, Germany, who is widely known and also considered antiestablishment. He studied the effects of Serrapeptase on plaque accumulations in the arteries. A book about Dr. Nieper's work, entitled, The Curious Man: The Life and Works of Dr. Hans Nieper (Avery Penguin Putnam, December 1998), provides insight into his studies. An Italian study done at the University of Naples in the department of vascular surgery, did show that Serrapeptase was effective and well tolerated in patients with inflammatory venous diseases. But more research is necessary to accurately and specifically determine the effects Serrapeptase can have on cardiovascular health.
Safety As with every substance one consumes (from food to pills), there is the potential for risk. Just because something is ``natural'' doesn't mean it is automatically harmless. Certainly, the ongoing and recent controversy over the regulation of nutritional supplements indicates that one needs to be cautious and informed when using any supplement. While naturally derived supplements can be beneficial and safe, they can also be harmful if used carelessly or without the help of a medical professional.
That said, Serrapeptase is a powerful enzyme that comes with a few cautions. In elderly people who use the product over a long period of time, gastrointestinal irritation can occur, though this is rare. There is also the increased risk of infection of the lung and pneumonia when using Serrapeptase. This is rare (as evidenced by a few isolated letters to the editor in medical journals)6 but is a possibility because Serrapeptase thins mucus secretions, which can lead to lung complications if one has a history of lung problems. Also note that the studies involving Serrapeptase do not extend over a long period of time. Therefore, the long-term effects of this supplement have not yet been determined.
Dosage The recommended dose is 10 mg to 30 mg per day. For prevention, 10 mg daily. For arthritis, sinusitis, fibrocystic breast, bronchitis and cardiovascular problems, 20 mg daily. For pain, start with 10 mg daily and work up to 20 mg if needed. For injury, trauma or post surgery recovery, take 30 mg daily for two days, then go down to 20 mg daily until swelling and pain subside. Be sure to take Serrapeptase on an empty stomach, meaning that Serrapeptase should be taken at least two hours after eating, and no food should be consumed for a half hour after taking Serrapeptase.
It is important to note that not all Serrapeptase products are created equal. The enzyme activity is measured in units and clinical studies are based on the ratio of 10 mg of Serrapeptase equaling 20,000 units of activity. When purchasing the product be sure that the ratio of mg to units is 10 mg for every 20,000 units, or 5 mg for 10,000 units and so on. The average dose, therefore, is 20 mg-or 40,000 units.
Posts: 6286 | From Oregon | Registered: Jan 2006
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posted
Wow!...great information...Thanks everyone! Alan
-------------------- Charter member of the ~ Delux Toasting Club ~ Our Moto: "Take No Prisoners" Posts: 95 | From San Diego | Registered: Nov 2005
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posted
I second the Boluke. The lumbrokinase is made from earthworms...I know...gross, but I have talked w/multiple lyme docs, and researched it and it seems to work well for me.
Good luck!
jloisu
-------------------- jloisu Posts: 197 | From Seeing Lyme Green in Iowa | Registered: Jun 2005
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I have found Serraflazyme and Yunan Baiyao(a Chinese formula) to be the most effective fibrin busters for me.
Yunan Baiyao contains pseudoginseng root which promotes blood circulation and promotes healing from trauma and injury at the same time.
So I find it to be quite helpful to prevent the sticky blood issues but also to promote healing from the injuries that Lyme inflicts inside the body. Each of them serraflazyme, or Yunan Baiyao work well individually.
The Serraflazyme is really cheap from VitaminShoppe.com, which is where I get it.
Farah
Posts: 208 | From New Mexico | Registered: Dec 2005
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posted
You might want a doc to run a test to check your fibrin levels first. Mine did. Very high fibrin. Fibrin is bad because it keeps the bugs & abx and everything else in. Doc started me on NattoK first but then switched to Persciption heparin before I was to start abx, he says it works better and faster, i've found that to be true, He won't do abx if your fibrin is high and you haven't done heparin.
Posts: 31 | From Los Angeles, Ca | Registered: Oct 2005
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
I have used Rechts Regulat and found it to be a useful product. www.BioPureUS.com is where I get mine from.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Pulling a file...for some starters:
Fibrinogen and antifibrinolytic agents
binding could be completely inhibited by the lysine analog epsilon-aminocaproic acid
epsilon aminocaproic acid Information
Antifibrinolytic (an-tee-fye-bri-noh-LIT-ik ) agents are used to treat serious bleeding, especially when the bleeding occurs after dental surgery (particularly in patients with hemophilia) or certain other kinds of surgery.
These medicines are also sometimes given before an operation to prevent serious bleeding in patients with medical problems that increase the chance of serious bleeding.
Antifibrinolytic agents may also be used for other conditions as determined by your doctor. Antifibrinolytic agents are available only with your doctors prescription, in the following dosage forms: � Oral � Aminocaproic acid o Syrup (U.S. and Canada) o Tablets (U.S. and Canada) � Tranexamic acid o Tablets (U.S. and Canada) � Parenteral � Aminocaproic acid o Injection (U.S. and Canada) � Tranexamic acid o Injection (U.S. and Canada)
The exact mechanism by which magnesium influences thrombus formation is not clear. Potential mechanisms include effects on platelets, coagulation, and fibrinolysis.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1544.) � 2001 American Heart Association, Inc.
Thrombosis
Intravenous Magnesium in Experimental Stent Thrombosis in Swine
The mechanism of action of antifibrinolytic agents is to block plasmin and plasminogen binding sites and completely inhibit fibrinogen's conversion to fibrin.
These are very potent drugs with a myriad of risk factors including renal failure, thrombosis, and anaphylactic shock. These drugs are used in cases of excessive bleeding, post-surgery and in bypass surgery.3
Be aware that you can deplete your stores of magnesium and potassium by ingesting too much salt or
Mg also has a fibrinolytic action [13], prolongs clotting time, delays peak thrombin time [15], slows down platelet clumping [27] and appears to reduce fibrinogen levels, all of which may prevent development or extension of an infarct.
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Alan
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