posted
no but may be helpful. controls glutamate overactivity at the NMDA receptor. this is likely a known excitotoxic route, and may be worth trying to block with memantine/Namenda. favourable response may be obfuscated by initial overstimulation if it causes release of catecholamines into a dysfunctional neurology, as with lyme, and how stimulants can commonly make this worse, sometimes extremely worse, not better.
may be worth asking if anyone has had any unexpected benefits with Symmetrel/amantadine while adding it to augment antibiotics. one of its actions is like memantine/Namenda, and is also sometimes effectively anti-parkinsonian.
if experienced, note if feelings of rigidity and tension subside. i have tried neither drug, but i have both of these problems, and typical neuro uses of these drugs are often to address symptoms like this. i worry that it may be anticholinergic, though that may be a simplistic worry that doesn't convert in practice.
yay, that was coherent i think. yay, nerdy-me. now watch me get my clothes on and get out the door properly in clothes i haven't already been wearing for the whole past week. sigh!
anyway, good luck.
(ARG! i forgot how it may help with fog. how do i lose every topic?! anyway! people take it psychiatricly to deal with cognitive problems, and it is also in research for OCD. it's cognitive effects are unclear, but definately helps some people. likely especially with CFS/cog.fog related symptoms, presuming that translates well to lyme patients. NMDA receptors and glutamate are a hot topic with some CFS doctors/reseachers following a 'neurosomatic' type philosophy and approach, like jay a. goldstein)
Posts: 244 | From Ottawa | Registered: Dec 2005
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"Namenda has been a Godsend for me." Brain fog has eased up, but a least now I can still function, there where days I had a very hard time recogonizing what numbers & letters mean/who people were that knew me (I would think ,ok this person knows about me, but who the heck is this person,dah: my sister-in -law!!!)Things like that.I still have days like that just not as many. It takes a long time to responsed to a questions(Thank goodness for spell check & a dictionary) My energy gets drained fast. I highly recommend "Namenda"!!!!!!"Peace be with us All",Robin
Posts: 139 | From Panama City, FL., USA | Registered: Jun 2005
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Lymelighter
Frequent Contributor (1K+ posts)
Member # 5310
posted
Robin, what dose are you on? 5, 10mgs?
Posts: 1010 | From Mars | Registered: Feb 2004
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posted
Lymelighter, I'm on 10mg twice a day(1 morning when I get up, 1 before bed) It has worked wonders for me. Robin
Posts: 139 | From Panama City, FL., USA | Registered: Jun 2005
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posted
I tried it. It really helped mine a bunch. It turns of one of your neurotranmitters that gets affected by neurotoxins. Wow i was prescibed the stuff like last year, when I did a search here there was nothing on it. FFC is really ahead of things i see.
Posts: 31 | From Los Angeles, Ca | Registered: Oct 2005
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posted
is namenda stimulating or relaxing?? i dont need anything that will make me more hyper than i already am!! thanks radha
Posts: 392 | From New York | Registered: Dec 2005
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Boomerang
Frequent Contributor (1K+ posts)
Member # 7979
posted
quote:Originally posted by Somerset: "Namenda has been a Godsend for me." Brain fog has eased up, but a least now I can still function, there where days I had a very hard time recogonizing what numbers & letters mean/who people were that knew me (I would think ,ok this person knows about me, but who the heck is this person,dah: my sister-in -law!!!)Things like that.I still have days like that just not as many. It takes a long time to responsed to a questions(Thank goodness for spell check & a dictionary) My energy gets drained fast. I highly recommend "Namenda"!!!!!!"Peace be with us All",Robin
Oh my gosh. this was good for you? Sorry, I'm clueless about this. Is this a prescription thing?
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Brain fog can be due to various problems.
Yeast die off.
And certainly too much glutamate.
CoQ10 can help.
Normally, Mg and Zinc block the NMDA receptors. But those nutrients are deficient in lyme.
Mg works with B6...always.
Lots of people find Ginkgo helps...via dilating the vessels = more nutrients delivered.
Works, but not if your vertebral arteries are too small, then will trigger a seizure.
Do you have a history of ADHD, Learning Disabilities, seizures, migraines...PRIOR to lyme?
If not...ginkgo might be okay to try.
It is in Pharmanex vit-mineral supp.
IMO, it is safer to go a more natural route if possible.
This drug looks to leave the body via the urine. I will research more later, but for now:
What should I tell my health care provider?
"Tell your health care provider if you:
have kidney problems
have a condition or take other medicines that make your urine alkaline
are pregnant, are trying to become pregnant, or are breast-feeding
Tell your health care provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Namenda and other medicines may affect each other, causing serious side effects. Especially tell your health care provider if you take:
medicines called NMDA antagonists such as amantadine (Symmetrel), ketamine (Ketalar) and dextromethorphan
other medicines that pass out of the body through the kidneys such as hydrochlorothiazide (HCTZ), triamterene (TA), cimeditine (Tagamet), ranitidine (Zantac), quinidine and nicotine medicines that make your urine more alkaline such as carbonic anhydrous inhibitors and sodium bicarbonate"
Will repost below old brain fog files:
BRAIN FOG
Brain fog includes symptoms of forgetfulness, spaciness, feelings of confusion and inability to focus and think clearly. Many people have been this way for most of their life and think this is normal.
Brain fog can be due to hypoglycemia, candida overgrowth, chronic fatigue, food reactions, nutrient deficiencies, mineral toxicity, liver, kidney or bowel toxicity, poor oxygenation, structural misalignments, medications, genetics and other causes.
Let us examine the causes.
HYPOGLYCEMIA
Hypoglycemia can cause starvation of the brain for fuel. The brain uses about one-third of all our calories. Unlike the muscles, the brain does not store any fuel. Therefore, it must have a continuous supply. If for any reason the supply varies, it is like someone varying the voltage on a delicate computer or other piece of equipment.
Common symptoms are confusion, irritability and forgetfulness and blackouts. One patient called me during a hypoglycemic episode. She couldn't remember her own name. Symptoms usually occur several hours after a meal, and may come on suddenly. Eating something that contains sugar usually relieves the symptoms in about 10 minutes.
Many people, including school-age children and many adults experience huge blood sugar swings all day long! Their breakfast of sweetened cereal, donuts or juice drives up their blood sugar. This is followed by a drop at mid-morning that is relieved by a sweet snack, more juice, soda pop or a cup of coffee. This rockets the sugar up again, followed by a fall around noon.
Lunch may include soda pop, sweetened ketchup, mustard, sweet salad dressing, sweetened rolls, chocolate milk or other sugared food. The sugar rises again, then falls rapidly at mid-afternoon. It is time for another pick-up, or maybe time for happy hour, since alcohol will lift the blood sugar again for a short time. And we wonder why many students have difficulty learning, and why thousands can't think clearly?
CANDIDIASIS
Brain fog symptoms due to candidiasis are often due to the production of alcohol and acetaldehyde by the candida organism. It causes a person to behave as if slightly inebriated, although one consumes no alcohol. Acetaldehyde is also toxic to the brain. At times, the candida organisms can themselves invade the brain.
Fruit, juices, sugar or other sweets feed the yeast organisms and in susceptible people can bring on symptoms rapidly. Carbohydrates break down to sugar in the intestines. Excessive carbohydrate in the diet can also cause symptoms, usually of a more chronic nature.
Occasionally, brain fog may be caused by yeast die-off. This may occur due to a dietary change or health program, or just a shift in metabolism. As the yeast die, they may release various toxins that induce temporary symptoms of brain fog.
CHRONIC FATIGUE
Fatigue from any cause can cause mental confusion and other symptoms of brain fog. Causes include infections, illnesses, nutritional imbalances, toxins and other fatigue syndromes. The brain requires a lot of energy. Impaired energy production for any reason profoundly affects brain function.
Infections not only drain the body's energy. They produce endo and exotoxins that may cause brain fog. Chronic illnesses such as cancer or diabetes may directly affect brain function and impair normal metabolism causing fatigue.
Nutritional imbalances are a common cause of fatigue. Toxins from insect bites, impaired digestion, exposure to chemicals and many other sources affect energy production and cause fatigue.
FOOD REACTIONS
Allergic reactions to food or beverages may directly affect energy production, leading to fatigue and brain fog. Still other food reactions cause histamine release within the nervous system. These are sometimes called `brain allergies'. Nervous system allergies can be severe, inducing irritability, confusion and even psychotic behavior.
Very commonly, food reactions irritate the intestine, causing leaky gut syndrome and the absorption of excessive toxins into the bloodstream. The most common allergic foods are wheat and cow's milk dairy. Anyone with brain fog ought to eliminate these foods from the diet, as this will often help speed recovery. Gluten-containing foods - rye, oats, and barley - also cause reactions in susceptible individuals that may affect the brain.
Some food or water-borne substances are directly toxic to the brain. These include pesticide residues, heavy metals, bacterial toxins and fungal toxins, fluoride, chlorine and other substances added to drinking water, and other water contaminants. Any of these may contribute to brain fog.
NUTRIENT DEFICIENCIES
The brain requires many nutrients, including all the vitamins and two dozen or more minerals. A range of amino acids are required for the brain, as are essential fatty acids, antioxidants and other nutrients. Among the most important nutrients are calcium, magnesium, zinc, copper, L-glutamine, L-taurine, choline, thiamine, B6, B12 and other B-complex vitamins. B-vitamin deficiency is known to cause confusion, irritability, stupor and death.
The author recalls a 7-year old patient who had recurrent ear infections. The ear infections cleared up on a nutrition program. During a follow-up visit, her mother mentioned the girl's school grades also went from Cs to As. This is not an unusual story. Though part of the reason may have been better school attendance, improved brain function is often a side effect of nutritional correction.
Electrolyte imbalance, as occurs after excessive physical exertion or sweating, often causes symptoms of brain fog. This may be due to lowered blood pressure with impaired circulation to the brain, metabolic waste products in the blood or impaired cellular energy production.
MINERAL TOXICITY
A common cause of brain fog is copper imbalance. Copper induces the production of the biogenic amines, epinephrine, norepinephrine and dopamine. Copper also affects thyroid gland activity and female hormone levels. Excessive copper or biounavailable copper often result in spaciness, mood swings, racing thoughts which can cause confusion, and excessive emotions.
Causes of copper imbalance include weak adrenal glands, zinc deficiency, stress, fatigue, birth control pills, copper intra-uterine devices or copper contamination of water supplies or food. The week before the menstrual period the copper level rises, contributing to monthly episodes of brain fog in some menstruating women.
Vegetarian diets are high in copper and low in zinc, a mineral that balances copper. These diets are also often low in other nutrients essential for the brain, like taurine, carnitine, essential fatty acids, alpha lipoic acid, B-complex vitamins and others.
High tissue levels of calcium and magnesium frequently cause diminished awareness, mental fatigue and brain fog. The condition is sometimes called a `calcium shell', as the person is literally slightly numb. Elevated tissue calcium raises the voltage at which nerve cells fire, leading to mental heaviness and numbness that is common in the population. Magnesium is required for some 500 vital enzymes. Elevated tissue levels are often biounavailable or unusable by the body.
Excessive levels of other trace elements such as iron, manganese and chromium may also affect brain activity and give rise to symptoms of brain fog.
All the toxic metals such as lead, mercury, cadmium, arsenic, aluminum, nickel, beryllium and others are neurotoxic. Brain fog may accompany any heavy metal toxicity.
LIVER, KIDNEY OR BOWEL TOXICITY
Toxicity of sluggishness of the important eliminative organs will cause symptoms of brain fog. If these organs do not do their job properly, many toxic chemicals such as ammonia remain circulating in the blood. The brain is one of the first organs affected by toxins, as it requires a lot of blood and its functions are delicate and intricate.
Sluggish eliminative organs are common today, thanks to the enormous amount of chemicals we are exposed to on a daily basis. Liver diseases such as hepatitis, alcoholic cirrhosis and others may also impair the function of the liver.
Weak digestion, intestinal infections, stress, poor eating habits or an improper diet often cause food to putrefy or ferment in the intestines. Some of the food-related toxins produced are absorbed into the bloodstream. These can easily overwhelm the normal detoxification ability of the liver and kidneys. Constipation makes the problem one hundred times worse.
Drinking inadequate water or worse, drinking soda pop, excessive coffee and other irritating beverages can damage or overwhelm the kidneys and impair their ability to remove poisons from the blood.
Finally, the liver, bowel and kidneys are affected by emotions. Liver problems may be associated with anger, intestinal problems with perfectionism and holding on, while kidney problems are associated with fear.
Be wary of cleansing programs such as fasts to correct liver and kidney toxicity. These may give temporary relief, but do not address basic causes such as food allergies, toxic chemicals in the diet or environment and nutrient deficiencies. Fasting can easily cause one to become even more nutrient deficient. I highly recommend the low-temperature sauna at least once a week for 30 minutes unless you have very high blood pressure, very low blood pressure, in which case shorter time is better. Daily skin brushing when you shower is another basic detoxification method helpful for everyone. Acupuncture, acupressure, energy balancing and other natural therapies may also be helpful to reduce the body's toxic burden.
OXYGENATION
Another common cause of brain fog is reduced oxygen to the brain. This may be due to clogged arteries, but it is often due to shallow breathing or holding one's breath. This is far more common than imagined. If it is severe enough, one may pass out. If it is mild, it can cause spaciness, confusion and impairment of cognition.
Many people under stress forget to breathe deeply and regularly. Fear or anxiety often causes holding of the breath. Sometimes a physical disease such as asthma, chronic bronchitis or emphysema impairs respiration.
STRUCTURAL MISALIGNMENT
Misalignment of the spine, or any impingement on the cranial, cervical or other nerves may cause symptoms of brain fog. The cause may be a trauma to the head or to another part of the body. However, sleeping in the wrong position, lifting incorrectly or just normal daily activities can contribute to a nerve impingement that affects the brain. Chiropractic and osteopathic manipulation, physical therapy and craniosacral therapy can be most helpful to address structural misalignments and head trauma.
MEDICATIONS
A long list of prescription and over-the-counter drugs can cause mental confusion, irritability and other brain fog symptoms. The list includes drugs for allergies, pain, high blood pressure, heart arrythmias, glaucoma, infections, depression, anxiety, inflammation and other disorders. Many people are taking two to five of these drugs at once. Combinations of drugs may be toxic in ways that no one can anticipate. Combining medication with alcohol or recreational drugs may also produce unusual symptoms. Studies show that an important factor in mental impairment, particularly in the elderly, are the toxic effects of medications, especially combinations of drugs. Often this is misdiagnosed as Alzheimer's disease or another type of dementia.
If you must take medication, check the side effects and know that there may be side effects that are not listed on the labeling information.
OTHER CAUSES
Brain fog is occasionally caused by an illness like a brain tumor, epilepsy, meningitis or encephalitis. Electrical interference from computer screens or televisions can cause brain disturbance in sensitive people. Vision problems may affect mental clarity and cognition.
Conditions like dyslexia and autism syndromes may cause confusion, though they may also be the result of causes listed above. For example, many autistic children improve when the factors above are addressed. Emotional conditions such as neuroses, paranoia or mental fixations may cause brain fog.
CONCLUSION
Brain fog affects thousands of people and contributes to school failures, crime, delinquency, economic losses, accidents and ruined relationships.
I recommend that anyone with brain fog begin by improving their diet and lifestyle. Eliminate the junk food, excessive sugar and chemicalized foods. Eliminate wheat, dairy and other foods that may be cause reactions. Drink at least 6 glasses of filtered or bottled water every day, rather than soda pop. Be sure to get enough rest and sleep, and breathe deeply. Detoxification methods like enemas, colonic irrigation and dry sauna baths can be very helpful.
Go to a competent chiropractor or osteopath to rule out structural causes. Experiment with a diet low in sugars and starches, and perhaps try an anti-candida regimen if you suspect this cause. If symptoms continue, consider a hair mineral test that will identify nutrient deficiencies, toxic metals, and other imbalances such as an unbalanced oxidation rate or chronic fatigue. Some people need to meditate, do therapy or other techniques to help control unwanted thoughts and emotions. Other natural therapies may also be helpful.
In a few cases, more extensive testing for allergies, illnesses and brain diseases may be necessary. Many people start with a CAT scan or an MRI. However, this is not where I would begin. Brain fog due to diet, lifestyle, toxicity, medication, spinal misalignments and blood sugar imbalance will not show up on these expensive tests. In my experience, most cases of brain fog will clear up quickly when approached this way.
LTS: Apart from subjective reports of diminished ability. to concentrate by LTS patients (20), no data on cognitive impairment in LTS has been found, even though the abnormal sleep found in LTS (58) might be expected to lead to transient diminished cognitive capacity.
On the other hand, severe human Mg deficiency causes brain dysfunction that can include apathy, poor memory, confusion, disorientation and hallucinations, before coma or convulsions ensue (76).
Alcoholism, which has long been known to be one of the important causes of Mg deficiency (76-79), has more recently been implicated in the learning defects of infants borne to alcoholic mothers, via the resultant Mg loss-induced abnormality in regulation of the NMDA receptor (80, 81), which has been proposed to be important in learning (81,82).
Additionally, Mg administration has been shown to lessen cognitive dysfunction caused by experimental trauma (83) or directly by perinatal NMDA-induced brain damage in rats (84), mice (85) or piglets (86).
CFS: Cognitive dysfunction that includes impaired attention, loss of ability to concentrate, and memory loss is not uncommon in CFS (65,70,87-97). It is not often detectable by magnetic resonance imaging and single-photon emission computed tomography that indicate cortical lesions (95,96).
These changes may appear abruptly, and are often associated with mood changes (90). Response-related processes (91) and tasks requiring conceptually driven encoding and retrieval processes and conceptualization (92) are the findings in CFS that differ most from controls.
The overall pattern indicates a significant memory deficit, which is consistent with temporal-limbic dysfunction and differs from that of depressed patients and control subjects (94). Patients have been found to be impaired on tests of spatial span, spatial working memory, and selective reminding condition of pattern-location associated learning, but not in executive test of planning (97).
In an attentional test, eight patients were unable to learn a response set; the remainder exhibited no impairment in the executive set shifting phase of the test. CFS patients were also impaired on verbal tests of unrelated word association learning and letter fluency. Better performance on cognitive measures occurred with improvement in fatigue and depression (97).
Namenda appears to protect the brain's nerve cells against glutamate, a messenger chemical released in excess amounts by cells damaged by Alzheimer's disease or certain other neurological disorders.
When glutamate binds to N-methyl-D-aspartate (NMDA) receptors, this attachment permits calcium to flow freely into the cell.
Sustained elevation of glutamate leads to chronic overexposure to calcium, which in turn leads to brain cell death.
Namenda may prevent this destructive sequence by occupying the NMDA receptor sites."
Once again...NORMALLY Mg and Zn block that receptor.
In lyme...Mg deficient -> Ca tries to go into the cells -> TNF alpha -> angiotensin II.
See where blocking calcium comes into play? Is it blocking calcium entry into the thyroid cells too?
Or...restore Mg levels via CoQ10...3x/day...yea, I know...expensive.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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"Good morning everyone," Here are some more comments that my help people understand how Namenda effects me: Does Not make me Hyper, makes things clearer,easier to understand (relate to things). Namenda is a prescribed thourgh my Neuro. I'm also on:"Tegretol" for seizures, "Diovan" for high blood pressure,"Thyroid" for underactive thyroid, "Baby Aspirin" for the heart. Marnie good post, very informative. Robin
Posts: 139 | From Panama City, FL., USA | Registered: Jun 2005
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Lymelighter
Frequent Contributor (1K+ posts)
Member # 5310
posted
Has anyone else noticed their sleep has improved while on Namenda? I've been sleeping from 11:30 to 9 straight for the last week.
I don't think I've had such wonderful sleep since I was a baby. Posts: 1010 | From Mars | Registered: Feb 2004
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