posted
Does anyone have Bannwarth's syndrome? Could anyone give me some good infoon it. Thanks.
Posts: 47 | From WV | Registered: May 2006
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Tincup
Honored Contributor (10K+ posts)
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posted
Hope this helps.
Differential diagnosis of idiopathic facial paralysis: Bannwarth meningopolyradiculitis][Article in German]
Roloff A, Laskawi R, Argyrakis A.
Lymphocytic meningopolyradiculitis (Bannwarths' syndrome) is a tick-borne Borrelia infection of man. About 60 per cent of such patients exhibit a peripheral facial paresis whose characteristics are clinically not distinguishable from Bell's paresis. Of major importance for the diagnosis, besides the radicular pain that nearly always prevails, are particularly further motoric deficits, a previous erythema migrans and remembered thick bites. A tentative diagnosis can be verified by liquor examination which reveals a characteristic pattern of protein distribution and lymphocytic pleocytosis. Penicillin in high doses is the therapy of choice.
PMID: 3710842 [PubMed - indexed for MEDLINE]
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Actually there are many more but I just dropped from overly tired... sorry.. gotta quit here.
posted
Tincup, Do you know if too high of doses of abx for a particular weight could cause this? Could this syndrome intensify pain within nervous system or lymphatic system with hormonal changes or intensify pain when abx are given?
Posts: 47 | From WV | Registered: May 2006
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Michelle M
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posted
I believe it is simply another name for neuroborreliosis, or lyme infection of the brain/CNS and radicular pain.
However, I cannot begin to pronounce the most of words involved in the definition, so I will just link a good definition here:
posted
Tincup, I believe claforan via I.V..I just wondered it if could possibly through the body into a shock or the nervous system having that much abx when at a low weight.
I am not sure I am completely clear on what Bannwarth is since I am not finding a lot of info.. Is it damage to the central nervous system and the lymphatic system mainly?
Does it cause constant pain? Does anything make it worse or better? Could administration of abx make nerve pain worse or could hormonal changes make the nerve pain worse (this is different than herx.)? I mean if there is damage done to the nervous system could these changes make it worse?
Hope this is a little more clear. Thanks Tincup.
Posts: 47 | From WV | Registered: May 2006
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Tincup
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Also known as: Garin-Bujadoux syndrome Garin-Bujadoux-Bannwarth syndrome
Associated persons: Alfred Bannwarth A. Bujadoux Charles Garin
Description:
Lymphocytic meningoradiculitis probably due to infection by Borrelia burgdorferi, the cause of Lyme disease. It is an illness characterized by intense pain, mostly in the lumbar and cervical regions, and radiating to the extremities; migrating sensory and motor disorders of the peripheral nerves, peripheral radiculopathies, and cerebrospinal fluid abnormalities in the form of lymphocytic pleocytosis indicating blood-brain barrier damage. The symptoms may include facial paralysis, abducens palsy, anorexia, tiredness, headache, diplopia, paraesthesias, erythema migrans, and other disorders.
Bibliography:
Ch. Garin, A. Bujadoux: Paralysie par les Tiques. Journal de m�decine de Lyon, 1922, 71: 765-767.
A. Bannwarth: Chronische lymphocyt�re Meningitis, entz�ndliche Polyneuritis und "Rheumatismus". Ein beitrag zum Problem "Allergie und Nervensystem". Archiv f�r Psychiatrie und Nervenkrankheiten, Berlin, 1941, 113: 284-376.
Zur Klinik und Pathogenese der "chronischen lymphocyt�ren Meningitis". Archiv f�r Psychiatrie und Nervenkrankheiten, Berlin, 1944, 117: 161-185, 682-716.
Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Garin-Bujadoux-Bannwarth syndrome:
Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI GROUP.
The disease may affect elements of the central or peripheral nervous system in isolation or in combination.
Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions.
Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur.
In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)
Tincup
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posted
The immune response at onset and during recovery from Borrelia burgdorferi meningoradiculitis.
Cepok S, Zhou D, Vogel F, Rosche B, Grummel V, Sommer N, Hemmer B. Clinical Neuroimmunology Group, Department of Neurology, Philipps University, Marburg, Germany.
BACKGROUND: Borrelia burgdorferi causes a wide range of neurologic syndromes. In Europe, acute meningoradiculitis is the most common manifestation.
OBJECTIVE: To address the nature of the immune response during the course of B burgdorferi meningoradiculitis, with special respect to the early and late changes in cerebrospinal fluid (CSF).
METHODS: Serial immunophenotyping was performed and cytokine measurements were obtained in the peripheral blood and CSF of 12 European patients with definite B burgdorferi meningoradiculitis.
RESULTS: Early during infection and before initiation of treatment, we observed high levels of interleukin (IL) 10, IL-6, and IL-8, and large numbers of B cells and plasma cells in the CSF of most patients.
At the same time, we found a mainly unspecific intrathecal antibody synthesis.
During resolution of the infection, cytokine levels normalized rapidly and plasma cells disappeared from the CSF.
In parallel, the percentage of B cells in the CSF increased over several months, accompanied by rising levels of intrathecally produced B burgdorferi-specific antibodies.
CONCLUSIONS: Our findings demonstrate that the early phase of B burgdorferi meningoradiculitis is characterized by a well-coordinated immune response involving specific cytokine release and plasma cell recruitment, followed by a long-lasting, antigen-specific B-cell response in the central nervous system.
Tincup
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posted
[Diagnosis and therapy of Lyme neuroborreliosis][Article in German]
Pfister HW. Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen.
Lyme-Borreliosis which in Europe is transmitted by Ixodes ricinus presents in three stages with 1st a localised infection (erythema chronicum migrans), 2nd a disseminated infection (e.g., meningoradiculitis), and 3rd a persistent chronic infection (e.g., encephalomyelitis, cerebral vasculitis), whereby not all stages invariably become clinically apparent.
The diagnosis is based on the typical clinical presentation, the lumbar puncture (lymphocytic pleocytosis), and serological test from the blood as well as from the CSF (intrathecal antibody production!).
The frequency of positive serological results depends on the duration and the type of the disease.
In stage 1 20-50% of the patients show increased IgM-antibodies, in stage 2 70-90% show increased IgM- and or IgG-antibodies, and in stage 3 almost 100% of the patients have positive IgG-antibodies.
The Lyme-Neuroborreliosis usually is treated with Ceftriaxon 2 g/d intravenously over 14 (Stage 2) or 21 (Stage 3) days.
shazdancer
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posted
Ya gotta watch out when Tincup is awake -- she's good!
lymefighter, I'm not seeing anything that says that antibiotics cause Bannwarth's (which seems to be more of a British term). But several articles that point to Lyme itself as the cause.
It all reads like neuroborreliosis to me.
Regards, Shaz
Posts: 1558 | From the Berkshires | Registered: Jul 2001
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Tincup
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posted
Ok..
I've been doing a search on this to see if we could figure out anything for you. I've posted above and also posted a few other articles in the last hour on new posts on the board so others may see them if interested.
I am NOT a doctor.. and know little about this term they are using... "Bannwarth's Syndrome".
From what I am gathering though.. it appears it is a group of mainly neurological symptoms associated with Lyme disease. It appears it is more readily described in Europe than here.. but that is most likely due to the Infectious Disease ducks only focusing on arthritic symptoms here in the US. After all.. if you are not looking for symptoms.. you won't find them.
Now.. my thought is.. perhaps someone you know is getting treated for it.. or for Lyme basically.. using IV claforon. If this person has the symptoms associated with Bannwarth's Syndrome.. due to Lyme... they should be ready to experience a fairly wicked Jarrich Herxheimer reaction.. (a worsening of symtoms shortly after starting treatment.) That is my opinion and a total guess from the info you provided.
Yes.. these symptoms can be VERY painful. Yes.. it can be scarey and horrible. The worsening of symptoms after starting meds can appear to be a reaction (negative) to the meds.
I can NOT say what the problem is.. and my info is simply speculation.
I would suggest though that the doctor be contacted to be sure the reaction IS or is NOT a herx.. and if it is very much worse.. that the doc may need to back off the meds until the person becomes more stable... then restart them.
Not to scare anyone.. but herxes CAN kill... and they have in the past. Never assume it is a herx or that even the doctor knows best if the patient is much worse. ALWAYS contact the doctor if you see a worsening or have concerns. If not satisfied.. get another opinion.
As for a problem with the dose of the meds in relationship to weight... as you mentioned. I will try to find a recommendation on the drug doses if you would like.. BUT.. even if the patient is on a "normal" or appropriate dose for their weight.. they still could have a problem if the infection load is high... which could be causing a bad herx. With those severe symptoms Bannwarth's causes.. I would imagine there IS a high load of spirochetal infection.
I'll check back shortly to see if you would like more medication info. Perhaps someone else may look for it and post it before I return.
Did I come close to answering your questions or concerns?
Tincup
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posted
Hey Shaz...
GOOD to see you!
Hopefully I am reading this correctly?? If you pick up on anything I am missing.. do tell! I am not sure I am following the post. VERY tired and scattered tonight.
I have communicated with Lymefighter in the past, but couldn't really answer her questions.
She has been off all antibiotics for 6 years -- had a really bad experience with IV Claforan back then (was underweight and given extremely high dose). Since then any time she takes antibiotics (even orals I think) she has substantially increased back pain. Has been unable to identify the exact cause of the pain.
Besides antibiotics, the second trigger for her pain is hormonal -- it gets much worse during her monthly cycles. The pain has pretty much disabled her and as you know there are no LLMD's in WV and I don't think she even has a pain doc.
Don't think she has found a new LLMD since Dr B was her doc.
Bea Seibert
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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Yes, Bea has got it. I had some pretty major surgries spanned very close together in the abdominal area. I had these done several years ago. When I went through that I went from a weight of 115 to 60 some pounds. I then immediately did 4 grams of claforan via IV to resume my treatments. It was almost like it did damage or something to two areas in my back. It is mid back and on each side.
I am not sure if the dose was just to high for the physical state I was in or what. Ever since then I have had pain that has gotten progressively worse over the years. Not much helps for pain it is so bad, and the pain is debilitating.
I have had several tests done locally (that I dont' trust whatsoever for the most part). They missed some major things in the past here. So far nothing is really showing.
I guess what I am asking is could damage have been done to the nerves or anything do you think? I would think that if it was that though, when I took any kind of abx or had hormaonal changes that it would get worse like that.
I would think that an organ specifically a filtering organ (i.e. adrenal glands) would have this reaction. My cortisol however looks normal.
I got the Bannwarth's syndrome from looking at some of my past records. They had wrote that this might be a reason for this kind of pain happening. You said that there was or was not testing for this? No concrete conclusions have been made.
I am at my wits ends with this. Thanks so much for suggestions. I appreciate them so much.
Posts: 47 | From WV | Registered: May 2006
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Tincup
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posted
Thanks Bea for the explanation. It did help. My brain ain't always in the right place at the right time.
Not sure if anyone could say for sure what might be the cause of the pain. Only speculation.
For example.. scar tissue can be a place where antibiotics can't hit... and there seemed to be surgeries which might have prompted scar tissue?
Also... Lyme can affect the spinal column in many ways. Keets hide there. Could the additional pain while on antibiotics be due to the die off? I don't know?
And now.. after my brain has completely fallen asleep.. I am unable to think what all else I was going to suggest.
Sooooooooooo.. hopefully it will be fresh and perky later and I can offer something better.
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