"On the outer surface of the Lyme bacteria are various proteins. As they have been discovered, they have been assigned letters, such as outer surface proteins A, B, and C.
The following is a brief explanation of the test results. Again, each band is an antigen complexed (bound together) with an antibody made by the immune system, specifically for that antigen (part) of Borrelia burgdorferi.
18: An outer surface protein.
22: Possibly a variant of outer surface protein C.
23-25: Outer surface protein C (osp C).
28: An outer surface protein.
30: Possibly a variant of outer surface protein A.
31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).
37: Unknown, but it is in the medical literature that it is a borrelia-associated antibody. Other labs consider it significant.
39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.
45: Heat shock protein. This helps the bacteria survive fever. The only bacteria in the world that does not have heat shock proteins is Treponema pallidum, the cause of syphilis.
58: Heat shock protein.
66: Heat shock protein. This is the second most common borrelia antibody.
73: Heat shock protein.
83: This is the DNA or genetic material of Borrelia burgdorferi. It is the same thing as the 93, based upon the medical literature. But laboratories vary in assigning significance to the 83 versus the 93.
93: The DNA or genetic material of Borrelia burgdorferi.
In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.
These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93. This is true regardless of whether it is IgG or IgM."
posted
Just recieved results (like yours) that 41K band for IgG was positive (but no others...) and that my CD57 was pretty high-These were from MDL labs-
My LLMD said that indicates latent (chronic) Lyme arthritis in my case-and recommended 2 months of doxy at 400mg/day-
With only one band does it mean I have had LD-but have no active infection presently? A bit confused myself??? LLMD said I did not have Lyme with 2 bands?
Still having some minor joint symptoms-and do think I experienced some herxing during a 21 day low dose doxy following rash in July-
Can one of you eloquent Lymies simplify some more? Thanks, Sue
Posts: 249 | From finger lakes, ny | Registered: Jul 2006
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posted
Feel a bit "simpletonish" here, but truly would like to understand the significance or insignificance of test results showing only one band (41) -
Anyone patient enough today to give it a try or provide a link...?
..And feeling like I am at least catching on to how to keep a thread active
Next challenge-inserting those graemlins to duplicate the faces I make when I type!
Many thanks-Sue
Posts: 249 | From finger lakes, ny | Registered: Jul 2006
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