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» LymeNet Flash » Questions and Discussion » Medical Questions » What happens every 4 weeks?

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Author Topic: What happens every 4 weeks?
humanbeing
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If spirochetes life cycle is 24-48 hours, what happens during my 28 day flare--on or off abx this flare still happens?

Are they all doing something at the same time? or Is the body doing monthly housekeeping?

Wouldn't "die off" happen every two days?

I really want to know the answer to this, it is driving me crazy...help!

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We are spiritual beings on a human journey...

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seibertneurolyme
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Very good question and a subject I would like to know more about. Can't help you though as hubby has no monthly cycle that I am aware of.

I have often wondered if this was more common in ladies due to hormonal issues?

Bea Seibert

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Areneli
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Some parasites peaks sexual activity in full Moon.

Perhaps Bb does something similiar.

But perhaps it is a product of our own body that changes slightly by Moon phases.

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Lymetoo
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They replicate every 24-48 DAYS. [actually, every 3-5 wks] So if you're on abx you will get a bigger herx than if you were off....BUT, you'll get a herx either way if you've been taking abx for most of the 3-5 wks.

And most of us find that the full moon is a time when we herx the hardest.

--------------------
--Lymetutu--
Opinions, not medical advice!

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healthywealthywise
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Dang, I do NOT want to think about these spirochetes having sex in my body!! [Eek!]
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Jill E.
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quote:
Originally posted by tothepoorhouse:
Dang, I do NOT want to think about these spirochetes having sex in my body!! [Eek!]

Hey, at least THEY are having a good time! Many of us are too sick to be enjoying ourselves!

I never flared on oral abx, but do sometimes on Bicillin.

Jill

--------------------
If laughter is the best medicine, why hasn't stand-up comedy cured me?

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Lymetoo
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quote:
Originally posted by tothepoorhouse:
Dang, I do NOT want to think about these spirochetes having sex in my body!! [Eek!]

 -

--------------------
--Lymetutu--
Opinions, not medical advice!

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surfbabe
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quote:
Originally posted by Lymetoo:
They replicate every 24-48 DAYS. [actually, every 3-5 wks].

I thought they did replicate every 24-48 hrs but had a further growth phase every 4 weeks?

maybe i was wrong? is lymetoo correct? if so why not just take abx during the week when they replicate?

anyone else offer opinion?

i do relapse badly about every 4 weeks (not same as menstrual cycle) - feel all flu-like again, low fever & muscles really weak - i am on abx so i hope it is killing the buggers!!

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Areneli
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Every paper I have read so far says Bb replicates every 12-24-48 hrs (not days)
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Lymetoo
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OK, so I've lost my mind! [Big Grin]

--------------------
--Lymetutu--
Opinions, not medical advice!

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surfbabe
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up for any more opinions on lyme cycles & replication times?
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Lymetoo
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quote:
Originally posted by Areneli:
Every paper I have read so far says Bb replicates every 12-24-48 hrs (not days)

If so, then why are the major herxes every 3-5 wks?

--------------------
--Lymetutu--
Opinions, not medical advice!

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ldfighter
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I've read what surfbabe said - Bb replicates 24-48 hours, but there's an overall cycle with a growth phase that happens monthly, and that's when abx work best. Dr. B's guidelines say something about this.
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humanbeing
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This is interesting since I am on IV I wondered if they would come out of hiding long enough each month to do their thing or if the cystic form is capable of causing a die off or flare!

I am still going crazy wondering about this. How the heck can they be partying it up with rocephin on their backs??

Stupid disease...

--------------------
We are spiritual beings on a human journey...

www.ruggierogallery.com

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humanbeing
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http://www.lymenet.de/symptoms/cycles/statistics.htm#fig1

here is an excerp from this long study......

Key input to the models is an immune system switching function that turns the immune system activity up and down, either tied to the clock cycle of the mentruation or in a self-organized way, i.e. reacting to toxin levels.

The other input parameters are
the time constants of the compartments, describing Bb growth by cell division,
elimination of Bb and Bb-fragment (toxin) by the immune system and a toxin influx rate that may vary over time.

The analysis supports J.J. Burrascano's experience that a carefully kept daily symptom log helps to interpret the course of the infection and is an essential guide for the clinician adjusting the antibiosis.

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This is interesting...a patient followed during her illness--symtom log for 2 years of abx, cycles and flares studied...

Good news is she recovered after the two year mark and has had no relapses in nine years...

Don't really understand their flare explanation but I think it has something to do with the bodies threshold to the organism...the threshold gets crossed in oscillatory cycles.

Bb reroduces and hides in niches based on when the blood level of abx are low..(this seems implausible since they take so long to reproduce but maybe somebody with more than my lyme brain can figure this out...

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We are spiritual beings on a human journey...

www.ruggierogallery.com

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2mag
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from the biochemistry article--this is what i have on borrelia replication:

The cell division time of Bb is very long compared to other bacteria. A typical cell wall reproduction time for Streptococcus or Staphylococcus is less than 20 minutes, while the total reproduction time of Bb is from 12-24 hours.

Most antibiotics inhibit the formation of cell walls and are effective only when the bacteria are dividing with the formation of new cell wall.

With the slow replication time of Bb, an antibiotic would have to be present 24 hours a day for one year and six months to be present during the cell wall reproduction period.33

i agree -perhaps the 29 day cycle is a moon parasite relationship

2 mag

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humanbeing
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Thanks 2mag.

Since they have a cystic or non cell wall form then this may not mean they all die in a year and a half.

As far as the moon / bug love...I'd be willing to set them up in a nice hotel of their chosing for GD sakes!!!!

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We are spiritual beings on a human journey...

www.ruggierogallery.com

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Marnie
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Neutrophils, our most abundant white blood cells, have a 3-4 week cycle (old destroyed, new made).

They bind zinc. It is actually the calprotectin in them that does the trick.

Bb looks to utilize our zinc for its own benefit to avoid destruction from superoxide free radicals via SOD...an antioxidant enzyme. It also is protected against destruction from H2O2.

I suspect changes in barometric pressure impact cell wall deficient forms which is why many with "arthritis" feel pain when storms approach.

Mother Nature helps us...perhaps.

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Lymetoo
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quote:
Originally posted by humanbeing:
..... or if the cystic form is capable of causing a die off or flare!

I am still going crazy wondering about this. How the heck can they be partying it up with rocephin on their backs??


Flagyl works on the cystic form, and believe me, some of the worst herxes are while on flagyl.

While on abx, especially Rocephin, many cysts are being formed in an attempt to evade and hide from the abx.

--------------------
--Lymetutu--
Opinions, not medical advice!

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nan
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Managed to get a nine month reprieve from antibiotics, but noticed that each month I would have symptoms and feel really bad for about a week at a time.

My doctor is trying me on antibiotics during those days monthly when I feel bad. Have been taking tindamax along with antibiotics on those days.

Seems to be working, though I notice the abx make me feel even worse then.

Someone better come up with a cure because the IDSA Guidelines are definitely going to cause us many problems. Bad enough trying to deal with the little buggers without having IDSA attack us, too!

--------------------
nan

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treepatrol
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My herx's after treatment for a few months in the beginning went fron 2 times a month to once every 28 to 34 days every month after that and still do. Thats how we judged my progression well at least one of the ways. As I would continue to tret with abx and probiotics these herxs would become less and less in severity in the beginning I thought I would die it was horrible not only aching and sore and feverish and joint pain but about the third day in sometimes the 2nd day I would get horrendous cold symptoms it was my body trying to flush the toxins anyway it could.

I had a couple of strains Bb and had been bitten every year since 1988 also coinfection this is what LLMD told me I was loaded with infections and coinfections.

Now we think we missed one of the coinfections didnt get it all and its back the test was neg for babs but on the other hand that trest was done at local hospital,LLMD said he's not possitive but is going to treat me for babs as soon as I let him.Its deffinatley coinfection that has come back.

Sinse starting back up with abx's this early spring I only had what I would call very slight herx's just some aching and no joint pain has returned except my left knee which I folded backwards a few years ago.
So on to zith+mepron I have to talk to him about taking art to, So I figure zith will still go after lyme as well as babs with with mepron working it.

Then I go probaly minocyclene + tinny.

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

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MommaK
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Interstering posts!

My DD is trying low dose birth control pills to regulate her hormones, since she also had worse symptoms on a monthly cycle. She has taken them everyday for two months, skipping the placebo ones to not have a period. They may be helping, but still have worse symptoms on monthly cycles even without periods. Today we got some stronger ones to try. Guess they may not make much difference. You may have something!

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