Topic: Todays learning lesson...a tad of the research I did today
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
With
1. way too much inflammation AND
2. with insufficient choline and phosphorus (two of several nutrients that are needed to make bile salts which help to remove mercury) AND
3. with exposure to ethanol as the spirochete ferments sugar to ethanol (alcohol) AND
4. with the (likely) drop in Mg stores (from the liver) at the outset of this disease (and ongoing) =
Major liver problem. I repeat...major liver problems. Our largest ``detox'' organ has to be overwhelmed.
Side Note:
(``Non-steroidal anti-inflammatory drugs, such as indomethacin, and other pharmaceutically active compounds, are formulated with bile acids or their salts and conjugates.'' In other words, bile salts decrease inflammation.
Bile acids ALSO: ``participate in cholesterol metabolism by functioning as hormones that alter the transcription of the rate-limiting enzyme in cholesterol biosynthesis.''
Yo...that's HMG CoA reductase. This is what Mg Inactivates as well as some cholesterol lowering drugs.
So...bile salts help LOWER CHOLESTEROL too.
bile acid-derived HMG-CoA reductase inhibitors
PMID: 7986821
Taurocholate, a relatively hydrophobic * bile salt*, is a potent down- regulator of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase (C7 alpha H), the rate-determining enzymes of the cholesterol and bile acid biosynthetic pathways, respectively.
Taurocholate led me to a couple of hours of taurine - another amino acid - research. Bottom line: likely too low.
Fish - eating is promoted- contain Omega 3s and taurine BUT...Hg is a problem esp. in some types of fish.)
Add on top...abx. - many of which have to go thru our major ``detox'' organ, our liver. It appears to be stressed to the hilt.
The absence of choline alone -> fatty liver which certainly will impact its ability to function properly.
If bile salts from the liver fail to remove mercury, the kidney PROTEIN, metallothionein, helps out.
Go here (!) to read a very simple explanation talking about mercury (Hg) in the body:
Mercury is bound to (has an affinity for) the enzyme C-acetyltransferase which Bb has in its genetic code to stimulate the production of acetylcholine.
Good and bad...mercury dissolves aluminum.
Interesting trivia...WOW is mercury powerful:
``Unless you are a representative of a national meteorological bureau licensed to carry a barometer (and odds are you're not), bringing mercury onboard an airplane is strictly forbidden. Why? If it got loose, it could rust the plane to pieces before it had a chance to land. You see, airplanes are made of aluminum, and aluminum is highly unstable.
Applied to aluminum's surface, mercury will infiltrate the metal and disrupt its protective coating, allowing it to ``rust'' (in the more destructive sense) continuously by preventing a new layer of oxide from forming. The aluminum I-beam below rusted half away in a few hours, something that would have taken an iron beam years.
I've heard that during World War II, commandos were sent deep into German territory to smear mercury paste on aircraft to make them inexplicably fall apart. Whether the story is true or not, the sabotage would have worked. The few-micron-thick layer of aluminum oxide is the only thing holding an airplane together. Think about that the next time you're flying. Or maybe it's better if you don't.''
IF far infrared or ozone therapy trigger NO (nitric oxide) release/production:
Nitric oxide is also generated by macrophages as part of the human immune response. Nitric oxide is toxic to bacteria and other human pathogens. Many bacterial pathogens have evolved mechanisms for nitric oxide resistance.
Nitric oxide can contribute to reperfusion injury when excessive nitric oxide produced during reperfusion (following a period of ischemia)
reacts with superoxide to produce the damaging free radical peroxynitrite.
Inhaled nitric oxide has been shown to help survival and recovery from paraquat poisoning, which produces lung tissue damaging superoxide and hinders NOS metabolism.
Superoxide, damaging. Protective mechanism is an enzyme called superoxide dismutase (one of 3 main antioxidant enzymes). Bb appears to utilize SOD to protect ITSELF from destruction from superoxide and H2O2.
It would appear inhaled NO MIGHT help those who have lung associated lyme problems. (I've often wondered if nitroglycerin would help those with lyme related cardiac problems.)
A sample containing nitric oxide is mixed with a large quantity of ozone. The nitric oxide reacts with the ozone to produce oxygen and nitrogen dioxide.
This reaction also produces light (chemiluminescence),
which can be measured using a photodetector. The amount of light produced is proportional to the amount of nitric oxide in the sample.
NO + O3 → NO2 + O2 + light
Mercury and NO:
``Cells were treated with mercury in the presence
or absence of lipopolysaccharide (LPS).
Mercury (5-20 M) dose-dependently
decreased the production of NO in LPS-stimulated cells.
Concomitant decreases in the expression of inducible nitric oxide synthase (iNOS) mRNA and protein were detected. Treatment of J774A.1 cells with mercury alone did not affect the production of NO nor the expression of iNOS mRNA or protein.
Interestingly, mercury alone stimulated the expression of tumor necrosis factor (TNF ), and increased LPS-induced TNF and interleukin-6 mRNA expression.
Mercury inhibited LPS-induced nuclear translocation of nuclear factor B (NF- B) but had no effect alone.
In contrast, mercury activated p38 mitogen-activated protein kinase (p38 MAPK) and additively increased LPS-induced p38 MAPK phosphorylation.
These results indicate that mercury suppresses NO synthesis by
inhibition of the NF- B pathway
and modulates cytokine expression by p38 MAPK activation in J774A.1 macrophage cells.''
Nitric Oxide, Volume 7, Number 1, August 2002, pp. 67-74(8)
It is believed NFkB is the cells' signaling mechanism that triggers inflammation.
Several things can INactivate NFkB (including the lowly amino acid tyrosine) and it appears once again, the body is using a back-up route to try to turn off NFkB via mercury, but the ``side effect'' is, it suppress NO synthesis.
Why INactivate NFkB...because too much inflammation is harmful to our major detox organ, the liver. The body is trying to stop inflammation.
If the NUTRIENTS needed to MAKE BILE SALTS were available, Hg would be eliminated from it's storage in the liver cells and NO synthesis would be available to support macrophages (one of our WBCs). Think of them as the pac-men of our immune system.
Fun trivia:
Mercury is the ruling planet of , Gemini, and , Virgo. The planet is considered not very well placed in , Sagittarius, and , Pisces.
I'm a Sagittarius.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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trueblue
Frequent Contributor (1K+ posts)
Member # 7348
posted
Thanks Marnie, I did get some of that.
Does it follow that when the liver/GB/digestive tract is more comprimised then usual... it would not be able to produce the bile salts to reduce the mercury levels?
Am I getting this?
-------------------- more light, more love more truth and more innovation Posts: 3783 | From somewhere other than here | Registered: May 2005
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posted
My liver is very overworked. No gallbladder. Is there a product that contains choline?
Posts: 116 | From state of lyme | Registered: Oct 2006
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posted
Awesome Marnie, it all ties together! This is why so many Lymies( including myself) have high cholesterol. Because of low choline and phosphorus, our liver is not producing enough bile salts to keep our cholesterol in check. This helps Bb, because the bacteria use cholesterol in its cell wall. Finally, I am getting some of this Marnie.
I have started taking Lecithin to help me with Choline and phosphatides, so that should start helping----see I'm reading your posts
To begin the list.... 1) supplement with Mg (I like citrate to encourage the Krebs cycle and discourage the Cori cycle).
2) Supplement with choline and phosphates per above.
3) use antioxidents to minimize "oxidative stress" which starts the inflammation cycle which Lyme hides in.
4) Supplement melatonin to increase NO and decreases TNF-alpha (Thanks western fence Lizard)but not too much as we will deplete acetylcholine which I need for neurotransmitters in my brain. Also combine with aloe (baths?) which works with the melatonin(anti cancer).
OK it's only a start but Marnie has written so many posts luckily for us!!!
How do I keep C-acetyltransferase from dropping ?Should supplement acetylcholine? How?
I am wondering if the statin drugs which probably 1/4 of americans are on...actually help to control Lyme or at least slow the progression of Lyme in an individual by controling cholesterol????
Thanks Marnie for staying with us, we'll get there (slowly)!!!
Ernie
[ 24. October 2006, 12:24 AM: Message edited by: efsd25 ]
Posts: 546 | From Cascadia subduction zone | Registered: Mar 2002
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posted
Marnie, what is the best mg supplement to take, dosage etc? thanks Posts: 163 | From maine | Registered: Oct 2003
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JRWagner
Frequent Contributor (1K+ posts)
Member # 3229
posted
UP!!!!
Marnie...As usual...wow...
Could you please include a SIMPLE summary for those with LYME BRAIN???
A conclusion, with recommedndations would help those less scientifically inclined, or declined if one is lying down...!!!
Nitric Oxide (NO)...there are supplements for body building that address the issue of NO and increased blood flow (more nutrients for repair and better exercise)that one can purchase at health food stores, or the Vitamin Shoppe, and GNC. Do they work? Some do...
How much time have you spent through the years trying to help us? You should, along with a few others, get a medal (not Mercury or Aluminium, thank you!)!!!
Thanks again for all your work!
Ernie? I thought you beat this thing? I m sorry to see you back because that means you still have the curse...I know...the darned disease does not want to go away...12 years for me.
Be well all...
Peace, Love and Wellness, JRW
Posts: 1414 | From Ny, Ny | Registered: Oct 2002
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5dana8
Frequent Contributor (1K+ posts)
Member # 7935
posted
I understood very little but I greatly appreciate all your hard work & effort
Thanks marnie
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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posted
Hi JRWagner, I feel very good, in fact am continuing hiking and mountain climbing. But I think Lyme is with me for life. I can control it but not beat it. I rife weekly and thats keeps me "fit"(wrt Lyme) and working full time. I think once you go chronic, you've got for life. That does not mean you stop living as you know. Hope you are doing OK also....12 years is enough, right!
Take care and thanks for remembering me, Ernie
Posts: 546 | From Cascadia subduction zone | Registered: Mar 2002
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