posted
ha ha! Check this out people! Nitrous Oxide...
It has been demonstrated that NO is toxic to Borrelia burgdorferi, the causative organism of Lyme disease.11 Therefore, any inhibitor of PDE-5 is a potential therapeutic agent for Lyme disease. Inhibitors of PDE-5 in common use today are the drugs sildenafil (more commonly known as Viagra), Levitra, and Cialis. Whether these drugs act therapeutically against the Lyme spirochete has not been demonstrated clinically and remains unknown. (See Chart 8.)
In order to explain Oxegen AKG� , we must first begin with L-Arginine, a dietary supplement which has typically been used to stimulate the production of nitric oxide in the body. ==========
It's a vasodialator, which relaxes the blood vessels, so that more blood can flow through. Hmmm, more blood to the muscles for less fatigue. More blood to the brain so we can think more clearly.
I have some of this, but never tried it.
Carol
[ 28. October 2006, 03:15 PM: Message edited by: Carol in PA ]
Posts: 6956 | From Lancaster, PA | Registered: Feb 2004
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posted
No way LOL, that could also explain why ozone treatment can be helpful. WHen ozone is created not from pure oxygen some nitric oxides are created too. I have read something like that.
Posts: 641 | From Wroclaw, Poland | Registered: Mar 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
NO NO NO!!!
Nitric oxide (NO) and nitrous oxide (N2O) are 2 completely different things!!!
The latter is laughing gas.
The first is not to be laughed at!
It is a powerful germ killer and vasodilator. It impacts more than just you-know-where.
NO...NITRIC oxide looks to be overproduced.
It looks to take THIS AND the very powerful superoxide free radical to eliminate this infection.
Salivary gland extract (SGE) from Ixodes ricinus ticks inhibited the killing of Borrelia afzelii spirochetes by murine macrophages.
SGE also
reduced the production of two major defense molecules of phagocytes,
superoxide and nitric oxide.
It is likely that the suppression of macrophage microbicidal mechanisms contributes to the inhibitory effect of tick saliva on the killing of B. afzelii spirochetes, thus facilitating the transmission of this important pathogen.
Infect Immun. 2001 January; 69(1): 575-578.
There is a HUGE difference between INhaling NO to help with COPD and increasing this via Viagra which works systemically.
Too much NO is dangerous to your HEART.
In all three cases, clinical and laboratory findings provided the evidence of the borreliosis infection involvement in the development of dilated cardiomyopathy.
PMID: 17066741
Ozone saunas look to work by increasing NO and, at the same time, temporarily destroy the antioxidant enzymes...esp. SOD which would then theoretically, destroy Bb. Ozone is trivalent. (So is the botulism anti-toxin.) It is very powerful. NEVER, EVER BREATHE OZONE.
Far infrared saunas work in another way. They look to make more ATP (drive Mg back INTO the cells to INactivate PFK, to INactivate HMG CoA reductase)PLUS it looks to open acetylcholine channels and perhaps temporarily INactivate amylase and lipase.
Amylase breaks down carbs, lipase breaks down fats...which would THEORETICALLY starve Bb.
People who use far infrared saunas every day for about 30 minutes LOSE WEIGHT. They are "approved" for use by cerebral palsy patients who have constant muscle contraction problems due to a constant bombardment of acetylcholine.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
quote:Originally posted by Marnie:
Nitric oxide (NO) and nitrous oxide (N2O) are 2 completely different things!!!
quote:from the article:
Nitrous Oxide (NO), A Potential Lyme Therapeutic Agent
I'm a little confused (nothing unusual there). Is the article wrong - Nitrous oxide=(NO)? Which is good and which is bad? Please clarify.
Thanks! Ali
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Dictionary:
Nitric oxide
From Wikipedia, the free encyclopedia.
The chemical compound nitric oxide is a gas with chemical formula NO.
It is an important signaling molecule in the body of mammals including humans, one of the few gaseous signaling molecules known.
It is also a toxic air pollutant produced by automobile engines and power plants.
Nitric oxide (NO) should not be confused with nitrous oxide (N2O) or with nitrogen dioxide (NO2).
The nitric oxide molecule is a free radical which makes it very reactive and unstable. In air, it quickly reacts with oxygen to form the poisonous nitrogen dioxide.
Nitrous oxide, laughing gas, N2O
Nitric oxide, NO..."germ" killer and vasodilator. Think Nitric does the "trick".
They are often confused.
But you're getting close...
It's nitrogen.
Bb has an enzyme that is called C-acetyltransferase which stands for choline acetyltransferase. It triggers us to make acetylcholine. Bb can NOT breakdown acetylcholine, it wants US to. Then it can get the choline it is after.
Bb does NOT have an enzyme called N-acetyltransferase.
This enzyme above is one of (2) that is needed to convert serotonin to melatonin.
Melatonin is a POWERFUL antioxidant. It is believed it is the "indole" part that is the "working part". This is the H-N bond. Hydrogen-Nitrogen.
There's a lot of nitrogen in the air. We can't utilize it. Most of it we "blow off" (exhale). This nitrogen is taken up by plants which are eaten by animals which we eat (plants and animals) in order to supply the nitrogen we need.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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Are there drugs that inhibit the production or release of acetylcholine? Where did you get that Bb likes acetylcholine?
Thanks,
john
-------------------- "...reading the Meditations for long periods can be conducive of melancholy." --qtd. in intro to Meditations Posts: 122 | From San Diego, CA, California, United States | Registered: Mar 2005
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posted
I believe that what Bb does is interfere with the production or absorption (maybe both? Help, Marnie!) of acetylcholine -- in any case, it intereferes with the acetylcholine pathways. What we lymies want to do is increase the amount of acetylcholine that we produce, as we are getting too little of it ultimately.
-------------------- "Looks like freedom but it feels like death.. It's something in between, I guess"
Leonard Cohen, from the song "Closing Time" Posts: 822 | From California | Registered: Jan 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
"The lack of PE and the inability to synthesize PC from PE by methylation means that
B. burgdorferi is entirely dependent upon acquisition of exogenous choline from its hosts to synthesize PC.
Free choline is readily available in eukaryotic fluids, often as a by-product of signalling pathways that activate phospholipases.
Availability of choline may play a role in replication and recognition of a eukaryotic host by bacteria. It is also tempting to speculate that, by mimicking the high PC phospholipid content of eukaryotic cells and utilizing choline derived from these cells, PC in B. burgdorferi membranes may play a role in host immune evasion and/or in the development of autoimmune responses to the organism.
Infection with Brucella sp. has resulted in the development of anti-PC antibodies within eukaryotic hosts (Casao et al., 1998).
Establishment of the pathways by which B. burgdorferi synthesizes PC and PG is the first step towards a clearer understanding of the role of these phospholipids.
The relative paucity of different phospholipids in B. burgdorferi, and the existence of only a single pathway for synthesizing PC in this organism, presents opportunities for better understanding of the role of PC, which has not been as extensively studied because it is absent in the model Gram-negative and Gram-positive organisms E. coli and Bacillus subtilis.
Recent advances in the tools available for genetic manipulation of B. burgdorferi may eventually allow us to better dissect the roles of these phospholipids in disease pathogenesis."
Bb wants/needs choline. This is one of the nutrients in bile and of course is one of the nutrients needed to make acetylcholine.
Interfer with acetylcholine or the enzyme that is needed to make it...is called chemical warfare:
Bb cannot breakdown acetylcholine (has no acetylcholinesterase). It counts on US to do that, then likely Bb utilizes that choline once it is broken down. Follow?
We make and breakdown the neurotransmitters... ongoing...INCREDIBLY fast! In a manner of speaking, our brains function like chemically driven computers.
Acetylcholine (and calcium influx) = muscle contractions. That is what acetylcholine does i.e., it signals the muscles to contract.
You are making lots. It is the receptors that get pooped out. Same with insulin "resistance"...the RECEPTORS won't take it in.
A neurologist once told me...it is not the neurotransmitters (amt.) that causes problems, it is the number of receptors that makes the difference. I didn't believe him, but am finally BEGINNING to understand.
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LOL, that could also explain why ozone treatment can be helpful. WHen ozone is created not from pure oxygen some nitric oxides are created too. I have read something like that.
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