3.) ANOTHER GROUP OF PATIENTS HAVE MULTIPLE SCLEROSIS AND LYME.
There are some patients who have a clear-cut preexisting history of MS before the onset of Lyme disease. The Lyme appears to accelerate their clinical course. For others, it appears to be the initiating infection that triggers the MS.
These patients are most likely genetically predisposed to MS and the Lyme bacteria exerts its major effect by "turning on" immunologically directed CNS injury.
It is not uncommon to get a history of the onset of an exacerbation of MS related to infections, so Lyme exacerabating MS would be expected. HLA Class II molecules determine the intensity of the immune response to pathogenic foreign or self antigens.
With MS, the HLA-DR4 DQw8 haplotype has been associated with chronic progressive MS and the HLA-DR2 DQw6 haplotype has been associated with susceptibility to both chronic progressive and relapsing or remitting MS.
It is possible that in genetically predisposed patients of certain HLA types that infectioon by Lyme bacteria would cause a high production of cytokines that would mediate the demyelination and destruction of oligodendrocytes.
Has anyone been tested for the HLA-DR4 DQw8 haplotype? How do you get this test? Kim
-------------------- We are spiritual beings on a human journey...
posted
Sorry, I just don't buy the MS and lyme too,thing. Lyme causes neurological symptoms--we know that for sure. I would guess most people with lyme have some kind of neuro symtoms. Does this mean everyone with lyme also has MS?---phooy! That means my 9 year old with L'hermittes has MS and lyme, too. No, I think see just has lyme and we'll treat that and see what happens.
I guess you already know I don't think this theory is true-- Posts: 554 | From Naples, Italy | Registered: Jun 2006
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posted
This info is very old and there have been many studies which negate much of this info since this study was done oner 12 years ago.
Posts: 298 | From los angeles | Registered: Mar 2006
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Boomerang
Frequent Contributor (1K+ posts)
Member # 7979
posted
Very interesting, humanbeing. Thanks for the info.
Posts: 1366 | From Southeast | Registered: Sep 2005
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