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» LymeNet Flash » Questions and Discussion » Medical Questions » Glutathione

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Author Topic: Glutathione
savebabe
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Hi everyone,

I have been using glutathione for about 5 months now and I have noticed a significant improvement in my endocrine system.
For the first time in years my tsh is normal and my menstrual cycle is regular. I really believe that the gluta did the trick for me.
Has anybody else noticed an improvement in the endocrine system when using this supplement?

[ 22. January 2007, 12:54 PM: Message edited by: savebabe ]

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savebabe
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Here is some information about glutathione.

WHAT ARE SOME OF THE FUNCTIONS OF GLUTATHIONE (GSH)?

* Maintains proper oxidation-reduction (redox) potential
inside cells. Redox affects the oxidation state of sulfur in
enzymes, and thus affects the rates of biochemical reactions in
cells.

* Scavenges peroxides and oxidizing free radicals directly and
also serves as the basis for the antioxidant network.

* Performs Phase II detoxication of heavy metals (such as
mercury), organophosphate pesticides, chlorinated hydrocarbon
solvents, estradiol, prostaglandins, leukotrienes, acetaminophen,
and other foreign and endogenous toxins.

* Stores and transports cysteine throughout the body.

* Transports amino acids into cells, especially cystine into
kidney cells.

* Regulates the cell cycle, DNA and protein synthesis and
proteolysis, and gene _expression.

* Regulates signal transduction.

* Participates in bile production.

* Protects thyroid cells from self-generated hydrogen peroxide.

By means of several of the above functions, GSH plays very important
roles in (1) maintaining mitochondrial function and integrity, (2)
regulating cell proliferation, and (3) supporting the immune
system.

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serendipity
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Hi Savebabe,

How do you take the glutathione? Nebulizer, sublingual or another method.

Thanks for sharing your experience.

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savebabe
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One of the most effective ways of absorbing gluta is through your IV or you can do IM shots as well. I don't think oral supplements are effective.
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Carol in PA
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Supplementing glutathione is one of the "alternative" things I learned about by reading LymeNet.

However, it seems that having glutathione in the bloodstream is not the best way for the liver to get it...this would include delivery by intravenous and sublingual.

And glutathione is apparently absorbed poorly through the intestinal walls, so swallowing a supplement is not the best way.

I've read that the best way to supplement glutathione is to provide the precursors.
Precursors are the ingredients the body uses to make it.

Editing to add,
Some of the articles I've read about glutathione say that your level is likely to be low if you have a chronic illness.

The liver needs it to detoxify stuff, including the dead spirochetes and their toxins.

The liver uses it to detox tylenol.
I'm taking tylenol every day for pain, so I figured I better find some way to supplement this.

I don't recall all the things that are precursors to glutathione, but when I read that some here were being advised by their LLMD's to take undenatured whey, I looked into that.

Unless there are other factors of which I'm not aware, I believe that this topic is very important to our recovery.

Carol

[ 19. January 2007, 07:23 PM: Message edited by: Carol in PA ]

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Aniek
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I take a reduced glutathione orally. It's a liquid that looks like egg yolk.

It definitely has some impact. When I first started taking it, I had insmonia if I took it too late in the afternoon. So it does seem to do something.

I have noticed an energy connection. It also reduces nausea for me.

--------------------
"When there is pain, there are no words." - Toni Morrison

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serendipity
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Savebabe,

I've had glutathione via an IV, SL and enemas.
IV is by far the most effective. I feel better immediately.

Long term IV is not practical for me, so I take some SL and enemas with a tsp. of reduced L-glutathione to bypass the stomach and intestsines- I believe the glutathione is made inactive or broken down once it is in the stomach or intestines.

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MariaA
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My LLMD recommended undenatured whey as the precursor for glutathione , for when I start chelating for mercury. IT's stupidly expensive (like $50/tub). He also suggested taking it easy on the fats and eating simple and raw foods for a couple of weeks to help my liver deal with the chelation therapy. I've started on a milk thistle liver support formula while I wait for my whey and other chelation stuff to come in.

Maria

--------------------
Symptom Free!!! Thank you all!!!!

Find me at Lymefriends, I post under the same name.
diet: http://lymefriends.ning.com/group/healthylowcarbrecipes
Homemade Probiotics thread
Herbal Links Thread

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johnnyb
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Alpha Lipoic Acid helps increase your Glutathione production.
I also have a bottle of Glutathione precursors over here.... N-acetyl L-cysteine, L-glutamic acid, and L-glycine as ingredients.

- JB

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savebabe
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Hi MariaA,

I am interested in trying undenatured whey along with my glutathione. Could you please post where you order this supplement?
I am thinking of trying to get pregnant in the next few months, so anything that would detox my system I feel would be very beneficial.
Thanks.

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susan2health
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Any one tried nebulized glutathione?

I bought some that came in soft plastic bottles. No extra charge for the phalates.

The next month they sent it in hard plastic IV bottles, but I had what seemed to be a bad experience with the first, and I was hesitant
to try the second batch.

Thanks for the info.

Susan

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MariaA
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quote:
Originally posted by savebabe:
Hi MariaA,

I am interested in trying undenatured whey along with my glutathione. Could you please post where you order this supplement?
I am thinking of trying to get pregnant in the next few months, so anything that would detox my system I feel would be very beneficial.
Thanks.

I haven't received it yet, but my doc recommended the ones listed at this place. He also doesn't exactly endorse the site for good info on mercury detox- says 'take everything they say with a grain of salt'

www.y2khealthanddetox.com

--------------------
Symptom Free!!! Thank you all!!!!

Find me at Lymefriends, I post under the same name.
diet: http://lymefriends.ning.com/group/healthylowcarbrecipes
Homemade Probiotics thread
Herbal Links Thread

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MariaA
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I also did a search and found a couple of good-looking websites which talked about undenatured whey and seemed to assess several brands. I don't feel like I know anything about this subject though, I just went with what the doctor suggested this time

http://www.dfwcfids.org/medical/whey.html

--------------------
Symptom Free!!! Thank you all!!!!

Find me at Lymefriends, I post under the same name.
diet: http://lymefriends.ning.com/group/healthylowcarbrecipes
Homemade Probiotics thread
Herbal Links Thread

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savebabe
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I also found a webcast of docs explaining the benefits of glutathione. Check out www.nutritionadvisor.com. They are advertising an oral supplement and I was wondering if anyone has tried this?
Also do you need a prescription for the nasal spray glutathione?
Thanks everyone. Keep detoxing! [Smile]

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Cate
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Several docs have told me to take a teaspoon or two of undenatured whey along with 600 mg N-Acetyl Cysteine twice daily to help my body make glutathione.

I have done this for several years, but also have periodically done IM glutathione shots as well as the nasal spray. Didn't notice much with the spray, but the shots work great. However, they hurt like hell, even with lots of procaine in them.

As to undenatured whey, the brand many docs recommend is Immunocal, but it is extremely expensive and doesn't dissolve in liquid well. I prefer either ProHealth's ImmunPlex or Custom Probiotics brand, both taste better and are much cheaper. You can find both via a simple web search.

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clairenotes
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When I started taking a whey protein drink, I had no idea what the benefits would be, with the exception that I knew, per my PA/naturopath, that it benefitted the liver. I started feeling a lot better almost immediately. I had also begun taking NAC a little before taking the whey product. Like Cate, this was a good combination for me, also.

Claire

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farah
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I have been taking 1800 milligrams of NAC a day. It is a precursor to glutathione. It also seems to have antimicrobial properties, probably because of its sulfur content. It has been used a lot in people with HIV to control AIDS related infections, and it seems to work well for most of the people I know who take it for Lyme. For AIDS some people take up to 3000 milligrams/day. It is important to take it with food, and not to take such a high dose all at once, because it is hard on the gut. It has been very beneficial for me.

Farah

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MarsyNY
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Savebabe, it is interesting that you noticed its effects on your endocrine system.

Since I cannot afford the glutathione by IV anymore I am using a sublingual, not sure if it is having any effect, as I was sure with the IV that it made a big difference.

By the way 500mg of Vitamin C increases GSH in the blood by 50%, seems easy enough.

I was thinking about trying Oral Recancostat. Has anyone tried it? quite pricey so I dont want to waste my money if it is not well absorbed.

Glutathione should be on everyones list,
as Martha would say"it's a good thing"

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luvs2ride
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My doctor has had me on bi-weekly shots of glutathione and lipostabil since last May. At my Dec visit, I was asking what supplements we could back off of to save money. He made some suggestions and also suggested we try backing the glut and lipo injections to once a month. This was good news to me as he is 2 1/2 hrs away. It always involves a day away from the office which is a great strain on my husband (we own a business together).

Directly after that visit, our one employee gave her notice. I called the doctor and changed my appt for my glut/lipo from Jan 22 to Jan 12 as the employee would still be with us on that day and I could get away.

Unfortunately, my one good vein decided on that day that it had had enough and wouldn't take the medicine. So, essentially, I have not had glut/lipo since 12/21/06. MY SYMPTOMS ARE RETURNING RAPIDLY!!! I'm trying Dr. K's detox method with cilantro and chlorella, but so far, the pain continues to grow. Scary, since my symptoms are rheumatoid arthritis and I fear joint damage. My doctor had me in a nearly painfree state for 7 mths.

If I had any doubts about the effectiveness of this treatment, I no longer doubt. I'm reading this particular thread with great interest, but I do not think I will spend my dollars on the orals. We are trying to hire another employee and have a good prospect. Hopefully, I will be able to return to my very good doctor soon.

Luvs

--------------------
When the Power of Love overcomes the Love of Power, there will be Peace.

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MarsyNY
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Luvs,

When you said shots I was wondering if you could have the dr. give you a perscription to give them to yourself. But you did mention vein, is this an IV Push?

That is bit scarey that your symtpoms are returning so rapidly. You mentioned the chlorella and cilantro. Did you recently do amalgam removal?

What is the Lipostabil used for?

-----------

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Foggy
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I did IVs for a few months. Helped bring my metals levels down.
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savebabe
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Here is another suggestion; Glutathione suppositories by Wellness pharmacy. I know it does not sound pretty, but believe me they work.

Wellness Pharmacy (205)879-6551

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MarsyNY
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Wow,

Never even heard of that! Wow and it really works
Thanks again

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luvs2ride
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Savebabe, Thanks. I'll look into those.

Mars, I'm too squimish to give myself shots. God forbid I ever get diabetes. They are pushes into the vein.

Luvs

--------------------
When the Power of Love overcomes the Love of Power, there will be Peace.

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TerryK
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Years ago my doctor had me on glutathione lotion that he had compounded by a compounding pharmacy. It seemed to help my energy but then it stopped working. He said that is not unusual. He wanted me to take shots but he stopped treating anyone but autistic patients and I didn't know anyone at the time who would prescribe the shots so I never got back on it.

Prior to getting the lotion, my doctor ran some tests that said my glutathione was dangerously low. I guess this is common in fibro patients so it's probably not unusual with lyme patients either.

I tried the expensive whey and at first I got a detox reaction (some people have terrible reactions) but after awhile that stopped and I really didn't notice any improvement in my condition with the use of whey.
Terry

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MarsyNY
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Sav,

Do you need a perscription for the glutathione suppositories?

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susan2health
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Yes, it is a prescription product.

I tried their topical, and it did nothing for me.

I tried nebulized, and it help sound sensitivity, but I had more cognition, speech, balance problems.

I may have doing too much, especially because I was combining it with sauna.

My environmental doc said too much of either can loosen and redistribute mercury to the brain, which seemed to be what happened to me.

Let us know how you do.

Susan

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savebabe
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Yes, you do need a prescription. I think most of the llmd are familiar with Wellness pharmacy so I don't think it would be a problem getting a script.

I also found information regarding fertility and gluta. Since lyme has totally made me body toxic, I am very concerned about eliminating as much poison in my system as I can before I decided to get pregnant.

Here is an interesting article to check out.

Glutathione for a Healthier Pregnancy - By Priya F. Shah




Copyright � 2004 Priya F. Shah

All parents-to-be nurture the dream of a healthy pregnancy and baby.

But the modern environment and diet is deficient in many factors essential for the health of mother and fetus. One of those factors is antioxidants.

The role of antioxidants like folic acid in preventing birth defects like spina bifida and cleft palate is well known. It is now included in all prenatal vitamin supplements.

But the role of antioxidants like glutathione and Vitamin E in pregnancy is often overlooked.

Glutathione is the body's master antioxidant. It helps to regenerate stores of other antioxidants like Vitamin C and E.

It also protects both mother and fetus from the damaging effects of free radicals and oxidative stress.

Many pregnancy complications and birth defects have been linked oxidative stress, free radical damage and low glutathione levels in the mother and fetus.

Environmental and lifestyle factors are known to cause oxidative stress and lower glutathione levels - resulting in birth defects, abortion and miscarriages in pregnancy.

Some of the known teratogens (causing birth defects) in pregnancy include:

o Radiation
o Pesticides and Persistent Organic Pollutants (POPs)
o Air pollution
o Heavy metals (mercury, cadmium, arsenic)
o Vinyl chloride
o Acryonitrile
o Excess Oxygen (hyperoxia)
o Anti-psychotic and anti-epileptic drugs (AEDs)
o Thalidomide
o Cigarette smoke
o Alcohol (ethanol) consumption

Maternal health factors that increase free radicals and cause birth defects include:

o Diabetes
o Pre-Eclampsia
o Infection and Inflammation

Numerous studies have shown that glutathione (GSH), vitamin C, and E are crucial in the development and growth of the fetus, maintenance of a healthy pregnancy - and, even before pregnancy, in fertility and conception.

Glutathione and other antioxidants attenuate oxidative stress in pregnant women with inflammation or maternal conditions like diabetes and pre-eclampsia, and in fetuses at risk for developing cystic fibrosis.

Supplementation with glutathione precursors and antioxidants can decrease the incidence of birth defects and protect both mothers and the fetus from the damaging and possibly fatal consequences of pregnancy complications.

Glutathione (GSH ) also prevents or minimizes the oxidative stress that occurs during labor and the birth process.

Perinatal or birth asphyxia/hypoxia (deprivation of oxygen supply to the brain) in preterm deliveries and labor can lead to cerebral palsy, respiratory distress syndrome, irreversible brain injury, and permanent neurological and intellectual handicaps.

Administration of the glutathione precursor, N-Acetyl-Cysteine (NAC), to the pregnant mother partially prevents oxidative stress during the birth process in premature infants.

Currently, the American College of Obstetrics and Gynecology advises all pregnant women to take a prenatal vitamin containing antioxidants.

In addition, they advise eating lots of fresh fruits and vegetables, the best sources of antioxidant protection.

For a detailed report with references on the role of glutathione in pregnancy, visit:
http://www.1whey2health.com/glutathione_pregnancy.htm


--------------------------------------------------------------------------------

Priya Shah is the Editor of "Health eBiz," an ezine for Health & Wellness Entrepreneurs. Subscribe here: http://www.health-ebiz.com Get a Free Report on Glutathione and Health at http://www.1whey2health.com

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Carol in PA
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quote:
Originally posted by TerryK:
... I really didn't notice any improvement in my condition with the use of whey.
Terry

If the whey were working, I would think that it would show normal results for your liver enzymes.

Carol

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