Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I've been doing a lot of research the past couple of days, piecing more together.
Now...I am going to greatly simplify and not link the following information, but I guarantee you...it IS all documented from reputable sources.
Okay, here goes:
The langerhans cells (a WBC) are ``capturing'' Bb and transporting it to the lymph nodes.
It appears lactoferrin can inhibit langerhans cell migration and reduce inflammation. It appears to do so by binding Bb's zinc ``fingers''.
Langerhans cells are immature dendric cells and immature dendric cells express 11 BHSD1 which converts cortisone to cortisol.
Interleukin 1 doesn't help out in that respect. It raises the cortisol set point. Low cell potassium LOWERS cortisol, but IL 1 is upregulating it. This means intracellular potassium / KCL is not available to destroy Bb. Instead of K in the cells, Na is in the cells. That cellular pump (Na-K) isn't functioning as it should.
(You might be interested to know that 11 BHSD1 is also linked to obesity, insulin resistance, osteoporosis and glaucoma. Bottom line...too friggin much cortisol.)
We all here know that cortisol = disaster for lyme.
Cortisol impacts Na transport of choline which we know Bb wants.
It appears lactoferrin can indeed help, but still...there is a tremendous need for the antioxidants.
Lactoferrin is also able to diminish the ability of heparin to stabilise tryptase. Tryptase is released from mast cells and
triggers histamine.
"Mast cells are found in connective tissue that contains numerous basophilic granules and releases substances such as heparin and histamine in response to injury or inflammation of bodily tissues."
It is curious that the following is currently a nutritional approach to HIV:
From the internet:
"Review
Very low concentrations of hydrogen peroxide, an extremely reactive ROS (reactive oxygen species), promotes HIV synthesis via activation of NF-kappaB.
The anti-oxidant NAC inhibits this response.
ALA is a particular important anti-oxidant because it increases the level of glutathione in HIV infected cells.
In addition, ALA directly inhibits the activation of NF-kappaB.
(NAC and ALA AND calcium and biotin are in a product called Juvenon.)
DOSAGE
Niacinamide, 6-10 grams a day based on body weight. This molecule is water soluble and quite bioavailable.
Lactoferrin, 2 grams a day, 1 gram twice a day, preferably dissolved in warm cream or 1/2 and 1/2. This improves bioavailability.
Ibuprofen, 1.2 grams a day, 200 mg individual doses 6 times a day. (My note here. I'd switch this to good old ASA and use 2 baby aspirin (about 164mg) dissolved in the mouth for the 6 doses because aspirin looks to slow down NAT2..one of the n-acetyltransferase enzymes.
Vitamin A, 15000IU a day.
Anti-oxidants. 600 mgs ALA, 2 grams NAC, 2 grams vitamin C ester or ascorbyl palmitate. Vitamin E as desired.
Selenium, 250 micrograms a day. No NOT use yeast derived selenium. It is poorly bioavailable. Purchase sodium selenite only.
Cimetidine, 800 mgs a day, 400 mgs twice a day. (Cimetidine is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers.) It is know as Tagamet.
The ability of lactoferrin/lactoferrin peptides to stimulate IL-18 release is considered fundamental to its ability to active innate immunity."
Lyme patients are ``stuck'' in an allergic response to Bb. There is a huge imbalance between tryptophan + histidine and tyrosine + phenylalanine.
Bb isn't the only pathogen to cause the above imbalance. So does Bacillus subtilis.
All of the above is not to say there are not other effective treatments. Rife works (IMO only the most powerful units).
Ozone saunas work.
Inactivating HMG CoA reductase works.
These work from different angles, but they do indeed work.
Hyperthermia treatments (likely far infrared) are toxic for LC whereas they have little or no effect on keratinocyte viability. But BEWARE...hyperthermia depletes the minerals (you should know this...kids with fevers need Pedialyte!) so it is essential to restore them. The ``most reactive'' minerals will be depleted first...lithium, potassium, sodium, calcium and magnesium...is the order from most reactive to least.
Healing takes TIME.
Meanwhile...it is vital to keep the antioxidants and antioxidant enzymes up to avoid as much DNA damage as possible.
[ 08. February 2007, 02:38 AM: Message edited by: Marnie ]
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cantgiveupyet
Frequent Contributor (1K+ posts)
Member # 8165
posted
Thanks Marnie, i will have to reread this tomorrow when I am more awake.
My AM and PM cortisol levels are triple what they should be, so i found this interesting.
You also mentioned Bb likes Choline is that the same asPhosphatidyl Choline?
Thanks again.
-------------------- "Say it straight simple and with a smile."
"Thus the task is, not so much to see what no one has seen yet, But to think what nobody has thought yet, About what everybody sees."
-Schopenhauer
pos babs, bart, igenex WB igm/igg Posts: 3156 | From Lyme limbo | Registered: Oct 2005
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Not so sure Tagamet is such a good idea. Many who think they have too much stomach acid actually have too little stomach acid.
Without stomach acid can't absorb such critical items as amino acids from protein (needed to produce neurotransmitters). Acid also needed to absorb the B vitamins.
Bea Seibert
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5dana8
Frequent Contributor (1K+ posts)
Member # 7935
posted
Thanks so much marine
Is the ALC antioxidant Acetyl-L-Carnitine?
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Dana, yes. In Juvenon it is "acetyl-L-carnitine HCL".
Bea...are you watching...HCL. Also...timing Tagamet not too close to meals would be logical. When we eat something, this triggers the release of the stomach acids.
In order to fight H. Pylori (stomach ulcer) the OTC remedy is Zantac with Pepto bismol tablets. First lower the stomach acids (Zantac) and then give bismuth + subsalicylate.
Are you catching "salicylate"? Did you catch the reduce NAT2? Interesting that cats (who rarely get lyme) don't have this enzyme/less.
This is one of the 2 enzymes needed to make melatonin from serotonin. Melatonin is a powerful antioxidant. But our defense system uses oxygen to kill invaders as well as knock off precancerous cells. Lone oxygen (superoxide) is very, very powerful.
Licorice
can also kill H. Pylori. It acts on arylamine N-acetyltransferase (inhibits it). Licorice is NOT a good thing for Bb... it elevates Na and K is lost. It increases cortisol in the kidneys. It is abundant in...get this...cigarettes. It is in many things as a sweetener. It functions as an expectorant.
Regulation of cortisol happens thru activating and deactivating the molecule with a ketone/alcohol conversion on the C=11 carbon. This switch regulates androgens and estrogens.
It DOES cure Kaposi sarcoma associated herpes virus (HIV co-infection) which is present in B lymphocytes.
It LOWERS testosterone and increases 17-hydroxyprogesterone.
It does inhibit several viruses including herpes simplex.
It IS a free radical scavenger and protects DNA.
So...licorice...good to fight some infections, NOT to fight others.
LC = langerhans cells. LF usually stands for lactoferrin. It binds iron, but also zinc.
Many pathogens use the above minerals.
In the news just a day ago...obesity believed to be caused by too many of one of the beneficial bacteria. Balance is off. They didn't say which one...darn!
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5dana8
Frequent Contributor (1K+ posts)
Member # 7935
posted
Thanks marnie
Just one more question:
is Lactoferrin...Colostrum?
I googled it & colostrum seems to come up alot.
Blessings Dana
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
In colostrum, yes. We have some...maybe just not enough.
"Lactoferrin "Lactoferrin is an 80-kDa, iron-binding ***glycoprotein*** present in milk and, to a lesser extent, in exocrine fluids such as *bile* and tears."
"Owing to its iron-binding properties, lactoferrin has been proposed ...to act as a bacteriostatic agent by withholding iron from iron-requiring bacteria."18 Lactoferrin is found in high concentrations in human colostrum but the level of lactoferrin in bovine colostrum is very low."
And yes, it DOES work topically (the cream).
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CaliforniaLyme
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posted
I really enjoy your posts!!!!
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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dmc
Frequent Contributor (1K+ posts)
Member # 5102
posted
do any of you think the diet pills ie: relacor, cortislim which supposedly lower cortisol would be benificial?
Marnie, thanks for your interesting posts.
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Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
Marnie, could you clarify this for me. You said:
quote:We all here know that cortisol = disaster for lyme.
Does that mean that cortisol is bad for the lyme OR bad for us WITH the lyme.
I have extremely low cortisol and take very low doses of cortisol to bring me into sort of low normal.
Then someone else who posted above said they have high cortisol.
Also, if yor adrenal are cranking out massive cortisol constantly as I think happens in dysautonomia where does this leave us?
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
I hope this one is a keeper
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
"Interleukin 1 beta upregulates iron efflux in rat C6 glioma cells."
The combination of LPS plus cytokines can induce NOS activity in C6 glioma cells.
These cells apparently are linked to fibronectin and collagen. BOTH. This is why heparin is only partially helpful.
The glial cells (glioma) surround the nerves.
Oops...back on track, Marnie!
It is curious that in Parkinson's Disease, the number of lactoferrin RECEPTORS is increased.
It looks like the body is trying to bind iron.
Stuck in an allergic response...IgE primarily.
There is a strong link between estrogen levels and lactoferrin.
"We conclude that combination therapy with LFcinB (bovine lactoferricin) and tamoxifen warrents further investigation for possible use in the treatment of breast cancer." (Pubmed)
Tamoxifen is a man-made PKC inhibitor. PKC...protein kinase C INhibitors cause cell death. We want to trigger the death of breast cancer cells.
To prevent sudden and excessive cell death, we upregulate PKC. Bb's genetic code indicates it posesses a PKC INhibitor.
But...we need infected cells to die...hence Tamoxifen to treat estrogen related cancer cells. These are cells whose DNA is damaged...and they multiply out of control.
Estrogen (and testosterone)comes FROM cholesterol.
Estrogen helps keep calcium IN our bones. But too much isn't good. Testosterone is protective too, but once again...too much is a warning. The body is breaking down "excess" cholesterol.
Enough for now...gotta get in my sauna.
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cantgiveupyet
Frequent Contributor (1K+ posts)
Member # 8165
posted
Thanks again Marnie....
From what I read Bb could have triggered my cortisol levels to rise and for some reason it is still on hyper mode, never went back down?
I also just started taking Phosphatidyl Choline- should I be concerned since you say Choline is what Bb likes?
-------------------- "Say it straight simple and with a smile."
"Thus the task is, not so much to see what no one has seen yet, But to think what nobody has thought yet, About what everybody sees."
-Schopenhauer
pos babs, bart, igenex WB igm/igg Posts: 3156 | From Lyme limbo | Registered: Oct 2005
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cantgiveupyet
Frequent Contributor (1K+ posts)
Member # 8165
can also kill H. Pylori. It acts on arylamine N-acetyltransferase (inhibits it). Licorice is NOT a good thing for Bb... it elevates Na and K is lost. It increases cortisol in the kidneys. It is abundant in...get this...cigarettes. It is in many things as a sweetener. It functions as an expectorant.
Marnie, Does this refer to DGL after the component that raises your blood pressure is removed or plain old licorice herb?
Thanks for all the research you do. I wish my brain worked one fourth as good as yours.
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