Just wondering if anybody has considered doing a cholestymine (sp?)enema. I know the colon just hold the toxic stuff and all vitamins are absorbed up in the small intestine, which is Questran's biggest drawback (absorbing everything in it's path. So theoritcally I would just get rid of the bad stuff.
I have had colon discomfort for ever but the questran is hard on my liver plus I can tell it obsorbs vitamins (my teeth hurt).
Any thoughts?? Especially with those with stomach/colon issues
Thanks a million,
CaliLymer
Edit: Just found this article by considence about a new product coming soon.
At present, antibiotics are our best weapon for treating Clostridium difficile-associated disease (CDAD). The sad reality is that they fail to cure CDAD in up to 25% of cases.1
But several new developments may soon change our approach to C. difficile. Tolevamer sodium, a new toxin binder formerly known as GT160-246, is a "non-antibiotic" that can stop CDAD and prevent a relapse.1-3
Tolevamer is an anionic polymer that binds C. difficile's toxins in the gut, like cholestyramine resin (Questran) binds cholesterol. Unlike cholestyramine, however, tolevamer won't bind and remove antibiotics, so it can be used prophylactically, too--to prevent CDAD in patients receiving antibiotic therapy.
[ 26. February 2007, 02:47 PM: Message edited by: CaliLymer ]
Posts: 215 | From CA, USA | Registered: Nov 2004
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"Illnesses, hover constantly above us, their seed blown by the winds, but they do not set in the terrain unless the terrain is ready to receive them."---Claude Bernard. Posts: 131 | From US | Registered: Dec 2006
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WildCondor
Unregistered
posted
Hi!
I've never heard of a Questran enema! When I took it, it was always powder mixed with water, spaced out in between antibiotics. I have heard of coffee, butyrate, probiotic, and fecal transplant enemas though. Yes, tolevamer is a much anticipated drug for the c.diff community! There are not a heck of a lot of options for those who are critically ill with relapsing c.difficile. Tolevamer is supposed to bind to the toxins, pulling them out of the body, while at the same time not binding to the antibiotics (Flagyl, Vancomycin)
Maybe it will have a place in treating chronic Lyme disease as well. Hopefully soon enough we will have our answers!
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Check this article out. Cholestyramine resin (Questran) has been used as an adjunct to treatment because it binds toxins A and B, similar to the way it binds cholesterol.1,7,16 It's been used with moderate success--but only in chronic cases. Because cholestyramine also binds with vancomycin, the two drugs should be given at least an hour apart.
I have had some success, but can seem to hold it very long. Can seem to get the hang of it. Very frustrating
calilymer
Posts: 215 | From CA, USA | Registered: Nov 2004
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
I don't see how that would be useful. You need to get the binding to occur starting where the bile comes out and all along the way through the rest of the digestive system. If you are only getting it partially into the colon via an enema, it likely has an opportunity to reabsorb a large potion before it ever gets to where the Questran is.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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timaca
Frequent Contributor (1K+ posts)
Member # 6911
posted
Where did you find the info about the GT160-246?
I would tend to agree with what Scott said about a questran enema....but I am not a doctor and don't personally use enemas....
Timaca
Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005
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WildCondor
Unregistered
posted
Thanks CaliLymer!
I had seen it before but don't have it on me now. Tolevamer is in advanced trials now. There is a GI in NY city who is doing well with it in his c.diff patients. C. diff is one nasty beast and a scary one too, trust me!
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