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» LymeNet Flash » Questions and Discussion » Medical Questions » Minocycline and What?

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Author Topic: Minocycline and What?
Yashin
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i have a question-
what is this abx usually paired with for lyme babs erlich treatment? and what treats toxoplasmosis infection?

Posts: 33 | From newenglandusa | Registered: Feb 2007  |  IP: Logged | Report this post to a Moderator
trueblue
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I don't know...


I'm taking a guess... Mino is related to Doxy and so "should" be good for Ehrlichia.

Babs... maybe adding Mepron, Malarone or Bactrim and Artemisinin?


Someone smarter should be by any time now. [Wink]

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more truth and more innovation

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Geneal
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My neighbor is on mino and flagyl.

The mino is 300mg a day and the flagyl is 500mg 2 x a week.

This is to treat Lyme and Ehrlichia.

Hope this helps.

Hugs,

Geneal

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tory2457
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Hi,

I'm a neuro lymie for lots of years, and have MS.

Here's my regimen.

Mino, and Diflucan for a month
then
Mino, Zith, Mepron for 3 months

don't know what's next.
treating for I'm guessing a bunch of things: Babs, Bart, Ehrlicia? haven't really been tested yet.

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treepatrol
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CLARITHROMYCIN + MINOCYCLINE AS A TREATMENT FOR CEREBRAL TOXOPLASMOSIS (CT) IN HIV-INFECTED PATIENTS (PTS).

Conf Retroviruses Opportunistic Infect 1996 Jan 28-Feb 1; 3rd:160 (abstract no. 578)

Rabaud CH, Arniel C, Maignan M, Hoen B, May TH, Canton PH; Department of infectious disease, CHU Nancy, France.


--------------------------------------------------------------------------------

The treatment of CT should not be discontinued in HIV-infected pts. Pyrimethamine in combination with sulfadiazine or clindamycin is the standard therapy, but side-effects of these drugs are reported in 20-30%. of the cases, leading to the discontinuation of the treatment. In such occurence, alternative therapy is required. The efficacy of clarithromycin combined with minocycline was previously reported in mice. We studied the efficiancy of this treatment in HIV-infected pts presenting CT unable to tolerate the conventional treatment. Eight HIV-infected pts (mean CD4+ lymphocyte count = 58/mm� ) were treated for CAT scan-confirmed CT with pyrimethamine 100 mg/d combined with either sulfadiazine 6 g/d (7 pts) or clindamycin 3.6 g/d (1 patient). In all cases, severe side effects (hematologic: 7 pts or diarrhea: 1 patient) percluded the continuation of this therapy. Before these side effects were reported, the mean duration of initial treatment was 114 days (15 - 180). At that time, CT was considered to be cured or significantly improved in all pts who were subsequently treated with clarithromycin 2 g/d + minocycline 200 mg/d. Nausea and vomiting occured after few days of clarithromycin treatment at 2 g/d but disappeared after dosage reduction to 1 g/d. In all the but one pts, this treatment was continued until patient's death and is still ongoing in 2 pts. In one patient, neutropenia reoccured after 11 months and treatment was replaced by atovaquone. No other side effect was noted. Mean duration of follow-up was 11.75 months. No relapse was reported. No Mycobacterium avium complex infection occured in these pts.

Clarithromycin associated with minocycline appeared to be an effective alternative therapy of CT in HIV-infected pts when used after intolerance to standard treatment.


CLARITHROMYCIN + MINOCYCLINE AS A TREATMENT FOR CEREBRAL TOXOPLASMOSIS

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Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

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treepatrol
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googled yeee [Big Grin] ha

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Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

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mtnwoman
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Minocycline (and doxy, and tetracycline) are used for the non-cell wall form of Bb (along with the macrolides like zith, biaxin and ketek).

I believe Dr.B recommends adding either abx from the amoxicillin family or the cephalosporin (ceftin) family to get the cell wall variety of Bb.

The goal is to have abx on board to get Bb in all it's forms. Thus, flagyl or tinidazole is added at some point.

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mtnwoman
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Minocycline (and doxy, and tetracycline) are used for the non-cell wall form of Bb (along with the macrolides like zith, biaxin and ketek).

I believe Dr.B recommends adding either abx from the amoxicillin family or the cephalosporin (ceftin) family to get the cell wall variety of Bb.

The goal is to have abx on board to get Bb in all it's forms. Thus, flagyl or tinidazole is added at some point.

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Yashin
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thank you-I couldn't find your responses for a while, here on page two-duh!
I appreciate your help. I am now trying a regimen which one of you reccomened. good to know my llmd is on the right track-thnakyou again.


Yashin

Posts: 33 | From newenglandusa | Registered: Feb 2007  |  IP: Logged | Report this post to a Moderator
   

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