Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
It appears Bb's NH2 OspB may impact the androgen receptors...specifically...and ultimately...estrogen receptor alpha.
In this study, a primary sequence homology comparison identified a 14-amino acid NH2-terminal motif of the human androgen receptor (AR) that is common to AR from all species reported, including the lower vertebrates.
Likely Bb's OspB maybe ``recognizing'' and impacting the human androgen receptor...perhaps the estrogen receptor.
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), also called modulator of nongenomic activity of estrogen receptor (MNAR), a novel coactivator of estrogen receptor, modulates estrogen receptor transactivation functions.
Using deletion analysis, we have identified the PELP1 COOH-terminal region as the histone 1 binding site.
(Bb's zinc fingers contain histidine.)
Genistein Inhibits Protein Histidine Kinase
The fact that male estrogen receptor alpha (ERa) knockout mice are infertile indicates a role for this receptor in male reproduction.
at least one strain-related cascade responsible for adaptive control of bone architecture is mediated through estrogen receptor (ER) alpha, the number and activity of which are regulated by estrogen.
In industrialized countries, breast cancer is the most common tumor in women. The tumor expression of estrogen receptors (ERs) is a very important marker for prognosis and a marker that is predictive of response to endocrine therapy.
The loss of ER expression portends a poor prognosis and, in a significant fraction of breast cancers, this repression is a result of
the hypermethylation of CpG islands within the ER- promoter.
Hypermethylation is one of the best known epigenetic events in mammalian cells. Over the last few years, many studies have found that other epigenetic events, such as deacetylation and methylation of histones, are involved in the complex mechanism that regulates promoter transcription.
The exact interplay of these factors in transcriptional repression activity is not yet well understood.
Inhibitors of some of these are currently being studied as new drugs able to restore ER- protein expression in ER- -negative breast cancer cells and to promote apoptosis and differentiation.
Demethylating agents and histone deacetylase (HDAC) inhibitors are candidates for becoming potent new drugs in cancer therapy .
***Artemisinin acts in breast cancer cells by inhibiting the production of the estrogen receptor-alpha (ERα) gene without altering the level of the related estrogen receptor-beta gene (ERα).***
"Proliferation of Estrogen Receptor alpha Positive Mammary Epithelial Cells is Restrained by TGFbeta 1 in Adult Mice" (March 3, 2005).
Estrogen receptor-alpha deficiency
promotes increased TNF-alpha secretion
and bacterial killing by murine macrophages in response to microbial stimuli in vitro.
Multiple sclerosis is an inflammatory, neurodegenerative disease for which experimental autoimmune encephalomyelitis (EAE) is a model.
Treatments with estrogens have been shown to decrease the severity of EAE through anti-inflammatory mechanisms.
Treatment with either estradiol or the ER ligand significantly reduced this gray matter pathology. In conclusion, treatment with an ER ligand is highly selective in vivo, mediating both anti-inflammatory and neuroprotective effects in EAE.
[ 20. April 2007, 06:17 PM: Message edited by: Marnie ]
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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posted
these look like random out-of-context quotes from research papers in molecular biology having to do, or having nothing to do, with Lyme (half of the quotes seem to be from papers on breast cancer).
Perhaps the point was that technical language is hard to understand to non-specialists. There is nothing one can do about it. It's like complaning that Chinese is hard to understand to an English speaker.
If you need a paper explained you can post a reference, and I can do my best to explain it in a paragraph of non-technical language. No guarantee that you wll find any immediate implications for the patient, since there is a huge gap between fundamental research and an ISGA-approved treatment protocol (say, 10 years from the original discovery to the patient - unless you are willing to experiment on yourself).
[ 20. April 2007, 03:42 PM: Message edited by: runcyclexcski ]
Posts: 59 | From CA | Registered: Dec 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
The subject heading should have warned you.
Don't even attempt to read the medically complex stuff if you don't have a medical background.
You were warned. Several on this board do have medical backgrounds and will find this information as another piece of the puzzle.
There are MANY diseases Bb can "trigger". Cancer (esp. breast and prostate) is among them.
WHY it can lead to other diseases may be the result of various co-infections OR the particular strain of Bb...which are many.
Virtually all pathogens are sugar lovers...as we are. They NEED sugar (and fats to make proteins) just as we do.
Cancer cells thrive solely on glucose. They are high in lactic acid. They originate from epithelial cells...
I linked my original post for you to translate, runcyclexcski.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I CHOSE not to be so pessimistic!
I will find and understand the ways (plural) to destroy Bb and have done so with help from others on this board. Thank you Bea, Scott, Gudrun, Jill, Robert...and many others!
The vast majority of "old-timers" on this board already know a LOT more about lyme than 99.9% of doctors.
And the remaining 0.1% of doctors have a hard time keeping up with current research...yet alone try to piece this together.
It is in OUR HANDS to get well. We must stay "current" and very pro-active.
And healing starts with our perspective...in our brains...our thoughts.
We must BELIEVE it is possible to get well and THEN figure out how to accomplish this.
Cave, do you BELIEVE you are ever going to recover completely from lyme disease?
IF you answered, "No."...change your perspective!
When you believe it, THEN you will see it.
Healing STARTS in the mind-gut connections.
This IS a major neurotransmitter imbalance. It CAN be corrected.
You CAN get well...and will.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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