CaliforniaLyme
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Member # 7136
posted
The only thing I have ever heard of helping ALz Lyme is IV Rocephin. We had one woman in our local group with an Alz diagnosis- she was in her 80s and went on IV Rocephin- helped a lot and her musical hallucinations stopped after years of them (opera if I remember righT!)!!!!
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
Frequent Contributor (5K+ posts)
Member # 7136
posted
However, if someone wants to do herbal stuff here are some good potentials to read up on!! Personally I drink rosemary tea for my brain*)! But if I had an Alz diagnosis I would go on IV Rocephin- AND drink mulberry leaf tea, too*)! *****************
Neuroreport. 2007 May 28;18(8):813-816. Links
Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity.
Niidome T, Takahashi K, Goto Y, Goh S, Tanaka N, Kamei K, Ichida M, Hara S, Akaike A, Kihara T, Sugimoto H. aDepartment of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences bDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University Departments of cBiomolecular Engineering, Kyoto Institute of Technology dApplied Biology eExperimental Farms, Faculty of Textile Science, Kyoto Institute of Technology, Kyoto, Japan.
Mulberry leaf has been reported to possess medicinal properties, including hypoglycemic, hypotensive and diuretic effects. Little is known, however, about its medicinal properties for central nervous system disorders, including Alzheimer's disease.
Accumulating evidence suggests that amyloid beta-peptide (1-42) plays an important role in the etiology of Alzheimer's disease. Here we show that mulberry leaf extract inhibits the amyloid beta-peptide (1-42) fibril formation by both the thioflavin T fluorescence assay and atomic force microscopy.
Furthermore, mulberry leaf extract protected hippocampal neurons against amyloid beta-peptide (1-42)-induced cell death in a concentration-dependent manner. These results suggest that mulberry leaf extract provides a viable treatment for Alzheimer's disease through the inhibition of amyloid beta-peptide (1-42) fibril formation and attenuation of amyloid beta-peptide (1-42)-induced neurotoxicity.
PMID: 17471072
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
Frequent Contributor (5K+ posts)
Member # 7136
posted
If you go to pubmed and put in Alheimer's and herbal in the search box there are 106 citations!!! ******************************************** Items 1 - 106 of 106 One page.
2007 Jan 10. No abstract available. PMID: 17218017 [PubMed - indexed for MEDLINE]
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PMID: 10921134 [PubMed - indexed for MEDLINE] 88: Arai H, Suzuki T, Sasaki H, Hanawa T, Toriizuka K, Yamada H. Related Articles, Links [A new interventional strategy for Alzheimer's disease by Japanese herbal medicine] Nippon Ronen Igakkai Zasshi. 2000 Mar;37(3):212-5. Review. Japanese. PMID: 10879069 [PubMed - indexed for MEDLINE] 89: Patocka J. Related Articles, Links Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine. Acta Medica (Hradec Kralove). 1999;42(4):123-5. PMID: 10812678 [PubMed - indexed for MEDLINE] 90: Koch E, Jaggy H, Chatterjee SS. Related Articles, Links Evidence for immunotoxic effects of crude Ginkgo biloba L. leaf extracts using the popliteal lymph node assay in the mouse. Int J Immunopharmacol. 2000 Mar;22(3):229-36. PMID: 10685005 [PubMed - indexed for MEDLINE] 91: Kobayashi MS, Han D, Packer L. 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Related Articles, Links Different changes in concentrations of monoamines and their metabolites and amino acids in various brain regions by the herbal medicine/Toki-Shakuyaku-San between female and male senescence-accelerated mice (SAMP8). Neurochem Res. 1999 Jul;24(7):825-31. PMID: 10403621 [PubMed - indexed for MEDLINE] 96: Patocka J. Related Articles, Links Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine. Acta Medica (Hradec Kralove). 1998;41(4):155-7. Review. PMID: 9951045 [PubMed - indexed for MEDLINE] 97: Rosler M, Retz W, Thome J, Riederer P. Related Articles, Links Free radicals in Alzheimer's dementia: currently available therapeutic strategies. J Neural Transm Suppl. 1998;54:211-9. Review. PMID: 9850930 [PubMed - indexed for MEDLINE] 98: Oishi M, Mochizuki Y, Takasu T, Chao E, Nakamura S. Related Articles, Links Effectiveness of traditional Chinese medicine in Alzheimer disease. Alzheimer Dis Assoc Disord. 1998 Sep;12(3):247-50. PMID: 9772030 [PubMed - indexed for MEDLINE] 99: [No authors listed] Related Articles, Links Benefits of ginkgo for Alzheimer's are still unclear. Mayo Clin Health Lett. 1998 Jan;16(1):4. No abstract available. PMID: 9516350 [PubMed - indexed for MEDLINE] 100: Skolnick AA. Related Articles, Links Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy. JAMA. 1997 Mar 12;277(10):776. No abstract available. PMID: 9052690 [PubMed - indexed for MEDLINE] 101: Sugaya E, Sugaya A, Kajiwara K, Yuyama N, Tsuda T, Motoki M, Shimizu-Nishikawa K, Kimura M. Related Articles, Links Nervous diseases and Kampo (Japanese herbal) medicine: a new paradigm of therapy against intractable nervous diseases. Brain Dev. 1997 Mar;19(2):93-103. Review. PMID: 9105654 [PubMed - indexed for MEDLINE] 102: Bhattacharya SK, Kumar A. Related Articles, Links Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats. J Altern Complement Med. 1997 Winter;3(4):327-36. PMID: 9449054 [PubMed - indexed for MEDLINE] 103: Coleman LM, Fowler LL, Williams ME. Related Articles, Links Use of unproven therapies by people with Alzheimer's disease. J Am Geriatr Soc. 1995 Jul;43(7):747-50. PMID: 7602024 [PubMed - indexed for MEDLINE] 104: Kimura T, Yoshida H. Related Articles, Links [Clinical study of neuroleptic malignant syndrome in demented patients--examination of our case and reported cases] No To Shinkei. 1994 Sep;46(9):859-62. Review. Japanese. PMID: 7999444 [PubMed - indexed for MEDLINE] 105: Takahashi M, Sugaya K, Kubota K. Related Articles, Links Kangenkaryu prevents the decrease of cholinergic markers following the nucleus basalis magnocellularis lesion. Jpn J Pharmacol. 1992 Nov;60(3):307-10. 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-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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posted
Suggest you contact Boomerang here at LymeNet. Her hubby (not sure of his age) was originally diagnosed with Alzheimer's by a neuro. Is currently being treated for Lyme disease (not sure about coinfections) by Dr C in Missouri. Has had significant improvements I think.
Bea Seibert
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Michelle M
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Minocycline.
It is neuroprotective.
New research on it.
Michelle (Who doesn't have the research handy because of my Alzheimer's -- oops, I mean neuro brain --!!!) Also, I am on Minocycline for months now
P.S. Please make SURE co-infections are ruled out....by an LLMD, not a reg'lar doc, who rarely will trouble to even look for them.
Posts: 3193 | From Northern California | Registered: Apr 2005
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CaliforniaLyme
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Here it is- I posted it on the first- oh- and Shirley Forsman from the memorial page had Alheimrers reverse on Rocephin!!! (but then they took her off & she declined & died! insurance refused it even though IT WAS WORKIN!G) (((((((((((((((((((((
posted 01 May, 2007 11:01 AM -------------------------------------------------------------------------------- 1: Neuropsychopharmacology. 2007 Apr 4;
Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models.
Choi Y, Kim HS, Shin KY, Kim EM, Kim M, Kim HS, Park CH, Jeong YH, Yoo J, Lee JP, Chang KA, Kim S, Suh YH. 1Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer's Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea.
Minocycline is a semi-synthetic tetracycline antibiotic that effectively crosses the blood-brain barrier. Minocycline has been reported to have significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, and Huntington's and Parkinson's diseases.
In this study, we demonstrate that minocycline has neuroprotective effects in in vitro and in vivo Alzheimer's disease models. Minocycline was found to attenuate the increases in the phosphorylation of double-stranded RNA-dependent serine/threonine protein kinase, eukaryotic translation initiation factor-2 alpha and caspase 12 activation induced by amyloid beta peptide(1-42) treatment in NGF-differentiated PC 12 cells.
In addition, increases in the phosphorylation of eukaryotic translation initiation factor-2 alpha were attenuated by administration of minocycline in Tg2576 mice, which harbor mutated human APP695 gene including the Swedish double mutation and amyloid beta peptide(1-42)-infused rats.
We found that minocycline administration attenuated deficits in learning and memory in amyloid beta peptide(1-42)-infused rats.
Increased phosphorylated state of eukaryotic translation initiation factor-2 alpha is observed in Alzheimer's disease patients' brains and may result in impairment of cognitive functions in Alzheimer's disease patients by decreasing the efficacy of de novo protein synthesis required for synaptic plasticity.
On the basis of these results, minocycline may prove to be a good candidate as an effective therapeutic agent for Alzheimer's disease.
PMID: 17406652
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
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Shirley Forsman Shirley Forsman February 6, 1930 - November 9, 1999
Shirley Forsman was mis-diagnosed with Alzheimer's disease for 9 years before she died of Lyme disease in Pine County, Minnesota.
Many thanks to Lyme Alliance for allowing this excerpt-written by Tom Grier, from their newsletter:
"Shirley Forsman, RN, had a history of Lyme disease at age 59 and was treated with two weeks of Doxycycline. It was about two years later that Shirley was diagnosed with early progressive Alzheimer's disorder and her health steadily and quite rapidly declined. Within a few short years, Shirley needed complete around the clock care that was provided by her daughter, Katie Harp. Shirley was no longer able to walk, talk or perform daily functions such as dressing, having conversations or controlling her bodily functions.
"Always suspecting that her mother's mutli-system problems were caused by unresolved Lyme disease, Katie fought for years to have her tested and treated. Her requests were always met with resistance until she found a young Bemidji internist who was willing to do a trial of IV Rocephin just to see if the patient responded. Amazingly, the patient responded favorably and almost immediately.
After having been nearly completely non-responsive to any outside stimuli for over two years, Shirley was now beginning to recognize family members. She could form sentences that were a few words long and was now standing and walking short distances. In fact, the physician was now recommending physical therapy and a walker.
The most dramatic change was perhaps the change in the frequency and severity of Shirley's seizures. Grand mal seizures could be expected almost every week and they were often violent enough to throw her out of bed. The nightly thrashing and lashing about in her bed came to an abrupt stop shortly after antibiotics were introduced. In the end, Shirley was going as long as two months without any major seizures or bed thrashing. Her muscle twitches in her face were completely gone.
Upon seeing this change in Shirley's health, the attending doctor changed the diagnosis from Alzheimer's to neurological Lyme disease. However, shortly after switching Shirley from her IV Rocephin to a combination of orals, her health began to decline. After a series of seizures, Shirley died at age 69."
Her death certificate lists Cause of Death as: seizure disorder as a complication of Lyme disease.
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
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14 Alzheimers/Lyme Patients Review: 0 1: J Alzheimers Dis. 2004 Dec;6(6):639-49; discussion 673-81. Links Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. University Institute of Pathology, Division of Neuropathology, University Medical School (CHUV), 1011, Lausanne, Switzerland. [email protected] The cause, or causes, of the vast majority of Alzheimer's disease cases are unknown. A number of contributing factors have been postulated, including infection. It has long been known that the spirochete Treponema pallidum, which is the infective agent for syphilis, can in its late stages cause dementia, chronic inflammation, cortical atrophy and amyloid deposition. Spirochetes of unidentified types and strains have previously been observed in the blood, CSF and brain of 14 AD patients tested and absent in 13 controls. In three of these AD cases spirochetes were grown in a medium selective for Borrelia burgdorferi. In the present study, the phylogenetic analysis of these spirochetes was made. Positive identification of the agent as Borrelia burgdorferi sensu stricto was based on genetic and molecular analyses. Borrelia antigens and genes were co-localized with beta-amyloid deposits in these AD cases. The data indicate that Borrelia burgdorferi may persist in the brain and be associated with amyloid plaques in AD. They suggest that these spirochetes, perhaps in an analogous fashion to Treponema pallidum, may contribute to dementia, cortical atrophy and amyloid deposition. Further in vitro and in vivo studies may bring more insight into the potential role of spirochetes in AD. PMID: 15665404
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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Michelle M
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Thanks, Sarah. I knew I could count on you to dig it up!
That is so sad about Shirley. Idiot doctors.
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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