posted
I have been trying to find info on overmethylation on this forum as some are saying we are undermethylated, because I have concerns about geting overmethylated possibly with taking anymore supplements with methyl groups besides MSM (taking 1000mg daily, if I don't forget).
I had wanted to start taking DMG (dimethyl glycine - possibly the active and only form of Vit B15 that is available here in US) after reading posts here...but maybe would be over methylating. We seem to need the L-glycine at least, but thought the DMG would be better.
After reading some of this post on a forum and links contained in it, I am thinking about going off of MSM. The poster seems to do alot of literature searches, but one thing I am finding on under/overmethylation is that this is a new science or as some people in the forum where I found the link to this post by "Trouble", think that it is a psuedo science. So, here is the post link: http://www.ironaddicts.com/forums/showthread.php?t=8655&highlight=methylation
and please see the link http://www.nutriwest.com/articles/homovmsm.htm that "Trouble" had in the post. It is a good illustration of the pathway from methionine to homocysteine and ultimately to sulphur in the "natural" form that can be used to detox and build joint and cartilage tissue. The title of the article is HOMOCYSTEINE REDUX vs MSM. Very good info I believe. Of course, Nutriwest authored the article and they are trying to sell a product.
Anyone else have any info along these lines that they want to share?
-------------------- God's mercies are new every morning.
Karla Posts: 85 | From KANSAS | Registered: Jul 2006
| IP: Logged |
posted
Whew, you are venturing into rarified climes when you start questions like this. I haven't any idea what the answer is, but if you figure it out, you get an honorary Ph.D.
Posts: 8430 | From Not available | Registered: Oct 2000
| IP: Logged |
posted
Thanks for chiming in Lou - I'm hoping Marnie will be along and give me her input.
I thought I had remembered there was a veterinarian on this forum that might be able to give us some insight.
-------------------- God's mercies are new every morning.
Karla Posts: 85 | From KANSAS | Registered: Jul 2006
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Tough one...the FEW websites that list symptoms of both (hypomethylation and hypermethylation) don't completely agree and as Bea and I found out...our loved ones didn't exhibit EVERY symptom in ONE category. Makes it really confusing. Err on the side of caution...always best.
When my son was at his worse (not lyme, food poisoning + appendectomy + abx = no beneficial bacteria = NO neurotransmittes, N/V, severely depressed, etc.) for awhile I really weighed SAMe. But in the end, I stuck with the "basics"...5HTP, GABA, Mg with B vitamins, loads of probiotics, etc. with the help of a nutritionist (dual degree, RN - psych nurse). It took a lot of supplements and a long time to rebalance him. 2 years later (almost) and his liver enzymes are FINALLY coming down. (Keep in mind that during this time...2 trips to ER for urinary urgency, and via ambulance for tachycardia...and then the panic attacks...)
It was a double whammy...he has genetically "extremely small vertebral arteries". Translation: nutrients have a hard time reaching the frontal lobe.
Healing takes TIME!!! Once the neurotransmitters are messed up, it takes time to restore them and to rebalance, but it IS possible.
I think, from what I've read...basically they can test DNA methylation...genetic testing...
Logical since the pathogen IS locking onto our DNA.
$$$, I bet. Likelihood of that being available...so we know for sure...nil.
Then there is always the possibility that this varies depending on how many keets decide to hit the road, curl up in a ball and not cause any problems...etc. It could be okay and then not...okay, not.
Our bodies are in a constant state of flux, really fast.
Sometimes we are left on our own to try different things (carefully!!!) and see how our body responds. Does it seem to help? Of course, it is imperative you run all supplements by your doctor/pharmacist FIRST for any interactions.
Learn to listen to your own body. What makes YOU feel better, what do you crave, etc.
I wish I could be of more help about this!
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Info re Genetic Testing, call 510-206-7665.
Take care.
Posts: 9834 | From Washington State | Registered: Oct 2000
| IP: Logged |
GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Info re Genetic Testing, call 510-206-7665.
Take care.
Posts: 9834 | From Washington State | Registered: Oct 2000
| IP: Logged |
posted
Thanks Marnie & GiGi! I do have a few symptoms that are on both the over/under methylated list. I don't have insurance so will not get the genetic testing...kind of curious as to how much it would cost!
Not sure what is exactly going on with my body since I have started having UTIs lately (think I just started one again yesterday, so got the D-mannose and started taking it). Was on Bactrim for 2 weeks in early April for that UTI and having cravings for pickles, tomatoes & kraut about that time. Eclectrolyte imbalance??
Saw Dr. C on April 27 and he told me to start clindamycin & quinine and also 5000IU of Vit D. So started the clindamycin with no herxing, then the Vit D3 (no herxing right away), then the quinine(tonic water)...that's when I started herxing quite a bit (of course it probably didn't help that my basement flooded and relatives came to stay and we had graduations going on and no one to lift a finger but hubby!). I had gotten on Lymenet a little over a week ago and read where you and some others had said that Vit D supplementing was not good, so read some more and decided to go off the 5000IU Vit D3. That seemed to help and I also decreased the quinine and on the 2 graduation days I didn't take any...felt really good those 2 days.
I am going to start the D-ribose and L-glycine as soon as I figure out what is going on with my bladder (or possibly kidneys) as I have been having some back pain today...funny thing is, it started on my right side and I thought maybe it was something to do with my liver. Took a couple charcoal pills (have been forgetting them most of the time) and I noticed a couple hours later that I had pain in my back on that side, but not on the side.
I am also thinking I will get the Fulvic acid minerals...maybe I should get those before doing anything else since I may be having some kidney problems. I haven't read anything about Bb in the kidney, just that it likes our organs and really likes the bladder.
Recently I have been reading that Babesia is considered worse than Bb!! Which the increasing symptoms with quinine treatment seems to indicate I have Babesia.
Hubby is hiring a new guy to help him starting next week, but I have to go with him to do an easy job the next two days...pray that the D-mannose takes care of this UTI!
-------------------- God's mercies are new every morning.
Karla Posts: 85 | From KANSAS | Registered: Jul 2006
| IP: Logged |
GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Thanks GiGi! This has helped immensely. I will have to read this article again for it all to sink in...I didn't realize how much methylation was going on in our bodies!
Dr C had also wanted me to start BetaineHCl because he feels that our digestive juices are not strong enough to be digesting our food to get the proper nutrition. But I found a few days ago that betaine = TMG or trimethylgycine...so, if I used this BetaineHCl, maybe the betaine part would be accessible for the methylation pathway for homocysteine back to methionine and subsequently the enzyme used for TMG synthesis would not be needed from choline -> TMG and could instead be used to make carnitine (Choline is in my multivitamin and I have not started supplementing w/carnitine yet, just got the carnitine on Monday).
I'm not sure though if there are other compounds, like DMG (dimethylglycine) or MSM that could also be used in that specific methyl pathway (methionine -> homocysteine) to act as a methyl donor. In the link http://www.nutriwest.com/articles/homovmsm.htm posted earlier in this thread, it suggests that MSM could be very dangerous as it may cause a molybdenum deficiency.
It boogles my mind to think how this universe that is so fine tuned could have come about by a BIG BANG Happenstance! God is the only one who could have done all this!!!
-------------------- God's mercies are new every morning.
Karla Posts: 85 | From KANSAS | Registered: Jul 2006
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
![[confused]](graemlins/confused.gif)
![[dizzy]](graemlins/dizzy.gif)
![[Roll Eyes]](rolleyes.gif)
Printer-friendly view of this topic