Topic: Pause and consider ...Forskolin..yes or no?
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
"It is also interesting that motility of B. burgdorferi requires a high concentration of NaCl and pH 7.6, which are the normal physiological conditions for interstitial fluids.
In any case, our data suggest that chemotaxis may indeed be important for the pathogenesis of B. burgdorferi.
Growth of muscle cells in the presence of agents that mimic cyclic AMP (cAMP) action or increase intracellular cAMP levels including 8-bromo-cyclic AMP (8-BrcAMP), cyclic nucleotide phosphodiesterase inhibitors, and
forskolin increased sodium channel density up to 125%.
We conclude that cytosolic calcium decreases and cAMP increases sodium channel number by modulating the rate of biosynthesis and/or processing of channel components. The biochemical mechanisms of these regulatory effects are considered. J. Neurosci. (1985)
PMID: 2409245
``In humans, there are currently five known types of Na+-dependent glutamate transporters...''
forskolin-stimulated chloride secretion across T84 epithelial cell monolayers with a Ki of 8 �M.
What we NEED in the cells is KCL. NOT NaCL.
Some evidence Il-1B upregulates (NOT INHIBITS) PDE4 thus LOWERING cAMP...too low and the cell (and Bb?) will die.
"TNF-alpha released by activated glial cells inhibits glutamate transport in astrocytes and neurons,
promoting accumulation of extracellular glutamate and neuronal death."
posted
I actually have been considering forskolin recently, but have not ordered it as yet. It seems to speed up the metabolism, which is a good thing for most people with this illness. It's effect on cAMP seems interesting also. It seems to improve energy at a cellular level from what I have read.
Farah
Posts: 208 | From New Mexico | Registered: Dec 2005
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I give up. What is the answer....yes or no? Make it simple please. I had gotten the impression from other reading that forskolin was at least worth considering.
Posts: 8430 | From Not available | Registered: Oct 2000
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
If you want to preserve the infected cell...yes.
If you want the infected cell to die...no.
How to destroy Bb AND preserve the cell.
It will take the EXACT negative charge (amino acid/ protein/ enzyme) to destroy Bb and the EXACT form of sugar to preserve the cell (one which Bb cannot use) to do this.
I think it might be glycine (a very pecular amino acid in gelatin) and D-ribose.
Just a guess.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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D-cycloserine seems to act like glycine at low dose, if i am remembering correctly. it is being investigated for assorted neurological uses. anxiety and fear, neuropathic pain, to borderline personality disorder hang-ups. it seems to potentially help the brain dislodge and give up on processes that aren't helping, or are specifically detrimental, and move on.
i wonder what it would do with lyme rage and executive dysfunction, or for lyme related pain. i think have heard of people using glycine therapeutically, for what i don't remember, but the doses were something like 18 grams or something. D-cycloserine may replace it in this case, i don't know?
[ 28. May 2007, 07:43 PM: Message edited by: danielb ]
Posts: 244 | From Ottawa | Registered: Dec 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
glycine -> serine...which if phosphorus is added...
Rebalances the HPA axis.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Vermont_Lymie
Frequent Contributor (1K+ posts)
Member # 9780
posted
Hi Marnie,
Thanks for your research, which is always interesting and clear (digestable!) here.
Speaking from a strictly consumer and non-researcher perspective, I tried forskolin last month for about 8 days, and found it to be a mixed bag.
The first day that I took a small amount -- about 4.5 mg -- I felt a surge of energy and probably whatever transmitter it encourages (dopamine?).
However, it did not seem to have any noticeable cognitive or affective impact on the other days that I used this supplement. Except that I felt more spacey that usual on some of those days; so I dropped it.
I cannot be sure that it impacted my concentration and cognitive skills adversely. Like many here, I am an experiment-in-treating-TBD-in-progress.
Of course I try to be somewhat cautious with supplements, and short of solid documentation of benefits, try not to take them.
Thanks for the info on glycine. So my grandmothers awful Jello-tuna creations were actually good for us!
Daniel: That is interesting info on D-cycloserine . Do you know of any lyme patient that has tried that for similar symptoms?
Posts: 2557 | From home | Registered: Aug 2006
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