posted
How accurate is the CD 57 test. I have all negative WB's (1st one was very boreline to being +) and i have a positive ELISA on the second round of testing.
I just read my LLMD's bloodwork on me and my CD 57 score: 31 (range 60 - 360). Anything below 60 is supposed to be chronic lyme and close to 20 suggest a flaming chronic case.
Also, my absolute CD 3 is 913 (range 960-2600). What is this for?
My Percent CD 57 is 3 (range 2 - 17).
Interesting, trying to decipher what the CD 57 is.
thx,
jamie
Posts: 44 | From Lafayette, LA | Registered: Apr 2007
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posted
After 1 1/2 yrs of treatment, I just had my CD57 done for the first time by a new doctor. It was 56. He says he would like to see it above 200. Below is some info I found, hope it answers your question.
Our ability to measure CD-57 counts represents a breakthrough in Chronic Lyme Disease treatment. It can be used to help determine how active the infection is, how well the treatment is working, and whether, after treatment ends, a relapse is likely to occur!
This is how it works: Chronic Lyme infections are known to suppress the immune system. The Lyme spirochete can affect all major cell types of the immune system, but it most clearly can impact a specific subset of the natural killer cells.
This is called the CD-57 subset. Just as in HIV infection, which suppresses T-cell counts, Lyme suppresses Natural killer cell count such as CD57. As in HIV infection, where abnormally low T-cell counts are routinely used as a marker of how active the infection is, in Lyme we can use the CD-57 count to indicate how active the Lyme infection is.
When Lyme is active, the CD-57 count is suppressed. We currently are having our tests run by LabCorp because published research on this test was based on their methods. At this lab, the expected range for the CD 57 count is above 60. However, in the chronic Lyme patient, CD-57 counts are usually well below 60 and may be at risk with levels of 60-100.
This test can be run at the start of therapy, then every several months to document the effectiveness of treatment. One hopes to see a stable number or a rising trend over time. When antibiotic therapy is finally at an end, if the CD-57 count is not above 60, then a Lyme relapse is more likely to occur.
Test interpretation: Low CD57 occurs in chronic Lyme or when the disease has been active for over 1 year. A review of the affects of other infections, only Lyme spirochetes lowers the CD57.
Following is the criteria established by research.
Test interpretation: Low CD57 occurs in chronic Lyme or when the disease has been active for over 1 year. The count reflects the degree of infection. It is not a diagnostic test but is used as a marker for Lyme being active. Test done by LabCorp.
>200 is normal < 20 severe illness 0-60 is seen in chronic Lyme disease > 60 Lyme activity indicates improvement
Posts: 873 | From WA | Registered: Dec 2005
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