Formic acid is used in labs to separate proteins. Apparently really high levels of this can destroy the MAT enzyme.
Insects are high in formic acid.
Guess what lizard eats insects at night.
Red ants (really high in formic acid). Stinging Nettles. Valerian Root. Bee stings...
HMG CoA reductase (Mg, statins, etc. inhibit) is used before the above MAT enzyme in the making of cholesterol via our liver.
And anyone who has been bitten by a red ant in Florida knows this triggers a histamine (from histidine)response.
OUCH.
[ 16. September 2007, 05:46 PM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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bejoy
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posted
Bee venom also contains formic acid. I have been getting very good results from transdermal bee venom ointment. I thought that the good results were from the mellitin in the venom. Sounds like there may also be a formic acid connection.
I just read that dark chocolate reduces myalgia. Maybe next I'll join the lizards in my own fashion and try some chocolate covered fire ants. Tee hee.
Thanks for the info, Marnie.
-------------------- bejoy!
"Do not go where the path may lead; go instead where there is no path and leave a trail." -Ralph Waldo Emerson Posts: 1918 | From Alive and Well! | Registered: Feb 2007
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Jellybelly
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Well then I have an excuse to keep drinking those margaritas with fresh limes!!! Posts: 1251 | From california | Registered: Apr 2005
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Marnie
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posted
Co(NH3)4PO4.
Cobalt, ammonia and phosphorus.
It is a MgPO4 complex analogue.
Impacts Na-K atpase. The sodium-potassium ATP pump.
(Bb needs NaCl for its motility and moves away from KCL. NORMALLY, K is supposed to be IN the cells. Bb doesn't look to want it that way.)
How do we get there? To Co(NH3)4PO4?
Somehow...NH3, ammonia, is critical...NH2 is in B12...structurally... as is cobalt...
BTW...Co3, trivalent cobalt can react with Cr2, divalent chromium -> Co2, divalent cobalt + Cr3, trivalent chromium. Trivalent chromium...
A good thing...
"Chromium Polynicotinate: It is the only form of Chromium proven to promote insulin function, balance blood sugar metabolism, and lower cholesterol. Chromium Polynicotinate is 300 times more effective than the commonly used Chromium Picolinate. It is a family of Niacin-bound chromium compounds required for normal protein, fat and carbohydrate metabolism. Chromium Polynicotate is absorbed and retained up to 311% better than Chromium Picolinate and 672% better than Chromium Chloride.
Chromium lowers the level of bad cholesterol (LDL) while increasing levels of good cholesterol (HDL). It is a good remedy for elevated blood cholesterol and triglycerides. It works well in combination with Inositol to lower LDL and increase HDL levels."
Back to NH3...
NH3 inhibits both DIF-1 and cAMP induction of the gp2 gene
GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins
Glycogen phosphorylase is one of the phosphorylase enzymes (EC 2.4.1.1). It breaks up glycogen into glucose subunits.
If NH3 compounds can inhibit glycogen phosphorylase...Bb can't get glucose to survive.
triphosphate competed-with
= Co
Phosphate binding and ATP-binding sites coexist in Na+/K(+)-transporting ATPase, as demonstrated by the inactivating MgPO4 complex analogue Co(NH3)4PO4.
HELP! Where are the biochemists?
Want to know how I got there?
The blue belly. Cobalt (transported by cAMP)...Blue "absorbs" red/orange. Orange is directly related to NH3...ammonia.
Look at the colored pictures...and read the sentences that begin...Figure 1 and Figure 2...
Put it together...
Co(NH3)...
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ByronSBell 2007
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posted
can someone explain this 5th grade style...
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CaliforniaLyme
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posted
Byron-
The Western Fence Lizard may contain formic acid which may be what kills the chetes in them!! When nymphs molt to adults in CA if they feed on the WFL they will be uninfected as adults- something in the lizard kills them!!! But what? Marnie is postulating Formic Acid!!!!
Exposure to formic acid can occur through inhalation, ingestion, and eye or skin contact [Sittig 1991, p. 840]. * Summary of toxicology
1. Effects on Animals: Formic acid is severely irritating to the eyes, skin, and mucous membranes. The oral LD(50) in rats is 1,100 mg/kg and 700 mg/kg in mice [NIOSH 1992]. A dose of 610 mg formic acid applied to a rabbit's open skin produced mild irritation. A dose of 122 mg applied to the eye of a rabbit caused severe irritation [Sax and Lewis 1989]. Instillation of 10 percent formic acid solution in the eye of a rabbit caused an immediate dense, white, local opacification of the cornea that cleared slightly after 5 days. Application of pure liquid formic acid, however, caused immediate, local corneal opacification as well as opacification of the lens, inflammation of the iris, and damage to the anterior chamber of the eye [NLM 1992]. Administration of formic acid in a monkey's eye produced the same type of optic atrophy and blindness as that caused by exposure to methanol [Grant 1986]. Intravenous doses of formic acid of 0.46 to 1.25 g/kg given to rabbits caused central nervous system depression, vasoconstriction, and diuresis. Intravenous doses of 4 mg/kg caused convulsions and death in rabbits and methemoglobinuria in dogs [NLM 1992]. Studies of chronic exposure to formic acid have shown that young rats given 0.5 or 1 percent formic acid in their diets or drinking water for 6 weeks had reductions in their rates of body weight gain and reduced organ size when compared with controls [NLM 1992]. No histopathologic changes were noted in mice whose ears had been painted with an 8-percent formic acid solution in water for up to 50 days [Clayton and Clayton 1982]. Formic acid was not teratogenic after injection of doses as great as 20 mg into fertilized chick eggs [Clayton and Clayton 1982]. Formic acid is mutagenic in some, but not all, bacterial species and in Drosophila germ cells [Clayton and Clayton 1982].
2. Effects on Humans: Formic acid is dangerously irritating to the skin, eyes, and mucous membranes and may also be toxic to the kidneys. Workers exposed to formic acid in a textile plant complained of nausea at an average formic acid concentration of 15 ppm [NLM 1992]. Atmospheric concentrations as low as 32 mg/l may be corrosive; however, a dilute solution of 10 percent formic acid apparently is not corrosive [Clayton and Clayton 1982]. Acute, overexposure to formic acid causes corrosion of the skin, eyes, and mucous membrane of the mouth, throat, and esophagus and may be associated with complications such as cardiovascular collapse and ischemic damage to the heart, liver and kidneys, swelling of the airway, and respiratory distress. Ingesting causes ulceration of the gastrointestinal tract, which results in perforation and peritonitis and late scarring of structures of the gastrointestinal tract which, in turn, produces obstructions that require surgical repair [Gosselin 1984]. A worker splashed in the face with formic acid developed respiratory distress and difficulty in swallowing, and died within 6 hours [Hathaway et al. 1991]. Other reports indicate that splashes of formic acid in the eye have caused permanent clouding of the cornea, with loss of visual acuity. In one case, the injury required removal of the affected eye [Grant 1986]. Chronic absorption of formic acid may cause damage to the kidneys, which is indicated by albuminuria and hematuria [NLM 1992]. Chronic skin contact may cause sensitization dermatitis, particularly in workers previously sensitized to formaldehyde [NLM 1992].
Signs and symptoms of exposure
1. Acute exposure: Symptoms of acute exposure include redness, swelling, and blistering of the skin and mucous membranes of the mouth and throat, eye irritation, nausea, vomiting, diarrhea, difficulty in swallowing, difficulty in breathing, headache, dizziness, blood in the urine, decreased or absence of urine production, and unconsciousness. Signs of shock and impending cardiovascular collapse including clammy skin, a weak and rapid pulse, shallow respirations, and scanty or absent urine production.
2. Chronic exposure: Signs and symptoms of chronic exposure may include kidney damage, dermatitis, and skin sensitization.
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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Marnie
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posted
Yes...formic acid is too toxic. It also is not destroyed when boiled...which is what Lane did and determined it was an enzyme or protein that was the "protective factor" in the blood.
That's not to say that formic acid doesn't play a PART. It DOES separate proteins.
But re-read about NH3...ammonia...cmpds.
Rifers...
PM me.
There is more than one way to impact the Na-K ATPase channels besides Co(NH3)4PO4, NO and CO.
Meanwhile...
PERSONALLY...GlucoReg by Solaray is looking mighty good. In combo with CoQ10 please.
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