Topic: Lyme Sx for many Yrs - Dxd w/Cancer - too late for LLMD? any ideas for Uncle?
AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
I'd been trying to get my Uncle to go to an LLMD for a couple of years. He had negative tests for Lyme, but has had symptoms for a long time. I had been unsuccessful at finding an LLMD in Indiana or close enough that I could talk him into travelling to.
He was Dxd with small cell lung cancer. It was cleared with radiation & chemo back in April. It had recently metastacized to his brain. He had been given 4-6 months (same prognosis with or without Tx). He opted to stop Txing and likely only has a few more months.
He's trying to tie up loose ends and has been getting horrific headaches that sneak up and crush him. He's recently e-mailed a plea for prayers to hold off the headaches for just another month, so he can finish up what he feels he needs to do.
I've been praying as hard as I can but I don't think it's enough. He's still having trouble. If anyone else would be willing to say a prayer for John Cook, I would be very grateful.
I'm guessing that even if he has Lyme, and the Lyme is somehow responsible for the cancer taking him down, it's likely too late for a LLMD to make a difference.
I'm guessing that at this point, he probably wouldn't be able to stand the Herxes.
I don't even really know why I'm posting this because in thinking this out AGAIN, I realize that there's no way I'd get anybody to tell me that a LLMD could make a difference now.
I'm going to see if I can get him to try the Rhodiola that Sarah had posted about. I'm forwarding him that thread. (Thanks Sarah)
Can anyone else think of anything that might have use in both diseases, that wouldn't require trying to start up with a doctor? I know I won't be able to get him to do that now.
I think he had tryed lots of alternative Txs for Lyme, but I'm not sure which ones. The last thing I know he had done was HBO. I think he may have tried Rife. I know he had tried several different ABX on his own (used veterinary ABX obtained online). He also tried Essiac.
I just don't know how to help him & I'm hoping maybe someone else can give me some uncomplicated ideas for a best last ditch effort at taking down.... this just gets more ridiculous as I go on.
People have been searching for years for a fast way out of this, if there was one it would have been plastered all over this board.
Maybe I can get some ideas how to get him another month without the headaches. Any ideas would be appreciated.
Thanks, Ali
PS- Ideas for shrinking my grandmothers nasopharyngeal tumor without chemo or radiation would be helpful too. Thanks. She was just given 4-6 months, as well. (My poor Mom )
[ 23. September 2007, 09:53 AM: Message edited by: AliG ]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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sometimesdilly
Frequent Contributor (1K+ posts)
Member # 9982
posted
Ali-
sweetie, you can't save your uncle. i am so sorry.
i know watching someone you love die without being able to help is one of the most difficult things in the world to deal with.
i can ask my dad (has brain cancer) if his DR has any goods strategies for pain control.
also, i found this quote on a site about small cell lung cancer. helping make sure your uncle is not in pain IS something you can do, especially if no one else is right there advocating for him:
" Pain control is of critical importance, and the tools to achieve control are available even for the most advanced cases.
These include the use of pain-relieving (analgesic) drugs such as non-steroidal anti-inflammatory agents, mild narcotics, strong narcotics, continuous narcotics and narcotics delivered into the spinal canal (epidural).
Pain control can generally be achieved without interfering with mental competence."
You might also call up a local hospice and ask them for advice about what you and other family members can do to help.
meanwhile, you know i'll be praying for him, for you, and for your whole family.
dilly
Posts: 2507 | From lost in the maze | Registered: Aug 2006
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Thanks Dilly, you really are such a sweetheart.
He has hospice care. He ASSURED me that they were going to keep him from being in pain, when I was upset about his giving up the fight.
I guess that's why I was so freaked out by his request for prayers to stop the headaches.
Maybe he needs to get them to change his medications or something.
I still feel like there has to be SOMETHING I can do to help him.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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kelmo
Frequent Contributor (1K+ posts)
Member # 8797
posted
Gosh, Ali, I saw the topic and thought it was about you!
I'm sorry about your uncle. I hate going through the season of someone's impending, you know. Been there, done that, will do it many times over before I go. It doesn't get easier.
You can be a comfort to him.
God Bless Kelly
Posts: 2903 | From AZ | Registered: Feb 2006
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bettyg
Unregistered
posted
quote:Originally posted by AliG:
Maybe he needs to get them to change his medications or something.
I still feel like there has to be SOMETHING I can do to help him.
yes, to all what dilly stated above.
yes, ali, i'd mention to someone in hospice about changing his meds due to horrific headaches.
"I still feel like there has to be SOMETHING I can do to help him."
ali, you are doing it now! asking for additional prayers for uncle and dear grandma; asking about pain meds, and just being the wonderful, caring, loving niece/granddaughter that you are!
i'm so sorry for losing both at the same time; yes, your poor mom, but have her ask god for extra strength to help them both in her limited way.
when 2 members of our extra family were both diagnosed with brain cancer; each had almost 6 months, dying within 2 weeks of each other.
my best wishes and prayers to all of you.
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
So sorry to hear of your pain and his.
I don't know if this will help.. and excuse me for saying this.. but I have seen it work for a dog. And have known a person who took doxy and ended up without signs of cancer afterward.
I am simply offering it as a thought for you to consider. If it were my family member.. I would want to try something. I doubt most doctors would.. but here it is... for what it is worth.
Hope it helps... and my prayers will be with your family too.
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Virology. 2000 Apr 25;270(1):98-110.
Conditional cell transformation by doxycycline-controlled expression of the ASV17 v-jun allele.
Scientists find way to 'turn off' cancer -
Antibiotic halts aggressive tumours in mice
Tim Radford, Science Editor, Monday October 11, 2004, The Guardian
Scientists in California have found a way to "turn off" a gene that makes cancerous cells lethal.
They eliminated aggressive, incurable liver tumours in laboratory mice in four weeks, they report in an advance paper in Nature today.
The study, based on a gene called Myc, could lead to new ways of treating cancer.
Cancer Research UK scientists in Glasgow, working with colleagues in Seattle, last year worked out the details of how Myc cranks up the rate of growth of dividing cancer cells by sending one of the cell's factories into overdrive.
In cancer, cells divide uncontrollably.
The California team based their studies on mice with genetically modified liver cells. The type of cell that becomes cancerous is called an epithelial cell, and these form cancers in breast, colon and prostate.
So the same approach might work in all of them. Liver cancer is common and difficult to treat. "This is a terrible cancer.
Anything that is encouraging in liver cancer may be important," said Dean Felsher of Stanford University, who led the research. "The exciting thing is that you can turn cancer cells into something that appears to be normal."
The mice under study had a mutated Myc gene that was constantly on. It produced a Myc protein that served as a kind of conductor, sending a signal to cells to divide.
Cancer cells produce too much Myc protein all the time, and are constantly dividing. Dr Felsher and his colleagues fed the mice an antibiotic called doxycycline, which turned the gene off, and stopped the protein flow.
As long as the mice had the antibiotic diet, they remained healthy. Once the antibiotic was withheld, they developed aggressive liver cancer in 12 weeks.
When they were put back on the diet, all of them showed rapid regression: the liver cancer was eliminated, and liver cells seemed to behave normally.
In effect, the scientists turned the Myc gene on and off like a tap, and turned cancer on and off at the same time.
They also found that some of the apparently normal cells retained the ability to become cancerous, which could explain why cancers often recur after chemotherapy.
Cancer hits one person in three, and kills one in five. In recent years, researchers have concentrated on a number of new approaches.
They have tried to cut off the blood supply to tumours, to halt their growth. They have tested search-and-destroy toxins, designed to make for and eliminate only cancerous cells.
They have experimented with scalpels made of ultrasound, and they have tried to "burn" cancerous cells with infrared radiation.
But cancer is, above all, a disease of the DNA, and British researchers have launched a cancer genome project to collect all the genetic mutations involved in the making of a cancer. There are more than 100.
But the Myc protein seems to play a role in many cases of the disease.
The Glasgow study immediately suggested that it would be a good target. If researchers could find a drug that blocked the action of Myc, they could study its effect on cancer cases.
The Stanford study shows that they were right. But what works in mice may not work so well in humans.
The next step is to hunt for a drug that would be safe for human patients, and yet have the same impact.
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Int J Cancer. 2004 Jun 20;110(3):336-42.
Reversible lymphomagenesis in conditionally c-MYC expressing mice.
Marinkovic D, Marinkovic T, Mahr B, Hess J, Wirth T.
Department of Physiological Chemistry, Ulm University, Ulm, Germany.
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this process are only partially understood. We have established a transgenic mouse model in which c-MYC is conditionally expressed in lymphoid cells using the tetracycline-regulated system of gene regulation.
Mice with continuously expressed transgenic c-MYC died of invasive T- or B-cell lymphomas within 4 months.
Lymphomas developing in transgenic mice were c-MYC dependent since doxycycline treatment led to tumor regression.
Using transplantation of established tumor cell lines labeled with GFP, we followed the fate of neoplastic cells in recipients upon MYC inactivation.
This approach allowed us to elucidate both apoptosis and differentiation as mechanisms of tumor elimination.
Comparative genomic hybridization (CGH) and FISH analyses were performed in order to analyze possible chromosomal aberrations induced by c-MYC.
We observed that overexpression of c-MYC is sufficient to induce recurrent patterns of genomic instability.
The main observation was a gain of genomic material that corresponded to chromosome 15 in several T-cell tumors, which could be identified as trisomy. Copyright 2004 Wiley-Liss, Inc.
PMID: 15095297 [PubMed - indexed for MEDLINE]
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Virology. 1999 Jan 20;253(2):193-207.
Conditional cell transformation by doxycycline-controlled expression of the MC29 v-myc allele.
Oberst C, Hartl M, Weiskirchen R, Bister K.
Institute of Biochemistry, University of Innsbruck, Peter-Mayr-Str. 1a, Innsbruck, A-6020, Austria.
To investigate the molecular basis of oncogenesis induced by the v-myc oncogene of avian myelocytomatosis virus MC29, we developed a conditional cell transformation system in which expression of the MC29 v-myc allele is dependent on a doxycycline-sensitive transactivator (tTA).
Clonal lines of quail embryo fibroblasts transformed by doxycycline-controlled v-myc revert to the normal phenotype and lose their ability to grow in soft agar after the addition of doxycycline.
Repression of v-myc causes the cells to withdraw from the cell cycle, and long-term survival in culture requires reexpression of v-myc.
Although complete repression of v-myc mRNA and v-Myc protein in these cells occurs within 14 h after the addition of doxycycline, the first morphological alterations are observed after 24 h, and after 3 days, the morphology changed entirely from small rounded cells showing a typical myc-transformed phenotype to large flat cells resembling normal fibroblasts.
Cells exposed to doxycycline for 3 days reexpressed v-myc within 24 h after withdrawal of the drug from the culture medium, partial retransformation occurred after 2 days, and complete morphological transformation was reestablished after 6 days.
Analogous results were obtained with a cell line in which expression of the v-myc allele is dependent on a reverse transactivator (rtTA) that is activated by doxycycline.
The striking differential expression of known transformation-sensitive genes and of new candidate v-myc target genes revealed the tightness of the doxycycline-controlled v-myc expression system.
The data also indicate that expression of v-myc in these cells is indispensable for enhanced proliferation, transformation, and immortalization. Copyright 1999 Academic Press.
PMID: 9918878 [PubMed - indexed for MEDLINE]
Institute of Biochemistry, University of Innsbruck, Peter-Mayr-Str. 1a, Innsbruck, A-6020, Austria.
To investigate the molecular basis of oncogenesis induced by the v-jun oncogene of avian sarcoma virus 17 (ASV17), we developed a conditional cell transformation system in which transcription of the ASV17 v-jun allele is controlled by a doxycycline-sensitive transactivator (tTA) or a reverse (doxycycline-dependent) transactivator (rtTA), respectively. Permanent cell lines of quail embryo fibroblasts conditionally transformed by a doxycycline-controlled v-jun allele revert to the normal phenotype within 3 days and lose their ability to grow in soft agar, strictly dependent on the addition or removal of the drug, respectively. The reverted cells are rapidly retransformed on conditional activation of v-jun. While full-level synthesis of v-jun mRNA and v-Jun protein in these cells is established within 2 and 14 h, respectively, after switching to the permissive conditions, the first morphological alterations are observed after 24 h, and as early as 2 days later the morphology has changed entirely from flat cells resembling normal fibroblasts to spindle-shaped fusiform cells showing a typical jun-transformed phenotype. Kinetic expression analysis revealed that transcriptional activation of the direct jun target gene BKJ precisely coincides with the establishment of full-level v-Jun protein synthesis. Furthermore, we have analyzed the expression of a novel candidate v-jun target gene, termed JAC, which shows no sequence homology to known genes. Similar to BKJ, JAC is specifically activated in jun-transformed fibroblasts, and induction of JAC is tightly linked to the conditional expression of oncogenic v-Jun. These results demonstrate the high stringency of the doxycycline-controlled v-jun expression system, and they also indicate that expression of v-jun in these cells is indispensable for enhanced proliferation, cell transformation, and the induction of specific expression patterns of downstream target genes. Copyright 2000 Academic Press.
PMID: 10772983 [PubMed - indexed for MEDLINE] xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx J Am Acad Dermatol. 1997 Feb;36(2 Pt 2):311-4. Borrelia burgdorferi-associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a.
Kutting, et al Department of Dermatology, University of Munster, Germany.
We report two patients with low-grade malignant primary cutaneous B cell lymphoma in association with Borrelia burgdorferi infection. Extracutaneous manifestations were ruled out by standard staging procedures. Infection with Borrelia burgdorferi was confirmed by cultivation from lesional skin in both patients. In the first patient skin lesions cleared completely after pulse therapy with cefotaxime, whereas in the second patient antibiotic treatment failed. In this patient, however, skin lesions completely cleared after intralesional injection of interferon alfa-2a. Antibiotic treatment or intralesional injection of interferon alfa-2a should be considered as a first-line treatment of Borrelia burgdorferi-associated primary cutaneous B cell lymphoma before more aggressive conventional therapeutic modalities (e.g., radiation therapy) are applied.
Publication Types: Case Reports PMID: 9039207 [PubMed - indexed for MEDLINE] xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13601-6. Epub 2001 Nov 6.
JAC, a direct target of oncogenic transcription factor Jun, is involved in cell transformation and tumorigenesis.
Hartl M, et al
Institute of Biochemistry, University of Innsbruck, Peter-Mayr-Strasse 1a, A-6020 Innsbruck, Austria. [email protected]
Using subtractive hybridization techniques, we have isolated a gene termed JAC that is strongly and specifically activated in avian fibroblasts transformed by the v-jun oncogene of avian sarcoma virus 17 (ASV17), but not in cells transformed by other oncogenic agents. Furthermore, JAC is highly expressed in cell lines derived from jun-induced avian fibrosarcomas. Kinetic analysis using a doxycycline-controlled conditional cell transformation system showed that expression of the 0.8-kb JAC mRNA is induced rapidly upon activation of the oncogenic v-jun allele. Nucleotide sequence analysis and transcriptional mapping revealed that the JAC gene contains two exons, with the longest ORF confined to exon 2. The deduced 68-amino acid chicken JAC protein is rich in cysteine residues and displays 37% sequence identity to mammalian high-sulfur keratin-associated proteins. The promoter region of JAC contains a consensus (5'-TGACTCA-3') and a nonconsensus (5'-TGAGTAA-3') AP-1 binding site in tandem, which are both specifically bound by the Gag-Jun hybrid protein encoded by ASV17. Mutational analysis revealed that the two AP-1 sites confer strong transcriptional activation by Gag-Jun in a synergistic manner. Ectopic expression of JAC in avian fibroblasts leads to anchorage-independent growth, strongly suggesting that deregulation of JAC is an essential event in jun-induced cell transformation and tumorigenesis.
PMID: 11698665 [PubMed - indexed for MEDLINE]
Infection. 1992 Jul-Aug;20(4):201-6.
Solitary borrelial lymphocytoma: report of 36 cases.
Strle F, et al Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia.
Thirty-six cases of borrelial lymphocytoma were detected during the period 1986 to 1990 in Slovenia. Borrelial lymphocytoma was located on the ear lobe in 17 persons, ten female and seven male, with a median age of 12 years (range 2-56). Fourteen of these 17 were children under 14 years of age. A tick bite was remembered by 15 patients a median of 30 days before borrelial lymphocytoma developed. The most frequent month of onset was September. Erythema migrans preceded or accompanied borrelial lymphocytoma in eight cases. In 15 cases, eight female and seven male, borrelial lymphocytoma was localized on the mamilla. Median age of these patients was 42 years (range 15-72). Twelve had a tick bite about 45 days (median value) before the onset of borrelial lymphocytoma, which occurred most frequently in August. Erythema migrans was reported in 13 patients and preceded borrelial lymphocytoma in ten cases. In another four patients borrelial lymphocytoma was localized on the nose, scrotum, upper arm and shoulder. Antibiotic treatment with phenoxymethyl-penicillin (n = 16), ceftriaxone (n = 8), doxycycline (n = 9), azithromycin (n = 2) and penicillin G (1) led to complete recovery within an average of three weeks in all cases.
There are some great herbs for fighting cancer that your uncle can take on his own without an Rx. The first one is Graviola, and you can buy it at Rain Tree.
The other one is Artemisinin; the same one that we use for Babs. It has been used with good success against cancer for many years. Here's some info on it: Now if you can only convince him to take them.
posted
Oh AliG - I'm so sorry to hear what u and family are going thru. Prayer sent...
Just lost my friend & neighbor to lung cancer last week. Only 44, battled stage 4 for 3 long yrs, which is almost unheard of. I miss her...
Thru this time I forwarded much info on alternatives to her, but she pretty much stuck to the Dr's RX. I know the last thing I sent her was just a few weeks ago - on resveratrol - from grapes - not the knotweed, for cancer.
Also if u do a googlesearch on cancer/ grapes there was a diet that was posted with good results - which was a fast of nothing but this wholegrape (seeds, skins, etc)blended & drank exclusively thru out the day for so many days.It was very informative. You will know it when u read it cuz the theory was when u are hungry - the cancer cell is starved, then u drink this grape mixture & the "medicine" of the grape mixture was the only thing for the cancer cell to eat - (cuz no other food was avail for it due to fast)and thus it had greater absorbtion of the drink mixture, and cancer cells died.
Also - if u have Buhner's book he mentions several herbs that have cancer fighting ability. If u don't have the book, PM me I will send the names & you can research them. Plus, they are also TBI herbs - so 2 birds kinda thing, since u think he has Lyme.
I would not give up. And no, YOU cannot save him, but GOD can! Prepare for the worst, but hope for the best!
sometimesdilly
Frequent Contributor (1K+ posts)
Member # 9982
posted
Ali-
i'm glad your uncle is in hospice and so has people nearby who know how to help him.
here's just a thought. maybe you already know the answer. is your uncle trying to let go? is he asking family to let him go? or is he deciding to stop invasive procedures and let what happens happen?
those are two different things. if he is undecided or hoping for the best, then every idea you can throw to him would likely be welcome.
but, if he is ready to let go but you are not, i'm thinking you might find it very helpful to call up his hospice and to speak with someone directly.
an important part of what a hospice does is to help family deal with a life ending.
my grandmother at 93, every last bit of cherished independence long gone and in constant awful pain, finally told her children it was time to let her go.
she gave them a whole year to do so, was ok even then, but slid downhill to the end within a few weeks.
with death supposedly imminent, all of her children came to say goodbye and stayed by her bedside for days. she was NEVER left alone, though she couldn't speak or acknowledge anyone in any way. after more days, my out of town aunts and uncles went home.
one night in the middle of the night, when the nurse was out of the room as was the aunt designated to stay throughout the night- for a grand total of 4-5 minutes-- my grandmother died, alone.
at first we all grieved that she was alone when she died. i have come to believe, though, that she waited for that moment so she COULD let go.
A friend once told me that she thought perhaps dying was like the process of giving birth. Do you remember when you were heavy-duty deep into labor and you knew that the only way you could possibly DO it was to block out every last thing and person in the room at times?
The process was so all-consuming, so requiring of every last molecule of heart and body and spirit, there was no way to be there with others AND give birth.
What i'm trying to say in such a long round-about way, hopefully gently, is that maybe what is most important right now is knowing what your uncle wants, and bracing yourself to let go if that is what he asks you to do.
That kind of doing "nothing" and lettign go is the most difficult thing anyone can do for someone else they love.
hugd and prayers to you all..
dilly
Posts: 2507 | From lost in the maze | Registered: Aug 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
In a jam...our brain cells can use ketones to sub. for glucose.
The antioxidants that cross the BBB may help too.
God Bless. Follow his wishes, just tell him you love him, respect him, and are so grateful that he was a part of your life and you will see him again - someday.
I know it is hard.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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tailz
Unregistered
posted
Maybe I'm the oddball here, but I don't think your uncle has been given a death sentence at all. My mom died of lung cancer that had metastasized to her brain - oat cell - the most aggressive form of lung cancer there is. She died, but I didn't know then what I know today.
In all honesty, about a year ago I had something major going on in my lungs. I looked like a chemo patient, too, hair loss and everything. Not sure if it was Lyme or some other bug, but lung cancer, with all the chest x-rays I had received, was certainly not out of the question.
True, cigarettes contain chemical carcinogens, but I don't think chemical carcinogens alone cause lung cancer. In fact, the fact that I had occupational levels of arsenic in my bloodstream last year, and arsenic has been proven to kill syphilis, makes me wonder if my body's holding onto arsenic from my cigarettes saved me, intially anyway, from a lung infection that would have killed me back then.
I strongly suggest you get your uncle involved in a number of things:
1) Reading about electromagnetic fields (EMFs) and how they basically 'charge' toxins in his body, allowing them to adhere more readily to damaged tissue. Also, reading about how they cause pathogens (germs and toxins) to cross the blood-brain barrier and how they cause cancer cells in a culture dish to replicate out of control.
2) Trying to reduce his exposure to artificial electromagnetic fields. Does he live near a transformer? (Look for a black cylindrical box around electrical distribution lines.) Does he live near a cell phone tower? Does he use a cell phone or a computer (VDT) frequently?
Please get your uncle to research these things. I think it will give him hope that although we are drowning in these dangerous fields that inevitably cause cancer, maybe a strong-willed desire to bring this to light, in spite of opposition from government and industries that are involved in a cover-up, will give him the determination to stay alive and beat this disease.
This determination is the only thing that gets me through each day myself. The research is there. The proof is there that these electromagnetic fields are involved in the development of cancers of all kinds. Only a few researchers though are involved in exposing this truth, and unfortunately, the cover-up continues.
I'll pray for your uncle. I think it would help for him to take baking soda baths, too. I use 1-2 cups of baking soda in the hottest water I can tolerate, and stay there until the sweat literally pours out of me.
Also, tell him to read 'Cross Currents', 'The Body Electric', and 'Currents of Death'. There are some books available of the health effects of cell phone towers, too. I don't think he has to die at all. I think all of this advice applies to your grandma, too, and I'll include her in my prayers, too. Good luck!
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D Bergy
Frequent Contributor (1K+ posts)
Member # 9984
posted
One easy thing to incorporate would be LDN (Low Dose Naltrexone). No nasty side effects and has had some success in some preliminary trials.
D Bergy
Posts: 2924 | From Minnesota | Registered: Aug 2006
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randibear
Honored Contributor (10K+ posts)
Member # 11290
posted
i am so sorry. to have both, well, i don't know how you can treat the lyme right now.
i just don't know.
bless you for caring tho.
-------------------- do not look back when the only course is forward Posts: 12262 | From texas | Registered: Mar 2007
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Aniek
Frequent Contributor (1K+ posts)
Member # 5374
posted
Ali,
I'm so sorry to hear about your uncle. Please don't look at it like he is giving up though.
He has probably decided that he would rather live a shorter, higher quality life then spending his last days in chemo. He will probably be much more comfortable with hospice than in a hospital.
And, in a way, he has taken control. He has made the decision of how he will go.
My aunt passed away this spring from a brain tumor. My uncle had her fight so hard for so long, and hospice came in so late. Honestly, it was awful to see her change and lose her spirit over two years.
My advice to keep on hospice, and make sure they really are helping his pain. Hospice is great with that, but your uncle has to be sharing how much pain he has in order for them to treat the pain.
-Aniek
-------------------- "When there is pain, there are no words." - Toni Morrison Posts: 4711 | From Washington, DC | Registered: Mar 2004
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The results showed that all patients in the trial reported that they used fewer painkillers and did not lose weight during cancer treatment. In addition, 6 patients showed signs of remission i.e. tumor regression.
...anecdotal reports also recorded that adjunctive CoQ10 supplementation has increased the survival of patients with cancers of the pancreas, lung, colon, rectum, and prostate cancer.
Posts: 6956 | From Lancaster, PA | Registered: Feb 2004
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
Stopping Cancer Good News tetracycline minocycline and doxycycline Borrelia burgdorfei
I thought everyone should Know about this. Stopping Cancer Good News tetracycline minocycline and doxycycline And you thought nothing good could come out of me having Lyme & Coinfections through searches for my problem I found this.
Scientists find way to 'turn off' cancer - Antibiotic halts aggressive tumours in mice !!!!!
Tim Radford, Science Editor,
Monday October 11, 2004, The Guardian
Scientists in California have found a way to "turn off" a gene that makes cancerous cells lethal.
They eliminated aggressive, incurable liver tumours in laboratory mice in four weeks, they report in an advance paper in Nature today. The study, based on a gene called Myc, could lead to new ways of treating cancer.
Cancer Research UK scientists in Glasgow, working with colleagues in Seattle, last year worked out the details of how Myc cranks up the rate of growth of dividing cancer cells by sending one of the cell's factories into overdrive. In cancer, cells divide uncontrollably.
The California team based their studies on mice with genetically modified liver cells. The type of cell that becomes cancerous is called an epithelial cell, and these form cancers in breast, colon and prostate.
So the same approach might work in all of them. Liver cancer is common and difficult to treat. "This is a terrible cancer. Anything that is encouraging in liver cancer may be important," said Dean Felsher of Stanford University, who led the research. "The exciting thing is that you can turn cancer cells into something that appears to be normal."
The mice under study had a mutated Myc gene that was constantly on. It produced a Myc protein that served as a kind of conductor, sending a signal to cells to divide. Cancer cells produce too much Myc protein all the time, and are constantly dividing.
Dr Felsher and his colleagues fed the mice an antibiotic called doxycycline, which turned the gene off, and stopped the protein flow.
As long as the mice had the antibiotic diet, they remained healthy. Once the antibiotic was withheld, they developed aggressive liver cancer in 12 weeks.
When they were put back on the diet, all of them showed rapid regression: the liver cancer was eliminated, and liver cells seemed to behave normally.
In effect, the scientists turned the Myc gene on and off like a tap, and turned cancer on and off at the same time.
They also found that some of the apparently normal cells retained the ability to become cancerous, which could explain why cancers often recur after chemotherapy.
Cancer hits one person in three, and kills one in five. In recent years, researchers have concentrated on a number of new approaches. They have tried to cut off the blood supply to tumours, to halt their growth.
They have tested search-and-destroy toxins, designed to make for and eliminate only cancerous cells. They have experimented with scalpels made of ultrasound, and they have tried to "burn" cancerous cells with infrared radiation.
But cancer is, above all, a disease of the DNA, and British researchers have launched a cancer genome project to collect all the genetic mutations involved in the making of a cancer. There are more than 100.
But the Myc protein seems to play a role in many cases of the disease.
The Glasgow study immediately suggested that it would be a good target. If researchers could find a drug that blocked the action of Myc, they could study its effect on cancer cases. The Stanford study shows that they were right. But what works in mice may not work so well in humans.
The next step is to hunt for a drug that would be safe for human patients, and yet have the same impact.
Int J Cancer. 2004 Jun 20;110(3):336-42.
Reversible lymphomagenesis in conditionally c-MYC expressing mice.
Marinkovic D, Marinkovic T, Mahr B, Hess J, Wirth T.
Department of Physiological Chemistry, Ulm University, Ulm, Germany.
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this process are only partially understood. We have established a transgenic mouse model in which c-MYC is conditionally expressed in lymphoid cells using the tetracycline-regulated system of gene regulation.
Mice with continuously expressed transgenic c-MYC died of invasive T- or B-cell lymphomas within 4 months. Lymphomas developing in transgenic mice were c-MYC dependent since doxycycline treatment led to tumor regression. Using transplantation of established tumor cell lines labeled with GFP, we followed the fate of neoplastic cells in recipients upon MYC inactivation.
This approach allowed us to elucidate both apoptosis and differentiation as mechanisms of tumor elimination. Comparative genomic hybridization (CGH) and FISH analyses were performed in order to analyze possible chromosomal aberrations induced by c-MYC. We observed that overexpression of c-MYC is sufficient to induce recurrent patterns of genomic instability.
The main observation was a gain of genomic material that corresponded to chromosome 15 in several T-cell tumors, which could be identified as trisomy. Copyright 2004 Wiley-Liss, Inc.
PMID: 15095297 [PubMed - indexed for MEDLINE]
Virology. 1999 Jan 20;253(2):193-207.
Conditional cell transformation by doxycycline-controlled expression of the MC29 v-myc allele.
Oberst C, Hartl M, Weiskirchen R, Bister K.
Institute of Biochemistry, University of Innsbruck, Peter-Mayr-Str. 1a, Innsbruck, A-6020, Austria.
To investigate the molecular basis of oncogenesis induced by the v-myc oncogene of avian myelocytomatosis virus MC29, we developed a conditional cell transformation system in which expression of the MC29 v-myc allele is dependent on a doxycycline-sensitive transactivator (tTA).
Clonal lines of quail embryo fibroblasts transformed by doxycycline-controlled v-myc revert to the normal phenotype and lose their ability to grow in soft agar after the addition of doxycycline.
Repression of v-myc causes the cells to withdraw from the cell cycle, and long-term survival in culture requires reexpression of v-myc. Although complete repression of v-myc mRNA and v-Myc protein in these cells occurs within 14 h after the addition of doxycycline, the first morphological alterations are observed after 24 h, and after 3 days, the morphology changed entirely from small rounded cells showing a typical myc-transformed phenotype to large flat cells resembling normal fibroblasts.
Cells exposed to doxycycline for 3 days reexpressed v-myc within 24 h after withdrawal of the drug from the culture medium, partial retransformation occurred after 2 days, and complete morphological transformation was reestablished after 6 days.
Analogous results were obtained with a cell line in which expression of the v-myc allele is dependent on a reverse transactivator (rtTA) that is activated by doxycycline. The striking differential expression of known transformation-sensitive genes and of new candidate v-myc target genes revealed the tightness of the doxycycline-controlled v-myc expression system.
The data also indicate that expression of v-myc in these cells is indispensable for enhanced proliferation, transformation, and immortalization. Copyright 1999 Academic Press.
PMID: 9918878 [PubMed - indexed for MEDLINE]
Canadian Breast Cancer Research .... Comparisons between tetracycline, minocycline and doxycycline
Doxycycline and other tetracyclines in the treatment of bone metastasis.
MINIREVIEW PAPER
Anti-Cancer Drugs. 14(10):773-778, November 2003. Saikali, Zeina a; Singh, Gurmit a b Abstract: The tetracycline family includes tetracycline, doxycycline and minocycline, all of which have been used as antibiotics effectively for decades. New uses emerged for these compounds after their effect on mitochondrial function was discovered. Cytostatic and cytotoxic activity of these compounds was shown against cell lines of various tumor origins. In addition, tetracyclines and chemically modified tetracyclines inhibit the activity of several matrix metalloproteinases (MMPs). Given the importance of these enzymes in tumor cell invasion and metastatic ability, the potential use of tetracyclines in cancer therapy needed to be investigated. Col-3, a chemically modified tetracycline, is now the subject of clinical trials in cancer patients. However, the potential of tetracyclines in cancer therapy takes on an added dimension in the bone. MMPs have been shown to be important mediators of metastasis formation in the bone, contributing largely to the morbidity of breast cancer and prostate cancer patients. The natural osteotropism of tetracyclines would allow them to be highly effective in the inhibition of MMPs produced by osteoclasts or tumor cells in the bone. This hypothesis has now been confirmed by experimental evidence showing that doxycycline reduces tumor burden in a mouse model of breast cancer-derived osteolytic bone metastasis. This effect is likely due to a combination of multiple roles of doxycycline, including MMP inhibition and a negative effect on osteoclast differentiation and survival. These encouraging results have now paved the way for an ongoing trial of doxycycline in early combination therapy for breast cancer and prostate cancer patients.
(C) 2003 Lippincott Williams & Wilkins, Inc.
S. Gilbertson-Beadling1, E. A. Powers1, M. Stamp-Cole1, P. S. Scott1, T. L. Wallace1, J. Copeland1, G. Petzold1, M. Mitchell2, S. Ledbetter1, R. Poorman1, J. W. Wilks1 and C. Fisher1
(1) Cancer and Infectious Diseases Research, Upjohn Laboratories, The Upjohn Company, 7252-267-412, 49001 Kalamazoo, MI, USA (2) Medional Chemistry Research, Upjohn Laboratories, The Upjohn Company, 7252-267-412, 49001 Kalamazoo, MI, USA
Received: 3 August 1994 Accepted: 20 November 1994
Abstract The tetracycline analogs minocycline and doxycycline are inhibitors of metalloproteinases (MMPs) and have been shown to inhibit angiogenesis in vivo. To further study the mechanism of action of these compounds we tested them in an in vitro model of angiogenesis: aortic sprouting in fibrin gels. Angiogenesis was quantitated in this system by a unique application of planar morphometry. Both compounds were found to potently inhibit angiogenesis in this model. To further characterize the activity of these compounds against MMPs, we determined the IC50s of both compounds against representatives of three classes of metalloproteinases: fibroblast collagenase, stromelysin, and gelatinase A. Doxycycline was found to inhibit collagenase, gelatinase A and stromelysin with IC50s of 452 M, 56 M and 32 M, respectively. Minocycline was found to inhibit only stromelysin in the micromolar range with an IC50 of 290 M. Since these results suggest that these compounds may not have been inhibiting in vitro angiogenesis by an MMP-dependent mechanism, we decided to test the effects of the potent MMP inhibitor BB-94. This compound failed to inhibit aortic sprouting in fibrin gels, thus strongly suggesting that both doxycycline and minocycline act by an MMP-independent mechanism. These results have implications for the mechanism of action of tetracycline analogs, particularly where they are being considered for the treatment of disorders of extracellular matrix degradation including periodontal disease, arthritis, and tumor angiogenesis.
Many More:
Bruins NA, Oswald JE, Morreau H, Kievit J, Pavel S, Smelt AH. Papillary thyroid carcinoma in a patient with sarcoidosis treated with minocycline. Neth J Med. 2007 May;65(5):185-7. PMID: 17519514 [PubMed - in process
Hanna H, Benjamin R, Chatzinikolaou I, Alakech B, Richardson D, Mansfield P, Dvorak T, Munsell MF, Darouiche R, Kantarjian H, Raad I. Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial. J Clin Oncol. 2004 Aug 1;22(15):3163-71. Erratum in: J Clin Oncol. 2005 May 20;23(15):3652. PMID: 15284269 [PubMed - indexed for MEDLINE]
Yajima M, Ohnishi Y, Fujimoto N, Komatsu T, Tajima S. Minocycline hydrochloride injection therapy for ganglion and mucous cyst: a preliminary study. Dermatology. 2004;209(3):241-2. No abstract available. PMID: 15459543 [PubMed - indexed for MEDLINE]
Liu FS, Hung MJ, Hwang SF, Lu CH, Ke YM, Ho ES. Management of pelvic lymphocysts by ultrasound-guided aspiration and minocycline sclerotherapy. Gynecol Obstet Invest. 2005;59(3):130-3. Epub 2004 Dec 22. PMID: 15627779 [PubMed - indexed for MEDLINE]
Ishimori S, Okada S, Yamagata S, Satoh S. [Intrathoracic infusion with a combination of low-dose minocycline, OK-432 and cisplatin for malignant pleural effusion] Gan To Kagaku Ryoho. 2005 Mar;32(3):345-9. Japanese. PMID: 15791817 [PubMed - indexed for MEDLINE
She M, Jim Yeung SC. Combining a matrix metalloproteinase inhibitor, a farnesyltransferase inhibitor, and a taxane improves survival in an anaplastic thyroid cancer model. Cancer Lett. 2006 Jul 18;238(2):197-201. Epub 2005 Sep 8. PMID: 16154259 [PubMed - indexed for MEDLINE]
Young SD, Whissell M, Noble JC, Cano PO, Lopez PG, Germond CJ. Phase II clinical trial results involving treatment with low-dose daily oral cyclophosphamide, weekly vinblastine, and rofecoxib in patients with advanced solid tumors. Clin Cancer Res. 2006 May 15;12(10):3092-8. PMID: 16707607 [PubMed - indexed for MEDLINE]
Lowenstein M, Metzler G, Rocken M, Schaller M. [Confluent and reticulated papillomatosis Gougerot-Carteaud successfully treated with minocycline] J Dtsch Dermatol Ges. 2006 Jul;4(7):556-8. German. PMID: 16827913 [PubMed - indexed for MEDLINE]
1: Oncol Rep. 2005 Dec;14(6):1599-603. Links
Artesunate in the treatment of metastatic uveal melanoma--first experiences.
Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO, Baur A, Schuler G. Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany. [email protected]
Artesunate (ART) is a derivative of artemisinin, the active principle of the Chinese herb Artemisia annua L. Artesunate is approved for the treatment of multidrug-resistant malaria and has an excellent safety profile.
It has been shown that Artesunate, apart from its anti-malarial activity, has cytotoxic effects on a number of human cancer cell lines, including leukemia, colon cancer and melanoma.
We report on the first long-term treatment of two cancer patients with ART in combination with standard chemotherapy.
These patients with metastatic uveal melanoma were treated on a compassionate-use basis, after standard chemotherapy alone was ineffective in stopping tumor growth.
The therapy-regimen was well tolerated with no additional side effects other than those caused by standard chemotherapy alone.
One patient experienced a temporary response after the addition of ART to Fotemustine while the disease was progressing under therapy with Fotemustine alone.
The second patient first experienced a stabilization of the disease after the addition of ART to Dacarbazine, followed by objective regressions of splenic and lung metastases. This patient is still alive 47 months after first diagnosis of stage IV uveal melanoma, a situation with a median survival of 2-5 months.
Despite the small number of treated patients, ART might be a promising adjuvant drug for the treatment of melanoma and possibly other tumors in combination with standard chemotherapy.
Its good tolerability and lack of serious side effects will facilitate prospective randomized trials in the near future.
Now the reason I searched for anti cancer links because its quite common for people with lyme=Borrelia burgdorferi or coinfections to get one type or another of cancer.
Histopathology. 2000 Dec;37(6):501-8.
Histopathology. 2001 Jan;38(1):73-7.
Borrelia burgdorferi-associated cutaneous marginal zone lymphoma: a clinicopathological study of two cases illustrating the temporal progression of B. burgdorferi-associated B-cell proliferation in the skin.
Goodlad JR, Davidson MM, Hollowood K, Batstone P, Ho-Yen DO.
Department of Pathology, Raigmore Hospital, Inverness, UK. [email protected]
AIMS: A relationship between Borrelia burgdorferi and primary cutaneous B-cell lymphoma (PCBCL) has recently been confirmed following demonstration of the organism in lesional skin of patients with PCBCL.
We report herein two cases of B. burgdorferi-associated PCBCL which strengthen this association by demonstrating the organism in cutaneous B-cell infiltrates present at sites in which PCBCL subsequently developed.
METHODS AND RESULTS: All studies were performed on formalin-fixed paraffin-embedded tissues. These were examined by routine light microscopy and immunohistochemically by a standard streptavidin-biotin-complex technique.
Genotypic studies were also undertaken using semi-nested polymerase chain reaction (PCR) for immunoglobulin heavy chain gene rearrangement, and nested PCR for B. burgdorferi flagellin gene.
Both patients presented with erythematous skin lesions, biopsy of which showed dense perivascular infiltrates comprising small T-lymphocytes and collections of B-blasts.
Primary cutaneous marginal zone lymphoma (MZL) developed subsequently in both cases at the same site. PCR for B. burgdorferi flagellin gene was positive in the perivascular lymphocytic infiltrates and the succeeding lymphomas in both patients.
CONCLUSIONS: These results show that, at least in some instances, PCBCL arises from chronically stimulated lymphoid tissue acquired in the skin in response to B. burgdorferi infection. This may have significant therapeutic implications and warrant further studies on the extent of this association.
PMID: 11122431 [PubMed - indexed for MEDLINE]
Am J Surg Pathol. 2000 Sep;24(9):1279-85.
Primary cutaneous B-cell lymphoma and Borrelia burgdorferi infection in patients from the Highlands of Scotland.
Goodlad JR, Davidson MM, Hollowood K, Ling C, MacKenzie C, Christie I, Batstone PJ, Ho-Yen DO. Department of Pathology, Raigmore Hospital, Inverness, Scotland, UK.
Although a link between primary cutaneous B-cell lymphoma (PCBCL) and Borrelia burgdorferi infection has long been suspected, previous studies have not demonstrated a significant association.
The authors looked for evidence of B. burgdorferi in 20 cases of PCBCL from the Scottish Highlands, an area with endemic Lyme disease, and compared their findings with those in 40 control patients (20 undergoing wide reexcision at sites of malignant melanoma and 20 biopsies of inflammatory dermatoses).
All studies were performed on formalin-fixed, paraffin-embedded tissues. The cases of PCBCL were classified according to criteria described by the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group using a combination of morphology, immunohistochemistry, and seminested polymerase chain reaction (PCR) for immunoglobulin heavy chain gene rearrangement.
A nested PCR was performed on deoxyribonucleic acid (DNA) extracts from the lymphoma and control cases using primers to a unique conserved region of the B. burgdorferi flagellin gene.
B. burgdorferi-specific DNA was detected in seven of 20 lymphoma cases (five of 12 marginal zone lymphomas, one of five primary cutaneous follicle center cell lymphomas, one of three diffuse, large B-cell lymphomas of the leg) and in one melanoma reexcision patient of 40 control subjects.
The relationship between B. burgdorferi and PCBCL was significant when compared with the control groups separately (p 0.05) or in combination (p 0.01). These results provide strong evidence to support the concept of B. burgdorferi-driven lymphomagenesis in the skin.
PMID: 10976703 [PubMed - indexed for MEDLINE]
Rev Neurol (Paris). 1998 Feb;154(2):170-2.
[Nervous system borreliosis with pseudo-lymphoma cells in cerebrospinal fluid] [Article in French]
Kaminsky P, Grignon Y, Deibener J, Maurer P, Duc M.
Service de M�decine Interne, Centre Hospitalier Universitaire de Nancy, H�pitaux de Brabois, Vandoeuvre.
We report the case of a 44-year-old woman, who experienced acute back pains, leg paraesthesia, and diplopia. Analysis of the cerebrospinal fluid revealed, in addition to increased protein and decreased glucose levels, an elevated number of large atypical cells, resembling lymphoma cells.
Magnetic resonance imaging of the brain and spine was normal. High levels of antibodies against Borrelia burgdorferi were found in both serum and cerebrospinal fluid. The patient completely recovered with ceftriaxone therapy.
PMID: 9773040 [PubMed - indexed for MEDLINE]
Hum Pathol. 2000 Feb;31(2):263-8.
Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin.
Roggero E, Zucca E, Mainetti C, Bertoni F, Valsangiacomo C, Pedrinis E, Borisch B, Piffaretti JC, Cavalli F, Isaacson PG. Istituto Oncologico Svizzera Italiana, Department of Medical Oncology, Ospedale San Giovanni, Bellinzona, Switzerland.
Primary cutaneous B-cell lymphomas have been associated with Borrelia burgdorferi, the spirochete responsible for Lyme disease. Recently, cutaneous marginal zone B-cell lymphoma has been proposed as a distinct clinical-pathological entity.
We report a case of primary cutaneous marginal zone lymphoma, associated with B burgdorferi infection. Polymerase chain reaction (PCR) amplification of the third complementarity determining region (CDR3) of the immunoglobulin heavy chain gene showed the presence of a monoclonal lymphoproliferation, therefore strengthening the histological diagnosis of a malignant process.
B burgdorfer-specific hbb gene sequences were detected by PCR in the lymphoma tissue at diagnosis but not after antibiotic treatment.
A nearly complete clinical and histological regression was observed after B burgdorferi eradication, with immunohistochemistry studies showing disappearance of plasma cell differentiation and a marked decline in the number of CD3+ T cells and Ki-67+ cells.
Our case confirms the link between B burgdorferi and some cutaneous lymphomas. The disappearance of the microorganism accompanied by the unequivocal decrease of most indicators of active T- and B-cell immune response strongly supported a pathogenetic role for B burgdorferi in sustaining an antigen-driven development and growth of this cutaneous marginal zone lymphoma.
Antibiotic therapy (analogous to Helicobacter pylori infection in gastric MALT lymphoma) might be helpful with the aim of averting or at least deferring the indication for more aggressive treatment.
PMID: 10685647 [PubMed - indexed for MEDLINE]
Hematol Oncol. 1999 Sep;17(3):107-16.
Positive serology for Lyme disease borrelias in primary cutaneous B-cell lymphoma: a study in 22 patients; is it a fortuitous finding?
Jelić S, Filipović-Ljesković I.
Institut za Onkologiju i Radiologiju Srbije, Belgrade, Yugoslavia.
BACKGROUND: The historical association of acrodermatitis chronica atrophicans (ACA), now known to be a late manifestation of Lyme disease caused by Borrelia afzelii, with cutaneous lymphoma, and several small series of PCBCL with positive Lyme disease borrelial serology initiated a study of this association.
Material and methods
In the last 9 years, 30 patients with PCBCL have been observed and followed, 22 of them were tested for borrelial serology.
The control group consisted of 85 patients with NHL (10 cutaneous T-cell, 25 extranodal B-cell non-PCBCL, 50 nodal B-cell), 30 patients with breast cancer and 60 blood donors.
The screening tests were two different ELISA tests for B. burgdorferi sensu lato and sensu stricto, and reactive sera were further tested with the ELISA test for B. garinii, a Western blot (WB) test for Swiss Borrelia strains and a WB test for Bavarian Borrelia strains, since an immunoblot made with local strains was not available.
Studies with a differential WB test for B. burgdorferi sensu stricto, B. garinii and B. afzelii was performed afterwards, as well as serological studies ruling out cross-reactions with Leptospiras and Treponema.
RESULTS: Fifteen of 22 patients with PCBCL were positive on the screening tests, three of them falsely. Thus, the incidence of positive borrelial serology was 12/22 (55 per cent) in the PCBCL group.
No positives were detected in the cutaneous T-cell lymphoma group; 2/25 patients (8 per cent) were positive in the extranodal B-cell NHL group (the localizations being vestibulum nasi and oral cavity), 2/50 (4 per cent) were positive in the nodal B-cell NHL group, 2/30 (7 per cent) in the breast cancer group and 2/60 (3 per cent) in the blood donor group. The cumulative incidence in the control groups was 8/175 (4,6 per cent).
The incidence was significantly higher in PCBCL patients as compared to each of the control groups, p value ranging from 0.004 to 0.0001. Two positive patients had ACA, one arthritis.
Borrelia afzelii was most often implied for positive serology in the differential WB. No cross-reactions with Treponema and the Leptospiras were documented.
CONCLUSION: In conclusion there appears to be a clustering of positive serology for Lyme disease Borrelias in PCBCL patients possibly related to an ethiopathogenic relationship. Mechanisms of Borrelia escape from immunosurveillance mechanisms, persistence of both their mitogenic and antigenic stimuli for B-cells, and SALT formation may be involved in the pathogenesis of a subset of PCBCL.
Copyright 1999 John Wiley & Sons, Ltd.
PMID: 10641031 [PubMed - indexed for MEDLINE
Med Hypotheses. 2007;69(1):117-9. Epub 2007 Jan 2.
Lyme borreliosis and multiple sclerosis are associated with primary effusion lymphoma. Batinac T, Petranovic D, Zamolo G, Petranovic D, Ruzic A.
Department of Dermatovenerology, Rijeka University Hospital, Kresimirova 42, 51000 Rijeka, Croatia.
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by chronic inflammation and demyelination. Studies suggested that the viral, especially Epstein-Barr virus infection, and bacterial infections, especially [Lyme] Borrelia burgodorferi infection, play a role in etiology of MS.
MS prevalence parallels the distribution of the Lyme disease pathogen B. burgdorferi.
Criteria used for diagnosis of MS can also be fulfilled in other conditions such as Lyme disease, a multisystem disorder resulting from infection by the tick-borne spirochete, B. burgdorferi.
In the late period of Lyme disease demyelinating involvement of central nervous system can develop and MS can be erroneously diagnosed.
A Lyme borreliosis can mimick central nervous system lymphoma. Also, B. burgdorferi has been implicated not only in etiology of MS, but also in etiology of lymphoma.
Studies suggested that there is an increased risk of non-Hodgkin lymphoma in patients, who had a history of autoimmune diseases such as MS and that both non-Hodgkin's lymphomas and Hodgkin's disease were associated with Epstein-Barr virus infection.
A small group of lymphomas called primary effusion lymphomas (PEL) is a recently individualized form of non-Hodgkin's lymphoma (WHO classification) that exhibit exclusive or dominant involvement of serous cavities, without a detectable solid tumor mass.
These lymphomas have also been linked to Epstein-Barr virus and human herpes virus type 8 infections but virus negative cases have been described.
Therefore, we propose that MS and neuroborreliosis are linked to central nervous system primary effusion lymphomas.
As a first step in confirming or refuting our hypotheses, we suggest a thorough study of CSF in the patients suspected for the diagnosis of MS and Lyme borreliosis.
PMID: 17197115 [PubMed - in process]
Dermatology. 2001;203(2):168-70.
Multilesional primary cutaneous diffuse large B-cell lymphoma responsive to antibiotic treatment. Hofbauer GF, Kessler B, Kempf W, Nestle FO, Burg G, Dummer R.
Department of Dermatology, University Hospital, Z�rich, Switzerland.
Borrelia burgdorferi infection has been implicated in cutaneous B-cell lymphoma. We report a case of multilesional primary cutaneous large B-cell lymphoma without extracutaneous spread in a patient with elevated B. burgdorferi titers.
After antibiotic therapy, clinical remission and a subsequent drop in B. burgdorferi antibody titers were obtained. Copyright 2001 S. Karger AG, Basel
Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK.
PMID: 11135050 [PubMed - indexed for MEDLINE]
Ann Hematol. 2001 Apr;80(4):232-5.
Paraneoplastic polyneuropathy preceding the diagnosis of Hodgkin's disease and non-small cell lung cancer in a patient with concomitant Borrelia burgdorferi infection.
Behringer D, Spyridonidis A, Fetscher S, Schmitt-Gr�ff A, H�gerle S, Kaiser R.
Department of Hematology/Oncology, University of Freiburg, Germany. [email protected]
A patient with painful peripheral neuropathy is presented, whose symptoms were thought to result from an infection with Borrelia burgdorferi sensu lato.
Investigations of the cerebrospinal fluid for signs of inflammation and borrelial antibodies were negative, and the patient did not benefit from repeated antibiotic treatment.
Electrophysiologic studies and sural nerve biopsy showed axonal neuropathy consistent with a paraneoplastic syndrome. Further workup revealed mediastinal Hodgkin's disease (HD; nodular sclerosing subtype) Ann Arbor stage II and non-small cell cancer of the lung (stage T1N0M0).
Surgical resection of the lung cancer and combined chemo- and radiotherapy for HD resulted in complete remission of both malignancies. While the preexisting neurologic symptoms persisted during treatment, neurography showed some improvement of the distal nerves.
During radiation therapy the patient developed transient left-sided brachial plexopathy. This case illustrates that the diagnosis of borreliosis in patients with isolated painful peripheral neuritis cannot be based solely upon positive IgG titers and supports the requirement for a thorough workup for an underlying--potentially curable--disease.
In addition, singular pulmonary lesions in the setting of HD should be suspected to have a separate cause.
PMID: 11401090 [PubMed - indexed for MEDLINE]
Rinsho Ketsueki. 2000 Dec;41(12):1273-6.
[Occurrence of angioimmunoblastic T-cell lymphoma six months after onset of Lyme disease] [Article in Japanese]
Hatanaka K, Miyagishima T, Kamata T, Nakagawa M, Miura Y, Arai S, Kishimoto A, Kamishima Y, Shibata M, Choi GH, Kudo M, Okabe M, Tsukamoto T, Miyamoto K.
Department of International Medicine, Kushiro Rousai Hospital.
A 68-year-old man, who had suffered a tick bite one week previously, consulted his home doctor because of fever and an erythematous rash around the bite scar.
He underwent a skin biopsy, and Borrelia garinii was detected, from which Lyme disease was diagnosed. He received amoxicillin for two weeks and his symptoms disappeared.
After 6 months he noticed swelling of his cervical, axillary and inguinal lymph nodes. A biopsy sample was taken from a left cervical lymph node, and this revealed angioimmunoblastic T-cell lymphoma.
The patient achieved a complete remission after chemotherapy. The relationship between Lyme disease and lymphoma is discussed.
PMID: 11201153 [PubMed - indexed for MEDLINE]
Brain Dev. 2000 Sep;22(6):403-6.
Lyme borreliosis mimicking central nervous system malignancy: the diagnostic pitfall of cerebrospinal fluid cytology.
Kieslich M, Fiedler A, Driever PH, Weis R, Schwabe D, Jacobi G.
Department of Pediatric Neurology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany. [email protected]
We report two children with acute loss of neurological functions and signs of an increased intracranial pressure.
Imaging techniques ruled out space occupying lesions, whereas CSF cytology indicated CNS involvement of a non-Hodgkin lymphoma in the form of abnormal lymphocytic pleocytosis with malignancy criteria fulfilling lymphoid cells.
CSF protein electrophoresis and Borrelia burgdorferi serology revealed neuroborreliosis which was successfully treated with antibiotic therapy.
The malignancy mimicking cytology is based on a blastoid transformation of B- and T-lymphocytes due to the antigenic stimulus of B. burgdorferi infection.
Lymphoid cells in the CSF of a patient with acute or chronic neurological symptoms raise the differential diagnosis of inflammatory etiology versus CNS lymphoma.
Monomorphism and higher quantity of the lymphoid cells point to CNS lymphoma. A lower quantity and polyclonal pattern of lymphoid cells associated with an elevated protein fraction caused by intrathecal immunoglobulin synthesis suggest an inflammatory etiology.
PMID: 11185583 [PubMed - indexed for MEDLINE
Dermatology. 2000;201(4):353-5.
Comment on: Dermatology. 2000;201(4):351-2.
Exploring the causes of cutaneous B-cell lymphoma: we should learn from the Lyme disease experience.
Naldi L, Minelli C.
Epidemiological studies rely on the uneven distribution of disease within and between populations and represent a simple but efficient way of studying disease causation.
The incidence of non-Hodgkin's lymphomas (NHLs) has increased dramatically over the past few decades and the epidemic calls for epidemiological studies.
The study of Munksgaard and colleagues, in this issue of Dermatology, is a good example of an epidemiological study based on the so-called ecological correlation.
It focuses on cutaneous B-cell lymphoma (CBCL) and fails to document a correlation between CBCL incidence and Lyme disease as a surrogate indicator for the exposure to tick bites.
Although ecological studies neither inform about the time relationship between exposure and disease nor usually allow control for confounding variables, they can provide important information that would guide the direction of further research.
There is a number of analytical studies focusing on risk factors for NHLs. One drawback of these studies is that they consider NHLs as a single category. One merit of the paper of Munksgaard et al. is that it focused on a rather specific disease, i.e. CBCL. Copyright 2000 S. Karger AG, Basel
PMID: 11146350 [PubMed - indexed for MEDLINE]
Dermatology. 2000;201(4):351-2.
Comment in: Dermatology. 2000;201(4):353-5.
Incidence patterns of lyme disease and cutaneous B-cell non-Hodgkin's lymphoma in the United States.
Munksgaard L, Frisch M, Melbye M, Hjalgrim H. Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark. [email protected]
BACKGROUND: Several reports have suggested a link between infection with Borrelia burgdorferi (the spirochete causing Lyme disease) and development of cutaneous B-cell non-Hodgkin's lymphoma (CBCL).
METHODS: We did a correlation analysis of CBCL and Lyme disease using data from the Surveillance, Epidemiology and End Results program and from the Centers for Disease Control and Prevention.
RESULTS: We could not demonstrate a geographic correlation between incidence rates of Lyme disease and CBCL.
CONCLUSION: This observation suggests that infection with B. burgdorferi is not a major risk factor for CBCL in the USA. Copyright 2000 S. Karger AG, Basel
PMID: 11146349 [PubMed - indexed for MEDLINE
J Am Acad Dermatol. 2005 Sep;53(3):479-84.
Primary cutaneous B-cell lymphoma.
Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M. Department of Dermatology, University of Texas and M. D. Anderson Cancer Center, Houston, Texas 77030, USA. [email protected]
Primary cutaneous B-cell lymphomas include extranodal marginal zone B-cell lymphoma, follicular lymphoma, large B-cell lymphoma, and, rarely, mantle cell lymphoma.
Our purpose in conducting this review was to determine the clinical and behavioral characteristics of primary cutaneous B-cell lymphomas, their relationship to infectious triggers, and therapeutic response.
We conducted a retrospective chart review of 23 adult patients presenting to the dermatology clinic at M. D. Anderson Cancer Center with primary cutaneous B-cell lymphoma between January 1999 and May 2003.
Primary cutaneous B-cell lymphomas generally present on the head and neck, with the trunk and extremities afflicted to a lesser extent. Patients were found to have serologic evidence of prior infection with Borrelia burgdorferi (n = 10), Helicobacter pylori (n = 5), and Epstein-Barr virus (n = 6).
Overall, treatment of primary cutaneous B-cell lymphoma should involve multiple modalities; however, specific treatment aimed at concurrent or suspected infection, particularly B burgdorferi, is a helpful adjunct and may achieve complete remission in a small subset of patients.
PMID: 16112357 [PubMed - indexed for MEDLINE
Leuk Lymphoma. 2004 Aug;45(8):1721-3.
Demonstration of B. burgdorferi-DNA in two cases of nodal lymphoma.
Munksgaard L, Obitz ER, Goodlad JR, Davidson MM, Ho-Yen DO, Hamilton-Dutoit S, Hjalgrim H. PMID: 15370236 [PubMed - indexed for MEDLINE
Walther EU, Seelos K, Bise K, Mayer M, Straube A. Department of Neurology, Klinikum Grosshadern, Munich, Germany.
PMID: 14639029 [PubMed - indexed for MEDLINE
Folia Biol (Praha). 2003;49(1):40-8.
Interaction of Borrelia burgdorferi sensu lato with Epstein-Barr virus in lymphoblastoid cells. Hul�nsk� D, Roubalov� K, Schramlov� J.
National Reference Laboratory on Borreliosis, Electron Microscopy, National Institute of Public Health, Prague, Czech Republic.
Since the possibility of interruption of latent EBV infection has been suggested by the induction of the lytic virus cycle with chemical substances, other viruses, and by immunosuppression, we hypothesized that the same effect might happen in B. burgdorferi sensu lato infection as happens in Lyme disease patients with positive serology for both agents.
We have observed EBV replication in lymphoblastoid cells after superinfection with B. garinii and B. afzelii strains after 1 and 4 h of their interaction.
We found that viral and borrelial antigens persisted in the lymphoblasts for 3 and 4 days. Morphological and functional transformation of both agents facilitate their transfer to daughter cells.
Association with lymphoblasts and internalization of B. garinii by tube phagocytosis increased replication of viruses more successfully than B. afzelii and chemical inductors.
Demonstration of such findings must be interpreted cautiously, but may prove a mixed borrelial and viral cause of severe neurological disease.
PMID: 12630667 [PubMed - indexed for MEDLINE]
Improving the specificity of 16S rDNA-based polymerase chain reaction for detecting Borrelia burgdorferi sensu lato-causative agents of human Lyme disease. [J Appl Microbiol. 2005]
Use of CFSE staining of borreliae in studies on the interaction between borreliae and human neutrophils. [BMC Microbiol. 2006]
Early stage of Epstein-Barr virus lytic infection leading to the "starry sky" pattern formation in endemic Burkitt lymphoma. [Arch Pathol Lab Med. 2004]
[Prevalence of Borrelia burgdorferi sensu lato species among patients in the Czech Republic; direct sequencing analysis and real-time polymerase chain reaction] [Epidemiol Mikrobiol Imunol. 2004]
Substantial rise in the prevalence of Lyme borreliosis spirochetes in a region of western Germany over a 10-year period. [Appl Environ Microbiol. 2004
Ugeskr Laeger. 2002 Dec 9;164(50):5927-32.
[Infectious causes of non-Hodgkin lymphomas] [Article in Danish]
Munksgaard L, Hjalgrim H, Melbye M. Afdeling for Epidemiologisk Forskning, Statens Serum Institut, Artillerivej 5, DK-2300 K�benhavn S. [email protected]
The etiology to non-Hodgkin's lymphoma remains incompletely understood.
Chronic infection with certain viruses and bacteria has attracted interest in recent years because of the association with lymphoma development.
In this article we present an overview of the current evidence of infectious causes to non-Hodgkin's lymphomas.
PMID: 12553112 [PubMed - indexed for MEDLINE
Srp Arh Celok Lek. 2001 Nov-Dec;129(11-12):340-5.
[Primary B-cell cutaneous lymphoma: a model for study of lymphogenesis associated with a specific infectious agents] [Article in ]
Jelić S. Institut za onkologiju i radiologiju Srbije 11 000 Beograd, Pasterova 14. [email protected]
PMID: 11928622 [PubMed - indexed for MEDLINE
The European strains of Lyme (once thought to not be in the USA) are present in North America. This study used only one strain found in the USA, however, it linked lymphomas to the other strains which we now recognise in the USA and other areas.
1: J Cutan Pathol. 2001 Nov;28(10):502-7.
Absence of Borrelia burgdorferi DNA in cutaneous B-cell lymphomas from the United States.
BACKGROUND: An association between Borrelia burgdorferi and cutaneous B-cell lymphoma (CBCL) has been made in several European countries.
The evidence in favor of such an association has recently been based on more definitive tests for the pathogenetic role of B. burgdorferi in CBCL, including positive cultures or polymerase chain reaction (PCR) amplification of borrelial DNA from lesional skin.
However, there is only one report of B. burgdorferi in four North American cases of B-cell lymphoma.
METHODS: We retrieved 38 cases of primary and secondary CBCL from different geographic regions of the United States. Two separate techniques were used to detect borrelial DNA by PCR, a nested PCR method to amplify a B. burgdorferi-specific gene as well as a borrelial chromosomal Ly-1 clone amplification method.
Southern blot hybridization was used for confirmation of the PCR results. RESULTS: No B. burgdorferi-specific DNA was detected in any of the 38 CBCL cases, whereas detectable PCR products were obtained with our positive controls.
CONCLUSIONS: Our findings, in light of previous studies, suggest that B. burgdorferi plays a minimal role in the development or pathogenesis of CBCL in the United States.
The findings also suggest that the geographic variations in the clinical manifestations of B. burgdorferi are indeed real and may be secondary to the genetic and phenotypic differences between B. burgdorferi strains present in Europe and North America.
I posted this in another post but thought we should know about it on its own thread.
I have had mild headaches and slight fever since starting minocycline last month.
Minocycline
Tetracycline
Doxycycline
Cautions and side effects In addition to those common to the Tetracycline antibiotics group, minocycline may be used in renal impairment, but may aggravate systemic lupus erythematosus.[1]
Also, more so than other tetracyclines, minocycline can cause the rare condition of secondary intracranial hypertension which has initial symptoms of headache, visual disturbances, and confusion.
Minocycline, like all Tetracyclines, becomes dangerous past its expiration date. While most prescription drugs lose potency after their expiration dates, tetracyclines are known to become toxic over time; expired tetracyclines can cause serious damage to the kidneys.
Minocycline's absorption is impaired if taken at the same time of day as calcium or iron supplements. Unlike some of the other tetracycline group antibiotics, it can be taken with calcium rich foods such as milk, although this does reduce the absorption slightly (by ~5%).
Headache caused by cyclines could be Idiopathic intracranial hypertension. Idiopathic intracranial hypertension
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Had a great big reply but lost it bummer. Anyway get LLMD to put him on minocin. It helps fight effects of chemo and colorectal cancer and othe cancers. I would take that and at different times good probiotics, like magnesium Vitamin d, B complex,cq10,acidophilis,yogurt low carb plain mix with fresh blueberries or,strawberries,drink some red wine moderate,magnesium,Check with Chemo Dr. about this Melatonin super antioxident.
1: Bruins NA, Oswald JE, Morreau H, Kievit J, Pavel S, Smelt AH. Papillary thyroid carcinoma in a patient with sarcoidosis treated with minocycline. Neth J Med. 2007 May;65(5):185-7. PMID: 17519514 [PubMed - in process]
2: Hsu LH, Soong TC, Feng AC, Liu MC. Intrapleural urokinase for the treatment of loculated malignant pleural effusions and trapped lungs in medically inoperable cancer patients. J Thorac Oncol. 2006 Jun;1(5):460-7. PMID: 17409900 [PubMed - indexed for MEDLINE]
3: Kapadia M, Rolston KV, Han XY. Invasive Streptomyces infections: six cases and literature review. Am J Clin Pathol. 2007 Apr;127(4):619-24. PMID: 17369139 [PubMed - indexed for MEDLINE]
4: Shiomori T, Miyamoto H, Udaka T, Okochi J, Hiraki N, Hohchi N, Hashida K, Fujimura T, Kitamura T, Nagatani G, Ohbuchi T, Suzuki H. Clinical features of head and neck cancer patients with methicillin-resistant Staphylococcus aureus. Acta Otolaryngol. 2007 Feb;127(2):180-5. PMID: 17364350 [PubMed - indexed for MEDLINE]
5: Azumi M, Kato Y, Saga Y, Kakizaki H. [A case of infected renal cyst suspected of originating from retrograde infection] Hinyokika Kiyo. 2007 Jan;53(1):53-6. Japanese. PMID: 17310770 [PubMed - indexed for MEDLINE]
6: Pantanowitz L. Black thyroid. Diagn Cytopathol. 2007 Feb;35(2):135-6. No abstract available. PMID: 17230575 [PubMed - indexed for MEDLINE]
7: DeWitt CA, Siroy AE, Stone SP. Acneiform eruptions associated with epidermal growth factor receptor-targeted chemotherapy. J Am Acad Dermatol. 2007 Mar;56(3):500-5. Epub 2006 Dec 12. PMID: 17166623 [PubMed - indexed for MEDLINE]
8: Nguyen J, Norwood C. Photo quiz. What is your diagnosis? Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome). Cutis. 2006 Oct;78(4):236, 239-40. No abstract available. PMID: 17121058 [PubMed - indexed for MEDLINE]
9: Yamane M, Kobayashi S, Kurosaki A, Nanki N, Ando M, Maeda H. [Thoracoscopic repair of peritoneopleual communication with a giant diaphragmatic bullae in a patient with liver cirrhosis; report of a case] Kyobu Geka. 2006 Nov;59(12):1127-30. Japanese. PMID: 17094556 [PubMed - indexed for MEDLINE]
10: Scheinfeld N. Confluent and reticulated papillomatosis : a review of the literature. Am J Clin Dermatol. 2006;7(5):305-13. Review. PMID: 17007541 [PubMed - indexed for MEDLINE]
11: Lowenstein M, Metzler G, Rocken M, Schaller M. [Confluent and reticulated papillomatosis Gougerot-Carteaud successfully treated with minocycline] J Dtsch Dermatol Ges. 2006 Jul;4(7):556-8. German. PMID: 16827913 [PubMed - indexed for MEDLINE]
12: Kalia S, Adams SP. Dermacase. Minocycline-induced pigmentation. Can Fam Physician. 2006 May;52:595-6. Review. No abstract available. PMID: 16739831 [PubMed - indexed for MEDLINE]
13: Young SD, Whissell M, Noble JC, Cano PO, Lopez PG, Germond CJ. Phase II clinical trial results involving treatment with low-dose daily oral cyclophosphamide, weekly vinblastine, and rofecoxib in patients with advanced solid tumors. Clin Cancer Res. 2006 May 15;12(10):3092-8. PMID: 16707607 [PubMed - indexed for MEDLINE]
14: Yamamoto Y, Kadota M, Nishimura Y. A case of maxacalcitol-resistant confluent and reticulated papillomatosis successfully treated with minocycline. J Dermatol. 2006 Mar;33(3):223-4. No abstract available. PMID: 16620232 [PubMed - indexed for MEDLINE]
15: Oertel YC, Oertel JE, Dalal K, Mendoza MG, Fadeyi EA. Black thyroid revisited: cytologic diagnosis in fine-needle aspirates is unlikely. Diagn Cytopathol. 2006 Feb;34(2):106-11. PMID: 16514674 [PubMed - indexed for MEDLINE]
16: Miller BT, Lewis C, Bentz BG. Black thyroid resulting from short-term doxycycline use: case report, review of the literature, and discussion of implications. Head Neck. 2006 Apr;28(4):373-7. Review. PMID: 16477607 [PubMed - indexed for MEDLINE]
17: Sapadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol. 2006 Feb;54(2):258-65. Review. PMID: 16443056 [PubMed - indexed for MEDLINE]
18: Davis MD, Weenig RH, Camilleri MJ. Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome): a minocycline-responsive dermatosis without evidence for yeast in pathogenesis. A study of 39 patients and a proposal of diagnostic criteria. Br J Dermatol. 2006 Feb;154(2):287-93. PMID: 16433798 [PubMed - indexed for MEDLINE]
19: Ozan U, Er K. Endodontic treatment of a large cyst-like periradicular lesion using a combination of antibiotic drugs: a case report. J Endod. 2005 Dec;31(12):898-900. PMID: 16306827 [PubMed - indexed for MEDLINE]
20: Rocchetti R, Talevi S, Margiotta C, Calza R, Corallini A, Possati L. Antiangiogenic drugs for chemotherapy of bladder tumours. Chemotherapy. 2005 Oct;51(6):291-9. Epub 2005 Oct 13. PMID: 16224178 [PubMed - indexed for MEDLINE]
21: She M, Jim Yeung SC. Combining a matrix metalloproteinase inhibitor, a farnesyltransferase inhibitor, and a taxane improves survival in an anaplastic thyroid cancer model. Cancer Lett. 2006 Jul 18;238(2):197-201. Epub 2005 Sep 8. PMID: 16154259 [PubMed - indexed for MEDLINE]
22: Birkedal C, Tapscott WJ, Giadrosich K, Spence RK, Sperling D. Minocycline-induced black thyroid gland: Medical curiosity or a marker for papillary cancer? Curr Surg. 2001 Sep-Oct;58(5):470-1. PMID: 16093068 [PubMed - in process]
23: Stein JA, Shin HT, Chang MW. Confluent and reticulated papillomatosis associated with tinea versicolor in three siblings. Pediatr Dermatol. 2005 Jul-Aug;22(4):331-3. PMID: 16060870 [PubMed - indexed for MEDLINE]
24: Montoro J, Freixenet N, Lozano A, Bertomeu F. An unusual adverse drug reaction? Allergol Immunopathol (Madr). 2005 Jul-Aug;33(4):235-7. PMID: 16045865 [PubMed - indexed for MEDLINE]
25: Fernandez-Gomez FJ, Galindo MF, Gomez-Lazaro M, Gonzalez-Garcia C, Cena V, Aguirre N, Jordan J. Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. Neuroscience. 2005;133(4):959-67. PMID: 15964487 [PubMed - indexed for MEDLINE]
26: Diez E, Alonso LM, Zambrano B, de Eusebio E. Confluent and reticulated papillomatosis without papillomatosis. J Am Acad Dermatol. 2005 May;52(5):E8. No abstract available. PMID: 15858464 [PubMed - indexed for MEDLINE]
27: Ogawa M, Kubo S, Uenishi T, Hirohashi K, Tanaka H, Shuto T, Yamamoto T, Takemura S. Nonoprerative management of obstructive jaundice caused by a benign hepatic cyst. Osaka City Med J. 2004 Dec;50(2):95-9. PMID: 15819304 [PubMed - indexed for MEDLINE]
28: Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 2005;18(1):89-115. Review. PMID: 15802955 [PubMed - indexed for MEDLINE]
29: Ishimori S, Okada S, Yamagata S, Satoh S. [Intrathoracic infusion with a combination of low-dose minocycline, OK-432 and cisplatin for malignant pleural effusion] Gan To Kagaku Ryoho. 2005 Mar;32(3):345-9. Japanese. PMID: 15791817 [PubMed - indexed for MEDLINE]
30: Liu FS, Hung MJ, Hwang SF, Lu CH, Ke YM, Ho ES. Management of pelvic lymphocysts by ultrasound-guided aspiration and minocycline sclerotherapy. Gynecol Obstet Invest. 2005;59(3):130-3. Epub 2004 Dec 22. PMID: 15627779 [PubMed - indexed for MEDLINE]
31: Patterson JW, Wilson B, Wick MR, Heath C. Hyperpigmented scar due to minocycline therapy. Cutis. 2004 Nov;74(5):293-8. Review. PMID: 15605966 [PubMed - indexed for MEDLINE]
32: Yajima M, Ohnishi Y, Fujimoto N, Komatsu T, Tajima S. Minocycline hydrochloride injection therapy for ganglion and mucous cyst: a preliminary study. Dermatology. 2004;209(3):241-2. No abstract available. PMID: 15459543 [PubMed - indexed for MEDLINE]
33: Wiesenborn A, Hengge U, Megahed M. [Confluent and reticulated papillomatosis. Gougerot-Carteaud disease] Hautarzt. 2004 Oct;55(10):976-8. German. PMID: 15375622 [PubMed - indexed for MEDLINE]
34: Hanna H, Benjamin R, Chatzinikolaou I, Alakech B, Richardson D, Mansfield P, Dvorak T, Munsell MF, Darouiche R, Kantarjian H, Raad I. Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial. J Clin Oncol. 2004 Aug 1;22(15):3163-71. Erratum in: J Clin Oncol. 2005 May 20;23(15):3652. PMID: 15284269 [PubMed - indexed for MEDLINE]
35: Shigeto N, Shimizu S. [Eradication of Helicobacter pylori for idiopathic thrombocytopenic purpura] Nippon Shokakibyo Gakkai Zasshi. 2004 Jun;101(6):598-608. Review. Japanese. PMID: 15233261 [PubMed - indexed for MEDLINE]
36: Shiotani J, Takehana K. [Sensitivity of MRSA isolated in our hospital to various antibacterial agents: changes over 5 years] Jpn J Antibiot. 2004 Apr;57(2):196-203. Japanese. PMID: 15224661 [PubMed - indexed for MEDLINE]
37: Kobayashi K, Yano S, Kato K, Morita M, Tatsukawa T, Ikeda T, Tokushima T. [A case of M. fortuitum lung disease with small-cell lung cancer] Nihon Kokyuki Gakkai Zasshi. 2004 May;42(5):424-8. Japanese. PMID: 15168461 [PubMed - indexed for MEDLINE]
38: Dukic R, Derragui A, Geiss S, Wilhelm JM, Thannberger P, Colson A, Kieffer P. [Minocycline-induced lymphomatoid papulosis] Rev Med Interne. 2004 May;25(5):401-4. French. No abstract available. PMID: 15110963 [PubMed - indexed for MEDLINE]
39: Retter AS, Figg WD, Dahut WL. The combination of antiangiogenic and cytotoxic agents in the treatment of prostate cancer. Clin Prostate Cancer. 2003 Dec;2(3):153-9. Review. PMID: 15040858 [PubMed - indexed for MEDLINE]
40: Raghavan R, Snyder WH, Sharma S. Pathologic quiz case: tumor in pigmented thyroid gland in a young man. Papillary thyroid carcinoma in a minocycline-induced, diffusely pigmented thyroid gland. Arch Pathol Lab Med. 2004 Mar;128(3):355-6. No abstract available. PMID: 14987144 [PubMed - indexed for MEDLINE]
Just a few anticancer colon minocyclines ability to help fight cancer and help fight the debilitating effects of chemo.
colon cancer minocycline googled
I would get on minocycline while treating with cancer chemos. Have LLMD put on minocin and have Chemo Doc do his thing.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
The product Stem Enhance may help. It pulls stem cells out of the bone marrow and moves them to where they are needed.
I just started this product a few days ago, so I cannot say it works. I have no affiliation with selling it. Hiker53
-------------------- Hiker53
"God is light. In Him there is no darkness." 1John 1:5 Posts: 10180 | From Illinois | Registered: Aug 2004
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Beverly
Frequent Contributor (5K+ posts)
Member # 1271
posted
Keeping your family in my prayers...
Posts: 6641 | From Michigan | Registered: Jun 2001
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
I don't know if this is true for all types of cancers, but on pubmed (I just did a search for it today) mangosteen (sp) fruit is hailed by some as cancer-fighting.
When my lyme headaches got really bad a couple of months ago, I took hydrocodone. It didn't work completely, but did take the edge off.
I will say some prayers for him and for the rest of your family. I was sad to hear about your sad news.
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
I squeezzzzeedddddddd everything I could find so page wasnt so wide.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Michelle M
Frequent Contributor (1K+ posts)
Member # 7200
posted
Oh, dear AliG.
Has Hospice talked about the possibility of a morphine pump? It could make a huge difference in his comfort level. It can be self administered. Overdose is impossible with a built-in regulator. No one should have to suffer so and I expect a brain tumour must be excruciating.
I don't doubt the above are all great suggestions if he's up for trying them. But pain control is first and foremost, IMO.
There's good material out there on hospice care and the art of letting go. Those who are letting go are exquisitely sensitive to those they love. It's almost as if they need your permission, and need to know you will be ok without them. It is a very fine line.
Please be gentle with yourself. Spending time with them is one of the most important things you can do, along with agitating for pain control.
Hugs,
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
OMG! I JUST LOST MY EPIC NOVEL REPLY!!!! I can't do it again tonight.
Know that I love you all and am tremendously grateful for ALL of your support. Extra for Tree, even going the extra mile to shrink the links. (So, so sweet!)
I will try again to post my ridiculously lengthy explanation tomorrow, for leaving you all hanging, for which I am REALLY sorry.
My uncle's pain has been taken away. He is at peace as of 3pm yesterday. I was still spinning around trying to figure out how to get out there to rescue him and figuring out what I needed to bring with me.
The Graviola would have been too dangerous for him from what I read on the cancertutor link. Very interesting link BTW. There was some stuff on there that I think might benefit us Lymies.
I hope to go back & read that link again along with a lot of the other posted info. I was in a brain-scrambled, OCD-driven fit, so I could not seem to retain much more than what actually pertained to his immediate crisis.
I do believe that the last remaining issue that he had wanted to deal with, was taken on by a trusted member of his parish. In that, his/our prayers were answered in that he was able to accomplish what he wanted to before he passed on and is finally at peace.
I'm so very sorry for those of you who have gone through this with your loved ones.
I thank you ALL for being there for me and throwing me the research, when I would never have been able to take it on myself. I hope that someone else may be able to pull this thread up and benefit from it, as there is a lot of great info here.
I thank those of you who supported me with your prayers, kind words, empathy, sympathy and general concern.
I pray that you are ALL rewarded for your kindness and that God eases the burdens that you bear.
Thank you all for being there for me. Ali
[ 27. September 2007, 08:43 PM: Message edited by: AliG ]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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Michelle M
Frequent Contributor (1K+ posts)
Member # 7200
posted
Oh AliG, I'm so sorry. Yet so happy that he is at peace and not in pain any longer. As I know you must be. I know you have many cherished memories of him from which to draw strength.
Hugs,
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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