Pauliina Hartialaa, b, , , Jukka Hyt�nena, Juha Suhonena, c, Outi Lepp�rantaa, Helena Tuominen-Gustafssona and Matti K. Viljanena aDepartment of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland bTurku Graduate School of Biomedical Sciences, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland cDeparment of Medicine, Helsinki University Central Hospital, PL 340, 00029 HUS, Helsinki, Finland Received 8 July 2007; accepted 11 October 2007. Available online 18 October 2007.
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Microbes and Infection Article in Press, Accepted Manuscript
Neutrophil: A type of white blood cell, specifically a form of granulocyte, filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis.
The mature neutrophil has a segmented nucleus (it is called a seg or poly) while the immature neutrophil has band-shape nucleus (it is called a band). The neutrophil has a lifespan of about 3 days.
Neutrophilia, an increased proportion of neutrophils in the blood, is a common finding with acute bacterial infections.
Neutropenia, a decreased proportion of neutrophils, may be seen with viral infections and after radiotherapy and chemotherapy. Neutropenia lowers the immunologic barrier to bacterial and fungal infection.
[ 27. November 2007, 08:02 PM: Message edited by: AliG ]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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Michelle M
Frequent Contributor (1K+ posts)
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posted
Intriguing find!!
My daughter's CBC just came back with low neutrophils. LLMD did not act too worried but I am, of course. She relapses about once a year, but resides in the fabled teenaged land of De Nile. But Mother notices many symptoms which she cleverly conceals or minimizes.
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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posted
HI Michelle-- After reading this topic I started a poll asking who else had neutropenia (low neutrophills). I ALWAYS have low WBC due to low neurtophills.
I didn't know if this was common or not with Lyme. Now I'm VERY curious.
Allie
Posts: 300 | From Northeast | Registered: Dec 2006
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AliG
Frequent Contributor (1K+ posts)
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posted
quote:Originally posted by Michelle M:
fabled teenaged land of De Nile
My neutrophils jumped up after Txing Babs & continued to elevate while I was improving on Doxy. When the improvement stopped & I started backsliding, they dropped by 1/2 of what they were.
They were still in the mid-normal range at that point. I wonder what they will be when my latest labs come back. I'm very curious.
My WBC & platelets followed the same pattern as the neutrophils.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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Michelle M
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posted
Hmm. Her other labs are OK, though some are on the low end of normal.
She tests clear for babesia, but I actually think she has it.
I'm giving thought to sending a sample to the brilliant Dr. F's lab.
Too much sighing/deep intakes of air, daily tiredness for my comfort level.
Mother's gut feeling stuff.
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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AliG
Frequent Contributor (1K+ posts)
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posted
I also got a more positive WB after my neutrophils, WBC & platelets were elevated for 2 series of labs (would've been 3 months).
That must be when you're putting up a fight. The Lyme must have done whatever it does to knock them back down so I couldn't fight anymore because then my symptoms started worsening again.
I think maybe they should be elevated to fight an infection but Lyme keeps them from doing that.
[ 28. November 2007, 12:25 AM: Message edited by: AliG ]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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cantgiveupyet
Frequent Contributor (1K+ posts)
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posted
my neutrophils are on the high end of the range or slightly above it. My WBC dropped to the 4 range a month after illness hit.
No dr has yet to wonder why my neutrophils are high.
-------------------- "Say it straight simple and with a smile."
"Thus the task is, not so much to see what no one has seen yet, But to think what nobody has thought yet, About what everybody sees."
-Schopenhauer
pos babs, bart, igenex WB igm/igg Posts: 3156 | From Lyme limbo | Registered: Oct 2005
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AliG
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posted
cantgiveupyet,
I'm curious, how's your blot? Do you get positive bands on the WB?
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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posted
My wBC's and most recently my neutrophils have dropped below normal after being on abx since 11/05.
I was/am CDC pos Lyme, and neg other coinfections.
I wonder if the abx are causing this. A short search shows that Septra, Ketek and minocin call all lower WBC's.
Altho, my CD57 has also dropped to 58.
I wonder if that is from the disease or from the abx?! I know erlichiosis can have low WBC's, less so lyme.
Posts: 211 | From NC | Registered: Dec 2005
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cantgiveupyet
Frequent Contributor (1K+ posts)
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posted
AliG- Im just seeing your reply to me- My recent blot shows positive IGM band 30 and 41. Thats it. Do you think the high neutrophils is good?
mntwoman- abx can lower your WBC's as can other drugs what abx are you on?
Im not sure of the affect on your cd57 inregards to abx lowering that numbner.
quote:Originally posted by AliG: cantgiveupyet,
I'm curious, how's your blot? Do you get positive bands on the WB?
-------------------- "Say it straight simple and with a smile."
"Thus the task is, not so much to see what no one has seen yet, But to think what nobody has thought yet, About what everybody sees."
-Schopenhauer
pos babs, bart, igenex WB igm/igg Posts: 3156 | From Lyme limbo | Registered: Oct 2005
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