posted
I hope someone answers this. As far as I know, the only proven cross-reactivity is at band 41, which is for the flagella common to all sprirochetes. Many bands are still unknown.
Posts: 422 | From Luck home | Registered: Sep 2005
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Geneal
Frequent Contributor (5K+ posts)
Member # 10375
posted
Not sure how accurate this is, but just googled it and found this.
Bands 44, 56, 62, 64, 72 and 82 kDA are known to cross react with other virus'.
Bands 18, 22-23, 32, 34, 39, 46, 58 and 92-93 are specific to bb.
Hugs,
Geneal
Posts: 6250 | From Louisiana | Registered: Oct 2006
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timaca
Frequent Contributor (1K+ posts)
Member # 6911
posted
There was some talk about this at the LDA/ILADS conference. I think the doctor from Igenex said that band 30 could be a problem.
If you look at Igenex's IgM WB, it talks about false positives occuring due to viral infections.
You could call Igenex to discuss this with them.
Also, if you think you have infection with EBV, go to www.hhv-6foundation.org. There is lots of info there about viral infections.
I, apparently, do have chronic viral infections too!
Timaca
Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005
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posted
Well, the Igenex doc told me that an acute mono (Epstein Barr) infection could lead to false positive results on the IGM blot. He also suggested that a static [chronic] EB infection could monkey up the IGG portion of the test. He did not specify particular bands that cross react so that leads me to believe that all bands can potentially cross react--even Bb specific bands.
Since acute mono is the initial raging phase of infection, it seems to me that viral levels would have to be sky high to affect the IGM result. The IGG is a different ball game. It seems a chronic level of EB may screw with the blot results.
It's looking more like Lyme for me. I did have mono last year but I'm thinking it was brought on by the burden of the Lyme disease in my system. Plus I'm 36 so mono is a little unusual at my age.
I suppose it may be good to treat viral possibilities and Lyme.
-------------------- "Whatever can go wrong will go wrong." Posts: 36 | From Connecticut | Registered: Oct 2007
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timaca
Frequent Contributor (1K+ posts)
Member # 6911
posted
Lemon2Lyme~
In my case, I think I had lyme and it activated viruses in me.
In January of 2007 I had a CDC positive IgM WB from Igenex, with only a 41 band on the IgG (previously I had many bands on the IgG). In May I was found to have chronic viral infections (diagnosed in July at Stanford Medical center).
I wondered whether my IgM WB was a false positive or not. I did talk with Igenex at the time, and they didn't think it was.
However, my guess is that this is murky waters...
My story can be found at www.hhv-6foundation.org. I'm Timaca. I've posted in the testing section and the treatment section.
If you had mono last year, I would look first at viral issues, then secondarily lyme issues.
Best wishes, Timaca
Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
read link So ospC is the one they should look for thats why they say it cross reacts just to remove the only true expression from beginning to end disease progression.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Forgive my brain fog...what relevance does OspC have with cross-reactivity and EB on the western blot test?
Thanks...
-------------------- "Whatever can go wrong will go wrong." Posts: 36 | From Connecticut | Registered: Oct 2007
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
OspC or band 41Kda is the one that they say is cross reacting with EBV.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
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