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» LymeNet Flash » Questions and Discussion » Medical Questions » Experienced opinions please - Cipro/Ibuprofen/CNS

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Author Topic: Experienced opinions please - Cipro/Ibuprofen/CNS
lymebytes
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I have taken Cipro long before LD for UTI's. I know I took it with Ibuprofen & I had no problems.

Now, the insert reads high dosing of Cipro w/anti inflammatory such as Ibuprofen can cause seizures. What is considered a high dose of Cipro? I asked my doctor he said he didn't think the 2 together would cause a problem.

I have read nothing but horror stories lately about the quinolones.

I now am very afraid to try it, because w/LD I have very bad nerve pain and even nerve damage in my right leg - no reflexes. Supposidly the quinolones can cause perm damage to the nervous system, (afraid of more damage) and not to mention I take prescription strength Ibuprofen.

Anyone here had seizure taking it w/Ibuprofen? Have the quinolones caused perm nerve damage to any of you?

I recently talked with an LD patient who said 1 dose of cipro hospitalized her for 10 days. Everytime I turn around something ugly pops up about these drugs that stop me cold from taking them.

I am never going to get well at this rate, it is getting to the point I can't or I won't try anything new.

Opinions of expereinced patients on the quinolones w/Ibuprofen and without - are much appreciated.

--------------------
www.truthaboutlymedisease.com

Posts: 2003 | From endemic area | Registered: May 2007  |  IP: Logged | Report this post to a Moderator
Looking
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Hi Lymebytes:

I haven't taken your medication combo but I've been reading about the quinolones and Cipro is to be used with caution on those with CNS disorders. Here's a link to a pubmed bit on seizures related to these drugs.
http://tinyurl.com/3347jh


I thought the MedlinePlus write-up on Cipro was quite comprehensive and would alert anyone taking this drug to possible interactions or side effects to be wary of. I find the pharmacists seem to know the most about drug interactions.

************
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a688016.html

A Couple of Excerpts:

What special precautions should I follow?

Includes Ibuprofen & Naproxen cautions.

What special dietary instructions should I follow?

Do not take ciprofloxacin with dairy products (like milk, ice cream, cheese, or yogurt) or calcium-added juices alone. You may take ciprofloxacin with a meal that includes these foods.

Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Ciprofloxacin may increase nervousness, sleeplessness, heart pounding, and anxiety caused by caffeine.
***********

As far as what dose would be high enough to cause seizures, I would think that would be an individual thing with many contributing factors perhaps unique to certain people. This is supposed to be a rare event.

Maybe if you learn all you can about the drug and know what to expect if you do have a bad reaction, then you will feel more comfortable about taking it and you could stop right away if you think something serious is going on. Some people do okay on it but some don't so it is a gamble as with a lot of drugs.

In the end, it is your decision because even if someone reassures you that they did fine on this drug, it's no guarantee that you will react the same as they did as I'm sure you know.

I truly hope you will find something you are comfortable with taking that will help you get well.

Looking

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tailz
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I'm in the same boat. I have Cipro sitting here, but I'm scared to death to take it. I also recently started coral calcium, so now I'm even more scared. My doctor thinks I have bart.

Just be glad you don't live in PA though. I'm not sure whether to trust my current doctor or not. Once again I had a noon appointment and didn't see him until after dark - like midnightish again, and he was falling asleep on me.

I didn't get home until just before 3am, because I still had a 2 hour drive home with pupils that no longer open all the way. What's going to happen if I have problems on Cipro???

I test positive for babs, too, but I can't afford the $343 copay for Mepron. So now I'm waiting for my doctor to get his act together and get me a pre-auth for qualaquin and zith to treat my babs.

I'm about ready to give up though, too, so I know where you're coming from.

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tailz
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I took the Cipro. My anxiety increased, but so far I do not notice any change for the worse (or better for that matter). Some mushy stools earlier, but this happens occasionally still anyway, so I'm not sure if this was the Cipro or not.

Maybe I have a virus or some resistant strain of fungus? My doctor thinks I have parvo, but I don't really think he knows any better than I do what I have - we're both guessing.

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lymeflox
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I have taken Cipro long before LD for UTI's. I know I took it with Ibuprofen & I had no problems.

You probably will not have problems now but every time you take cipro your chances of getting undamaged are smaller because its toxicity is cumulative.

What is considered a high dose of Cipro? I asked my doctor he said he didn't think the 2 together would cause a problem.

A high dose of cipro for anyone with a normal liver and about 140 pounds of body weight, is more than 1.000 mg/day. Cipro plus ibuprofen increases a lot the risks of nerve damage, even for not so high doses, and in some cases the combination causes permanent nerve injury, as the package insert states clearly. However it is not common, and it is less probable if you have taken cipro successfully in the past.

What is considered a high dose of Cipro? I asked my doctor he said he didn't think the 2 together would cause a problem.

No wonder since they are one of the most toxic antibiotics on the market, although very needed for severe and complicated infections.

Taking a fluoroquinolone having your nerve problems seems to run a huge risk of getting irreversible injuries because fluoroquinolones are distinctive specially for their nerve toxicity and causing CNS disorders (brain impairement, short memory loss, agitation, seizures, convulsions, anixety, depression, depersonalization) and neuropathies (of all sort, on all areas of the body). It is much more likely that cipro causes nerve damage than seizures for taking it with ibuprofen.

I know of two persons that had seizures combining both drugs, and both got permanent brain injuries (disabled after 6 and 8 years respectively) but I believe that they did not tolerate cipro well, what does not seem to be your case.

Posts: 94 | From canada | Registered: Nov 2006  |  IP: Logged | Report this post to a Moderator
sixgoofykids
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I'm taking Levaquin and have made great progress with it. I don't take ibuprofen though. It's a good drug, but has its risks. In the end, I'm glad I have taken it.

--------------------
sixgoofykids.blogspot.com

Posts: 13449 | From Ohio | Registered: Feb 2007  |  IP: Logged | Report this post to a Moderator
   

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