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» LymeNet Flash » Questions and Discussion » Medical Questions » how big a deal is it if you take Rifampin w/ food

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Author Topic: how big a deal is it if you take Rifampin w/ food
adamm
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Because I get QUITE uncomfortable if I don't.
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sixgoofykids
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Oh, I didn't know it was supposed to be taken without food ... I've been taking it with the rest of my meds with food .... I guess I need to know this, too.

I wonder why my jar doesn't say no food?

edit to add, I found this on drugdigest.org -- It is best to take rifampin on an empty stomach; 1 to 2 hours before food, or at least 2 hours after food. If rifampin upsets your stomach you can take it with food.

Since I've been having an upset stomach ever since starting it, I think I'll continue taking it with food.

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disturbedme
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I always take my antibiotics with food. I never used to, but now I do. I guess I don't really eat WITH Rifampin since I take Rifampin right before bed. I didn't know you weren't supposed to eat with Rifampin though?

The only medicine that REALLY bothers me so far if not taken with food is Doxy. I HAVE to take food with Doxy. [Razz]

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Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007  |  IP: Logged | Report this post to a Moderator
LocalMan
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I have been on rifampin (with minocycline, bicillin injections and plaquinil) for about 2 months now, was doing ok till until last week, when I started getting some real stomach upset...just about doubling me over now.

I have been trying to follow directions and take rifampin on an empty stomach, with lot of water.

Does anyone know how much is compromised if you take rifampin with food?

That's what I've been doing with all the others and have mostly dodged the GI bullet, until now.

LM

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viva
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The general instructions on taking abx that my husband's LLMD distributes actually says to take Rifampin WITH food.
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LocalMan
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Just another wonderful inconsistency...label on bottle says "take on empty stomach" and insert says 1 hour before or two our after food.

I had started taking with food until a read more closely...and my stomach went out. That's waht I get for following directions?

lm

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Jill E.
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I always took it with food - otherwise it would be too hard on my stomach. And I herxed like mad on it, so obviously I was absorbing it well enough, even with food!

Jill

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Dancer
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I kept the insert that came with Rifampin, the one with all the medical info in teeny tiny print, and this is what it says in the Oral Administration section:

Absorption of rifampin is reduced by about 30% when the drug is ingested with food.

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seibertneurolyme
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Hubby's LLMD told him to take all antibiotics with food because he has so many G.I. problems.

He started at 75 mg of Rifampin and is now up to 300mg. At 225 mg he switched it after 1 or 2 weeks and started taking only this antibiotic on an empty stomach.

He definitely absorbs more on an empty stomach -- urine is oranger and he has more headaches.

Bea Seibert

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LocalMan
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So this leads to next question:

Does this principle (30 percent less absorbtion with food) apply to all antibiotics, or just rifampin?

And is the GI discomfort actually causing damage, or just suffering?

lm

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adamm
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So could I have conferred Rifampin resistance to my

bart by taking the drug with food?

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