LymeNet Flash: Aminoglycosides for Bart?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Aminoglycosides for Bart?

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Topic: Aminoglycosides for Bart?

Vermont_Lymie
Frequent Contributor (1K+ posts)
Member # 9780

posted

Has anyone tried aminoglycosides for Bart?

Abstract:

Journal of Antimicrobial Chemotherapy (1995) 36, 101-108

Lack of bactericidal effect of antibiotics except aminoglycosides on Bartonella(Rochalimaea) henselae

D. Musso, M. Drancourt and D. Raoult*
Unit� des Rickettsies, Facult� de M�decine 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Received 1 September 1994; returned 29 December 1994; accepted 30 January 1995

*Corresponding author. Phone: +33-(91)-385517; Fax: + 33-(91)-830390.

Bartonella (Rochalimaea) henselae is a cause of peliosis hepatis and bacillary angiomatosis, and one of the putative agents of cat scratch disease. Specific therapy for B. henselae infections is not available.

Treatment failures and relapses are frequent, especially following brief antibiotic courses, and this contrasts with the in-vitro susceptibility of B.henselaeto most antibiotics.

We decided to test the antibiotic susceptibility of B.henselae associated with murine macrophage-like cells (P388 D1) and a human endothelial cell line.

We carried out a bactericidal assay in this model and in axenic broth. In both models, only aminoglycosides were bactericidal.

These results suggest that aminoglycosides may be effective in the treatment of B. henselae infections.

Posts: 2557 | From home | Registered: Aug 2006 | IP: Logged |

swedish lyme sufferer
LymeNet Contributor
Member # 14579

posted

Hi, I think I will try gentamicin, which belong to this group I believe. Dr. B says in his lecture on BLO that this medication might work! So will see, I come back!

Posts: 347 | From sweden | Registered: Feb 2008 | IP: Logged |

savebabe
Frequent Contributor (1K+ posts)
Member # 9847

posted

I believe this type of abx has to be taken IM or IV.

I am seeing my llmd on tues and I am going to ask about the IM version..

Feel better VL [Smile]

Posts: 1603 | From ny | Registered: Aug 2006 | IP: Logged |

stormton
Member
Member # 14412

posted

I would keep the aminoglycosides as a last resort option against bartonella. There is too much risk with hearing/equilibrium damage.

I would try the following which are much safer. Rifampin, Bactrim, Zithromax, Biaxin high dose 2000mg, Minocycline or even ketek.

Levaquin and cipro can be risky too.

If you must resort to streptomycin or gentamicin then I recommend looking into alpha lipoic acid(super antioxidant) supplementation to possibly prevent hearing damage. Alpha lipoic acid has been used before to possibly fend off this side effect. Try reading up on it.

Posts: 25 | From Ohio | Registered: Jan 2008 | IP: Logged |

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