posted
i have been treating babesia for 2 months now with zith/mepron and i have tinnitis that I have been ignoring (mainly because I didn't know- I thought my ears were clogged and causing the pulsing).
so, what are my options if i can't take zith/biaxin? i can't take mepron alone, right? will another abx. make it effective?
i already take artemisinin. any other options?
Posts: 871 | From NJ | Registered: Mar 2007
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sixgoofykids
Honored Contributor (10K+ posts)
Member # 11141
posted
Malarone does not need zith/biaxin.
I take Malarone, Lariam, and Art (plus mino and Plaquenil).
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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isn't the malarone not nearly as strong as the mepron though? that may be my only option if i can't take zith/biaxin anymore.
Posts: 871 | From NJ | Registered: Mar 2007
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posted
I can't take Zithro or any sulfas. I was treated with Mepron, Artimisinin and Clyndamyacin. Now I'm on Mepron, Artimisinin and Levaquin.
I think the Mepron, Artimisinin and Clyndamyacin addressed the babs pretty well.
-------------------- Mountaingirl
"What lies behind us and what lies before us are tiny matters compared to what lies within us." ~ Ralph Waldo Emerson Posts: 138 | From West Virginia | Registered: Sep 2007
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Often the best combo tends to be Mepron/Zithromax/Bactrim or Malarone/zithromax/bactrim. That way you can cover all 3 at once, Babesia, Bartonella and lyme.
Posts: 25 | From Ohio | Registered: Jan 2008
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
-
If you decide to try allicin, start slow. My already high level of tinnitus is increased when I use allicin. However, I am the only person who has this reaction of many whom I have asked.
It could be my own personal reaction to the salycilates (sp?) in it - similar to aspirin in that regard. Or it could be how well I detox. You may be fine with it. If not, there's always another way.
-
[ 04. March 2008, 03:44 PM: Message edited by: Keebler ]
Posts: 48021 | From Tree House | Registered: Jul 2007
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Keebler
Honored Contributor (25K+ posts)
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Antimalarial activity of allicin, a biologically active compound from garlic cloves.
Coppi A, Cabinian M, Mirelman D, Sinnis P.
Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
The incidence of malaria is increasing, and there is an urgent need to identify new drug targets for both prophylaxis and chemotherapy.
Potential new drug targets include Plasmodium proteases that play critical roles in the parasite life cycle.
We have previously shown that the major surface protein of Plasmodium sporozoites, the circumsporozoite protein (CSP), is proteolytically processed by a parasite-derived cysteine protease, and this processing event is temporally associated with sporozoite invasion of host cells.
E-64, a cysteine protease inhibitor, inhibits CSP processing and prevents invasion of host cells in vitro and in vivo. Here we tested allicin, a cysteine protease inhibitor found in garlic extracts, for its ability to inhibit malaria infection.
At low concentrations, allicin was not toxic to either sporozoites or mammalian cells. At these concentrations, allicin inhibited CSP processing and prevented sporozoite invasion of host cells in vitro. In vivo, mice injected with allicin had decreased Plasmodium infections compared to controls.
When sporozoites were treated with allicin before injection into mice, malaria infection was completely prevented.
We also tested allicin on erythrocytic stages and found that a 4-day regimen of allicin administered either orally or intravenously significantly decreased parasitemias and increased the survival of infected mice by 10 days.
Together, these experiments demonstrate that the same cysteine protease inhibitor can target two different life cycle stages in the vertebrate host.
The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses.
Wang JX, Tang W, Zhou R, Wan J, Shi LP, Zhang Y, Yang YF, Li Y, Zuo JP.
1First Department of Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Background and purpose:Our previous study showed that SM905, a novel artemisinin derivative, exhibited potent immunosuppressive activity.
In this study, we evaluate preventive and therapeutic effect of SM905 on collagen-induced arthritis (CIA) in DBA/1 mice, and investigate its mechanisms both in inflammatory and autoimmune aspects of the disease.Experimental approach:CIA was induced by type II bovine collagen (CII) in DBA/1 mice.
SM905 was given orally either before (continuously 1 day before booster immunization) or after disease onset (continuously 14 days after booster immunization).
Disease incidence and severity were monitored, mRNA expression of proinflammatory mediators was determined by real-time PCR, purified T cell proliferation was assessed using [(3)H]-thymidine incorporated assay, and T helper (Th) 17/Th1/Th2 type cytokine production was examined by ELISA.
Key results:Oral treatment with SM905 delayed disease onset, reduced arthritis incidence and severity, and suppressed the enhanced expression of pro-inflammatory cytokines, chemokines and chemokine receptors in draining lymph nodes.
The CII-induced T cell proliferation and production of interleukin (IL)-17A by T cells were strikingly inhibited.
Correspondingly, the mRNA expression of IL-17A and RORgammat (a specific transcription factor for Th17) was also reduced. This effect was coupled with a striking reduction of IL-6 production, which has a critical role in Th17 development.
In established arthritis, SM905 profoundly inhibited disease progression, reduced IL-17A and RORgammat mRNA expression, and suppressed pro-inflammatory mediator expression in arthritic joints.
Conclusions and implications: SM905 had beneficial effects on CIA by suppressing inflammatory and pathogenic Th17 responses. ---------------------------
British Journal of Pharmacology advance online publication, 11 February 2008; doi:10.1038/bjp.2008.11.
PMID: 18264129 [PubMed - as supplied by publisher]
BIDENS:A Popular Remedy Escapes Notice of Western Practitioners
by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon
excerpts:
According to A New Compendium of Materia Medica (12), the Bidens species have the following properties (with B. pilosa listed as the main species and B. bipinnata and B. tripartita listed as having the same uses):
Good for diminishing inflammation to cure common cold, bronchitis, hepatitis, tonsillitis, pneumonia, appendicitis, and child-fever, eliminating sputum and relieving cough and asthma; also for curing snake bite or for external applications.
In Thousand Formulas and Thousand Herbs of Traditional Chinese Medicine (30), Bidens parviflora is mentioned twice (lujiaocao, cizhencao) within the section on herbs that clear heat and remove toxin. It is said to clear heat, detoxify, motivate blood circulation, and remove stasis.
Uses include fever, coughing, and sore throat in common cold; enteritis, diarrhea, and appendicitis; infantile fever with convulsions; trauma, frostbite, itching skin rash, carbuncles and furuncles, or snake bites (for the latter applications it can also be used topically, by pulverizing the herb).
. . .
The polyacetylenes from Bidens pilosa have also been shown to inhibit the malarial parasite Plasmodium falciparum, which may explain its use in the Amazon region to treat malaria (24).
. . .
(citation] 24. Brandao MG, et al.,
Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species correlated with the presence of acetylene and flavonoid compounds,
Journal of Ethnopharmacology 1997; 57(2): 131-138.
- full article, charts and illustration at link above.
SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
NutraMedix Enula MMS
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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savebabe
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posted
The new herb from nutramedix is coming out this month called enula. It is suppose to treat the chronic form of babs.
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posted
thank you all for the really great suggestions! i appreciate it!
Posts: 871 | From NJ | Registered: Mar 2007
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pamoisondelune
Frequent Contributor (1K+ posts)
Member # 11846
posted
As for enula, i think it's made from Elecampane, which is a terrifically strong grower in my garden, and i want to know how to process it. Why should i pay for something that grows in big abundance right in front of my eyes?
Posts: 1226 | From USA | Registered: May 2007
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pamoisondelune
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posted
For Keebler: Have you tried Allimax? It's 100% allicin, so you'd know if it was the salicylates or not.
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pamoisondelune
Frequent Contributor (1K+ posts)
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posted
I read that someone said that Neem is good against Babesia. I take about 3 Neem pills a day, 475 mg each. That's unchecked hearsay.
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sixgoofykids
Honored Contributor (10K+ posts)
Member # 11141
posted
Yes, Mepron is stringer than Malarone, that is true. I took Malarone after my night sweats were greatly diminished, and I take it with Lariam.
My LLMD also mentioned starting me on Enula along with the Malarone, Lariam, and Artemisia.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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posted
I think enula contains 2-3 other herbs in combination with Elecampane.
Has anyone noticed anything from this new enula liquid???
Posts: 25 | From Ohio | Registered: Jan 2008
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
It has been out for about a week so it is too early for anyone to have much to report on it. I am using it now.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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lymewreck36
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Member # 4395
posted
I'm book marking this page. It is really good.
I've had every babs treatment under the sun, I believe, for five years now.
The best treatment or combo of treatments I have ever had is 4 malerone pills a day.
Unfortunately, I had a drug reaction and had to stop taking this two weeks into it, but during those two weeks, I had the best remission of babs symptoms I ever had.
Cannot take Lariam after fluroquinoline floxing either.
Cleocin/quinine caused the ringing in the ears.
Malerone x four daily would be my best advice, if you can tolerate it.
mary
Posts: 1034 | From North Carolina | Registered: Aug 2003
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lymewreck36
Frequent Contributor (1K+ posts)
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posted
I'm book marking this page. It is really good.
I've had every babs treatment under the sun, I believe, for five years now.
The best treatment or combo of treatments I have ever had is 4 malerone pills a day.
Unfortunately, I had a drug reaction and had to stop taking this two weeks into it, but during those two weeks, I had the best remission of babs symptoms I ever had.
Cannot take Lariam after fluroquinoline floxing either.
Cleocin/quinine caused the ringing in the ears.
Malerone x four daily would be my best advice, if you can tolerate it.
mary
Posts: 1034 | From North Carolina | Registered: Aug 2003
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why can't you take lariam? I really don't know anything about lariam. can it cause floxing like cipro/levaquin? does lariam treat babesia too- is it combined with malarone?
i am leaning towards going off the mepron/zith because of the ear symptoms. i can't figure out if it is from the zith. or not, but i am afraid to keep taking it.
Posts: 871 | From NJ | Registered: Mar 2007
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lymewreck36
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posted
I'm not aware of fluroquinolones being used for treating babesia, BUT, if you have been floxed, you might have trouble taking Lariam afterwards.
don't know about combining malerone with Lariam.
But doc says the best babs treatment to day is 4 malerone pills a day, for a month, and then re-discuss symptoms. Treatment can be repeated.
If you can't take mepron/zith, try mepron/biaxin. It is more gentle.
Mary
Posts: 1034 | From North Carolina | Registered: Aug 2003
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luvs2ride
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Member # 8090
posted
My doctor has just completed giving me 4 weekly pushes of MTE9 specifically for babs. MTE 9 is an herbal formula. Dr says it grabs the parasite and pulls it from the body intact, therefore, no herx.
I truly did not herx. I wasn't having any obvious babs symptoms, so can't tell if it worked or not.
I was bloodtest positive for babs wa-1 and I assume Dr will test again at next appt. I'll let you know.
Luvs
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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Hubby is adding in Bidens pilosa tincture to his regimen. Buhner actually suggested it as a treatment for serratia.
But the good news is that since switching from minocycline to doxycycline hubby's fevers had gone away -- for about 10 days. But for some reason he ran a temp of 99.1 today. His WBC is still running slightly low and RBC is borderline but normal and not currently low. Platelets still seem to be struggling as well.
We still don't know if the doxy is working on babesia or rocky mountain spotted fever or anaplasma. His LLMD thinks the low WBC could be caused from bone marrow suppression from all the meds. I am not so sure as his WBC did not bounce back when he tried pulsing his meds for a week. That will probably remain one of those treatment mysteries -- but for now at least the doxy seems to be helping much more than the mino was.
For now hubby is on high dose malarone, high dose lariam, high dose artemisinin plus diflucan, doxycycline and levaquin.
We plan to switch the diflucan to flagyl in a couple of weeks. But first I added in 2 different herbal tinctures.
He started with the one Buhner suggested for general immune function -- a combo of isatis, licorice and lomatium. That one seems to make him ache all over and he is at half the suggested dose. He has taken all those herbs before but not in combination.
And he just started the bidens tincture today.
Hubby did last for 4 1/2 days this last time he tried pulsing his babesia meds. That beat the 1 1/2 days the first month he tried that. So maybe we are making progress. Dry heaves, increased nausea and vomiting and Parkinsonian tremors are the first symptoms to come back when he decreases his babesia meds. This time I only added back the malarone and kept him off the lariam, artemisinin and diflucan for an entire week.
Will be interesting to see how he responds to the bidens tincture over the next 2 weeks. And then he will try pulsing meds again.
I am not sure when I will make the switch from diflucan to flagyl -- will depend on how things go in the next week or so.
I still plan on ordering the sida acuta tincture as well from Woodland Essence in another 3 or 4 weeks when they should have it back in stock from Africa. That is what Buhner suggested hubby take for babesia.
I wish we would have had all 3 tinctures to try at the same time, but I do still have an 8 ounce bottle of cryptolepis tincture in my stash and may add that in again at some point. He took that for a month or so with the quinine, clindamycin and malarone combo. Have not tried it with the lariam, artemisinin and malarone combo.
It looks like I will have to continue experimenting with herbs as I am not sure how long hubby can remain on 6 malarone a day. He has already been on 3 - 6 malarone daily (depending on what else was going on med and symptom wise) at least 6 months. And we are pretty much running out of meds to try.
Bea Seibert
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