What do you think of minocycline 2 x 100g /Day and Plaqu�nil for troubles neurologics?
Many thanks.
L.
-------------------- L.French. Posts: 14 | From France. | Registered: May 2008
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Keebler
Honored Contributor (25K+ posts)
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Minocycline can have some wonderful attributes. However, it can also cause much disturbance with the inner/middle ear balance systems. Vertigo, nausea, tinnitus and increased hyperacusis (sound sensitivity) are common reactions with mino.
Some researchers say it is toxic to the vestibular system (that inner/middle ear system). Other researchers say nothing about that.
Some here do fine with it and it has helped. Others have had to discontinue due to the vestibular reactions.
It could be that a timed-released version would be better - more slowly metabolized - but just recently one batch was found to have problems.
Medicis and FDA notified healthcare professionals of the recall of lot numbers B080037 (Exp: 12/09) and B080038 (Exp: 12/09) of Solodyn Extended Release Tablets.
The product was recalled because one of the bottles contained Azasan (azathioprine tablets) 75mg instead of Solodyn 90mg Tablets. Azasan is an immunosuppressive agent used in transplant patients to prevent kidney rejection and for the treatment of rheumatoid arthritis.
Taking Azasan instead of Solodyn presents a health hazard and safety risk to patients.
Side effects associated with the use of Azasan, particularly in the elderly, include myelosuppression, infection, bleeding, chills, nausea, vomiting and diarrhea. Joint and muscle pain are also common side effects.
Additionally, unanticipated interactions with other drugs may also lead to serious adverse events.
The recall is limited to the lots referenced above. Healthcare professionals are urged to check their inventory and pull the referenced lot numbers from their stock and make arrangements with the manufacturer to return the product.
ANTIVERTIGINOUS ACTION OF VITAMIN B6 ON EXPERIMENTAL MINOCYCLINE-INDUCED VERTIGO IN MAN
[Article in German]
Claussen CF, Claussen E.
Neurootologie, Universit�ts-HNO-Klinik W�rzburg.
By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type.
It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways.
As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, (2)
2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously.
These trials were checked against an additional placebo or initial non drug investigation.
In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only.
However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as (the)
the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced remarkably reduced. . . .
The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests.
All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.
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Now, one question I would have is if the B6 negated a toxic reaction itself or simply short-circuited the reaction?
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