SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
Dr S suggests that a HIGH c4a with a low or normal C3a would lead you to look at MOLD or NASAL STAPH but not as much at Lyme disease. Have you considered those? Take a look at some info on www.biotoxin.info. There are several videos there that are quite good.
I just had a high 9000 c4a and normal c3a not too long ago and still trying to figure out next steps regarding that aspect of lab results.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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posted
I just got my test results from LabCorp and saw my integrative doc that ordered them.
C4a Level = 6887 with a range of 0-2830......this is HIGH
C3a Complement Protein = 706 with a range of 0-940.....this is normal
Leptin, Serum = 58.2 with a range of 1.1-27.5.....this is HIGH
MSH = less than 8 with a range of 0-40....LabCorp said they prefer to see your number around 30-35 so if it's less than that you probably have mold issues. Mine was pretty LOW
So with these results.....my integrative doc said that with the LD lowering my immune system and creating biotoxins it has left my body open for other invaders to come in and take over....ie, mold toxins, organisms, pollutants/chemicals...etc and that is what is causing all these biotoxins and my numbers to be so high.
I just started to take Cholestyramine to help bind and remove the toxins. Once my numbers go down for the C4a then I am going to take something to help control the Leptin which is high. With that number so high, I have gained so much weight over the past few years where I have literally no control over it.
Posts: 261 | From NW Pa ~ Crawford County | Registered: Oct 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Very generally speaking...
a reflects alpha (has to do with inflammaton)
b refects beta (we are not sure of the significance)
d is delta (this has to do with whether or not a cell lives or dies)
e is "gamma" (this is related to oxidiative stress/antioxidant protection)
We have gamma-delta T cells and alpha-beta T cells.
CD3/delta is the one impacted. That cell is supposed to send a signal to the CD4 T cells.
But the signal is disrupted.
(The gamma-delta T cells happen first. Then the alpha beta.)
"Gamma delta T cells ***assist*** alpha beta T cells in adoptive transfer of contact sensitivity."
Without a "conversation"/signal between CD3 cells and CD4 cells...this impacts the functions of CD4 cells:
CD4+ T cells bind epitopes that are part of class II histocompatibility molecules.
Only specialized antigen-presenting cells express class II molecules.
These include:
dendritic cells phagocytic cells like macrophages and B cells!
***Mature*** Th cells are believed to always express the surface protein CD4. T cells expressing CD4 are also known as CD4+ T cells.
The importance of helper T cells can be seen from HIV, a virus that infects cells that are CD4+ (including helper T cells).
Towards the end of an HIV infection the number of functional CD4+ T cells falls, which leads to the symptomatic stage of infection known as the acquired immune deficiency syndrome (AIDS).
There are also some rare disorders that result in the absence or dysfunction of CD4+ T cells.
and look at the picture on the right...the one below the primarily blue picture.
That picture shows the importance of the CD4 cells.
Also read activation of naive T cells.
Our immune defense cells come from bone marrow and hence are called B cells. Some of these B cells go off to the thymus gland to "mature" and become working T cells.
CD3d molecule, delta (CD3-TCR complex), also known as CD3D, is a human gene.
That gene maybe being turned off.
"Cd3a cells showed a 2-fold increase in NF- kappa B activation compared to VC cells, and, more importantly..."
"Immunodeficiency Is A Tough Nut to CRAC: The Importance of Calcium Flux in T Cell Activation"
Bb is impacting the Na-Ca pump. It needs Na, not Ca.
Now...keep your mammograms up to date! And guys...watch your PSA levels like a hawk.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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