IGG Igenex Negative CDC Negative **31 IND **39 IND **41 ++
Babesia microti suggests evidence of infection but I may be recovering... but I haven't treated it yet. I also have high ebv, cpn, and myco titers! My LLMD said these are some of the highest bands he has seen! Thanks! Can you freak me out more?????
Could the ebv cross-reacted on this 31 band? Does it look like this is still fairly early on based on my IGG results?
Thank you Mandy
Posts: 348 | From maryland | Registered: Jul 2008
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METALLlC BLUE
Frequent Contributor (1K+ posts)
Member # 6628
You have active infection with borrelia burgdorferi (Lyme Disease)
Band 30 unknown; probably an outer surface protein; common in European and one California strain - Has cross-reactivity with several different types of viruses
Band: 31 outer surface protein A (OspA), specific for Bb - Has cross-reactivity with several different types of viruses
Band: 34 outer surface protein B (Osp; specific for Bb)
Band: 39 is a major protein of Bb flagellin; specific for Bb
Band: 41 flagellin protein of all spirochetes; this is usually the first to appear after a spirochete infection but is NOT specific to Lyme (i.e, other spirochete diseases have flagellas - see link above "Western Blot Made Easy" for more info)
Band: 66 cross-reactive for all Borrelia, common in all bacteria
quote: IGG Igenex Negative CDC Negative **31 IND **39 IND **41 ++
You have the Chronic Form, based on the IgG's lacking.
All IND's are actually considered positive given the context of your other bands. It is a clear clinical positive test.
quote: Babesia microti suggests evidence of infection but I may be recovering... but I haven't treated it yet.
You have Babesia, it must be treated when it's found in conjunction with Lyme Disease. Treatment consists of Mepron, Zithromax, Artimisia (Or varients like Artimisinin, Lariam, and other options).
quote:I also have high ebv, cpn, and myco titers! My LLMD said these are some of the highest bands he has seen! Thanks! Can you freak me out more?????
Typical co-infections that accompany Lyme Disease, as a result of Lyme suppressing the immune system. The EBV, was reactivated, the the Chlamydia was a co-infection passed on by the tick.
All of these should be treated, though the EBV should actually decrease on it's own once the bacterial infections are resolved. An antiviral or Valcyte, Valtex, or Olive Leaf Extract or Grapefruit Seed Extract (I'd use the last two), will work well for that infection.
You can get those from Vitacost. Nutribiotics GSE, and Seagate for Olive Leaf Extract (Though you can use others from Vitacost too).
quote: Could the ebv cross-reacted on this 31 band? Does it look like this is still fairly early on based on my IGG results?
Thank you Mandy
This looks like a chronic infection based on the contributory infections, and the IGG results. Yes it's possible Band 31 could cross react, as it does with a number of viruses, but given your test result, it is surely the OspA of borrelia burgdorferi. Band 31 is "very specific" to that protein.
As far as Mycoplasma goes, that too was a co-infection passed on by the tick (Very probable), and must be treated. The Tetracycline family would treat the form of Mycoplasma that showed up on your test, as well as Rifampin.
-------------------- I am not a physician, so do your own research to confirm any ideas given and then speak with a health care provider you trust.
sixgoofykids
Honored Contributor (10K+ posts)
Member # 11141
posted
Metallic, what do you mean it's chronic based on the IgG lacking? I'm wondering because I'm chronic and had 8 IgG positive bands with only 41 + on IgM.
I agree that it's a positive test. Don't be too freaked about all the bands, it's a good thing, it means you still have an immune system. The worst test results are when someone has it, but they're immune system is so over-worked that the don't have any antibodies at all.
Time for treatment ... and don't assume that your babs will go away on its own, be thankful for a positive test! My babs test was negative, but I clearly have babs, so got a clinical diagnosis and have been treating for quite some time now.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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METALLlC BLUE
Frequent Contributor (1K+ posts)
Member # 6628
posted
quote: Metallic, what do you mean it's chronic based on the IgG lacking? I'm wondering because I'm chronic and had 8 IgG positive bands with only 41 + on IgM.
I suspect her immune system is compromised and unable to establish IgG antibodies to the infection but it's strong enough still to pump out IgM antibodies. Patients with co-infections sometimes see that, especially a patient with a babesia test indicating older infection. The fact that you had a wild IgG test means your immune system is simply functioning differently. If you had an IGG test prior to testing, it's probably a consequence of the immune system shutting down and not having the ability to fight the infection anymore. Or that the infection was attacked, and then it went into dormancy. It can also be a sign that treatment isn't working, or treatment hasn't begun.
There are a number of variables, but given the numbers, it's co-infections in her case I believe that are driving that pattern.
I'm aware you too have co-infections. The time-frames have something to do with it too, and treatment. Treatment can instigate production of IgM antibodies, as a result of contant die-off and antigens being released.
Most Chronic Lyme patients see active IgM with Igenex, and only a few IGG, like 31, 41, 39
quote: I agree that it's a positive test. Don't be too freaked about all the bands, it's a good thing, it means you still have an immune system. [Smile] The worst test results are when someone has it, but they're immune system is so over-worked that the don't have any antibodies at all.
Yeah, that's really the worst of the worst. I know a few people showing up with just +41 on the IGG or none at all, who clearly have the infection based on PCR, culture, stain, etc.
quote: Time for treatment ... and don't assume that your babs will go away on its own, be thankful for a positive test! My babs test was negative, but I clearly have babs, so got a clinical diagnosis and have been treating for quite some time now.
Absolute freakin-lutely. This is one of the biggest assumptions made by doctors uneducated in TBD, that the infection will some just resolve in cases. A complex multi-coinfected patient showing symptoms, isn't going to just get better. I've never seen it once.
I have seen multiply co-infected patients who never showed any symptoms at all, of any of the illnesses, and they never went on to get sick yet. That's a different story.
-------------------- I am not a physician, so do your own research to confirm any ideas given and then speak with a health care provider you trust.
posted
Isn't it true that bands 31 and 34 are indicators of infection over a year?
I also had 31 ++++, does that mean anything that it is 4+? I had really thought this was a recent infection until reading info on this forum.
I moved to a house in the country 3 years ago and have numerous tick bites since then.
I had 7 positive and 1 IND on my IgM and 3 positive and 2 IND on IgG. I guess it is probably likely it is longer than a year.
My LLMD told me that he loves to see a good immune response(in my western blot) like that and told me that helps make my prognosis better...so don't take the positive bands as a bad thing at all.
METALLlC BLUE
Frequent Contributor (1K+ posts)
Member # 6628
posted
quote: Isn't it true that bands 31 and 34 are indicators of infection over a year?
I know nothing about this in regards to just the bands alone for the IgM or IgG. Time frame's seem to be highly skewed with Lyme Disease Western Blots. I've seen all IGG with a recent infection of only a few months, and all IgM in a case that went undiagnosed for 15 years.
quote: I also had 31 ++++, does that mean anything that it is 4+? I had really thought this was a recent infection until reading info on this forum.
The only certainty in that 31, means it's extremely prevalent -- the antibodies -- to that particular OspA protein, especially if your viral testing has come back entirely negative.
quote: I moved to a house in the country 3 years ago and have numerous tick bites since then.
I had 7 positive and 1 IND on my IgM and 3 positive and 2 IND on IgG. I guess it is probably likely it is longer than a year.
That's a very common test result for a Chronic Lyme Patient.
quote: My LLMD told me that he loves to see a good immune response(in my western blot) like that and told me that helps make my prognosis better...so don't take the positive bands as a bad thing at all.
He's right. A stronger immune response, the better chance someone has of recovery. This also explains why the NIH studies on Lyme Disease have shown that those with the bullseye rash and a CDC positive test through a commerical lab, often respond extremely well to only a few weeks of antibiotics.
Meanwhile, those who fail conventional testing, as well as Igenex Testing (Seronegativity), are at a great risk of significantly long term recovery and treatment.
Who are you all seeing for LLMD's, and what do you think of him/her? PM me. I'm continuing to track patient reports of the doctors.
-------------------- I am not a physician, so do your own research to confirm any ideas given and then speak with a health care provider you trust.
posted
Great! So I'm not a lost cause after all! Thank you for your advice I really needed a little reassurance.
I was wondering why he said I'd be well within 6 months...maybe he's telling me the truth OR maybe he doesn't want me to lose hope.
I'm on Biaxin for lyme and soon adding back in levaquin for all the co-infections.
Thanks again Mandy
Posts: 348 | From maryland | Registered: Jul 2008
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gemofnj
Frequent Contributor (1K+ posts)
Member # 15551
posted
This thread was really informative for me.
My results were: IGG Negative with **41 IND
IGM Negative with **31 IND **39 IND **41 ++
Does this mean I have chronic lyme because of 31 & 39 being IND-weak present?
And the Igenex interpretation states that results that have IND should be re-tested in 4-6 weeks.
Does anyone else get retested and if so, why?
Posts: 1127 | From atlantic city, nj | Registered: May 2008
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Gem, even as a negative blot your results are compelling because you are showing lyme specific bands at 31 and 39.
It may be wise to test for co-infections but retesting for lyme may not be that fruitful if you're already manifesting clinical signs of the disease.
But you can always try a course of antibiotics before redoing the lyme blots (as long as you stop the meds for a sufficient enough time prior to the retest). This may push you to positive...
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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gemofnj
Frequent Contributor (1K+ posts)
Member # 15551
posted
Thanks Lyme.
I have been tested for all co's and all are negative. LLMD is only treating me for Lyme.
I was dignosed in May and have been on antibiotic treatment for approx. 3 months.
Fortunately I have had significant response, but not totally better -- maybe 90%.
Thats why I was surprised when band 31 could indicate chronic lyme.
After researching this website, its seems like a rather speedy improvement for chronic lyme. Of course I am not totally better, and wonder if I will hang in this limbo for months.
CD57 was a 45. So, I am assuming my LLMD will not let me stop ABX to retest just yet.
Posts: 1127 | From atlantic city, nj | Registered: May 2008
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posted
And the Igenex interpretation states that results that have IND should be re-tested in 4-6 weeks.
Does anyone else get retested and if so, why? [/QB][/QUOTE]
My LLMD retested every 4-6 weeks with Elisa or other labs to check my numbers to see if I was getting better. Also, since he kept testing me, after a years and a half, Babesia came up positive which was always negative. Now that it was positive he has been treating it and now realize that's why I wasn't getting better. My doctor knew there was a piece of the puzzle missing. Now treating Babesia I feel so much better. He wrote me today and told me my last test came back negative. I hope it a true negative and not a false negative. But I feel so much better!!!!
Posts: 19 | From New Jersey | Registered: Dec 2007
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posted
Your results can at best tell you have been exposed to Lyme.
Your results are not that significant (so I would not worry) and many people test with more positive bands, like myself who tested positive IGG for all 10 bands.
You need to focus less on test results and more on TREATEMET & symptoms- move forward. In the end lyme is a CLINICAL DX, and not just a (+ -) blood test.
You should also be tested for common co-infections.
Take care
-------------------- Positive 10 bands WB IGG & IGM + Babesia + Bartonolla and NOW RMSF 3/5/09 all at Quest
posted
More- I would be more conscrned about your treatment protocal.
Quote ________________________________________________ I'm on Biaxin for lyme and soon adding back in levaquin for all the co-infections. ________________________________________________
Bixan is normally prescribed with Plaqunal to go after the cycstic form of lyme as well (Many LLMD's).
Levaquin is normally used to treat Bartonolla-- not all co-infections.
I would read the ILADS.org treatment guidelines
-------------------- Positive 10 bands WB IGG & IGM + Babesia + Bartonolla and NOW RMSF 3/5/09 all at Quest
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The worst test results are when someone has it, but they're immune system is so over-worked that the don't have any antibodies at all.
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