djf2005
Frequent Contributor (1K+ posts)
Member # 11449
posted
hey all-
theres so much info on here about rifampin and as clarissa posted, a lot of it contradicts one another.
ive been on it for a little over a week now @ 300mg day, had to take one day off, and am now wondering if i should bump my dose to the full 600/day because im not having as severe a herx as i did when i first started it.
my gut tells me to wait a few more days and then to bump it.
also, it is paired w/ bicillin as i could not tolerate mino or zith before i started it.
i am also on zhang, plaq, and a bunch of other stuff.
is this acceptable? (like anyone is going to giveme the same answer)
i believe my dr knows what hes doing so i think itll be fine, i just dont want rifampin to become ineffective because its one of the last drugs (maybe 4 or 5 left) i have to try to smack down blo.
thanks for your opinions.
derek
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
Rianna
Frequent Contributor (1K+ posts)
Member # 11038
posted
I am on IV Rifampin paired with IV Rocephin, I started 2gms Rocephin daily and then added Rifampin at 150mg/day and built gradullly to 600mg daily
I have my LFT's checked ever other week
You need to keep an eye on your SHBG (sex Hormone Binding Globulin) with Rifampin so my LLMD did a pre and post meds reading as in some patients it will change this dramatically
My LLMD insists it is taken with another AB to stop drug resistance
djf2005
Frequent Contributor (1K+ posts)
Member # 11449
posted
what does it do to your sex hormone globulin?
never heard that, but unfortunately my libido is already reduced to almost nothing so i dont think its a concern, or is it?
thanks for info rianna, i am glad someone else also had to ramp up. i started on 300mg day/am and i think after 2 weeks i will be able to bump to 600 daily.
cheers
derek
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
posted
If a person is getting their proper blood work every month, there shouldn't be a risk of Rifampin doing any damage to the liver. If the serum shows exceedingly high levels at the end of the month, the doc merely backs you down or stops, until the liver ranges are back in check.
The only way I could see it "damaging" your liver, is if your doctor ignored your blood tests and kept you on it, or if you weren't having your liver enzyme levels monitored regularly.
-------------------- Craig Posts: 207 | From Tallahassee, Florida | Registered: Nov 2007
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Rianna
Frequent Contributor (1K+ posts)
Member # 11038
posted
[QUOTE]Originally posted by djf2005: [QB] what does it do to your sex hormone globulin?
Rifampin can esculate the SHBG, SHBG binds to sex hormones mainly estrogen and testosterone and if it rises it will make you feel very tired. In women it will make you feel like you are menopausal - elevated SHBG values can cause symptoms of osteoporosis, osteopenia, muscle weakness, poor memory, depression, low ibido etc.
My LLMD did a presentation a while back and stated the SHBG test and LFT must be monitored whilst on Rifampin.
merrygirl
Frequent Contributor (1K+ posts)
Member # 12041
posted
My ILADS LLMD said that you should not miss any doses of Rifampin or you could hae an allergic reaction where something happens to your platelets. He said it was very serious. I didnt get into more detail than that- sorry
Posts: 3905 | From USA | Registered: May 2007
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djf2005
Frequent Contributor (1K+ posts)
Member # 11449
posted
lets say he does monitor shbg upon my request, what does one do if its out of range?
i do feel tired since starting it, but that is most likely a herx
as far as the lft's and your liver dying, i dont think so..
i get a cbc and lft every 4 weeks, its never been off and if it is im sure ill be the first to ehar about it.
but i am interested in hearing what u would do in the event the shbg is off.
thanks
cheers
derek
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
posted
Does anyone have any more info about SHBG and Rifampin? How common are problems with this?
Posts: 43 | From RI | Registered: Apr 2011
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
Derek, Your mailbox is full
hey guys, Why is Rifampin recommended on empty stomach?
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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