LymeNet Flash: High Vitamin D 1,25 Dihydroxy????

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»	LymeNet Flash » Questions and Discussion » Medical Questions » High Vitamin D 1,25 Dihydroxy????

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Author

Topic: High Vitamin D 1,25 Dihydroxy????

tickbattler
Unregistered

posted

Hi all

My Vit D 25-hydroxy is normal at 37.6, however my other Vit D 1,25 dihydroxy test was too high at 66.3.

My LLMD said this was an inflammatory response, meaning I have some type of infection (e.g., lyme, coinfections, etc...).

Does anyone have any additional info about this? Do you have this too? What did your LLMD say about it?

Thanks,

tickbattler

IP: Logged |

DoctorLuddite
LymeNet Contributor
Member # 13853

posted

Your LLMD needs to pursue further testing, to be on the safe side. If your 25D is at 37.5 after being very low for a long time and you are supplementing or spending lots of time in the sun, your 1,25 will climb at first then return to normal, so at the very least the test should be repeated in 6-12 weeks. In addition, high levels of parathyroid hormone can upregulate the enzyme in the kidney that converts 25 to 1,25, and parathyroid hormone levels can be tested for. Inflammation can drive 1,25 up, because macrophages also make the enzyme that converts 25 to 1,25, but it should not simply be assumed. Granulomatous disease is known for this. A serum calcium can also be an indicator of parathyroid dysfunction, if the ca level is normal, this is unlikely.

Posts: 442 | From Biddeford, ME | Registered: Nov 2007 | IP: Logged |

antsettler
LymeNet Contributor
Member # 7236

posted

my results are:
25-OHvitD3 ng/ml [12-54] 25 18.7 7.8
1,25-OH2vitD3 pg/ml [16-56] 40 39 50
in my case symptoms and the levels are parallel

Posts: 108 | From spain eur | Registered: Apr 2005 | IP: Logged |

Cass A
Frequent Contributor (1K+ posts)
Member # 11134

posted

I have been testing for 25D and 1,25D for some while, due to interest in the Marshall Protocol, which I've not started.

I've cut back on foods with Vit. D and lessened sun exposure, but not to the level required on the MP.

Here's my results:

Date 25-D 1,25-D

Oct 2006 33 46 usual diet and sun
Nov 2006 19 --
Feb 2007 14 29
June 2007 16 33
Dec 2007 8 72
June 2008 9 38

Just had a DXA scan, and I do have serious bone demineralization, which is consistant with high 1,25 D levels.

Cass A

Posts: 1245 | From Thousand Oaks, CA | Registered: Feb 2007 | IP: Logged |

Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359

posted

Dr.L-

Just curious...what can be done if there is in fact parathyroid dysfunction? Is that adjusted through tweaking thyroid hormones or another set of meds?

--------------------
"Whatever can go wrong will go wrong."

Posts: 2062 | From CT | Registered: Jul 2008 | IP: Logged |

SForsgren
Frequent Contributor (1K+ posts)
Member # 7686

posted

Hmm - but also consistent with low vitamin D. So how do you know the bone loss is related to high 1,25 and not low D overall? Could your restricting Vitamin D be worse for your BMD?

--------------------
Be well,
Scott

Posts: 4617 | From San Jose, CA | Registered: Jul 2005 | IP: Logged |

UnexpectedIlls
LymeNet Contributor
Member # 15144

posted

Weird I just had a 1,25D of 19 and a 25D of 15

Very low on both... [Embarrassed]

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"You'll be surprised to know how far you can go from the point you thought it was the end"

Posts: 946 | From Massachusetts | Registered: Apr 2008 | IP: Logged |

antsettler
LymeNet Contributor
Member # 7236

posted

i also had interest in marshall protocoll, but i have ortostatic intolerance, imposible touch the arterial pressure; i watch the vitD if change with treatments, when i'll feel better i hope see better values, as real pointers... support

Posts: 108 | From spain eur | Registered: Apr 2005 | IP: Logged |

DoctorLuddite
LymeNet Contributor
Member # 13853

posted

A parathyroid adenoma, if it can be reliably demonstrated, is removed surgically, just like other adenomas. Sforsgren is right, if D levels are low and have been for a long time, the enzymes that convert 25 into 1,25 may up regulated, and as a result 25 will convert immediately into 1,25. Such an individual will be prone to calcium loss and resulting insufficiency, and since bone is the storage depot for calcium, lowere bone density will be the result. No amount of fosamax will reverse this process, only careful repletion of vitamin D with calcium suplements and frequent monitoring of 25, 1,25, and parathyroid hormone.

Posts: 442 | From Biddeford, ME | Registered: Nov 2007 | IP: Logged |

Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359

posted

I gather from Dr. L and the recent D studies that it's better to add D in the right form than withdrawal it altogether....

--------------------
"Whatever can go wrong will go wrong."

Posts: 2062 | From CT | Registered: Jul 2008 | IP: Logged |

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