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» LymeNet Flash » Questions and Discussion » Medical Questions » Does Tindamax work on Babesia ?

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Author Topic: Does Tindamax work on Babesia ?
gvm76
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Member # 16380

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Hi All,

I have been on treatment for Lyme/Babesia/Erlichiosis I got a slight herx yesterday.

From today's LLMD visit, she changed the medication to Omnicef + Tindamax combination for
next 3 weeks.

I know Omnicef is ABX and Tindamax work on
Parasites like Babesia?

Appreciate any input.

Following is my treatment sofar and I think I have been making good progress since medication started in June.

Doxycycline - 6 weeks
Mepron + Zithromax - 2 weeks
Mepron + Biaxin - 5 weeks
Starting Omnicef + Tindamax - for next 3 weeks.


Thx
gvm

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Keebler
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I'm no expert on the pharmaceuticals, but usually tindamax is usually used as flagyl, for the cyst form of lyme. Tindamax is sometimes more easily tolerated than metrodiaz./flagyl.


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Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
sixgoofykids
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Tindamax is for the cyst form of Lyme.

I don't understand stopping babesia treatment if you're not babs symptom-free.

--------------------
sixgoofykids.blogspot.com

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Hoosiers51
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I second what "six" said.....you may want to phone your doc and get back on the Mepron......from what I have gathered, if you are really serious about getting rid of it, you will need 5 months of babesia treatment, uninterrupted.

I am just giving you that heads-up, because I thought I was finished treating babesia back in the day when I stopped at 3 months on Mepron and Zithromax, but now 2 years later I am back on it again.....this time planning on going 5 or 6 months.

It is hard to know for me what "symptom free" is because I have severe fatigue as a side effect of Mepron, but I'll do my best to figure it out.

It is a real bummer, but worth it I believe!

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Keebler
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Tindamax is a brand name for the drug Tinidazole. Their web site reads like an add in Seventeen magazine. Very little real medical information and lots of glossy, happy photos.


www.tindamax.com

Tindamax� is the only medication approved as both an antibacterial agent for BV (bacterial vaginosis) and antiprotozoal treatment for TV (trichomoniasis).


also used for: Giardia, Amebiasis


============


www.ncbi.nlm.nih.gov/sites/entrez

PubMed Search:

Tinidazole - 1073 abstracts

Tinidazole, protozoa - 171 abstracts


tinidazole, borrelia - 2 abstracts


Tinidazole, babesia - none

. . . and, as malaria is similar to babsesia:


Tinidazole, malaria - one (says Artemisinin derivatives are better)


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Keebler
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About Tinidazole and cyst form of borrelia burgdorferi (the real name for lyme).

-------------------

http://tinyurl.com/4dmjhu

Int Microbiol. 2004 Jun;7(2):139-42.


An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole.

Brorson O, Brorson SH.

Department of Microbiology, Vestfold Sentralsykehus, T�nsberg, Norway.


The susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole (TZ) was examined.


The minimal bactericidal concentration (MBC) of TZ against the mobile spirochetes was >128 microg/ml at 37 degrees C in micro-oxic atmosphere when incubated for 14 days.


TZ significantly reduced the conversion of mobile spirochetes to cystic forms during incubation.


The MBC for older (10-months-old) cysts at 37 degrees C in a micro-oxic atmosphere was >0.5 microg/ml, but >0.125 microg/ml for young (1-day-old) cysts.


Acridine orange staining, dark-field microscopy and transmission electron microscopy revealed that, when the concentration of TZ was > or = MBC, (the)

the contents of the cysts were partly degraded, core structures did not develop inside the young cysts, and the amount of RNA in these cysts decreased significantly.


When cysts were exposed to TZ, both the spirochetal structures and core structures inside the cysts dissolved, and the production of blebs was significantly reduced.


These observations may be valuable in the treatment of resistant infections caused by B. burgdorferi, (and)


and suggest that a combination of TZ and a macrolide antibiotic could eradicate both cystic and mobile forms of B. burgdorferi.


PMID: 15248163


============


This book, by an ILADS member LLMD, has a lot of good information:


http://tinyurl.com/6lq3pb (through Amazon)

THE LYME DISEASE SOLUTION

- by Kenneth B. Singleton , MD; James A. Duke. Ph.D. (Foreword)

You can read more about it and see customer reviews.


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backintherain
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gvm76,

Can you share what doses of omnicef and tindamax you are on? Are you pulsing or taking the same dose every day?

I have been lead to believe that you must take tindamax (or flagyl) for a minimum of 6 weeks to sufficiently kill cysts.

6 weeks sounds like such a long time!

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Keebler
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www.ilads.org

ILADS Treatment Guidelines

will have details.


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Wimenin
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Tindamax is for cysts. Im on it and even asked my LLMD about switching from it because of the high cost of copay on it..

He said that Tindamax is the best at busting open the cyst form.

Im currently taking 1500mg Tindamax, 1200mg Omnicef, and 1500mg Biaxin a day...along with a host of supplements (coq10, triple omega, oregano oil, Bs, Ds, digestive enzymes and floragen3 biotic)...

So yes, Tindamax...its suppose to be very good for the cyst form, but you also need other abx and supplements as well..

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