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» LymeNet Flash » Questions and Discussion » Medical Questions » Frontline Plus is NOT really AN INSECTICIDE

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Author Topic: Frontline Plus is NOT really AN INSECTICIDE
jamescase20
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Frontline plus is part of a whole entirely new generation of "insecticides". Both of frontline plus'es actives are "classified as insecticides" due to there ACTION on insects, BUT, that classification is largely due to the gov't requirements of insecticide laws (codes).

Fipronil uses a new way to kill...its an gaba interuptor...it dont kill directly...it causes gaba in insects (or viturally anything without a backbone) to screw up so much so that the being dies from the gaba interuption.

Methoprene..the other active, is also not an insecticide in the classical sense. Methoprene does also not kill bugs directly, in fact, methoprene does not kill bugs at all. What its mode of action is is to mimic a "juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator".

And so you see...the terrifiable word insecticide is not really what frontline plus is.

Fipronil is more like a drug...in fact more like a zole drug...in reality its formal chemical name ends in .zole. Flagyl is a zole, diflucan is a .zole. Athlete foot products are largely .zole drugs.

So, while offically its classed as an insecticide...(since it kills insects its required by law) its mode of action is entirely different then prior generations of "insecticides".

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Dawnee
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*bump*

interesting [Smile]

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djf2005
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sweet ill be sure to order 2x as much as i already ordered now that its as safe as azoles.

what a relief!

[lol] [bonk] [Big Grin]

--------------------
"Experience is not what happens to you; it is what you do with what happens to you."

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Posts: 2269 | From Lansdowne, Pa | Registered: Mar 2007  |  IP: Logged | Report this post to a Moderator
stormton
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Wow. That makes Bactrim the same as Fipronil and flagyl. Since bactrim contains Sulfamethoxazole. It has the zole in it. LOL. not.

Obviously you have not seen what a human goes through in fipronil poisoning. Central nervous system damage, seizures etc. You should keep the labratory adventures to yourself until you can prove what you are talking about is safe and effective. Your stories are a perfect example of how desperate some of us can become. I would love to take all your posts and put them in a book. Then mail them to the IDSA and show them what they have created and how desperate we really are.

And yes, if you spray some of this poison on your blood smears. I would not be surprised if all of the organisms die. But you are not seeing spirochetes or blo organisms with your mickey mouse scope and non patented dyes. If that was possible, all of the labs would be able to easily view these sub micron size creatures. Just for your information. Spirochetes do not hang out in the blood long, the have an affinity for nervous tissue and do not stand much of a chance against our immune systems out in the open.

You are not even a year into treatment and you need to concentrate on what works. You switched your antibiotic and antimalarial combos weekly due to complete ocd impatience. I'm not surprised you haven't made much progress. I think that the lariam has gotten to you. I wish you luck but you should stop putting frontline on your body or whatever you are doing with it. Our skin is far different than dogs and cats. Plus they put frontline on their fur.

Go take 2 Ivermectin and call me in the morning. [Razz]

Don't be offended, we are all entitled to our own opinion.

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jamescase20
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yeah it would take about 159 doses of frontline to come close to killing a human...boy...I am so scared that I took 1 dose of frontline. So scared.
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jamescase20
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your opinion is alarmist in nature.

Fipronil and methoprene both act in channels that backboned animals do not posses.

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Keebler
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-

James,

It's a killer to mice - and they have backbones. I don't know where it says this is okay - other than on sites that sell it.


It is really dangerous to suggest that this is safe. I know you say you have a disclaimer but some think this stuff is okay. It is toxic. TOXIC.


stormton really does say it well. This is serious stuff. Each week you bounce from one thing to another and new comers can think they should follow you.


Treatment takes time. Please choose a path that has some history to it. Many have gotten better. You do not have to endanger your life with these experiments.

I know we have much to learn and a long way to go in this area. Still, please find out who got well and ask what they did to get there. There are a few different avenues you can take but I hope you can find a tried and true method. Others have.


Success stories are posted in the general support forum.

If there is a university near you, your inquisitive mind might enjoy taking some biochemistry classes. You clearly have a desire to learn. It'd be great if you could find some professor who would like to mentor.

===============

Google has over 120 results for "fipronil poisoning"


PubMed has 19 abstracts relating to "fipronil poisoning" -- www.ncbi.nlm.nih.gov/sites/entrez


It's not pretty. From one of those:

. . .

All the mice acutely poisoned by fipronil at varied doses showed some exciting symptoms in the central nervous system (CNS), including convulsion.

Nuclear membrane space slightly expanded, neuroglia cells vacuolized and nerve fiber demyelinated under electron microscopy.

The number and area of cells positive in Glu in the cerebral cortex of mice acutely poisoned by fipronil increased significantly, . . . .


=============

There are no quick fixes but there are other ways to get better - safer ways.

Take care.


-

Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
jamescase20
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OMG!

did you know that the rat that was killed by fipronil took OVER 2000mg for each kg of weight?

GEEZ.
Your another alarmist.

Fipronil poisoning would take roughly like the rat, 2000mg per kg (approx 2 lbs)

Frontline has 9.8 percent fipronil in it...hard to say exactly how many "grams" are in a dose of frontline but I would guesstimate LESS then 1 gram.
So, using the rat (backboned mammal) lethal dose I would suggest fipronil poisoning in humans would take 80 doses at a minimum to poision a human. Thats 79 doses HIGHER then the required dose to kill insects (fleas..etc.) And so frontline's fipronil would be considered a drug with a very high margin of safety. 1 dose kills fleas for 30 days on a pet...79 doses might kill or poison a human.

Did you forget that the FDA or USDA or both, IDK which controls which drug, but they feed fipronil in viturally ALL cattle to prevent fruitflies in there stools (which spread diseases). Mushroom crops are commonly sprayed with fipronil AND methoprene in this country. Methoprene is added to the public drinking water in india to retard maleria.

And so you alarmists, be alarmists all you want...but you skew the facts..distort the reality so much so that nothing can get done.

And its interesting to notice you list fipronil poisoning...but you dont include the amount the humans consumed. Since fipronil was invented, there to date has only been 1 death from human fipronil poisoning. 1 death! Boy at 2000mg fipronil per kg that must of been alot of fipronil.

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treepatrol
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Case 1 - a 17-year-old man presented 18hrs after ingesting an unknown amount of mixed pesticides: Regent 50 SC�, dimethoate, fenthion and imidacloprid. He had previously received forced mechanical emesis with salty water (but not ipecac) at a peripheral hospital but no other therapy. He had not vomited spontaneously after the ingestion, and had no symptoms. His Glasgow Coma Score (GCS) was 15/15, pulse 74bpm, BP 110/70. Examination was unremarkable. He was not recruited to the RCT and blood samples were not taken for analysis. He had an uneventful clinical course, receiving no charcoal or other intervention besides IV fluids on the first hospital day. He was discharged well on the fourth hospital day.
Case 2 - a 31 year-old man was admitted 1hr after drinking 100ml of Regent 50 SC�. He was drowsy on admission, sweating profusely, and vomiting. His GCS was 12/15 (voice 2/5), pulse 76bpm, BP 110/80mmHg, pupils 4mm and chest clear. He was given 500ml of 0.9% N saline quickly by IV infusion and 10mg metoclopramide IV. He continued to retch repeatedly and was given a further 10mg of metoclopramide after 10 mins. Two mins later, he had a generalized tonic-clonic seizure lasting around one minute. He stopped fitting spontaneously and was given diazepam 10mg IV. He received MDAC and, during insertion of a nasogastric (NG) tube, another 5mg of diazepam IV.

Over the next few hours, he became more alert but also agitated for which he was given a further 10mg of diazepam IV, 4hrs after the second dose. His agitation settled and he then slept. He was asymptomatic within 12h of the ingestion and was discharged well on the fourth hospital day.

Case 3 - a 44-year-old man presented 3hrs after drinking 50mls of Regent 50 SC� together with alcohol. He had previously been admitted to a local hospital where he had received forced emesis. On admission, he had no symptoms, GCS was 15/15, pulse 100bpm, and BP 170/90. He was not sweating, pupils 4mm, and examination otherwise unremarkable. He had no history of hypertension and was receiving no medication; his blood pressure dropped to 140/80 within the next hour. He was given SDAC, remained well and was discharged after 48h; follow up was arranged to check his blood pressure in one month.

Case 4 - a 31-year-old male presented 5hrs after drinking an unknown amount of Regent 50 SC� with alcohol. He had previously been admitted to a local hospital where he had received forced emesis. He had also twice had generalized tonic-clonic seizures in that hospital for which he had received diazepam. On admission, he was vomiting, GCS was 15/15, pulse 88bpm, and BP 120/80. He received no charcoal but did receive two doses of diazepam 5mg PO and metoclopramide 10mg IV during his first day in the hospital. He developed an aphthous ulcer on his tongue on day two; otherwise, he was asymptomatic throughout his stay. He was discharged well on his fourth hospital day.

Case 5 - a 21-year-old male was admitted 3hrs after ingesting an unknown amount of Regent 50 SC�, together with an unknown organophosphorus pesticide and alcohol. Relatives had induced emesis at home but he received no other pre-hospital treatment. He was well and asymptomatic on admission, with GCS 15/15, pulse 70bpm, BP 130/80 and clear lungs. He received MDAC, amoxicillin 500mg q8h for three days for aspiration and pralidoxime 1g q6h for 36hrs, but did not require atropine. He remained asymptomatic and was discharged after three days.

Case 6 - a 34 -year old woman was admitted 3hrs after ingesting an unknown amount of Regent 50 SC�. She had received forced emesis at a peripheral hospital. On admission she had nausea, vomiting, and heart burn; her GCS was 15/15, pulse 76bpm, BP 130/80 and she had clear lungs. She did not receive charcoal, remained well throughout her stay and was discharged on her second hospital day.

Case 7 - a 30-year old man was admitted 1hr after ingesting 50ml of Regent 50 SC� with alcohol. He was asymptomatic on admission, GCS 15/15, pulse 88bpm and BP 120/80. He received MDAC and 50% dextrose on admission, but no other therapy, and was discharged well on his third hospital day

A 23-year-old man was admitted 3hrs after ingesting 100ml of Regent 50 SC�. The pesticide's identity was indicated by the bottle label, which was brought with him and stored in the notes. He was unconscious on admission and admitted directly to the intensive care unit (ICU) where he was intubated. He had generalized tonic-clonic fits several times during his time in ICU, despite therapy with benzodiazepines and phenobarbital. He developed pneumonia and died in ICU without regaining consciousness 17 days after admission.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1351141

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

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Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
treepatrol
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Keep in mind those are super doses Above and ingested!

I think though taken enough close together could bind the sites up and produce maybe the same effects?

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

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Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
Keebler
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-

From the study mentioned up a few posts - the mice actually had various doses. The exact amounts are not available in the abstract but, clearly, the experiment designers used a range and, at all levels, there were problems.


" . . .All the mice acutely poisoned by fipronil at varied doses showed some exciting symptoms in the central nervous system (CNS), including convulsion. . . ."


-

Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
djf2005
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and the sun does not produce uv rays....

[Wink]

or does it?

[bonk] [Roll Eyes] [Big Grin]

--------------------
"Experience is not what happens to you; it is what you do with what happens to you."

[email protected]

Posts: 2269 | From Lansdowne, Pa | Registered: Mar 2007  |  IP: Logged | Report this post to a Moderator
DebAz
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Wow James I think this is so interesting and i admire all you work.
Gael asked about garlic as well as salt. There has been a lot of talk lately about salt and some say it kills these bugs and parasites etc on contact and too if we put a lot of salt in or systems it could or would make an environment where they could not live.

Whats your view.

On the Front line.. How long have you been doing this and how exactly are you doing it and with what else etc/?

Would you mind sharing your personal protocl at this point in detail for us to learn from or ponder on or try.'


I admire you for continuing on and I understand it might be easier to talk to someone else who has a scope etc.

Have you shared any of this with any other doctors who are doing research etc. I see a doc who has his own lab and has been doing research for a long time on this issue.

Maybe there can be some sort of communication??

D

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