Topic: In vitro activity of tigecycline against Bb
TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
1: J Antimicrob Chemother. 2009 Jan 31
In vitro activity of tigecycline against multiple strains of Borrelia burgdorferi.
Yang X, Nguyen A, Qiu D, Luft BJ. Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Objectives To compare the antimicrobial activity of tigecycline and doxycycline against multiple isolates of Borrelia burgdorferi.
Methods In vitro antimicrobial assays were carried out using a microdilution assay. The time needed to inhibit, immobilize and kill the B31 strain of B. burgdorferi was determined.
The MIC, MBC and concentration needed to immobilize the organism were determined for each antimicrobial for various strains of B. burgdorferi.
Results Tigecycline inhibited the growth of and killed the organism more rapidly than doxycycline. Tigecycline was able to kill B. burgdorferi within 24 h at clinically achievable concentrations (<1 mg/L).
In contrast, doxycycline was bacteriostatic and required 48-72 h to achieve its maximal inhibitory effect. The anti-Borrelia activity of the antibiotics was tested against 20 different isolates from three species.
Tigecycline was 16- to 1000-fold more active than doxycycline at immobilizing Borrelia for the 20 isolates tested.
Conclusions We demonstrate that the in vitro activity of tigecycline against B. burgdorferi is superior to that of doxycycline. Tigecycline acted more rapidly and was bactericidal, whereas doxycycline was bacteriostatic and required a more prolonged co-incubation to achieve its maximal inhibitory effect.
PMID: 19182236 [PubMed - as supplied by publisher]
Posts: 6286 | From Oregon | Registered: Jan 2006
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lpkayak
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yes-just read about this in cure unknown...there are a couple other positive things on the horizon too
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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charlie
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I've been hollering about the doxy thing for years...it's bacteriostatic...In the case of many of us it's about as effective an antimicrobial as aspirin.
Maybe tigecycline will be the panacea.
Charlie
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CD57
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The question is, can anyone tolerate it? Apparently it makes you feel really sick!
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OptiMisTick
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Charlie, supposedly the crossover point for Doxycycline is 400 mg. at which point it becomes bacteriacidal (kills organisms) and not bacteriostatic (inhibits reproduction [ha-ha] but does not kill organisms). I can not reference specific drug studies on this, only the presentations of other speakers at Lyme conferences, to the best of my recollection.
Perhaps anyone who has experienced this dosage could respond. I do not know anyone and am interested as you may be.
Meanwhile, big hopes for Tigecycline!
Posts: 1338 | From Above the Clouds | Registered: Nov 2000
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kgg
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Exactly, CD57! I haven't heard of anyone that can stomach it, (literally) for very long.
If someone has found a med or supplement that helps to keep the stomach pain at bay, I would love to hear about it. So far I have heard that Zofran, Zantac and Phenergan do not help.
Best, Karen
Posts: 1686 | From Maine | Registered: Jun 2004
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I did 10 doses of tigecycline-it was fine at 1X's day, but when I went to 2 doses a day, thought I was going to die. severe stomach and esshopagas pain and my skin felt like it was on fire. However, after only 2 doses i felt almost well. I think it works, if you can tolerate it. I have switched to Rocephin.
Posts: 30 | From pennsylvania | Registered: Jan 2009
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OptiMisTick
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Member # 399
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One excellent MD gave a Lyme patient with vomitting problems a prescription for CARAFATE SUSPENSION.
The patient had such a problem with vomitting that staying on medication was a problem.
The Carafate Suspension worked miracles - and the patient was able to stay in treatment and make improvement.
Months to years later the patient no longer required the Carafate.
Those who suffer from nauseau due to Lyme and other tickborne diseases or from vomitting due to medication sensitivity and other related gastric problems might want to ask their physician about this since, of course, I am not a doctor.
It could be something that would help.
I do not know whether it would help with Tigecycline, this is unknown ground but it helped this person with Doxycycline sensitivity.
OTM
Posts: 1338 | From Above the Clouds | Registered: Nov 2000
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lpkayak
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i used carafete in the beginning with my ibuprofen
doxy never bothered me
has anyone else tried tigecycline?
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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