But...Bb needs PFK, an enzyme that is "rate limiting for glycolysis".
Insulin activates that enzyme.
So, our body responds by blocking insulin signalling via IL1B:
"Accordingly, IL1B suppressed insulin-induced glucose transport and lipogenesis"
We know that with ongoing high levels of TNF alpha and IL1 B, this will ultimately damage our pancreatic cells (alpha p. cells secrete glucagon and beta p. cells secrete insulin).
So...backing up...
IL1 B is suppressing insulin induced glucose transport...which will impact the amt. of glucose needed by the infected cells.
Glycolysis happens in the cytoplasm of the cell (where Bb is camped out). Oxidative phosphorylation happens in the mitochondria (powerhouses) of our cells.
Glycolysis uses glucose to make just a little ATP. Mitochondria need glucose AND oxygen to make a LOT of ATP.
Bb maybe gobbling up all the glucose so that not enough is left for the mitochondria of our defense cells to work.
And that EXTRAcellular INCREASE in Mg (normally Mg levels outside the cells is not huge), works like insulin would do...triggering the phosphate transfer to tyrosine = tyrosine phosphorylation.
Now when phosphate is added to tyrosine kinase:
"Phosphorylation of src tyrosine kinase (pronounced "sarc") by C-terminal Src kinase (Csk) induces a conformational change in the enzyme, resulting in a fold in the structure, which masks its kinase domain,
and is thus ***shut "off"***.
And:
"tyrosine kinase pathways are critical for cell growth, differentiation and metabolic regulation."
Getting much more complex:
"Tyrosine phosphorylation of type I insulin-like growth factor receptor (IGF-IR) is one of the early responses to potent mitogenic stimuli insulin-like-growth factor 1 (IGF-I).
This receptor binds IGF-I with high affinity to activate cellular proliferation in both normal growth and development and malignant transformation and has tyrosine kinase activity.
The IGF-I receptor plays a critical role in transformation events.
It is highly over expressed in most malignant tissues where it functions as an ***anti-apoptotic*** agent
by enhancing cell survival.
IGF-I signals are mediated via phosphorylation of a family of insulin receptor substrate proteins (IRS), which may serve both complementary and overlapping functions to insulin receptor (IR) in the cell."
There are literally hundreds, if not thousands, of links re: Mg deficiency and insulin resistance.
Here is one:
Magnesium and glucose metabolism In: Therapie (1994 Jan-Feb) 49(1):1-7 (Published in French)
The interrelationships between magnesium and carbohydrate metabolism have regained considerable interest over the last few years.
Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion.
Furthermore, experimental magnesium deficiency reduces the tissues sensitivity to insulin.
Subclinical magnesium deficiency is common in diabetes. It results from both insufficient magnesium intakes and increase magnesium losses, particularly in the urine.
In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance.
Furthermore, it may participate in the pathogenesis of diabetes complications and may contribute to the increased risk of sudden death associated with diabetes.
Some studies suggest that magnesium deficiency may play a role in spontaneous abortion of diabetic women, in fetal malformations and in the pathogenesis of neonatal hypocalcemia of the infants of diabetic mothers.
Administration of magnesium salts to patients with type 2 diabetes tend to reduce insulin resistance.
Long-term studies are needed before recommending systematic magnesium supplementation to type 2 diabetic patients with subclinical magnesium deficiency."
And here is one more:
Mg restores antioxidant parameters and decreases oxidative stress in diabetic...
Antioxidant enzyme activity was also increased significantly with magnesium supplementation in diabetic rats.
Our data clearly demonstrates that alloxanic diabetes is associated with decreased magnesium status and increased oxidative stress and that magnesium supplementation can in part restore the antioxidant parameters and ***decrease the oxidative stress*** in experimental diabetic rats.
PMID: 12735478
Bb is quite capable of dealing with the oxidative stress which is upregulated in an attempt to "oxidize" the lipoproteins in its cell wall. It appears to be robbing the infected cells (our defense cells) of glucose and oxygen which are needed by our mitochondria to make a LOT of ATP. Thus the infected cells can't work sufficiently.
So besides the above:
Mg is needed (along with Ca) to make healthy antibodies (esp. those that respond to Bb's OspB).
Mg is an anti-inflammatory and anti-histamine.
Mg INactivates HMG CoA reductase which shuts down the cholesterol pathway.
Mg is needed to make all our enzymes.
The list goes on.
I believe the "cure" is 2 fold: destroy Bb AND restore the very low levels of intracellular Mg.
From what I have read, the increase in ATP will drive Mg (if available)back into the cell where it will bind with ATP and once again form Mg-ATP.
For the hydrolysis of ATP to happen, Mg is needed.
"ATP occurs usually as a magnesium or a manganese salt.
For its hydrolysis, magnesium ions are necessary.
Whenever it is spoken of ATP-degradation, it is always the hydrolysis of the terminal phosphate group(s) that is meant. The reactions are ***reversible***:
ATP + H2O < > ADP + H3PO4 (= Pi)
or
ATP + H2O < > AMP + pyrophosphate (= PP) ADP + H2O < > AMP + Pi
In other words, it appears Mg is needed to "reduce" ATP -> ADP and
To "make" ATP from ADP.
Hence, Valletta's Patent (Magnesium for Autoimmune) which used Mg pyrophosphate (PPi) and sublingual B6 to cure Cancer, RA and other diseases.
IMO, this mineral is THE most important one for us and our Am. diets are far too low and are skewed to too much Ca. The ratio is off.
Note: newborn's NEVER have diabetes (even if they have the gene to trigger this). Why? I think it has to do with their Mg:Ca ratio.
Obviously newborns need a lot of Ca for their bones to "harden", but initially it appears that Ca maybe low(er) than Mg.
Since infants need to make a LOT of energy to grow, they need a LOT of Mg-ATP to do that.
It would be logical that their levels of intracellular Mg are very high...which is "protective".
[ 05-03-2009, 01:15 PM: Message edited by: Marnie ]
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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losferwrds
Unregistered
posted
I have the Peter Gilliam Calm Mag Supp
Will taking that help?
I sucked in Bio and Orgainic Chem, so alot of what you are posting is over my head.
You research is through but your not giving any info on what Mag suppliment and how much would be best to take to get the results
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I believe Mg levels are so low off the bat (Bb's need for Na is displacing intracellular Mg) that IV doses are really what is needed.
If you look at the Romanian abstract I posted and do the math (figure out the % difference between the first level of Mg and what it was raised to) that looks to be a 33% difference.
In other words, the Romanian doctors gave IV abx
AND
brought the patients Mg level back up by 33%.
That is a LOT.
In a "perfect world" you should be given IV Rx AND immediately followed by IV MgCl for several subsequent days.
It appears the chloride channels are triggered as Bb metabolizes (breaks down) glutamate -> GABA.
GABA A and GABA C = fast inhibition. These are *chloride* channels.
*In high enough* doses, Mg can displace Na and can even displace Zn.
So the key form of Mg looks to be MgCl.
Most of the Mg we take *orally* is not absorbed and the downward spiral continues.
MgCl CAN be purchased over the internet as a liquid (not cheap)and you can dilute some in distilled water and spray it on your skin and rub it in. It will dry and not leave your skin feeling strange. I have done this.
We do absorb things thru our skin.
Will it be "enough"? That is the key question.
Once again...in the "real world" you need several IVs of MgCl on subsequent days
in conjunction with your therapies (abx OR electromagnetic).
We have to destroy the pathogen AND restore the body's electrolyte balance.
P.S. Some persons are concerned about Hg (mercury) suddenly being "released".
Here are some links and possible ways to deal with this very toxic mineral:
***When there (above link)...scroll down to "selenium" - use your edit key to find it.***
(For those who don't know how to do that...once on that website, use your cursor to go way up and to the left of your screen and pull down "edit". At the bottom you will see the word "find on this page". Click on that. You will see a search window appear on the right and in that window, type in the word, selenium. Now it will zoom to the beginning of an abstract that has that word in it (= a summary). Click on "abstract" to read the full abstract/summary.)
BTW...
Apparently Hg impacts our immunoglobulins (IgG1 and IgE - they are increased):
Does this mean our body is USING/retaining Hg as a way to increase our immunoglobulins?
Food for thought.
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seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Marnie, I asked this before. Can you work with any world-class researchers that understand your ideas/research to enhance your suggestions?
There are so many ideas posted here with random thoughts. Who knows. Possibly you could find a cure for Lyme patients with the right help!!
Posting here is great, but 99% of us can't comprehend the final recommendation or deduce what it is supposed to be. One summary w/o tons of scientific stuff saying do this and this and this would be so much more helpful.
It's your free time and we all appreciate everything you do for your sister and the lyme community. I'm trying to think of ways to take it to the next level as I see you spend tons of time thinking about Lyme/co-infections.
For as hard as you work, I truly hope you discover the 'cure' someday. You deserve it!
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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Marnie
Frequent Contributor (5K+ posts)
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posted
Once again...the Romanians FOUND A CURE FOR LYME just a few years ago.
They gave abx. AND restored Mg levels.
Valletta, an Italian doctor cured RA, PLUS invasive bowel cancer, etc. using Mg pyrophosphate (PPi) and sublingual B6 in a matter of MONTHS. His patent is titled: "Magnesium for Autoimmune".
2 phosphates = PPi
Bb is robbing 2 phosphates from serine and transfering them to make glutamic acid (glutamate) which it then metabolizes (breaks down).
So, inside the infected cells, Bb is, for a brief time, increasing glutamate levels.
Since glutamate and acetylcholine look to be released *simultaneously*...
Does this temporary increase in glutamate signal the body to stop releasing it...AND simultaneously stop the release of acetylcholine?
We KNOW Bb's "toxin" (which looks to be its PKC INHIBITOR) prevents the release of acetylcholine.
P = protein K= kinase - phosphate (2 are involved) C = calcium activated.
Bb is PREVENTING a CALCIUM activated transfer of phosphates.
This channel is "open" : TRPM8. That channel is active also in many cancers. It is a Na-Ca channel and Ca is transported OUT.
Bb has a gene to transport Ca OUT.
Bb does not want Ca IN the cell because calcium would help to ACTIVATE PKC (calcium activated protein kinase).
Bb needs Na and NaCl to survive and the sodium is displacing Mg.
Why is this information being "ignored"? Why did I have to dig very deep to find the Romanian abstract? Why is it referred to on Pubmed but the abstract is not available there?
Are we not supposed to know?
Lots of money at stake. Sad, but regretfully true.
A cure for cancer (in a matter of months)...using Mg pyrophosphate and sublingual B6? Yes, it IS possible.
The cure for lyme IS already out there!
The Romanians figured it out. Valletta figured it out. Rifers have figured it out. And now those using infrared (and MgCl) have figured it out.
I'm telling you, this disease and many others CAN be cured.
The cure is already "out there". It is not something I figured out...others have.
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adamm
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posted
But aren't there many Lyme patients who've failed to get well despite massive Mg supplementation?
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Marnie
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IV abx. followed immediately by IV MgCl on several subsequent days?
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seekhelp
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posted
Where can you get this type of treatment in the U.S., if any places, Marnie?
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Marnie
Frequent Contributor (5K+ posts)
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posted
I wish I knew.
We are not "into" using nutrient therapies (IV) as much as we should be
IN CONJUNCTION with abx.
TIMING is an issue. First, abx. (IV) followed by IV MgCl it appears.
Years ago, the "Meyer's cocktail" offerred hope, but it fell by the wayside.
IMO..we shouldn't have to be forced to cross our boarders to get help at our own tremendous expense.
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seekhelp
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posted
Marnie, Meyers IV cocktails are easy to get at holistic medicine centers. I know of 3-4 here in my state. IV Abx are NOT.
What durations were they doing in Romania? IV Abx for how many days? Is this a month long or year long process? How long did a 'cure' take?
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Marnie
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looks to be that to a MD in Canada who just happens to have ties to Romania and she might be able to get more "specifics".
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