I have CFIDS for 10 years. 4/09 Lyme tests: IgM pos. by IGeneX and CDC; IgG pos. by IGeneX with ++++ on 31kDa, but neg. by CDC. IgG was pos. 1:80 for Ehrlichiosis. In 2006, IGeneX test IgM and CDC neg., and IGeneX test IgG pos. but CDC neg. Past "routine" labs(LabCorps) were Lyme neg., and I was told by 3 CFIDS M.D.'s that I didn't have Lyme. For 9 months I have been on hi dose Valtrex for early antigen Epstein-Barr virus. IGeneX states , you can get false pos.on the Lyme IgM test with EBV, but doesn't mention false pos. with IgG or Ehrlichiosis. Anyone know anything about this? Is it worth getting re-tested with IGeneX or another Lab(which one?). Could Valtrex, like antbx have made my Lyme test more pos.? I'd appreciate any input. Thanx. Heartof14k
Posts: 51 | From Boston, Ma. | Registered: May 2009
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
-
heartof14k,
many here have trouble reading large blocks of type. So that you'll get more replies, I'll break up the text:
-------- original post:
Hi All,
I have CFIDS for 10 years. 4/09 Lyme tests: IgM pos. by IGeneX and CDC; IgG pos. by IGeneX with ++++ on 31kDa, but neg. by CDC. IgG was pos. 1:80 for Ehrlichiosis.
In 2006, IGeneX test IgM and CDC neg., and IGeneX test IgG pos. but CDC neg. Past "routine" labs(LabCorps) were Lyme neg., and I was told by 3 CFIDS M.D.'s that I didn't have Lyme.
For 9 months I have been on hi dose Valtrex for early antigen Epstein-Barr virus. IGeneX states , you can get false pos.on the Lyme IgM test with EBV, but doesn't mention false pos. with IgG or Ehrlichiosis.
Anyone know anything about this? Is it worth getting re-tested with IGeneX or another Lab(which one?). Could Valtrex, like antbx have made my Lyme test more pos.? I'd appreciate any input.
posted
Ocean, did you mean "false positive"? Now I'm confused!
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disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
posted
I STRONGLY doubt it's a false positive when you are also positive for Ehrlichiosis. Whenever a co-infection is present, you can suspect pretty strongly that you have Lyme as well.
Of course CFIDS doctors are going to disagree that you have Lyme. Most doctors will disagree to that. Most of them follow IDSA guidelines which are hugely flawed.
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Disturbed makes a good point...if you have the co-infection you likely have lyme too. I've been through the false positive thing because I had mono...
It's good to run the band 31 confirmation, which is not fool-proof, but does make it around 97% clear that you have lyme if it returns positive...
Also the Igenex rep at the time said that only an "acute" mono infection is likely to skew the numbers...
Many feel that high EBV is just another facet of lyme and co's...
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Heart, also....has the Valtrex helped at all?
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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Ocean
Frequent Contributor (1K+ posts)
Member # 3496
posted
Btmb03,
Goodness, yes! Sorry, yes, I meant false positive, thanks for catching it =) I say things like that all the time, my poor husband generally has no idea what I'm talking about, lol!
Lymeorsomething, so you have to have acute mono for the test to be skewed?? I had mono 12 years ago and my EBV in Feb 2009 came back neg for IgM, but positive for IgG.
Please keep us posted as to what the Igenex rep says, I'm definitely interested.
Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Ocean, I'm a bit of a skeptic by nature so I questioned my initial positive wb with Igenex (2 yrs ago) and they, at the time, said only an acute mono infection would cause a false positive. Acute to me means infectious mono (not sure if a chronic EB infection would be included under this umbrella).
Regardless, the band 31 confirmation clears things up somewhat for me. I've been Igm positive on all 3 Igenex tests I've had. Lyme seems to be an issue for me, but I suspect that EBV is also an issue because of the compromised immune system.
Whether or not this viral issue needs treatment is debatable. If lyme treatment fails, I may have to ratchet up viral treatment.
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
I think it is very possible that you could have
both at the same time. Don't look for what to cross
out/rework the test. Let a LLMD do that. In Bb
anything is possible and when our immune systems
are low the crazy syndromes of Lyme is caused by
this influx. I believe once the Bb is addressed
the signs of viral and other bacteria entities
will rear their ugly heads. Ex. shingles, herpes,
parvo,etc. You are a great case to work and
should not have any trouble getting a LLMD.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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