Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
There are a lot of antimicrobials that are possible
cures. Many have unknown properties. Like Indian
Pipe. Yarrow. ETC. Many could be explored with
Lyme. Getting back to our roots so to speak.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Methylene Blue's anti-malarial properties have been known for over 100 years:
quote:MB isn't something brand new. It's been around for ages, used at concentrations way beyond 100nM (~1mg!) in humans ...
Considering ~200mg of MB is used routinely for methylhemoglobinemia, and anywhere from ~733mg (12mg/kg/day) to ~1,500mg (24mg/kg/day) in humans is used to treat malaria with few ill effects
(the minimal dosage needed to see any toxic effect what so ever from MB is estimated around 600mg from the rat toxicological studies)...
The thread is a long discussion on the long term use of MB.
They're discussing using it as an anti-aging agent. I take 200mcg or so every day.
I wonder if using it as an anti-parasite (higher dosage) will work as well.
Lots of interesting info in this thread.
MB is available as a lab chemical or from a fish store, where it's used to fight infections in fish ... and it's pretty cheap.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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posted
isnt that one of the dyes used to stain bacteria in labs?
...interesting.
-------------------- ...trying to be the coffee bean, not the egg. Posts: 420 | From East Coast | Registered: Jun 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Yep, it is the dye that's used to stain bacteria. But when given in the correct dosage Methylene Blue is considered to very safe when taken internally.
Methylene Blue is used in humans to treat the blood disorder, Methemoglobinemia or "smurf syndrome."
Methylene Blue has also been used as a treatment for various infections in humans because of it's anti-fungal, anti-bacterial, anti-viral and and anti-parasital/anti-protozoal propertie
Posts: 1223 | From U.S.A | Registered: Jul 2007
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lightfoot
Frequent Contributor (5K+ posts)
Member # 2536
posted
Thank you all!!!
-------------------- Healing Smiles.....lightfoot Posts: 7228 | From CO | Registered: May 2002
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bettyg
Unregistered
posted
so is anyone using this for PARKINSON'S only ??
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Particularly of note, for those taking antidepressants. It's toxic when taken with SSRIs.
It can also cause something called pseudo-cyanosis.
I would hope that anyone here would do their own research and talk to their physician before deciding to try taking anything they're not completely sure of, so I'm sure that my warning is probably not necessary, but I just felt compelled to share my own preliminary findings.
I like to try to check out things that look interesting, when I can, in case I ever feel I need to try them and happen to be in a bad brain fog or something at that time.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
I'm not saying it's definitely a bad thing, only that I wouldn't throw caution to the wind with it. It may cause problems for SOME people.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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quote:Originally posted by AliG: [QUOTE]Originally posted by ninjaphire: It's not toxic at all.
Particularly of note, for those taking antidepressants. It's toxic when taken with SSRIs.
It can also cause something called pseudo-cyanosis.
I like to try to check out things that look interesting, when I can, in case I ever feel I need to try them and happen to be in a bad brain fog or something at that time.
Well, pseudo-cyanosis is certainly not a risk at the dosages we're talking about (<1mg)
You're right, Methylene Blue is a MAO Inhibitor, and doesn't mix with SSRIs.
btw, Methylene Blue works nicely for brain-fog, but you gotta dilute it first.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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posted
Instructions for diluting MB starting with 2.303% solution for aquariums.
quote: Originally posted by Lufega A 2.303% solution is 2.303 grams MB per 100 ml solution or 23 mg/ml.
There are 20 drops to a ml so each drop will have 1.15 mg MB.
Now, I take 32 drops (=1.6 ml) of this (which equals 36.8 mg MB) and add it to 30 ml water.
This will equal 1.23 mg/ml. This divided by 20 = 0.0613 mg per drop, or 60 micrograms.
You can get a graduated cylinder to measure 30ml from ebay.
So take 1 drop 3x daily, that will maintain a relatively constant concentration of MB.
You can get 3X homepathic pills, but they are of unknown dosage.
If you can get a prescription, a pharmacy might be able to compound 60mcg of Methylene Blue.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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quote:Originally posted by emla999/Lyme: But Methylene Blue should not be taken by anyone who has a deficiency of the enzyme G-6-PD (glucose-6-phosphate-dehydrogenase)
Actually, low dose Methylene Blue (60 mcg) has an anti-oxidant effect rather than the pro-oxidant effect of higher dosages.
So it might be safe after all.
But I am not a Doctor or a Biochemist.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Ninjaphire,
I am glad that you mentioned the 60 mcg dosage of Methylene Blue as being an antioxidant.
And it looks like you may be correct when you say that Methylene Blue may be safe for people to take that have the G6PD enzyme deficiency when it's taking in small dosages.
Posts: 1223 | From U.S.A | Registered: Jul 2007
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quote:The IC50 value for MB inhibition of MAO A was 164�8 nM under this specific condition with 122 nM MAO A. (The activity of MAO A was reduced to 50% at an 164 nM concentration of MB)
In contrast, no inhibition of MAO B was seen in the spectrophotometric assay at 100 nM.
1mg of MB = ~100nM in the human body 60mcg = ~6nM
There should be very little MAO Inhibition at 60 mcg.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Here's an interesting article about the combination of Methylene Blue and Crystal Violet's usefulness in killing blood parasites.
"The two dyes appeared to wipe out any measurable concentration in the laboratory of T. cruzi from the blood samples, Ocariz said.
This means the dyes could prove a low-tech way to eliminate most of the parasites, allowing the body's immune system to fight the disease successfully.
The dyes also removed from blood a number of disease-causing organisms, including viruses and bacteria."Posts: 1223 | From U.S.A | Registered: Jul 2007
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quote:Originally posted by emla999/Lyme: Here's an interesting article about the combination of Methylene Blue and Crystal Violet's usefulness in killing blood parasites.
Here's a study of action against Malaria. This one shows effectiveness at very achievable concentrations (10-20nM).
Hmm. I do notice that I feel drowsy if I take 1mg of Methylene Blue. Perhaps a Herx ?
This is very interesting stuff.
Edit: Bah. Added link.
[ 07-02-2009, 04:05 AM: Message edited by: ninjaphire ]
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
quote: Originally posted by ninjaphire:
Hmm. I do notice that I feel drowsy if I take 1mg of Methylene Blue. Perhaps a Herx ?
Since Methylene Blue has antimicrobial properties I would have to think that it's possible.
Posts: 1223 | From U.S.A | Registered: Jul 2007
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Ninjaphire,
I agree, this stuff is very interesting!!! And it just keeps getting more interesting.
Yama****a M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M.
Department of Molecular Neurobiology, Tokyo Metropolitan Organization for Medical Research, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are major neurodegenerative diseases with TDP-43 pathology.
Here we investigated the effects of Methylene Blue (MB) and dimebon, two compounds that have been reported to be beneficial in phase II clinical trials of Alzheimer's disease, on the formation of TDP-43 aggregates in SH-SY5Y cells.
Following treatment with 0.05 muM MB or 5 muM dimebon, the number of TDP-43 aggregates was reduced by 50% and 45%, respectively. The combined use of MB and dimebon resulted in a 80% reduction in the number. These findings were confirmed by immunoblot analysis.
The results indicate that Methylene Blue (MB) and dimebon may be useful for the treatment of ALS, FTLD-U and other TDP-43 proteinopathies.
Posts: 1223 | From U.S.A | Registered: Jul 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
My goodness...start reading under medicine (uses)malaria, etc.:
emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
So Marnie, do you think that Methylene Blue might be helpful in the treatment of Lyme Disease?
Posts: 1223 | From U.S.A | Registered: Jul 2007
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So Methylene Blue is potentially a good treatment for Lyme too. It certainly gives me increased energy.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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posted
I got it from the aquarium store, simply because it was the quickest and cheapest way to get a hold of it.
Right now, I'm planning to use it indefinitely.
Yeah, something about get a few decades supply for <$10 really appeals to me.
Tropical fish are very sensitive to heavy metals and the liquid is going to be diluted further anyway, so it should be pretty safe.
The 60mcg dose is far too small to cause color changes. Urine color hasn't changed either.
Edit: Darn, I always have to edit my post atleast twice. Not entirely sure what I can blame on Lyme anymore.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Yanivnaced said:
quote: Looks like this stuff might be worth a try for Babesia.
I agree.
Quite often a drug or herb that has antimalarial properties also posses anti-babesia properties. And since Methylene Blue has been clinically proven as to having antimalarial properties I can't help but wonder if Methylene Blue would help with babesia.
Also, I thought this was interesting.
Apparently, Methylene Blue was the first synthetic drug ever used to treat malaria. It was first used as treatment for malaria in the late 1800's. So, Methylene Blue's effectiveness against malaria has been known for over 100 years.
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