LymeNet Flash: Fosmidomycin-clindamycin for Babs?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Fosmidomycin-clindamycin for Babs?

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Topic: Fosmidomycin-clindamycin for Babs?

suki444
Member
Member # 18960

posted

Hi
See the research for the use of this for malaria, however is Fosmidomycin even available?

Has anyone tried it?
Emma

Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria.Borrmann S, Issifou S, Esser G, Adegnika AA, Ramharter M, Matsiegui PB, Oyakhirome S, Mawili-Mboumba DP, Missinou MA, Kun JF, Jomaa H, Kremsner PG.
Medical Research Unit, Albert Schweitzer Hospital, Lambar�n�, Gabon, Germany.

It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action, but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act synergistically with fosmidomycin against Plasmodium falciparum. We conducted a study in pediatric outpatients with P. falciparum malaria in Gabon to evaluate the efficacy and safety of an oral combination of fosmidomycin-clindamycin of 30 mg/kg and 10 mg/kg of body weight, respectively, every 12 h. Patients 7-14 years old were recruited in cohorts of 10. The first 10 patients were treated for 5 days. The duration of treatment was then incrementally shortened in intervals of 1 day if >85% of the patients in a cohort were cured by day 14. All dosing regimens were well tolerated, and no serious adverse events occurred. Asexual parasites and fever rapidly cleared in all patients. Cure ratios of 100% on day 14 were achieved with treatment durations of 5 (10/10 patients), 4 (10/10 patients), 3 (10/10 patients), and 2 days (10/10 patients); 1 day of treatment led to a cure ratio of 50% (5/10 patients). Fosmidomycin-clindamycin is safe and well tolerated, and short-course regimens achieved high efficacy in children with P. falciparum malaria. Fosmidomycin-clindamycin is a promising novel treatment option for malaria.

PMID: 15478056 [PubMed - indexed for MEDLINE]

Posts: 37 | From Whitehead, Northern Ireland | Registered: Feb 2009 | IP: Logged |

Vermont_Lymie
Frequent Contributor (1K+ posts)
Member # 9780

posted

Good find. I have never heard of fosmidomycin before; is it available in the US?

Posts: 2557 | From home | Registered: Aug 2006 | IP: Logged |

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