posted
So what lowers NO in the body?
Posts: 191 | From Ontario | Registered: Feb 2006
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DaisyJane
Unregistered
posted
NO is also an important regulator of many normal (and vital!) biological functions within our bodies including the immune system. Our body's own cells naturally produce and use NO as a metabolite.
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
I would like to see some reports on Rife machines reduceing blood chloride levels. Just how much is removed?
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
-
PV,
Thanks for that link.
Of interest (although I don't how how to interpret this in light of the article above):
From the Townsend Letter for Doctors & Patients - February/March 2006
BIOCHEMISTRY OF LYME DISEASE: BORRELIA BURGDORFERI SPIROCHETE / CYST
by Prof. Robert W. Bradford and Henry W. Allen
EXCERPT:
2/3 of the way down the page:
. . .
Nitrous Oxide (NO), A Potential Lyme Therapeutic Agent
Nitrous oxide (chemical formula NO) is a gas, at one time commonly used as an anesthetic (laughing gas). In more recent times, the biochemical activity of NO has been related to the relaxation of the small muscle fibers in the walls of blood vessels. They serve to either relax or constrict the flow of blood passing through those vessels.
The mechanism of NO bioactivity has also been learned; this involves the substance c-GMP (cyclic guanosine monophosphate).
The amount of c-GMP at any time is regulated by the enzyme, phosphodiesterase type 5 (PDE-5), having the capacity to destroy it. c- GMP fits into a cavity on the surface of PDE-5, the "active site" of this enzyme.
Any other substance capable of being bound by the active site of PDE-5 inhibits the activity of the enzyme by blocking the entry of c-GMP, thus allowing a greater survival of c-GMP.
To summarize, any inhibitor of PDE-5 allows an increase in the amount of available c-GMP and consequent relaxation of blood vessels, permitting a greater flow of blood through those vessels.10
It has been demonstrated that NO is toxic to Borrelia burgdorferi, the causative organism of Lyme disease.11
Therefore, any inhibitor of PDE-5 is a potential therapeutic agent for Lyme disease. Inhibitors of PDE-5 in common use today are the drugs sildenafil (more commonly known as Viagra), Levitra, and Cialis. Whether these drugs act therapeutically against the Lyme spirochete has not been demonstrated clinically and remains unknown. (See Chart 8.)
. . . . ======
A note about this article: there are many fabulous pieces of information in it. However, bismuth (at the time the article was written) was one used by a few doctors. That is no longer the case (at least by IV) as it (or processes involved with it) caused some serious problems for some patients and, sadly, was even fatal in some cases.
Otherwise, this article is very much work reading and studying. And, as always, if something like bismuth has risks, it's good to ask "how else, then?" -
Posts: 48021 | From Tree House | Registered: Jul 2007
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DaisyJane
Unregistered
posted
Nitrous Oxide (laughing gas) is N2O
Nitric Oxide is NO.
Not the same thing.
Words of caution: Anything written by Robert W. Bradford or Henry W. Allen must be viewed with very high skepticism, as well as any information published or promoted through the Townsend Letter.
posted
Well, you can add anything by the CDC regarding lyme diagnosis is to be viewed with high skepticism as well. And the Townsend Letter has some very good info.
That said they are using the wrong chemical formula in that article posted but don't know if that's an editing error or what, or if they are using it as just an abbreviation for Nitrous Oxide which is confusing.
I do know that those from lymeneteurope trash the Townsend Letter though. IMO from what I've read any comments from LNE must be viewed with skepticism as well.
You can add the New England Journal of Medicine to the list too as they have also come under criticism for publishing erroneous information.
Let's just read everything with a grain of salt -- info and how it's presented is subject to change.
Posts: 590 | From Canada | Registered: Oct 2007
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I know hydroxycobalamin (Vitamin B12) in high doses is used as a NO quencher in CFS-treatment.
Posts: 39 | From Denmark | Registered: Mar 2009
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"The addition of NO to cultures of B. burgdorferi prevents growth, suggesting a protective role of NO for the infected host. NO is also a crucial effector in some models of arthritis."
posted
Is the Nitric Oxide (NO)* thing taking us somewhere to effective antibiotics against Lyme?
"Killing of Borrelia burgdorferi by macrophages is dependent on oxygen radicals and nitric oxide (NO) and can be enhanced by antibodies to outer surface proteins of the spirochete."
The above is half way through the following document:
Ref wiki: "whereas chronic expression of NO is associated with various carcinomas and inflammatory conditions including juvenile diabetes, multiple sclerosis, arthritis and ulcerative colitis.
*Nitric oxide should not be confused with nitrous oxide (N2O), a general anaesthetic and greenhouse gas, or with nitrogen dioxide (NO2) which is another air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity.
Despite being a simple molecule, NO is a fundamental player in the fields of neuroscience, physiology, and immunology, and was proclaimed ``Molecule of the Year'' in 1992"
Comments welcome
Posts: 47 | From Yorkshire, UK | Registered: May 2009
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Seems to me that the trick is going to be to achieve NO balance in the body as it is essential for many processes. Too much is bad & too little is bad. They already use NO inhibitors in cases of serious infection.
It will be interesting to see what researchers come up with in regards to antibiotics. Maybe inhibiting NO will only be possible for a short term but then if the antibiotics work more effectively because of this, short term may work.
I think it is going to be a while before they figure this all out and the research is ongoing as scientists say they still have much to learn about NO. -------------------
Here's some of what they have discovered:
In the atmosphere NO is a noxious chemical, but in the body in small controlled doses it is extraordinarily beneficial'.
Nitric oxide, NO, was discovered by in 1774. Pure NO is a colourless gas, acrid and very toxic, used in the bulk production of nitric acid for industry and nitrate fertilizers for agriculture.
It is the simplest stable molecule known to have an odd number of electrons, which contributes to its intense chemical reactivity.
It reacts readily with air or oxygen to form the brown gas nitrogen dioxide NO2 , and it also reacts with metals, one of its aspects which have been much studied by inorganic chemists.
Until recently it had no interest for biochemists or physiologists, except perhaps as a component of the nitrogen oxide mixture (`NO x ') forming part of the atmospheric pollution from petrol engines and adding to the troubles of asthmatics.
Until the later 1980s it was never expected that a molecule that is small, light, gaseous and reactive would have a previously undiscovered and subtle role in physiology: but since then it has been found to be essential in digestion, blood-pressure regulation and antimicrobial defence.
In the body, it is made from an amino acid (arginine) by an enzyme, NO synthase. When released by cells in the wall of blood vessels, it relaxes nearby muscle cells, the vessel dilates and blood pressure falls.
The effect has been used (without understanding its origin) since the discovery in the 1860s that nitroglycerin has a dramatic effect in providing relief to victims of coronary artery narrowing.
However, too much NO, in response to a bacterial infection, causes septic shock, a major cause of death in intensive care wards; from 1992 NO inhibitors have saved such cases. In the body's defence system NO acts as an antitumour agent.
It also combats bacteria, a reminder that nitrates and nitrites that release NO have been used for centuries in curing meat.
In the brain, NO acts as a neurotransmitter, usually desirably, but in stroke cases its release in excess is toxic and can be fatal.
Also in the brain, there is some evidence that it has a key place in learning and memory.
In the digestive system, the relaxation component in peristalsis (the wave-like movement of the gut that propels the food) depends upon NO. Lack of it is the cause of infantile pyloric stenosis, which can be fatal.
The intensive studies on NO by neuroscientists in the 1990s have shown conclusively that in male mammals this is the molecule that converts sexual excitement into potency. The possible clinical use of this knowledge makes the discovery of this sexual neurotransmitter the subject of intensive research.
The `discovery phase' for NO in physiology clearly will run for some years to come.
In 1998, three American pharmacologists, R F Furchgott (1916- ), L Ignarro (1941- ) and F Murad (1936- ) shared a Nobel Prize for their discovery that NO can transmit signals in the cardiovascular system.
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