posted
This is a friend's Igenex Western Blot. He's been diagnosed with ALS (not Lyme). Should he see an LLMD based on these numbers? He's critically perhaps terminally, ill.
IGG all negative except:
31 kDa IND 39 kDa IND 41 kDa +++
IGM results all negative except:
41 kDa + 58 kDa ++
Titer was: 1:80
Igenex rates all of his results as "negative".
(He is not currently seeing a LLMD.)
Posts: 135 | From Orlando, Florida | Registered: Feb 2009
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sutherngrl
Frequent Contributor (1K+ posts)
Member # 16270
posted
I sure would. If you are critically or terminally ill, what do you have to loose!
He has 2 bands positive on IGM, isn't that CDC positive? On my labcorp test I think it is. Obviously this is Igenex.
Also isn't IGM proof of a persistant chronic infection?
I would treat with antibiotics, even if NO bands showed up.
Posts: 4035 | From Mississippi | Registered: Jul 2008
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posted
Thanks, sutherngrl. It actually says on the Igenex test " Igenex test / CDC test: negative "
Posts: 135 | From Orlando, Florida | Registered: Feb 2009
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posted
duplicate post
Posts: 135 | From Orlando, Florida | Registered: Feb 2009
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bettyg
Unregistered
posted
quote:Originally posted by gridmonster:
Thanks, sutherngrl. It actually says on the Igenex test " Igenex test / CDC test: negative "
hi gm,
the CDC TEST NEGATIVE means this:
there were NOT enough protein positive bands to equal the no. CDC REQUIRES to consider you POSITIVE and be COUNTED IN CDC STATISTICS.
they have lyme; they just don't have enough to be counted in national federal lyme positive statistics!! hope this helps...
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Yes he has Lyme AKA Neuroborreliosis. Plus it is common to have co infections hiding also. Sorry it has taken him so long to find. I do hope you two find a great LLMD to treat.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- I hope he can call tomorrow and get in to a LLMD ASAP. I'd say the symptoms and the tests speak very loudly. Be sure he tells the receptionist of his dx and his current state.
In addition to considering lyme and othe tick-borne infection, a good LLMD should also assess for other chronic stealth infections (some of which are described in excerpts below).
Your friend REALLY needs to see this film. REALLY, there is a doctor featured who was dx with ALS, preparing to die. He really had a couple tick-borne infections and got better when treated:
If funds are tight, you might see if someone in your local lyme support group could loan this DVD to you for a few days. I cannot tell you how important it is to see this film, and how empowering.
This fully-loaded DVD is updated with new data and an hour of bonus footage, including interviews with the filmmakers and subjects . . .
CURE UNKNOWN: Inside the Lyme Epidemic (2008) - by Pamela Weintraub
In addition to discussion of lyme politics, this details what an entire family went through. Having this knowledge of their journey will help others to get better, faster treatment.
Motor neuron disease recovery associated with IV ceftriaxone and anti-Babesia therapy
W. T. Harvey, D. Martz
ABSTRACT
This report summarizes what we believe to be the first verifiable case of a significant and progressive motor neuron disease (MND) consistent with amyotrophic lateral sclerosis that resolved during treatment with i.v. ceftriaxone plus oral atovaquone and mefloquine.
The rationale for use of these antibiotics was (i) positive testing for Borrelia burgdorferi and (ii) red blood cell ring forms consistent with Babesia species infection. The patient has continued to be free of MND signs and symptoms for 15 months, although some symptoms consistent with disseminated Borreliosis remain.
========================
Excerpt: `` . . . one year after initiating the antibiotic and anti-protozoal treatment, he was declared to be free of motor neuron disease by his neurologist . . .'' from:
ALS Caused by Lyme Disease with Babesia Co-infection Posted March 15, 2008
After experiencing difficulty speaking during his nightly radio show, Charles McPhee was diagnosed with a bulbar (neck and throat) presentation of ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease, on June 23, 2006.
After researching the possible causes of ALS, Charles decided to treat his ALS with a combination of antibiotics (ceftriaxone, Flagyl, azithromycin) and anti-protozoals (Mepron and Malarone). His rationale for using them is based on a recently documented link between ALS, Lyme Disease, and Babesia.
In a paper published October 22, 2006, Dr. David Martz of Colorado Springs, CO, outlined a harrowing journey through ALS... and back. He was diagnosed in April of 2003, and soon was unable to drive, dress himself, or walk.
Over the next few months his health continued to deteriorate rapidly, and he was forced to retire from his medical practice. Eight months later, while bedridden and confined to a wheelchair, he learned from a friend who sent him a newspaper clipping that it was possible he really had been infected with Lyme disease, an infection commonly carried by ticks.
After 6 negative tests for Lyme (late-stage Lyme is notoriously difficult to detect in the human body), an antibiotic-provoked urinary PCR test in December, 2003, finally showed positive for Borrelia Burgdorferi (Bb), the spirochete bacteria that causes Lyme disease.
During a visual scan of his blood, rings around his red blood cells were also detected, indicating a probable co-infection with Babesia microti, a malaria-like protozoa that is estimated to be transmitted in over 60% of Lyme infections.
Based on this new information, Dr. Martz began using a combination of antibiotics and anti-protozoals to treat his ALS. He noticed dramatic improvement in his symptoms.
Within 12 weeks he was walking again without assistance, and in February, 2005, one year after initiating the antibiotic and anti-protozoal treatment, he was declared to be free of motor neuron disease by his neurologist, Steven A. Smith, M.D. That same month Dr. Martz was fully recovered and once again began treating Chonic Disease sufferers in private practice in Colorado Springs.
---------
(poster's note: He has since moved/retired to devote time to research/writing.)
Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis
Abstract Excerpts:
Background
The long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and granular forms of Treponema pallidum. We investigated whether a similar situation may occur in Lyme neuroborreliosis.
. . .
Conclusion
The results indicate that atypical extra- and intracellular pleomorphic and cystic forms of Borrelia burgdorferi and local neuroinflammation occur in the brain in chronic Lyme neuroborreliosis.
The persistence of these more resistant spirochete forms, and their intracellular location in neurons and glial cells, may explain the long latent stage and persistence of Borrelia infection. The results also suggest that Borrelia burgdorferi may induce cellular dysfunction and apoptosis.
The detection and recognition of atypical, cystic and granular forms in infected tissues is essential for the diagnosis and the treatment as they can occur in the absence of the typical spiral Borrelia form.
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The first article has much attention on both lyme and Cpn:
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