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» LymeNet Flash » Questions and Discussion » Medical Questions » Herxing off of Azithromycin

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Author Topic: Herxing off of Azithromycin
SarBear
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Does anyone know if you can herx off of 250mg twice daily off azithromycin? I took my first dosage today (this will be in addition to IV rocephin which is starting in a few days), and within 2 hours I was so dizzy that I couldn't even stand up without almost passing out. Laying down and even sitting seems to be okay.
Posts: 49 | From Minnesota | Registered: Jul 2009  |  IP: Logged | Report this post to a Moderator
polar blast
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yes it can
Posts: 593 | From long island ny | Registered: Apr 2006  |  IP: Logged | Report this post to a Moderator
Hoosiers51
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Might be a bartonella herx....

Bart reacts quickly to new drugs, and I have gotten vertigo after taking things targeting Bart...like within 30 min to an hour.

Or maybe it is hitting Lyme, or maybe the dizzyness is a drug side effect. But if it "seems" like a herx, it probably is, and my guess would be Bart or Lyme.

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sutherngrl
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My first impression would be a drug side effect. I have a hard time believing you can herx within a couple of hours. But you could most definetely get a drug effect within 2 hours.

A herx is when you kill bacteria and then the toxins from all the dead bacteria is released and then your body starts to react to the toxins. Not sure you are gonna get all that in 2 hours.

I tend to think a herx takes more like a couple of weeks, not hours. But this is just my opinion.

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Hoosiers51
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I have gotten Bart "herxes" within a couple hours.

I don't know if you could use the technical word, Herxheimer, because I'm not sure if the symptoms were from the toxins released from dying Bart (like would dying Bart even produce toxins like bb does?), or if it is moreso that the meds are drawing the Bart out of it's hiding place, etc.

But it was definitely the infection or my immune system responding to the antibiotic in a killing fashion, and it has definitely happened within 2 hours for pharamceuticals for me, or less (30 min to an hour) for some of the powerful herbal tinctures.

With Bactrim DS, I started feeling like I had the flu, hot to the touch, bad headache, crying, within 3 hours. Then it would fade until the next pill, then again I'd get it 2-3 hours after the Bactrim. Then it would fade, and I'd get it again the next pill.

Then after a few days, it stopped doing that to me, and I'd just get a bit of a headache.

THEN, in a couple weeks of taking Bactrim, my brain was drastically more clear.

Then when I stop Bactrim, my brain gets worse within like 4 days.

Bart has a very fast reproductive cycle, so things happen very quickly. Lyme is the opposite.

A lot of people may think they are dealing with classic Bart, but they may really have some kind of BLO.

I know it sounds crazy, reacting so quickly, since we're used to how long it takes with Lyme.....I wouldn't have believed it unless I experienced it.

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DaveNJ
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this is exactly what i have gone through so yes...and it was herxing not a drug reaction...no other abx had this type of effect.


Dave

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Hoosiers51
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Dave, are you talking about Bactrim DS?
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DaveNJ
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no...sorry about that...i meant zith...in fact i tooked bactrim for 2 months and never had a response...switched to zith and withing 24 hours of being on i was a mess...5 days later i was having new symptoms and long lost sypmtoms....3.5 months in i ma pulsing and each time teh response is getting less and less.

i hope that keeps up as i start pulsing tomorrow...

Dave

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On my journey to wellness - One day at a time.

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Hoosiers51
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Zithromax is the other drug that I believe affected my Bartonella (but only when combined with Plaquenil to help it penetrate).

With the Zith, I wasn't a mess 24 hours in (like you mentioned Dave), but within 5 days of adding the Plaquenil to the Zith, I was having new symptoms (phantom itching, pin pricks, muscle spasms) and long-lost symptoms from childhood, when I was first infected with a strange fever following a tickbite. (which we think was Bartonella because the fever appeared while tick was still attached...Lyme takes longer).

The childhood symptoms that came back were neck stiffness, and upper arm aches. I was sitting there, and I kept having flashbacks to being 6, sitting in the daycare center, with my neck hurting. It was WEIRD. Like the pain was triggering visual images of where I was when I used to have that pain.


The strange thing is, that I think perhaps (unless Biaxin and Bicillin are hitting something else) I am even having quick herxes from Biaxin and Bicillin.

When I take Biaxin, my knees hurt within like 4-5 hours. It creeps me out. And I had constant knee pain, just like that, for about a year or so before I "crashed." Then it disappeared on it's own.

And I started getting herx symptoms the day after my first Bicillin shot. Bad headaches, knee pain, elbow pain, extreme irritability/tearfulness.

So I'm not ruling out Lyme herxes can happen quickly either, but that is another topic!!!!

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CD57
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I remember my old LLMD saying he saw a lot of folks get huge die-offs from Bicillin shots, 24 hours after it was done.
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DaveNJ
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i have been on Biaxin for over a year and had my first herx in three weeks and then another at 2 months but nothing noticable until zith was added.

also on Doxy and Bactrim. Bactrim did nothing and Doxy gave me such severe headaches i had to get off.

Dave

ps..i pulse tomorrow...want me to report back? [Smile]

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On my journey to wellness - One day at a time.

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lymers
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I've herxed many times within just a few hours of a med change.

Lymers

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Erica741
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Oh very interesting about zith having such a quick effect!

I took 500 mg zith orally for a over a year. I don't think it ever gave me any reaction, since it was the first abx I took and I took it alone for 10 days before staring my 2nd abx.

I started 500 mg of IV zith about a month ago, and I still get very dizzy and woozy right away, as quickly as 1/4 through the infusion.

But then again I get a similar sensation on my other IV clindamycin...so maybe it is just a sensitivity rather than a herx?

Anway I just thought it was interesting that so many have had this quick reaction to zithromax with similar symptoms...

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