Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
With much help from Wikipedia !
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis.
``AMPK also phosphorylates and ***inactivates 3-hydroxy-3-methylglutaryl-CoA reductase***'' (that is the enzyme that shuts off the cholesterol pathway)
Since we know Bb is following the ''cholesterol pathway'' to build its cell walls, AMPK must be ``off'' (because it inactivates HMG CoA reductase as does Mg) and since AMPK inhibits ACC2, ACC2 thus would be ``on''.
There is another way we can inhibit ACC2.
In the liver, caprylic acid converts to a very specific ketone (beta-Hydroxybutyric acid) that inhibits ACC2 (acetyl-CoA carboxylase).
We need to inhibit ACC2!!!
Acetyl-coenzyme A carboxylase (ACC2), the enzyme responsible for the biosynthesis of malonyl-CoA, a physiological inhibitor of carnitine acyltransferase.
If we inhibit ACC2, no malonyl-CoA can be made which *inhibits* carnitine acyltransferase. So...carnitine acyltransferase is ``on''.
Carnitine O-palmitoyltransferase (also called carnitine palmitoyltransferase or carnitine acyltransferase) is a mitochondrial transferase enzyme involved in the metabolism of palmitoylcarnitine into palmitoyl-CoA.
Palmitoyl CoA is an acyl-CoA thioester used in the biosynthesis of sphingosine
Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are ***lipid signaling***molecules involved in diverse cellular processes.
Sphingosine-1-phosphate (S1P) is a signaling sphingolipid
Originally thought as an intracellular second messenger, it was discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998.
Although S1P is of importance in the entire human body, it is a major regulator of vascular and immune systems.
In addition, it might be relevant in the skin.
In the vascular system, S1P regulates angiogenesis, vascular stability and permeability.
In the immune system, it is now recognized as a major regulator of trafficking of T- and B-cells.
S1P interaction with its receptor S1PR1 is needed for the egress of immune cells from the lymphoiod organs (such as thymus and lymph nodes) into the lymphatic vessels.
Inhibition of S1P receptors was shown to be critical for immunomodulation.
Currently, an experimental compound, FTY720, is undergoing clinical trials to determine if it is useful in controlling the autoimmune reactions in multiple sclerosis.
S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P1 and EDG1 (endothelial differentiation gene 1) is a protein which in humans is encoded by the S1PR1 gene.
S1PR1 encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells.
It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]
S1PR1 has been shown to interact with 5-HT1A receptor,[2] GNAI1[3] and GNAI3.[3]
GNAI3 protein, human EC 3.6.1.46 *GTP-Binding Protein alpha Subunits, Gi-Go.
A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to
inhibit ADENYLATE CYCLASE.
Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
Adenylate cyclase catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate.
IF GTP- binding alpha subunits proteins inhibits adenylate cyclase = ATP is NOT broken down? And this also activates the potassium channels?
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Don't knock VCO...it is REVERSING Alzheimer's Disease.
A DOCTOR, a pediatrician, a woman (yea!) figured out how it might work.
And it IS.
Her husband WAS suffering with AD...and he IS recovering.
Nothing wrong with adding divided dosages of coconut milk to a smoothie!
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
OH I'm not knocking it. The stuff tastes weird. But
I eat it anyway. She will NOT. Need a way to make
it palatable. Ohhh. Smoothie sounds great, but I
would have to slip it in on her. LOL And I am no
med. expert. I just like learning.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
posted
Marnie - a long time ago, a doctor gave me caprylic acid pills to treat candida. I took one and had an enormous die-off. I always thought it was from the yeast situation. From reading this, it could have been a Lyme die-off?
Posts: 13116 | From San Francisco | Registered: May 2006
| IP: Logged |
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Eureka! I believe we have to have the acids to get to the borrelia.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
The key is the right acid/the combination of the right (hydrogen loaded = saturated) medium chain fatty acids = virgin coconut oil.
Bb NEEDS fatty acids...we know this for sure.
But lots of fatty acids
***shuts off fatty acid synthesis.***
We have to go SLOW!!!
Lauric acid (also in VCO) is in mother's milk.
It too is a powerful natural anti-bacterial (and anti-fungal and anti-viral).
I think the combination of the fatty acids in VCO is important (maybe to also hit co-infections simultaneously?) Capyrilic acid does not have all the "features" of lauric acid.
So I would not take "just" caprylic acid.
We all know garlic is good, but what we often try to do is to figure out which nutrient IN garlic is the "active" component, and then give just that.
It doesn't always work.
I think it is because all the nutrients in a "healthy food" work TOGETHER.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Right. Fish oil is a acid, Vitamin E is a acid,
coconut oil is a acid. Acids break down calcium.
Right again. Slow. It may be too hard on the kidneys.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Little mineral + lots of acids -> HYDROGEN.
Many of our cells are hydrogen powered.
pH = potential of hydrogen. Our pH is very closely regulated by our kidney cells which can be damaged by too many acids.
That is why the ORIGINAL Atkins diet was bad (-> kidney failure) and why Johns Hopkins Ketogenic diet can be very dangerous if not monitored closely.
Hydrogen goes right INTO our cells, but Bb maybe exchanging H for Na.
To carry hydrogen ***into the powerhouses of our cells***, we need a helper enzyme, CoQ10.
It takes Mg to MAKE that enzyme (and all others).
But Bb looks to be using Mg (and Ca and Fe and glucose) to build "his" biofilm which protects him from too much oxygen and which "he" uses to chemically "talk" to his buddies = quorum sensing.
Re: "fish oil" (Omega 3s). It is EPA, NOT DHA that is important.
They have DIFFERENT functions!
Yes, EPA can convert to DHA, but it takes several steps.
If you ever have breast cancer and are Rx'd Tamoxifen...
Keep this in mind:
"Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity"
posted
Marnie, thanks so much for all your research. Although I don't understand most of it, I do understand the words...VCO is reversing alzheimers.
That's enough for me. My mother has alzheimers and 4 of her siblings so I'm really scared I will get it. My memory is so bad already from the lyme. It's so embarrassing.
I'm going to get some VCO and try it and see if it helps me or my mom. She is getting steadily worse. I do not want to end up like that. It's a terrible disease.
Thanks again for all you do.
Connie
Posts: 495 | From KY USA | Registered: Dec 2004
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
You are welcome.
The doctor is giving her husband 3 T. of virgin coconut oil - divided doses - per day.
NOTHING ELSE.
It took about 3 months to begin to see the "turn-around"...slowly. He has been tested. He IS improving.
I've read we can substitute 10oz of coconut milk (also split up the dose) per day instead of the oil.
It must go thru the GI system...doesn't work if we try to give the fatty acids IV.
The coconut milk added to a "smoothie"...might make it more palatable?
AD...horrible to watch your loved ones go thru!
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
pamoisondelune
Frequent Contributor (1K+ posts)
Member # 11846
posted
VCO means Virgin Coconut Oil.
----Polly Polygonum
Posts: 1226 | From USA | Registered: May 2007
| IP: Logged |
RZR
Frequent Contributor (1K+ posts)
Member # 20953
posted
quote:Originally posted by Marnie: You are welcome.
The doctor is giving her husband 3 T. of virgin coconut oil - divided doses - per day.
NOTHING ELSE.
It took about 3 months to begin to see the "turn-around"...slowly. He has been tested. He IS improving.
I've read we can substitute 10oz of coconut milk (also split up the dose) per day instead of the oil.
It must go thru the GI system...doesn't work if we try to give the fatty acids IV.
The coconut milk added to a "smoothie"...might make it more palatable?
AD...horrible to watch your loved ones go thru!
Is that 3 tablespoons or teaspoons of coconut oil?
-------------------- Tick bite May 2009 Diagnosed June 2009 Posts: 2329 | From SouthEast | Registered: Jun 2009
| IP: Logged |
seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Capital T means Tablespoon Jennie.
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
| IP: Logged |
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
If you try it I wish to tell you now to start low
and slow like everything else in some lymies. I did
not know this and got a acute reaction to 3 TBS.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic