posted
I almost missed this abstract as I continue to research biofilms. This one looks particularly interesting - but could be dangerous to many Lyme patients. Don't try this combo without discussing it with your doctor; NAC even by itself can create some nasty herxes and perhaps more... ___________________________________
Study Title:
Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces.
Study Abstract:
The aim of this study was to evaluate the effect of ciprofloxacin (CIP), N-acetylcysteine (NAC) alone and in combination on biofilm production and pre-formed mature biofilms on ureteral stent surfaces. Two strains each of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebseilla pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris, recently isolated from patients undergoing ureteral stent removal and shown to be capable of biofilm production, were used in this study. The inhibitory effects of ciprofloxacin, N-acetylcysteine and ciprofloxacin/N-acetylcysteine combination were determined by static adherence assay. Ciprofloxacin (MIC and 2 MIC) and N-acetylcysteine (2 and 4 mg/ml) inhibited biofilm production by > or = 60% in all tested microorganisms.
Disruption of pre-formed biofilms of all tested microorganisms was found to be > or = 78% in the presence of ciprofloxacin (MIC and 2 MIC) and > or = 62% in the presence of N-acetylcysteine (2 and 4 mg/ml), compared to controls.
Ciprofloxacin/N-acetylcysteine showed the highest inhibitory effect on biofilm production (94-100%) and the highest disruptive effect on the pre-formed biofilms (86-100%) in comparison to controls. N-acetylcysteine was found to increase the therapeutic efficacy of ciprofloxacin by degrading the extracellular polysaccharide matrix of biofilms. These data are statistically significant.
The inhibitory effects of ciprofloxacin and N-acetylcysteine on biofilm production were also verified by scanning electron microscope (SEM). In conclusion, Ciprofloxacin/N-acetylcysteine combinations have the highest inhibitory effect on biofilm production and the highest ability to eradicate pre-formed mature biofilms.
Study Information:
El-Feky MA, El-Rehewy MS, Hassan MA, Abolella HA, Abd El-Baky RM, Gad GF. Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces. Pol J Microbiol. 2009 September 58(3):261-7. Microbiology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
-------------------- My biofilm film: www.whyamistillsick.com 2004 Mycoplasma Pneumonia 2006 Positive after 2 years of hell 2006-08 Marshall Protocol. Killed many bug species 2009 - Beating candida, doing better Lahey Clinic in Mass: what a racquet! Posts: 830 | From Mass. | Registered: Aug 2006
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posted
Interesting. Thanks for posting this. I don't think I've experienced herxes from NAC (I've been on 1200 mg 2x/ day for about 8 months per my MD for liver support), but I am taking so many things it's hard to know what causes what reaction at any given time.
Posts: 227 | From South of the North Pole | Registered: Jan 2007
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
That IS a good one, cold. Thanks for sharing it.
Just forwarded it to some docs interested in this stuff.
posted
I posted not long ago and asked about sweating with Milk Thistle. My Milk Thistle has NAC in it. I'm wondering now if it was a herx? I was drenched in sweat and felt pretty bad while on it. Once I stopped it, I felt better.
-------------------- The advice I give, should not be considered medical advice. My opinion comes from years of research and experience. Posts: 233 | From Somewhere | Registered: Sep 2009
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posted
Ok...too weird. My husband just recently added NAC (1200 mgs 2x per day) back into his regimen. Also started Lumbrokinase. This is in addition to IV tigecycline.
He is suffering big time!! Big headache and eyeballs feel like they will pop out---he went to bed a 6:30. Now, I don't know what is causing this. He has felt better on tig until now. Is it just a one month herx from the tig, or the addition of NAC or Lumbrokinase or all three...blahhhh!
Adding too many variables at once is DUMB.
Posts: 554 | From Naples, Italy | Registered: Jun 2006
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posted
"...Adding too many variables at once is DUMB..."
Well said indeed. But it's very typical and very human! Any way, at least you are taking notes and learning...which is so important!
It sounds like you are a great patient advocate. Keep up the good work!
-------------------- My biofilm film: www.whyamistillsick.com 2004 Mycoplasma Pneumonia 2006 Positive after 2 years of hell 2006-08 Marshall Protocol. Killed many bug species 2009 - Beating candida, doing better Lahey Clinic in Mass: what a racquet! Posts: 830 | From Mass. | Registered: Aug 2006
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