Topic: IV Doxycyline. What is a typical dose range used?
springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
For Doxy by IV what has your doctors given for dosages? and how often etc?
Posts: 2747 | From Unites States Of America | Registered: Apr 2009
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joalo
Frequent Contributor (1K+ posts)
Member # 12752
posted
Anyone?
-------------------- Sick since January 1985. Misdiagnosed for 20 years. Tested CDC positive October 2005. Treating since April 2006. Posts: 3228 | From Somewhere west of the Mississippi | Registered: Aug 2007
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posted
I am on 200mg twice a day. 5 days on, 2 days off. Very strong stuff, it hit me hard but it looks like it is working for me.
Posts: 191 | From va | Registered: Sep 2008
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WildCondor
Unregistered
posted
All this info is in the Lyme Disease Treatment Guidelines. Link below.
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Lymie since 2005 Live well, love much, laugh often Posts: 17 | From NJ | Registered: Mar 2008
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
Thanks for the reminder Wild
Here is what i found there
ANTIBIOTICS There are four types of antibiotics in general use for Bb treatment. The TETRACYCLINES, including doxycycline and minocycline, are bacteriostatic unless given in high doses. If high blood levels are not attained, treatment failures in early and late disease are common. However, these high doses can be difficult to tolerate. For example, doxycycline can be very effective but only if adequate blood levels are achieved either by high oral doses (300 to 600 mg daily) or by parenteral administration. Kill kinetics indicate that a large spike in blood and tissue levels is more effective than sustained levels, which is why with doxycycline, oral doses of 200 mg bid is more effective than 100 mg qid. Likewise, this is why IV doses of 400 mg once a day is more effective than any oral regimen.
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
I was thinking .. instead of doing 200mg a day 7 days a week.. 400 mgs a day for 3 days a week would be better.
Just my thoughts and speaking about IV DOxy
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
Also found
*Doxycycline- Requires central line as is caustic. Surprisingly effective, probably because blood levels are higher when given parenterally and single large daily doses optimize kinetics of killing with this drug. Always measure blood levels. Adults: Start at 400 mg q24h and adjust based on levels.
TREATMENT Standard treatment consists of Doxycycline, 200 mg daily for two to four weeks. Higher doses, parenteral therapy, and longer treatment durations may be needed based on the duration and severity of illness, and whether immune defects or extreme age is present. However, there are reports of treatment failure even when higher doses and long duration treatment with doxycycline is given. In such cases, consideration may be given for adding rifampin, 600 mg daily, to the regimen.
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
Can anyone explain the statement that Single Daily Large Doses optimize Kinetics of killing with this drug??
Not sure I understand fully what that means.
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