posted
My neuro (my PCP wanted me to see thinking he was more open minded then most) ordered Amantadine which I started taking 1/2/10.
He told me it would really improve my issues with fatigue/energy, effects Dopamine levels, stronger effects then otc CoQ10. Also should help with cognitive problems.
It didn't really help with that but hand tremors, jaw stiffness and walking (steadier) did improve so I kept taking it.
A couple weeks ago I was at a Lyme support meeting where they had an intergrative doc speaking. I couldn't follow alot of the discussion but did perk up when he mentioned something about how he uses Amantadine at times.
Something about there being some evidence that it somehow exposes intracellular Bb and when it becomes extracellular and then abx more effective against it.
I haven't been on abx since end of Oct. (Zith and Rifampin targeting possible Bartonella). LLMD stopped because I was not tolerating well.
Anyway I feel like I am slowly relapsing and wondering if the Bb is being drawn out and playing around freely now. I question if I should stop it.
I don't have an appt with my LLMD until the end of March. To complicated things I was admitted to hospital a week ago (ambulance to ER) after they found I had a subdural hematoma.
Fortunately the neurosurgeon says it is small enough that I don't need surgery and that it was an old event (a week or two). Makes me kind of nervous since I had no head trauma. I was on Coumadin but my PT/INR's where if anything too low.
Having a very difficult time with what's what...
Thanks for any input!
-------------------- "Courage is the mastery of fear-not the absence of it."-Mark Twain
Still trying hard to be brave...Deb Posts: 82 | From Upstate NY | Registered: Oct 2003
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posted
Studies were done on coxiella burnetti a while back showing a huge increase in bacterial kill rate when either hydroxychloroquine, ammonium chloride or amantadine were added to the culture media. Amantadine was less effective than the others but still showed about a 65% increase in bactericidal activity. It appeared to work by alkalinizing the pH of the intracellular lysosome where the bug was hiding. Borellia in cyst form is thought to be more susceptible to antibiotic effects of macrolides or tetracyclines for the same reason when given with any of the above. My own experience was to use lemon juice fresh squeezed or otherwise to accomplish the same thing (alkalinize lysosomal pH) but that is by the way.
Lemons and Lyme,
Beachinit
Posts: 448 | From Downeast Maine | Registered: Jul 2009
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Thanks Beachinit...I do like lemons. Like I said I am not on any abx right now, so I suppose any of those things are kind of useless unless u r on abx?
-------------------- "Courage is the mastery of fear-not the absence of it."-Mark Twain
Still trying hard to be brave...Deb Posts: 82 | From Upstate NY | Registered: Oct 2003
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I have been taking Amantadine 2xday for several months. Doc says it helps my energy. I would hate to think how I would feel without it! I am too tired for words.
I think it is an antiviral...does that mean it would be useful for XMRV???
I'm not sure if it helps or not. I do know that Bicillin shots have helped my poor speech so I think at least they are working.
-------------------- DOCTOR: "I don't think you are sick." PATIENT: "We are all entitled to our opinions. I don't think you are a doctor." Posts: 697 | From Northern California | Registered: Jul 2009
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"It has been suggested that when Bb is within a cell, it is held within a vacuole and bathed in fluid of low pH, and this acidity may inactivate azithromycin and clarithromycin. Therefore, they are administered concurrently with hydroxychloroquine or amantadine, which raise vacuolar pH, rendering these antibiotics more effective. It is not known whether this same technique will make erythromycin a more effective antibiotic in LB." (I think the LB was a typo and means LD)
Azithromycin- Adults: 500 to 1200 mg/d. Adolescents: 250 to 500 mg/d Add hydroxychloroquine, 200-400 mg/d, or amantadine 100-200 mg/d Cannot be used in pregnancy or in younger children. Overall, poor results when administered orally
Clarithromycin- Adults: 250 to 500 mg q6h plus hydroxychloroquine, 200-400 mg/d, or amantadine 100-200 mg/d. Cannot be used in pregnancy or in younger children. Clinically more effective than azithromycin
[ 02-20-2010, 10:11 PM: Message edited by: hopeful4 ]
Posts: 873 | From WA | Registered: Dec 2005
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MariaA
Frequent Contributor (1K+ posts)
Member # 9128
posted
LB= Lyme borreliosis?
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