posted
On the test it should say CDC positive/negative and IGeneX positive/negative. Does it say Igenex positive by the IgM? I'm thinking two bands that are IgM positive are considered a positive test.
Do you have symptoms? Lyme is a clinical diagnosis. If you have symptoms, I think this test would most likely support a Lyme diagnosis.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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posted
Sorry, I should have mentioned that I do have symptoms.
The results are negative by Igenex and CDC standards.
The difficulty is that I have (very) low pituitary hormones, so I don't know if this is a pituitary problem or Lyme. My brain MRI is neg for pituitary tumor.
Posts: 20 | From Stamford, CT | Registered: Dec 2009
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sutherngrl
Frequent Contributor (1K+ posts)
Member # 16270
posted
On a labcorp WB if you have 2 out of 3 IGM bands it is considered CDC positive.
I think band 30 is very specific.
Posts: 4035 | From Mississippi | Registered: Jul 2008
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posted
The results for both the IgG and IgM? It will say Igenex positive or negative in three or four different places on the results. I would be surprised if band 41 and 30 together was still considered a negative.
With symptoms, a test still only confirms Lyme since it's a clinical diagnosis. My daughter had a weaker positive than you do so we did a trial run of abx to see if she responded and she did.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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30: Possibly a variant of outer surface protein A.
31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).
37: Unknown, but it is in the medical literature that it is a borrelia-associated antibody. Other labs consider it significant.
39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.
45: Heat shock protein. This helps the bacteria survive fever. The only bacteria in the world that does not have heat shock proteins is Treponema pallidum, the cause of syphilis.
58: Heat shock protein.
66: Heat shock protein. This is the second most common borrelia antibody.
73: Heat shock protein.
83: This is the DNA or genetic material of Borrelia burgdorferi. It is the same thing as the 93, based upon the medical literature. But laboratories vary in assigning significance to the 83 versus the 93.
93: The DNA or genetic material of Borrelia burgdorferi.
In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.
These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93.
This is true regardless of whether it is IgG or IgM...
------------------- From his update around 2005---
The significant antibodies, in my opinion, are the 18, 23-25, 28, 30, 31, 34, 39, 58, 66 and 93.----DR C of MO
Regarding the IND on band 39:
Dr C says:
Many would say the " +/-" equivocal ["IND"] bands are not significant. The problem I have with that, is that there are "-" negative bands. The lab has no trouble calling some bands negative. So they must be seeing something when they put "+/-" at some bands.
The only thing that makes sense, is that there is a little bit of that antibody present in your serum. If the "+/-" equivocal is reported on the borrelia associated bands, it is usually significant, in my clinical experience. This is a strong clue that I am on the right track."
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96227 | From Texas | Registered: Feb 2001
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