posted
It's not. If you look carefully, Marnie was talking about anti-depressants, SRIs.
5htp is converted to Serotonin, so you don't want to use it with a Serotonin Reuptake Inhibitor.
Posts: 330 | From Colorado, USA | Registered: Nov 2008
| IP: Logged |
Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- However, if you have any sort of porphyria, tryptophan may not be for you. (5-HTP is a form of that.) There is an explanation of that here:
Topic: NATURAL SLEEP - Links to articles & supplements
=====
Sorry, I just checked that and it's not there. I will have to find it and come back with the link. -
Posts: 48021 | From Tree House | Registered: Jul 2007
| IP: Logged |
Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- As many try 5-HTP for sleep. If that works, fantastic. Your body is likely doing very well with it so continue to enjoy the benefits.
However, if it is a rough ride - at all - don't push it. I tried several times over the years, always with a terrible reaction to even a small dose.
I've know for years that I have two genetic porphyrias - but had been in the dark about 5-HTP. And, it just sounds (on paper) like such a great thing - everything I needed. But my body just could not tolerate it. Then I found out why: ---
Disordered tryptophan can also be a signal to assess porphyria, a deficiency of very specific enzymes made by the liver to help move out a certain classification of toxins that require the Cytochrome P-450 liver detox pathway. Porphyria also involves a disorder in the heme (blood stuff that I can't explain).
** One well-known LLMD estimates that 80% of lyme patients also have a type of porphyria that contributes to their inability(or difficulty) in eliminating toxins - and also trouble metabolizing chemicals and medicines that require the C P-450 set of liver detox pathways.
There are at least 11 kinds of porphyria - Some genetic and quiet until an acute attack that can even be life-threatening; some more chronic, acquired through toxic infections such as lyme or by chemical exposure that damages the liver.
Porphyria attacks with a sudden spike in porphyrin level - or even a lower but chronic level of elevated porphyrins in the body - can cause all the symptoms of lyme (and all the symptoms of a lyme herx).
It can be difficult sorting all this out but that is why liver support is so very essential for all lyme patients - as well as avoiding substances that require or push the C P-450 pathway. Tryptophan is one to avoid. That includes 5-HTP.
Science 2 December 1983:_Vol. 222. no. 4627, pp. 1031-1033 DOI: 10.1126/science.6648517
Science, Vol 222, Issue 4627, 1031-1033 Copyright � 1983 by American Association for the Advancement of Science
L-tryptophan: a common denominator of biochemical and neurological events of acute hepatic porphyria?
DA Litman and MA Correia
Excerpt:
These findings suggest that increased tryptophan and 5-hydroxytryptamine in the nervous system may be responsible for the neurologic dysfunctions observed in humans with acute attacks of hepatic porphyria.
Biochem Pharmacol. 2008 Feb 1;75(3):704-12. Epub 2007 Oct 2.
Hepatic alteration of tryptophan metabolism in an acute porphyria model Its relation with gluconeogenic blockage.
Lelli SM, Mazzetti MB, San Mart�n de Viale LC.
Laboratorio de Disturbios Metab�licos por Xenobi�ticos, Salud Humana y Medio Ambiente (DIMXSA), Departamento de Qu�mica Biol�gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Aut�noma de Buenos Aires, Argentina.
Excerpt:
This study focuses on the alterations suffered by the serotoninergic and kinurenergic routes of tryptophan (TRP) metabolism in liver, and their relation with gluconeogenic phosphoenolpyruvate-carboxykinase (PEPCK) blockage in experimental acute porphyria.
==================================
J Assoc Physicians India. 2002 Mar;50:443-5.
Respiratory failure in acute intermittent porphyria.
Tyagi A, Chawla R, Sethi AK, Bhattacharya A.
Department of Anaesthesiology, UCMS and GTB Hospital, Shahdara, Delhi.
We report two patients of acute intermittent porphyria (AIP) who presented with acute respiratory failure.
Only one such previous report could be found. Occasionally, neuropathy may be the presenting feature in AIP which may progress to respiratory embarrassment.
The cause of this neuropathy has been hypothesized to be direct neurotoxicity of delta-ALA by interaction with GABA receptor, altered tryptophan metabolism and may be heme depletion in nerve cells.
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic