posted
I am on it and over the years have stayed in touch with a few members here that went into recovery. Many including friends of mine could not tolerate benicar and had to stop it. I was going into recovery on it right about the time I had to make a major move where all the sudden I was exposed to way too much sun last year. I wouldn't do it without working with a Dr. that is very familiar with it. I should mention that I'm one of those that when I get a lot of sun at the beach or a cruise I crash and start sleeping so Vita D effects me in a negative way. Many on here feel better with supplementint with Vita D. So everyone is different. It's like all other treatments what works for one might not work for others.
Posts: 805 | From Utopia | Registered: Feb 2006
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- There are many threads in the archives. You can search here for both MP and "Marshall Protocol" -
posted
Hey thanks for the help. I am going to need it. I've been sick for a very long time. Inflammation level is at 67.43. Barely functioning at this time. I think after tons of research by me and my husband I am going to give it a shot. I have had lymes for over 20 years. My vit D level is just about non-existent even though I take 5000 mg per week. We will be using only parts of the mp. Hope everybody is feeling great soon!
-------------------- lymetwist Posts: 7 | From Virginia | Registered: Apr 2010
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
EPA converts to resolvin E1 and EPA converts to DHA which converts to resolvin D2 which prevents neutrophils from sticking to the walls of blood vessels and
initiating an *inflammation response*.
Source: "Fish oil is no snake oil" (Discover Magazine March, 2010 pg. 14)
I've been trying hard to tell you. Gotta get EPA and DHA levels UP (EPA especially).
A deficiency of Vitamin B3, B6, vitamin C, Zn and Mg may inhibit our ability to make EPA and DHA from ALA.
I believe (and correct me if I am wrong), he is sick (autoimmune) and began to research for a cure. Commendable!
Benicar in very high doses can be very dangerous. He was/is trying to hit the pathogen from a high blood pressure/inhibit angiotensin II standpoint. (Inflammation messes with blood flow.)
Lyme disease is in a class/group called "H16" = vascular disease.
Bb looks to locate in the basement membranes which are very very close to all our blood vessels.
See a picture here (click on it to make it bigger):
The function of increased 1-hydroxylase in sarcoidosis is uncertain, but our findings raised the possibility that 1,25-(OH)2 D3 might provide a compensatory mechanism to
inhibit the inflammatory process,
suppressing the activated helper T cell proliferation and cytokine production in sarcoid granulomas.
The body does very strange things to prolong our lives!
VDR = vitamin D receptor
RXRa = retinoid X receptor alpha = RXR-alpha. The receptor works with the gene (protein) RXRA and it mediates the working of retinoids - chemically related to vitamin A.
"1.25 (OH)2 D3-bound VDR enhances heterodimerization with RXRα, resulting in increased VDR activity [38].
The variable response of PPARγ and VDR to RXRα ligand binding is consistent with the idea that RXRα heterodimerization may serve as a dynamic switch in the ``decision'' to undergo adipogenesis or osteogenesis."
I'm going to simply say...what to do with calcium..where to use it?
(Calcium plays a key role in body weight regulation and especially on fat metabolism, but it is also needed to make bones which are being "remodeled" all the time.)
I vote for bones. I don't want to activate PKC (calcium activated phosphate transfer) 'cause if I do... someday I may have to use a PKC inhibitor - tamoxifen which blocks Cl channels, inhibits MMPs, etc. but which can cause liver problems.
Regulation of hepatic GSH levels by RXRalpha is essential to protect hepatocytes from *oxidative stress*.
PMID: 14978233
How important is PPARy?
Very.
Taken together, our results suggest that activation of PPARγ may represent a novel approach for the treatment of ***pancreatic cancer*** by increasing PTEN levels and inhibiting PI3K activity.
Our T cells come from B cells which originate in the Bone marrow.
Our T cells become infected in lyme.
Now...one of the worse cancers is called multiple myeloma (bone cancer). One of the effects is tremendous bone loss. Osteoclasts are "on". OsteoBlasts, build bone.
"Bone destruction in multiple myeloma results from increased osteoclast formation and activity that occur in close proximity to myeloma cells.
However, histomorphometric studies have demonstrated that MM patients with osteolytic bone lesions have
lower numbers of osteoblasts and decreased bone formation.
(Me...that maybe a protective feature, albeit a bad one! The reasoning follows.)
*Osteoblasts secret IL-6* in coculture systems with MM cells,20,58 contributing to the high IL-6 levels present in the bone marrow microenvironment that *support MM cell growth*.
In addition, osteoblastic cells may stimulate MM survival by blocking TRAIL-mediated apoptosis of MM cells.
So if the body is reducing osteoblasts = less MM survival. The body is trying to find a way to stop the cancer cells from surviving.
But there has to be a better way to block B cells (which can and do convert to T cells):
Eicosapentaenoic acid inhibits growth and induces apoptosis of human multiple myeloma cells
Eicosapentaenoic acid inhibits voltage-gated ***sodium channels*** and invasiveness in prostate cancer cells.
PMID: 19154441
Oddly - because our defense cells "present" CB2 receptors for our mAB CB2 antibody to Bb's OspB to lock onto:
"Chemopreventive dietary omega-3 fatty acids inhibit colonic PKCbetaII activity in vivo and block PKCbetaII-mediated hyperproliferation, enhanced carcinogenesis, and repression of TGFbetaRII expression in the colonic epithelium of transgenic PKCbetaII mice.
These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCbetaII signaling and restoration of TGF-beta responsiveness.
PMID: 12058013
I suspect Bb's PKC inhibitor IS PKCB2...which we then try to upregulate.
Sorta looks like we need to inhibit both CB1 and CB2. 2AC is the ligand (binder). It comes from a few nutrients, one of which comes from Omega 6 fatty acids.
The balance between the Omega 6 fatty acids and the Omega 3 fatty acids is off...way off because of what Bb depletes/triggers to be depleted.
Cannabinoid (CB2) receptor *deficiency* reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis (cell death).
At the outset of lyme, Mg levels drop very fast and significantly...this is both good and bad:
Therefore, magnesium deficiency has profound *immunosuppressive capabilities* in mice by significantly reducing the number of antibody synthesizing cells and serum immunoglobulin concentrations.
PMID: 1093189
Plasmapheresis...removes antibodies and in some diseases = a cure. Unique approach!
But...when Mg levels drop, this damages our antibodies which NEED Mg (and Ca) to be made.
"Characterization of the physiological requirements for the bactericidal effects of a monoclonal antibody to OspB of Borrelia burgdorferi by confocal microscopy.
The bactericidal effect of Fab-CB2 is not dependent on the induction of spirochetal proteases but is dependent on the presence of Ca2+ and Mg2+.
Supplementation of Ca2(+)- and Mg2(+)-free medium with these cations
restored the bactericidal effects of Fab-CB2.
The mechanism by which a Fab fragment of an antibody destroys a bacterium directly may represent a novel form of antibody-organism interaction.
In Romania, doctors restored deficient Mg levels AND gave (IV) abx.to cure a few early onset lyme patients. Mg is an anti-inflammatory and anti-histamine (important if and when IgE kicks in). It also inhibits HMG CoA reductase and this is what "statin" drugs do too.
Bb follows the "cholesterol pathway" to build "his" cell walls.
Okay, but then we are still left with cell wall deficient pathogens and we then have to finish the job (osmotic pressure changes/ultrasound).
Receptors on defense cells that are triggered:
2-arachidonoylglycerol = 2-AG
"2-AG then activates presynaptic CB1 receptors, which reduces glutamate releases and tempers excitotoxicity.
(But Bb follows the anaerobic glycolysis route -> lactate and glutamate is needed to clear lactate.)
2-AG will also activate CB1 receptors expressed by blood vessels, which will *decrease cerebral blood flow* and reduce edema expansion.
Finally, 2-AG will activate CB2 receptors expressed by microglial cells and invading immune cells, which
inhibits their ability to release cytotoxic agents.
CB1 = inflammation = ROS which oxidize LDL. CB2 inhibits the above.
Some people think we need to tame down CB1 and "help out" CB2 receptors.
Yes...for sure, we MUST get inflammation down!
TM, our liver cannot process caprylic acid (in our foods) -> BHB -> ATP in the presence of TNFa and IL6.
Our liver takes a huge hit immediately when all the inflammation happens.
BHB (ketone) crosses the BBB and it "helps" the nutrient deficient cells by supplying extra nutrients that go into the citric acid cycle. Citrates inactivate PFK.
Research the "medicinal food" called Axona - see the active ingredient.
Let's get inflammation down and help out our defense cells to rid Bb...slowly!
Ketones...but a very specific one. Caprylic acid is a known anti-bacterial, anti-viral, and anti-fungal.
Bb is not the only pathogen to benefit from a "wrong response". Bb NEEDS inflammation to happen. We help "pave the way".
It appears H1N1(virus) NEEDS "histamine" to kick in.
Ticky little bugs!
TM is a computer guru. He has massive computer systems to pluck from the internet new information regarding his disease and other "autoimmune" diseases.
We are both trying to figure out how to stop horrific diseases, but we don't always agree about everything (neither do the "experts"), but it appears we BOTH agree reducing inflammation is very very important.
Learning is brain exercise. Please keep trying to learn as much as you can. It is very important we excercise our mind and our body.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
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